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Citalopram increases the differentiation efficacy of bone marrow mesenchymal stem cells into neuronal-like cells

Neural Regeneration Research 2014年第8期9卷 845-850页

作者： Javad Verdi Seyed Abdolreza Mortazavi-Tabatabaei Shiva Sharif Hadi Verdi alireza shoae-hassani Department of Applied Cell Sciences School of Advanced Technologies in MedicineTehran University of Medical Sciences Department of Stem Cells and Tissue Engineering Research Center for Science and Technology in MedicineTehran University of Medical Sciences Department of Tissue Engineering School of Advanced Technologies in MedicineIran University of Medical Sciences

Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.

关键词： nerve regeneration citalopram stem cells bone marrow mesenchymal stem cells survival proliferation differentiation neurons neural regeneration

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The role of the fiber ply configurations on the biomechanics of the hip prosthesis

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International Journal of Modeling, Simulation, and Scientific Computing 2022年第3期13卷 149-160页

作者： Kamran hassani Mohammad Nikkhoo alireza Karimi Department of Biomedical Engineering Science and Research Branch Islamic Azad University TehranIran Department of Ophthalmology and Visual Sciences University of Alabama at Birmingham Birmingham ALUSA

The total hip replacement is the only approved procedure for restoring a degenerated hip joint through *** life span of a prosthesis could depend on the geometry and material properties of the *** study aims to analyze the biomechanics of the carbon/polyetheretherketone(PEEK)composite prosthesis having three different fiber ply configurations compared to traditional stainless steel(SS)*** implant-bone system was established and subjected to a load from the head of the femur and abductor muscle *** stresses and strains in the implant-bone systems were calculated and *** results revealed lower stresses and strains in composite prostheses compared to SS *** fiber ply orientation of the carbon/PEEK composite prosthesis is shown to be a key asset in stress and strain distribution of the 13 implant-bone *** fiber plies which orientated multidirectionally with−45 and+45 degrees exhibited uniform stress and strain *** results suggested the advantage of using composite prostheses in implant designs as they not only invoke lower stresses and strains in the implant-bone system but also amplify the life span of implants in the body.

关键词： Prosthesis hip joint composite stress strain finite element

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A numerical analysis on different-generation prototypes of ventricular assist device

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International Journal of Modeling, Simulation, and Scientific Computing 2019年第5期10卷 34-42页

作者： Ali Tavakoli Golpaygani Kamran hassani alireza Karimi Amin Nokhbe Zaeim Department of Biomedical Engineering Standard Research Institute KarajIran Department of Biomechanics Science and Research Branch Islamic Azad UniversityTehranIran Department of Mechanical Engineering Kyushu University 744 MotookaNishi-kuFukuoka 819-0395Japan

The ventricular assist device(VAD)assists the patients with heart diseases for limited and prolonged *** device synchronizes with normal heart activities to help foster its ***,its sensitive design requires high *** pumps are the essential part of every VAD which should operate in wide ranges of flow and *** there are various types of VAD under different designs,it is neither practical nor plausible to experimentally/clinically investigate their ***,in the concurrent study,a numerical study was carried out on four different generation prototypes of VAD pumps for reaching an optimum *** computational fluid dynamics(CFD)method,the software derived,showed and streamlined the flow field shear stress both inside the VAD and its ***,the vortices and flow rate-pressure curves were *** results showed that the curved blade pumps operate better compared to that of the straight blade types,concerning the provision of enough pressure and less damage to the red blood *** results have implications not only for comparing different types of VAD designs but also for understanding the resulted shear stresses and pressures as a result of the blade’s structure.

关键词： Pump generation CFD ventricular assist device numerical simulation ventricular blade

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应用波前像差引导的LASEK治疗近视散光和低、高度近视(英文)

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国际眼科杂志 2015年第2期15卷 192-197页

作者： Seyed Javad Hashemian Abbas Sheikh-hassani alireza Foroutan Mohammd Jafar Ghempanah Mohammad Ebrahim Jafari Mahsa Sadat Hashemian Shadrokh Nabili 伊朗医科大学 Rassoul Akram医院眼科研究中心伊朗德黑兰*** 伊朗医科大学药学院伊朗德黑兰*** Morecambe Bay NHS信托会大学医院英国兰开斯特肯德尔LA1 4RP

目的：对比在矫正低度近视,近视散光和高度近视时应用波前像差引导的激光上皮瓣下角膜磨镶术（LASEK）的安全性,有效性,可预测性,稳定性和并发症。方法：该回顾性分析共纳入416眼,分为3组,低度近视组159眼,等值球镜-3.68±1.33D;近视散... 详细信息

目的：对比在矫正低度近视,近视散光和高度近视时应用波前像差引导的激光上皮瓣下角膜磨镶术（LASEK）的安全性,有效性,可预测性,稳定性和并发症。方法：该回顾性分析共纳入416眼,分为3组,低度近视组159眼,等值球镜-3.68±1.33D;近视散光组161眼,等值球镜-5.99±2.24D,柱镜度2.41±1.07D;高度近视组96眼,等值球镜-7.41±0.80D.制瓣后,进行波前像差为基础的准分子激光削切术。在术后10d,2,6和12mo后评估其安全性,有效性,可预测性和稳定性。结果：术后12mo,低度近视组等值球镜-0.36±0.31D,近视散光组0.15±0.41D,高度近视组0.58±0.68D。低度近视组中,裸眼视力为20/20的患者占90.60%,近视散光组78.90%,高度近视组67%。疗效指标在三组中分别为0.98,1.04和0.92.安全性指标分别为1.00,1.07和1.05。低度近视组有5眼（3.1%）最佳矫正视力提升1行,近视散光组有44眼（27.3%）提升1~3行,高度近视组18眼（19.2%）提升1~2行。低度近视组只有2例产生角膜雾状混浊。在疗效和安全性方面三组比较均无统计学差异。结论：波前像差引导的激光上皮瓣下角膜磨镶术是治疗低度近视,近视散光和高度近视的一种有效安全的方法,而在治疗近视散光时其可预测性、有效性和安全性更佳。

关键词：波前像差引导激光上皮瓣下角膜磨镶术近视散光激光视力矫正

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Recent advances in biopolymer-based hemostatic materials

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Regenerative Biomaterials 2022年第1期9卷 1080-1105页

作者： Marvin Mecwan Jinghang Li Natashya Falcone Menekse Ermis Emily Torres Ramon Morales alireza hassani Reihaneh Haghniaz Kalpana Mandal Saurabh Sharma Surjendu Maity Fatemeh Zehtabi Behnam Zamanian Rondinelli Herculano Mohsen Akbari Johnson V.John Ali Khademhosseini Terasaki Institute for Biomedical Innovation Los AngelesCA 90064USA Department of Molecular and Cell Biology University of CaliforniaBerkeleyCA 94720USA Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Bioengineering&Biomaterials Group School of Pharmaceutical SciencesSao Paulo State University(UNESP)AraraquaraSP 14800-903Brazil Department of Mechanical Engineering University of VictoriaVictoriaBC V8P 5C2Canada Biotechnology Center Silesian University of TechnologyGliwice 44-100Poland

Hemorrhage is the leading cause of trauma-related deaths,in hospital and prehospital *** is a complex mechanism that involves a cascade of clotting factors and proteins that result in the formation of a strong *** certain surgical and emergency situations,hemostatic agents are needed to achieve faster blood coagulation to prevent the patient from experiencing a severe hemorrhagic ***,it is critical to consider appropriate materials and designs for hemostatic *** materials have been fabricated as hemostatic agents,including synthetic and naturally derived *** to synthetic polymers,natural polymers or biopolymers,which include polysaccharides and polypeptides,have greater biocompatibility,biodegradability and ***,in this review,we focus on biopolymer-based hemostatic agents of different forms,such as powder,particles,sponges and ***,we discuss biopolymer-based hemostatic materials currently in clinical trials and offer insight into next-generation hemostats for clinical translation.

关键词： hemostasis coagulation polysaccharides polypeptides biomaterials

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