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Aquaculture and Fisheries 2019年第5期4卷 214-218页

作者： Joaquim da Rocha soares Neto Felipe de Azevedo silva Ribeiro Alex Augusto Gonçalves Maurício Gustavo Coelho Emerenciano Universidade Federal Rural do Semi-Árido(UFERSA) Departamento de Ciência AnimalSetor de AquiculturaMossoró59625-900Brazil UFERSA Departamento de Ciência AnimalLaboratório de Tecnologia e Controle de Qualidade do PescadoMossoró59625-900Brazil Universidade do Estado de Santa Catarina(UDESC) Laboratório de Aquicultura(LAQ)88790-000LagunaSCBrazil and Programa de Pós-Graduação em Zootecnia(PPGZOO/UDESC)Chapecó89815-630Brazil

The aim of this study was to evaluate the growth performance of Litopenaeus vannamei juveniles reared under biofloc and clear-water conditions fed with different inclusion levels of tilapia processing waste silage(TPWS)*** experiment was performed in two individual systems:biofloc(BS)and clear-water systems(CWS).The trial used forty 40 L rectangular plastic bins(twenty per system)in a density of 63 shrimp/m^(2).The juveniles were distributed in a factorial completely randomized experimental *** treatments were based on the percentage of silage inclusion(control or 0,1.5%,3.0%,4.5%and 6.0%of inclusion)in BS or CWS,totalizing ten treatments and four *** was above 80%in all treatments and was not affected by both systems and *** final weight and SGR were statistically influenced by system(P<0.05)but not by the diet;and presented high values in *** inclusion of TPWS in *** diets did not affect shrimp *** addition,shrimp raised in BS demonstrated better growth performance as compared to CWS.

关键词： Silage Nutrition Waste BFT Pacific white shrimp

Pain during Arteriovenous Fistula Cannulation in Chronic Renal Patients on Hemodialysis

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Open Journal of Nursing 2016年第12期6卷 1028-1037页

作者： Olvani Martins da silva Eluani Rigon Jéssica Vanessa Corradi Dalazen aline Bissoloti Eneida Rejane Rabelo-silva Graduate Programa at Federal University of Rio Grande do Sul Porto Alegre RS Brazil Santa Catarina State University Chapecó SC Brazil West Renal Clinic Chapecó SC Brazil

This study aimed to evaluate pain intensity in chronic renal patients under hemodialysis during the arteriovenous fistula cannulation. It was a cross-sectional study conducted in a hemodialysis clinic in the second semester of 2014. 70 individuals participated in the research and were assessed by the visual analogue scale. The project was approved with opinion number 453.508-2013. During cannulation, the pain reported was moderate in 58.5% of patients, intense in 30% and mild in 11.5%. There was no association between the occurrence of pain in relation to gender, shift and time of hemodialysis. The study points out to the need for pre-cannulation analgesia to improve comfort during the procedure.

关键词： Pain Arteriovenous Fistula Renal Dialysis

Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus

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Animal Models and Experimental Medicine 2020年第4期3卷 304-315页

作者： Giorgio silva-Santana Juliet Cunha Bax Débora Cristina silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa silva aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi Health Sciences Center Institute of Microbiology Paulo de GóesFederal University of Rio de JaneiroRio de JaneiroRJBrazil Laboratory of Diphtheria and Corynebacteria of Clinical Relevance Faculty of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil The Collaborating Centre for Reference and Research on Diphtheria/National Health Foundation/Ministry of Health Rio de JaneiroRJBrazil Laboratory of Clinical Research and Molecular Diagnostic Prof.Marcílio Dias do Nascimento Department of Clinical Practice and PathologyFluminense Federal UniversityNiteróiRJBrazil Laboratory Bacterial Vaccines Department of ImmunologyNational Institute for Quality Control in HealthOswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Science and Technology in Biomodels Oswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Biology Federal Fluminense UniversityNiteróiRJBrazil Biomedical Center College of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil

Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental *** lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific *** study seeks to establish reference values for hematological and biochemical parameters of four lineages of ***:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 *** were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical ***:Results are shown as means and standard deviation,grouped by lineage and *** the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual ***:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model.

关键词： B6D2F1 BALB/c biochemical C57BL/6 hematological Swiss

Terpenes extracted from marine sponges with antioxidant activity:a systematic review

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Natural Products and Bioprospecting 2023年第1期13卷 516-527页

作者： Cintia Cristina Santi Martignago Beatriz soares-silva Julia Risso Parisi Lais Caroline Souza e silva Renata Neves Granito Alessandra Mussi Ribeiro Ana Cláudia Muniz Renno Lorena Ramos Freitas de Sousa Anna Caroline Campos Aguiar Departamento de Biociências Universidade Federal de São Paulo(UNIFESP)Rua Silva Jardim 136Edifício CentralSantosSP 11015-020Brazil Institute of Chemistry Federal University of Catalão(UFCAT)Av.Dr.Lamartine Pinto de Avelar1120 Vila ChaudCatalãoGO 75704-020Brazil

Marine biodiversity has emerged as a very promising resource of bioactive compounds and secondary metabolites from different sea *** sponge’s secondary metabolites demonstrated various bioactivities and potential pharmacological *** systematic review of the literature focuses on the advances achieved in the antioxidant potential of marine sponges in *** review was performed in accordance with PRISMA *** main inclusion criterion for analysis was articles with identification of compounds from terpene classes that demonstrate antioxidant activity in *** in three different databases,two hundred articles were *** screening abstracts,titles and evaluating for eligibility of manuscripts 14 articles were *** most performed analyzes to detect antioxidant activity were scavenging activity 2,2-diphenyl-1-picrylhydrazyl(DPPH)and measurement of intracellular reactive oxygen species(ROS).It was possible to identify 17 compounds of the terpene class with pronounced antioxidant activity in *** evidence of the studies included in this review was accessed by the GRADE *** play an important ecological role,moreover these molecules have a pharmaceutical and industrial application.

关键词： Antioxidant Marine drugs Sponge Free radical

Impacts of land use and land cover changes on hydrological processes and sediment yield determined using the SWAT model

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International Journal of Sediment Research 2022年第1期37卷 54-69页

作者： Edivaldo Afonso de Oliveira Serr?o Madson Tavares silva Thomás Rocha Ferreira Lorena Concei??o Paiva de Ataide Cleber Assis dos Santos aline Maria Meiguins de Lima Vicente de Paulo Rodrigues da silva Francisco de Assis Salviano de Sousa Denis José Cardoso Gomes Academic Unit of Atmospheric Sciences Federal University of Campina Grande Department of Physics Center for Natural and Exact Sciences Federal University of Santa Maria Institute of Technology Civil Engineering Graduate Program Federal University of Pará Earth System Science Center National Institute of Space Research Institute of Geosciences Federal University of Pará

Land use and land cover (LULC) changes strongly affect local hydrology and sediment *** current study focused on a basin in the Brazilian Amazon and had the following three objectives:(1) to perform an effective diagnosis of flow and sediment yield,(2) to evaluate the impacts of LULC changes over the last 40 years on the hydro-sedimentological variables,and (3) to investigate the impacts of the possible trends or breaking points in the flow,surface runoff,and sediment yield *** Soil and Water Assessment Tool (SWAT) model validation showed that the simulated results were consistent with the data measured in the dynamic reproduction of flow ***,changes in LULC altered surface runoff,sediment yield,and flow according to the Mann-Kendall and Pettitt non-parametric *** was also observed that the sub-basins in which pastureland is predominant are more susceptible to increased surface runoff and sediment *** to trend and homogeneity tests,these sub-basins had break points in the time series of these *** the other hand,in the sub-basins whose land cover is predominantly forest,the time series is homogeneous and *** current study highlighted the impacts that 40 years of LULC changes in an Amazonian basin had on hydro-sedimentological variables,which,in turn,can play an important role in changing the hydrological cycle,consequently these changes can also impact diverse human activities in the region,such as agribusiness,livestock,energy production,food security,and public water ***,it is concluded that the SWAT model is a good estimator of hydro-sedimentological processes in Amazonian basins and can be used by decision makers in the management of water and environmental resources.

关键词： Hydrological modeling Sediment yield Amazon basin SWAT model

Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease

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World Journal of Gastroenterology 2007年第7期13卷 1067-1073页

作者： Andre Castro lyra Milena Botelho Pereira soares luiz Flavio Maia da silva Marcos Fraga Fortes André Goyanna Pinheiro silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra Hos-pital Sao Rafael Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundacao Oswaldo Cruz Salvador Bahia Brazil BGStats Consulting Graz Austria

AIM： To evaluate the safety and feasibility of bone marrow cell （BMC） transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS： Ten patients （eight males） with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 mL of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS： The median age of the patients was 52 years （range 24-70 years）. All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 （2.19 ± 0.9） and 4 mo （2.10 ± 1.0） after cell transplantation that baseline levels （238 ± 1.2）. Albumin levels 4 mo after BMC infusion （3.73 ± 0.5） were higher than baseline levels （3.47 ± 0.5）. International normalized ratio （INR） decreased from 1.48 （SD = 0.23） to 1.43 （SD = 0.23） one month after cell transplantation. CONCLUSION： BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease.

关键词： Bone marrow Cell transplantation Liverfailure Stem cell Cirrhosis

Inherited Fanconi syndrome

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World Journal of Pediatrics 2023年第7期19卷 619-634页

作者： Anna Luiza Braga Albuquerque Rafael dos Santos Borges Ana Flavia Conegundes Erika Emmylaine dos Santos Frederico Moreira Man Fu Clara Tavares Araujo Pedro Alves soares Vaz de Castrol Ana Cristina Simoes e silva Interdisciplinary Laboratory of Medical Investigation Unit of Pediatric NephrologyFaculty of MedicineFederal University of Minas Gerais(UFMG)Belo HorizonteBrazil Department of Pediatrics Faculty of MedicineUFMGAlfredo Balena Avenue1902Nd FloorRoom#281Belo HorizonteMG 30130-100Brazil

Background Fanconi-Debré-de Toni syndrome(also known as Fanconi renotubular syndrome,or FRST)profoundly increased the understanding of the functions of the proximal convoluted tubule(PCT)and provided important insights into the pathophysiology of several kidney diseases and drug *** sources We searched Pubmed and Scopus databases to find relevant articles about *** review article focuses on the physiology of the PCT,as well as on the physiopathology of FRST in children,its diagnosis,and *** FRST encompasses a wide variety of inherited and acquired PCT alterations that lead to impairment of PCT *** children,FRST often presents as a secondary feature of systemic disorders that impair energy supply,such as Lowe's syndrome,Dent's disease,cystinosis,hereditary fructose intolerance,galactosemia,tyrosinemia,Alport syndrome,and Wilson's *** rare,congenital causes of FRST greatly impact the morbidity and mortality of patients and impose diagnostic ***,its treatment is diverse and considers the ability of the clinician to identify the correct etiology of the *** The early diagnosis and treatment of pediatric patients with FRST improve the prognosis and the quality of life.

关键词： Cystinosis Fanconi syndrome Fanconi renotubular syndrome Fanconi-Debre-de Toni syndrome Proximal tubule Renal tubular transport-Rickets

Visible Losses to the Mechanical Harvesting of Ratoon Sugarcane Using the Harvester John Deere 3520

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American Journal of Analytical Chemistry 2018年第11期9卷 580-590页

作者： Carmen Maria Coimbra Manhaes Francisco Mauricio Alves Francelino Rafael Alves de Araujo Danilo Gomes de Oliveira Helenilson de Oliveira Francelino Mirian Peixoto soares da silva aline da silva Santos Mauricio Donato de Moura Junior Federal Institute of Education Science and Technology of Tocantins—FTOPalmasBrazil State University of North Fluminense Rio de JaneiroBrazil

The aim of this study was to evaluate the visible loss of sugar cane and the damage to the knuckles, using the John Deere 3520 harvester on three different travel speeds (3.0;4.0 and 5.0 km·h-1), in DIC with five repetitions in Campos dos Goytacazes, Rio de Janeiro/Brazil. Each treatment was composed by six lines of harvested cane stumps, with a length of 290 m each. In these six lines, the remains of sugar cane left in the field were collected by placing the sampling frame in two central lines every 50 m, and separating 40 m of edge. The sampling area was surrounded by 2 m wide and 10 m long, totaling 20 m2. To calculate the damage to stumps, a visual methodology by [1], was used, which classifies the damage grade, ranging from 1 to 4. Fifty stumps were assessed randomly for each speed, in a sampling area of 1800 m2. The data were submitted to ANOVA and Tukey test at 5%, in order to compare the effect of different speeds on the losses and damages. There was no significant difference regarding the loss or damage by comparing the different speeds. Therefore, it is more advantageous to use the speed of 5.0 km·h-1, harvesting more in less time and causing the same level of damage.

关键词： Damages Saccharum spp. Travel Speed John Deere 3520 Harvester

Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

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Acta Pharmaceutica Sinica B 2014年第5期4卷 358-367页

作者： aline Augusti Boligon Robson Borba de Freitas Thiele Faccim de Brum Emily Pansera Waczuk Cláudia Vargas Klimaczewski Daiana silva deÁvila Margareth Linde Athayde Liliane de Freitas Bauermann Department of Industrial Pharmacy Center of Health SciencesFederal University of Santa MariaSanta Maria 97105-900RSBrazil Department of Physiology and Pharmacology Center of Health SciencesFederal University of Santa MariaSanta Maria 97105-900RSBrazil Department of Biochemistry Federal University of PampaUruguaiana 97500-970RSBrazil

Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric *** buxifolia,commonly known as coronilha,has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic *** this study,the preventive effects of the crude extract of Scutia buxifolia(ceSb)against gastric ulcer induced by 70%ethanol were evaluated in male Wistar *** addition,the composition of ceSb was clarified by high-performance liquid chromato-graphy(HPLC).*** extract(100,200 and 400 mg/kg body weight)attenuated oxidative and histopathological features induced by ***,all evaluated doses of ceSb caused significant(P<0.001 and P<0.0001)and dose-dependent increase in sulfhydryl groups(NPSH)levels,catalase(CAT)and superoxide dismutase(SOD)***,the administration of ceSb reversed the increase in lipid peroxidation produced by *** protective effect of the extract could be attributed to antioxidant compounds present in the ceSb,such as flavonoids and phenolic acids,which were quantified by ***,an antioxidant effect of the extract leads to a protection on gastric *** results indicate that *** could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury.

关键词： Scutia buxifolia Antioxidant Gastric ulcer HPLC

Increased basal plasma brain-derived neurotrophic factor levels in sprint runners

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Neuroscience Bulletin 2011年第5期27卷 325-329页

作者： Paulo Roberto Correia Fulvio Alexandre Scorza Sérgio Gomes da silva aline Pansani Michelle Toscano-silva Antonio Carlos de Almeida Ricardo Mario Arida 圣保罗联邦大学生理学系圣保罗联邦大学神经内外科系 So Joo del-Rei联邦大学实验与计算神经生物学实验室

Objective Exercise is known to enhance circulating brain-derived neurotrophic factor （BDNF） levels in healthy humans. BDNF changes have been measured in endurance but not in strength exercise. The present study aimed to investigate whether anaerobic activity such as sprinting differentially alters basal plasma BDNF concentration. Methods Brazilian sprinters （100 m） at either the international （Olympics and Outdoor World Championships）（n = 14） or the domestic level （n = 8）, and sedentary subjects （n = 15）, were recruited. Plasma BDNF concentrations were analyzed by enzyme-linked immunosorbent assay. Results The basal plasma BDNF concentrations were significantly higher in the international and the domestic sprinters than in the sedentary subjects. In addition, sprinters at the international level had higher plasma BDNF concentrations than those at the domestic level. Conclusion Our findings suggest that increased basal plasma BDNF level is related to enhanced exercise performance.

关键词： brain-derived neurotrophic factor physical exercise sprint plasma brain human