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Association of donor hepatectomy time with liver transplantation outcomes: A multicenter retrospective study

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World Journal of Transplantation 2024年第1期14卷 130-140页

作者： Geisiane Custodio Andrew Maykon Massutti aline Caramori Taynara Gonçalves Pereira Augusto Dalazen Gabriela Scheidt Ludmilla Thomazini Cristiane Bauermann Leitão Tatiana Helena Rech Department of Intensive Care Unit Hospital Santa IsabelBlumenau-Santa Catarina CEP-89010906Brazil Transplant Division Hospital Santa IsabelBlumenau-Santa Catarina CEP-89010906Brazil School of Medicine Universidade Regional de Blumenau(FURB)Blumenau-Santa Catarina CEP-89010906Brazil School of Medicine Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Brazil Departement of Endocrinology Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Department of Internal Medicine Hospital de Clínicas de Porto AlegreDivision of Intensive Care MedicinePorto Alegre 90035-903Brazil

BACKGROUND Prolonged donor hepatectomy time may be implicated in early and late complications of liver *** To evaluate the impact of donor hepatectomy time on outcomes of liver transplant recipients,mainly early allograft *** This multicenter retrospective study included brain-dead donors and adult liver graft ***-recipient matching was obtained through a crossover *** and laboratory data were recorded for both donors and *** hepatectomy,cold ischemia,and warm ischemia times were *** outcome was early allograft *** outcomes included need for retransplantation,length of intensive care unit and hospital stay,and patient and graft survival at 12 *** From January 2019 to December 2021,a total of 243 patients underwent a liver transplant from a brain-dead *** these,57(25%)developed early allograft *** median donor hepatectomy time was 29(23–40)*** with early allograft dysfunction had a median hepatectomy time of 25(22–38)min,whereas those without it had a median time of 30(24–40)min(P=0.126).CONCLUSION Donor hepatectomy time was not associated with early allograft dysfunction,graft survival,or patient survival following liver transplantation.

关键词： Brain death Hepatectomy Liver transplantation Early allograft dysfunction Graft survival

Treatment of Vulvovaginal Candidiasis with A Strategy Based on Phototherapy (M.A.C.^® Scar Acceleration Method)

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Modern Research in Inflammation 2024年第1期13卷 1-7页

作者： Marcus Vinicius de Mello Pinto Karin Yuri Fernández Iturra aline Ronis Sampaio María Elena Silva Álvarez Esteban Fortuny Celulare Institute Petrópolis Brazil Bienus Clinic Santiago Chile Fisiocare Curicó Chile Universidad Finis Terrae Santiago Chile

Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The MAC® Methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (Methylene blue 1% + Clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (MAC®). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.

关键词： Treatment of vulvovaginal Candidiasis Candidiasis Candida M.A.C. MAC®

Prevalence and Factors Associated with Anemia among People Living with Human Immunodeficiency Virus Followed at the Outpatient Treatment Centre of Panzi General Referral Hospital in Eastern Democratic Republic of Congo

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Journal of Biosciences and Medicines 2024年第3期12卷 259-274页

作者： Marlene Abedi Zalufa Jean-Paulin Mbo Mukonkole aline Byabene Kusinza Nicolas Vignier Dieudonné Bihehe Masemo David Willy Shamputi Omari Mukanga Lampard Marie Hatem Department of Internal Medicine Panzi General Referral Hospital Bukavu Democratic Republic of Congo Evangelical University in Africa Bukavu Democratic Republic of Congo Statistics Department Panzi General Referral Hospital Bukavu Democratic Republic of Congo International Centre for The Advanced Research and Training-ICART Panzi Foundation Bukavu Democratic Republic of Congo Faculty of Medicine University of Kisangani Kisangani Democratic Republic of Congo Service des Maladies Infectieuses et Tropicales CHU Avicenne Bobigny France Sorbonne University Paris France School of Public Health Department of Social and Preventive Medicine Université de Montréal Montréal Canada

Introduction: Anemia in people living with human immunodeficiency virus (PLHIV) is a major health problem. Although anemia often responds to combination antiretroviral therapy, many patients remain anemic despite treatment, and such persistent anemia continues to adversely affect prognosis, regardless of drug response. Scientists have identified some of the factors involved. However, the mechanisms put in place have not been effective in overcoming them. Examples include the withdrawal of zidovudine from antiretroviral treatment lines, iron and folate supplementation, etc. Anemia is still a major concern in HIV-positive patients. The aim of this study is to assess the prevalence of anemia and its associated factors among PLHIV followed up at the outpatient treatment centre (CTA) of the Panzi General Reference Hospital (HGR) in South Kivu, Democratic Republic of Congo (DRC). Method: We conducted a cross-sectional, comparative study of 276 HIV-infected adults on antiretroviral therapy (ART) followed up at the CTA of Panzi HGR. Socio-demographic and nutritional parameters were collected using a survey questionnaire, and clinical assessment and nutritional status were performed at the centre. Hemoglobin, seric albumin and viral load determinations were performed at the HGRP laboratory. We constructed univariate and multivariate logistic regression models to assess factors associated with anemia in people living with HIV/AIDS. Results: We found a prevalence of anemia of 39.4%, including 4.1% severe anemia, 17.7% moderate anemia and 17.5% mild anemia. After multivariate adjustment, the factors associated with anemia in our PLHIV were: moderate undernutrition (aOR = 1.26;95% CI: 1.50 - 4.20;p = 0.001), severe undernutrition (aOR = 115.4;95% CI: 2.04 - 164.52;p = 0.021), hypoalbuminemia (aOR = 2.11;95% CI: 1.87 - 5.10;p = 0.004) and the lower degree of dietary diversity (aOR = 1.56;95% CI: 1.10 - 4.32;p = 0.034). Conclusion: The prevalence of anemia in PLHIV on ART is high.

关键词： Anemia HIV/AIDS Undernutrition PANZI Hospital

Correlation between Intestinal Health and Coccidiosis Prevalence in Broilers during Different Seasons of the Year in Brazil from 2012 to 2018

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Food and Nutrition Sciences 2024年第3期15卷 179-198页

作者： Fabio Luis Gazoni Gabriela Miotto Galli Marcel Manente Boiago Lenita Moura Stefani aline Zampar Marco A. Juárez-Estrada Guillermo Tellez-Isaias Aleksandro S. da Silva Animal Health and Reproduction Veterinary Medicine Graduate Program Federal University of Santa Maria (UFSM) Santa Maria Brazil Animal Science Graduate Program Federal University of Rio Grande do Sul (UFRGS) Porto Alegre Brazil Animal Science Graduate Program Santa Catarina State University (UDESC) Chapecó Brazil Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autonoma de Mexico Ciudad Universitaria Ciudad de Mexico Mexico Department of Poultry Science Division of Agriculture University of Arkansas Fayetteville AR USA

Coccidiosis is a disease caused by intracellular protozoan parasites, specifically belonging to the genus Eimeria. These parasites target the gastrointestinal tract in different types of hosts, causing sores in the intestinal lining. The presence of these lesions reduces the animal’s ability to digest and absorb nutrients, significantly impacting their overall performance. The current study aimed to explore the potential correlation between seasonal variations and the incidence of Eimeria spp-induced lesions in broiler chickens’ gastrointestinal tracts in Brazil from 2012 to 2018. A total of 8,607 broiler chickens, aged 14 to 42 days, were sampled from 103 poultry integrated companies in Brazil to conduct intestinal health examinations. The sampling process involved selecting 3 to 6 chickens from each poultry house for examination. The assessment included various abnormalities such as shedding of intestinal cells and excessive fluid and mucus presence, thickening and tension of the intestines, food movement, roughened mucosal surface resembling a Turkish towel in the small intestine, tissue death, duodenal inflammation, intestinal inflammation, gizzard erosion, presence of worms and bedding material, and ingestion of mealworms. During the seasons, winter exhibited the highest average occurrence of Eimeria maxima microorganisms at 52.83%, with E. acervulina following closely at 26.42% in second place. In spring, E. maxima had an occurrence of 11.31%, while in fall, E. tenella had the lowest occurrence at 6.74%. When analyzing the seasonal occurrence of Eimeria, it was observed that E. maxima micro was more common during winter compared to summer (P = 0.0491). However, no discernible variation was observed in the occurrence of the remaining species across different seasons. Research findings suggest that subclinical coccidiosis is most prevalent during the winter season in Brazil. Likewise, clinical disease caused by E. acervulina is also prevalent during this time. I

关键词： Eimeria Epidemiology Intestinal Pathology Broiler Chickens Brazil

Aims and First Assessments of the French Hydrogen Pathways Project HyFrance3

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Journal of Energy and Power Engineering 2012年第1期6卷 34-40页

作者： Alain Le Duigou Marie-Marguerite Quemere Pierre Marion Philippe Menanteau Pascal Houel LaureSinegre Lionel Nadau aline rastetter Aude Cuni Philippe Mulard Loic Antoine Thierry Alleau I-Tese CEA Gif-Sur-Yvette Cedex 91191 France Departement EPI-ECUELLES EDF R＆D Moret Sur Loing Cedex 77818 France IFP Energies nouvelles 1 et 4 avenue de Bois Preau Rueil Malmaison Cedex 92852 France LEPII Universit# de Grenoble - CNRS Grenoble Cedex 9 BP 47 38040 France DRI GDF SUEZ 361 av du pdt WILSON Saint Denis La Plaine Cedex BP 33 93211 France ALPHEA EURODEV CENTER 4 rue Jules Verne Eurozone Forbach 57600 France AIR LIQUIDE 1 chemin de la porte des loges Jouy-en-Josas BP 126 78354 France TOTAL RAFFINAGE MARKETING La Defense 10 Paris la Defense Cedex 92069 France ADEME 20 avenue du Gresille Angers Cedex 01 BP 90406 49004 France AFH2 28 rue Saint Dominique Paris 75007 France

The HyFrance Group was originally formed in France to support the European project HyWays, by providing (former projects HyFrance1 and HyFrance2) the French data and possible hydrogen pathways according to national specificities. HyFrance3 is a new project that focuses on the economic competitiveness of different steps of the hydrogen chain, from the production to end usage, at the time horizon of 2030 in France. The project is coordinated by CEA with the other partners being: ADEME (co-funding), AFH2, CNRS, IFP, Air Liquide, EdF, GdF Suez, TOTAL, ALPHEA. The project is divided into 4 sub-projects, that address present and future French hydrogen industrial markets for chemical & refinery uses, the analysis of the interplay between wind energy production and storage of hydrogen for different automotive requirements (refuelling stations, BtL plants, H2/NG mix), massive hydrogen storage to balance various offer and demand characteristics, and the supply network (pipeline option competitiveness vs. trucked in supply) to distribute hydrogen in a French region for automotive applications. Technical and economical issues, as well as GHG emissions, are addressed.

关键词：法国氢链温室气体排放量评估经济竞争力时间跨度合作伙伴科学研究

减少营养损失和提高生长猪可持续性的饲养策略

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国外畜牧学（猪与禽） 2024年第2期44卷 1-11页

作者：孙丹彤(译) 王祎汀(校) 张配配(复校) 孟祥光(制图表) Candido Pomar Ines Andretta aline Remus 不详

多年来,利用营养物质养猪的效率有所提高。给猪饲喂能够满足其估算营养需要的饲料可以提高营养物质的利用率,利用率的提高相当于增加养猪生产的经济收益,同时最大限度地改善环境的影响。撰写本文的目的是回顾不同的日粮配伍法对动物营... 详细信息

多年来,利用营养物质养猪的效率有所提高。给猪饲喂能够满足其估算营养需要的饲料可以提高营养物质的利用率,利用率的提高相当于增加养猪生产的经济收益,同时最大限度地改善环境的影响。撰写本文的目的是回顾不同的日粮配伍法对动物营养物质利用率的影响,这些方法能向畜禽提供能够满足其所需营养水平的日粮,同时又能最大限度地减少营养物质的排泄量和温室气体的排放量。调整日粮配方来降低日粮中粗蛋白含量,可帮助畜禽最大限度利用日粮中氮和能量。减少动物生产碳足迹的重要技术是使用养殖场所在地的饲料原料和非人类食用产品(如菜籽粕),并在日粮中添加合成氨基酸。精准的饲喂和营养供给不仅可以通过每天定制畜禽所需的日粮,最大限度地提高动物对营养物质的利用率,还可以降低饲料成本,并提高日粮中氮的利用率。我们利用数学模型研究了减少日粮中粗蛋白水平对氮和能量利用率的影响。与不添加合成氨基酸的对照日粮相比,使用粗蛋白含量减少8%的试验日粮,可使氮利用率提高54%,同时使饲料成本降低11%。由于减少了由蛋白质脱氨基作用引发的能量损失,日粮中粗蛋白含量的同步减少意味着可利用能量有了较大的提高。与对照日粮相比,猪饲喂低蛋白日粮后,通过尿液和后肠发酵引发的能量损失降低了24%。与群体(group phase)饲喂相比,精准的饲喂和营养供给可以使畜禽减少30%的氮排泄量。用低蛋白日粮和精准饲喂技术可使养猪绩效具有相加性,产生61%的氮利用率。猪营养需要量的估算方法还有改进的空间。提高不同个体之间存在营养利用差异的认识,有助于进一步改善养猪生产对环境的影响。

关键词：低蛋白日粮可持续养猪生产精准饲喂精准营养营养物质利用营养物质利用率

Renin-angiotensin system in the central nervous system:focus on Huntington’s disease

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Neural Regeneration Research 2023年第10期18卷 2206-2207页

作者： aline Silva de Miranda Antonio Lucio Teixeira Laboratório de Neurobiologia Departamento de MorfologiaInstituto de Ciências BiológicasUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteMGBrasil Laboratório Interdisciplinar de Investigação Médica(LIIM) Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteMGBrasil Neuropsychiatry Program Department of Psychiatry and Behavioral SciencesMcGovern Medical SchoolUniversity of Texas Health Science Center at HoustonTXUSA Faculdade Santa Casa BH Belo HorizonteMGBrasil

The renin-angiotensin system(RAS)was originally conceived as a circulating hormonal system involved in the regulation of cardiovascular and renal *** the discovery of local RAS components in diverse organs,including t... 详细信息

关键词： Huntington organs angiotensin

Full-fat insect meals in ruminant nutrition:in vitro rumen fermentation characteristics and lipid biohydrogenation

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1102-1117页

作者： Manuela Renna Mauro Coppa Carola Lussiana aline Le Morvan Laura Gasco Gaelle Maxin Department of Veterinary Sciences University of TurinLargo P.Braccini 210095 GrugliascoTOItaly Independent Researcher Universite Clermont AuvergneINRAEVetAgro SupUMR 1213 HerbivoresSaint‑Genes‑ChampanelleFrance Department of Agricultural Forest and Food SciencesUniversity of TurinLargo P.Braccini 210095 GrugliascoTOItaly Universite Clermont Auvergne INRAEVetAgro SupUMR 1213 HerbivoresSaint‑Genes‑ChampanelleFrance.

Background:The most used protein sources in ruminant nutrition are considered as having negative impacts in terms of environmental sustainability and competition with human ***,the investigation of alternative and sustainable feedstuffs is becoming a priority in ruminant production ***:This trial was designed to evaluate eight full-fat insect meals(Acheta domesticus–ACD;Alphitobius diaperinus–ALD;Blatta lateralis–BL;Gryllus bimaculatus–GB;Grylloides sygillatus–GS;Hermetia illucens–HI;Musca domestica–MD;and Tenebrio molitor–TM)as potential protein and lipid sources in ruminant *** parameters and fatty acids(FA)of rumen digesta after 24-h in vitro ruminal incubation of the tested insect meals were measured and compared with those of three plant-based meals(soybean meal,rapeseed meal and sunflower meal)and fishmeal(FM).Similarly to FM,the insect meals led to a significantly lower total gas production(on average,1.75vs.4.64 mmol/g dry matter-DM),methane production(on average,0.33 vs.0.91 mmol/g DM),volatile FA production(on average,4.12 vs.7.53 mmol/g DM),and in vitro organic matter disappearance(on average,0.32 vs.0.59 g/g)than those observed for the plant *** insect meals also led to lower ammonia of rumen fluid,when expressed as a proportion of total N(on average,0.74 vs.0.52 for the plant and insect meals,respectively),which could be an advantage provided that intestinal digestibility is *** in ruminal fermentation parameters between the insect meals could be partially explained by their chitin,crude protein and ether extract contents,as well as by their FA *** particular,high content of polyunsaturated FA,or C12:0(in HI),seems to partially inhibit the ruminal ***:The tested full-fat insect meals appear to be potentially an interesting protein and lipid source for ruminants,alternative to the less sustainable and commonly used ones of plant *** FA profile of the rum

关键词： Ammonia Fatty acids In vitro digestibility Methane Nutritive value

MUTYH-associated polyposis: Is it time to change upper gastrointestinal surveillance? A single-center case series and a literature overview

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1891-1899页

作者： Lupe Sanchez-Mete Lorenzo Mosciatti Marco Casadio Luigi Vittori aline Martayan Vittoria Stigliano Gastroenterology and Digestive Endoscopy Regina Elena National Cancer InstituteIRCCSRome 00144Italy Department of Radiological Oncological and Pathological SciencesRegina Elena National Cancer InstituteIRCCSRome 00144Italy

BACKGROUND The presence of Spigelman stage(SS)IV duodenal polyposis is considered the most significant risk factor for duodenal cancer in patients with MUTYH-associated polyposis(MAP).However,advanced SS disease is rarely reported in MAP patients,and no clear recommendations on small bowel(SB)surveillance have been proposed in this patient *** To research more because that case reports of duodenal cancers in MAP suggest that they may develop in the absence of advanced benign SS disease and often involve the distal portion of the *** We describe a series of MAP patients followed up at the Regina Elena National Cancer Institute of Rome(Italy).A literature overview on previously reported SB cancers in MAP is also *** We identified two(6%)SB adenocarcinomas with no previous history of duodenal *** observations,supported by literature evidence,suggest that the formula for staging duodenal polyposis and predicting risk factors for distal duodenum and jejunal cancer may need to be adjusted to take this into account rather than focusing solely on the presence or absence of SS IV *** Tip:Case reports of duodenal cancers in MUTYH-associated polyposis suggest that they may develop in the absence of advanced Spigelman stage(SS)benign disease and often involve the distal portion of the *** our case series,we identified two(6%)small-bowel adenocarcinomas with no previous history of duodenal *** observations,supported by literature evidence,suggest that the formula for staging duodenal polyposis and predicting risk factors for distal duodenum and jejunal cancer should be adjusted to take into consideration the presence of SS IV disease,rather than focusing only on this *** of invasive adenocarcinoma.

关键词： MUTYH-associated polyposis Duodenal adenomatosis Duodenal cancer Endoscopic management Case report