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Open Journal of Endocrine and Metabolic Diseases 2015年第7期5卷 88-97页

作者： aline marcadenti Department of Nutrition Universidade Federal de Ciências da Saúde de Porto Alegre (UFSCPA) Porto AlegreBrazil Postgraduate Studies Program in Cardiology Instituto de Cardiologia/Fundacao Universitária de Cardiologia do Rio Grande do Sul (IC/FUC) Porto Alegre Brazil

Hypertension (HTN) is the risk factor that most contributes to mortality rates in the world, followed by physical inactivity and obesity. Despite the influence of genetic factors on the genesis of HTN, blood pressure levels are strongly influenced by environmental factors such as physical inactivity and overweight, characterizing it as a polygenic disease. Genetic components and environmental factors such as physical exercise may modulate the phenotype of individuals predisposed to medical conditions such as HTN, independently of modifiable factors such as increased levels of adiposity;however, studies have shown that polymorphic forms detected in genes involved in the mechanisms of blood pressure regulation and also related to body fat modulation may interact with physical activity levels and HTN. The aim of this article is to review the interactions between polymorphisms in ADRB2, ADRB3, BDKRB2 and MTNR1B genes, physical activity and blood pressure.

关键词： Receptors Adrenergic Beta-2 Receptor Bradykinin B Obesity Hypertension

Effects of Coconut Oil on Human Health

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Open Journal of Endocrine and Metabolic Diseases 2015年第7期5卷 84-87页

作者： Laura Boemeke aline marcadenti Fernanda Michielin Busnello Catarina Bertaso Andreatta Gottschall Postgraduate Studies Program in Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre (UFSCPA) Porto Alegre Brazil Department of Nutrition Universidade Federal de Ciências da Saúde de Porto Alegre (UFSCPA) Porto Alegre Brazil Postgraduate Studies Program in Cardiology Instituto de Cardiologia/Fundacao Universitária de Cardiologia do Rio Grande do Sul (IC/FUC) Porto Alegre Brazil

Coconut oil (CO) has generated discussions about its possible effects on health, especially for being an oil rich in saturated fat, which is known to contribute to the development of atherosclerosis and cardiovascular diseases. On the other hand, CO contains high levels of lauric acid that is directly absorbed by enterocytes and may prevent the fat deposition in blood vessels. In addition, flavonoids and polyphenols present in CO may be beneficial in reducing the oxidative stress involved in the etiology of various diseases, for instance, cardiovascular diseases and cancer. This article aimed to review the likely benefits of CO and its effects related to oxidative stress, hyperlipidemia and chronicle diseases in humans.

关键词： Coconut Oil [Supplementary Concept] Oxidative Stress Lipids Dietary Fats

Avocado and Cardiovascular Health

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Open Journal of Endocrine and Metabolic Diseases 2015年第7期5卷 77-83页

作者： Camila Weschenfelder Júlia Lorenzon dos Santos Priscilla Azambuja Lopes de Souza Viviane Paiva de Campos aline marcadenti Postgraduate Studies Program in Cardiology Instituto de Cardiologia/Fundacao Universitária de Cardiologia do Rio Grande do Sul (IC/FUC) Porto Alegre Brazil Department of Nutrition Federal University of Health Sciences of Porto Alegre (UFCSPA) Porto Alegre Brazil

Avocado is a fruit which had a caloric density of 1.7 kcal per gram and a half unit (~70 g) is composed by 114 kcal, 4.6 g of fibers, 345 mg of potassium, 19.5 mg of magnesium, 1.3 mg of vitamin E and 57 mg of phytosterols. Approximately 75% of fiber’s avocado contents are considered insoluble and 25% are soluble. The avocado contains lipids that consist of 71% from monounsaturated fatty acids (MUFA), 13% from polyunsaturated (PUFA) and 16% from saturated fatty acids (SFA). Recent researches have shown that avocado may improve hypercholesterolemia and may be useful in the treatment of hypertension and type 2 diabetes mellitus (T2DM). This way, avocado plays an important role in the cardiovascular health. This review summarizes the potential benefits of avocado consumption in the prevention of cardiovascular risk factors and metabolic diseases.

关键词： Persea Diabetes Mellitus Type 2 Dyslipidemias Nutritional Status Blood Pressure

The Impact of the Essential Fatty Acids (EFA) in Human Health

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Open Journal of Endocrine and Metabolic Diseases 2015年第7期5卷 98-104页

作者： Alberto Krayyem Arbex Vagner Rosa Bizarro Julio Cesar Salles Santos Lis Marina Mesquita Araújo Ana Luísa Conceicao de Jesus Minelli Salles Alves Fernandes Marcela Miranda Salles Denise Rosso Tenório Wanderley Rocha aline marcadenti Division of Endocrinology Faculdade IPEMED de Ciências Médicas (IPEMED) Rio de Janeiro Brazil Visiting Scientist of the Harvard School of Public Health Harvard University Boston USA Postgraduate Studies Program in Cardiology Instituto de Cardiologia/Fundacao Universitária de Cardiologia do Rio Grande do Sul (IC/FUC) Porto Alegre Brazil Department of Nutrition Universidade Federal de Ciências da Saúde de Porto Alegre (UFSCPA) Porto AlegreBrazil

Linoleic (LA) and α-linolenic acids (ALA) are considered essential fatty acids (EFA) because they are not produced by the human body. This way, EFAs sources must come from the diet. The primary dietary source of n-3 fatty acids is ALA, found in seeds and seed oils. Other important sources are fish oils such as tuna, salmon and herring. Currently, numerous studies suggest possible benefits of essential fatty acids in human health, such as in cardiovascular, cognitive and eye health, and also during pregnancy and childhood. This paper also discusses the impact of fatty acids in human metabolism, and the available evidence regarding its risks. It addresses the relevant debate regarding a general ban of trans fatty acids (TFA) from the world food market, because of the cardiovascular risks associated with its consumption.

关键词： Fatty Acids Linoleic Acid Alpha-Linolenic Acid Cardiovascular Health Trans Fatty Acids

Renin-angiotensin system in the central nervous system:focus on Huntington’s disease

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Neural Regeneration Research 2023年第10期18卷 2206-2207页

作者： aline Silva de Miranda Antonio Lucio Teixeira Laboratório de Neurobiologia Departamento de MorfologiaInstituto de Ciências BiológicasUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteMGBrasil Laboratório Interdisciplinar de Investigação Médica(LIIM) Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteMGBrasil Neuropsychiatry Program Department of Psychiatry and Behavioral SciencesMcGovern Medical SchoolUniversity of Texas Health Science Center at HoustonTXUSA Faculdade Santa Casa BH Belo HorizonteMGBrasil

The renin-angiotensin system(RAS)was originally conceived as a circulating hormonal system involved in the regulation of cardiovascular and renal *** the discovery of local RAS components in diverse organs,including t... 详细信息

关键词： Huntington organs angiotensin

Laboratory study on the formation of Al2O3 inclusions at the on-set of deoxidation and during reoxidation

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Frontiers of Materials Science 2011年第1期5卷 69-76页

作者： Marie-aline VAN ENDE Muxing GUO Bart BLANPAIN Patrick WOLLANTS Department of Metallurgy and Materials Engineering Katholieke Universiteit Leuven Kasteelpark Arenberg 44- bus 2450 BE-3001 Leuven Belgium Unite d＇lngeniede des Materiaux et des Procedes Universite Catholique de Louvain Place Sainte Barbe 2 B-1348 Louvain-la-Neuve Belgium

The formation of Al2O3 inclusions in liquid iron has been investigated in a resistance heated tube furnace to obtain deoxidation and reoxidation related data. The formation of inclusions during the early stages of deoxidation was simulated by bringing a piece of AI in contact for a short time with liquid Fe containing different dissolved oxygen levels. Reoxidation was studied by exposing AI containing Fe melts to a CO/CO2 atmosphere, Through modeling, an estimate of the local and time-dependent growth conditions for the inclusions can be made and linked to the inclusion characteristics.

关键词： steel cleanliness Al2O3 inclusions deoxidation reoxidation morphology

PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis

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World Journal of Hepatology 2017年第1期9卷 18-29页

作者： aline Awad Ama Gassama-Diagne Inserm Unite 1193 Hopital Paul Brousse Univ Paris-Sud UMR-S 1193Univsite Paris-Saclay

Hepatitis C virus(HCV) infects hepatocytes, polarized cells in the liver. Chronic HCV infection often leads to steatosis, fibrosis, cirrhosis and hepatocellular carcinoma, and it has been identified as the leading cause of liver transplantation worldwide. The HCV replication cycle is dependent on lipid metabolism and particularly an accumulation of lipid droplets in host cells. Phosphoinositides(PIs) are minor phospholipids enriched in different membranes and their levels are tightly regulated by specific PI kinases and phosphatases. PIs are implicated in a vast array of cellular responses that are central to morphogenesis, such as cytoskeletal changes, cytokinesis and the recruitment of downstream effectors to govern mechanisms involved in polarization and lumen formation. Important reviews of the literature identified phosphatidylinositol(Ptd Ins) 4-kinases, and their lipid products Ptd Ins(4)P, as critical regulators of the HCV life cycle. SH2-containing inositol polyphosphate 5-phosphatase(SHIP2), phosphoinositide 3-kinase(PI3K) and their lipid products Ptd Ins(3,4)P2 and Ptd Ins(3,4,5)P3, respectively, play an important role in the cell membrane and are key to the establishment of apicobasal polarity and lumen formation. In this review, we will focus on these new functions of PI3 K and SHIP2, and their deregulation by HCV, causing a disruption of apicobasal polarity, actin organization and extracellular matrix assembly. Finally we will highlight the involvement of this pathway in the event of insulin resistance and nonalcoholic fatty liver disease related to HCV infection.

关键词： Hepatitis C virus Phosphoinositide 3-kinase SH2-containing inositol polyphosphate 5-phosphatase Epithelial cell polarity Phosphoinositides

Natural stilbenes effects in animal models of Alzheimer’s disease

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Neural Regeneration Research 2020年第5期15卷 843-849页

作者： aline Freyssin Guylène Page Bernard Fauconneau Agnès Rioux Bilan University of Poitiers EA3808 NEUVACOD (Neurovascular Unit and Cognitive Disorders)P?le Biologie Santé

Alzheimer’s disease is one of the most frequent neurodegenerative *** pathology is characterized by protein aggregates,mainly constituted by amyloid peptide and tau,leading to neuronal death and cognitive *** currently proposed to treat this pathology do not prevent neurodegenerative processes and are mainly symptomatic ***,stilbenes presenting multiple pharmacological effects could be good potential therapeutic *** aim of this review is to gather the more significant papers among the broad literature on this topic,concerning the beneficial effects of stilbenes (resveratrol derivatives) in animal models of Alzheimer’s ***,numerous studies focus on cellular models,but an in vivo approach remains of primary importance since in animals (mice or rats,generally),bioavailability and metabolism are taken into account,which is not the case in in vitro ***,examination of memory ability is feasible in animal models,which strengthens the relevance of a compound with a view to future therapy in *** paper is addressed to any researcher who needs to study untested natural stilbenes or who wants to experiment the most effective natural stilbenes in largest animals or in *** review shows that resveratrol,the reference polyphenol,is largely studied and seems to have interesting properties on amyloid plaques,and cognitive ***,some resveratrol derivatives such as gnetin C,trans-piceid,or astringin have never been tested on ***,pterostilbene is of particular interest,by its improvement of cognitive disorders and its neuroprotective *** could be relevant to evaluate this molecule in clinical trials.

关键词： Alzheimer's disease amyloid animal models cognitive impairment inflammation natural stilbenes neuroprotection resveratrol tau

Natural polyphenols effects on protein aggregates in Alzheimer＇s and Parkinson＇s prion-like diseases

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Neural Regeneration Research 2018年第6期13卷 955-961页

作者： aline freyssin guylène page bernard fauconneau agnès rioux bilan University of Poitiers EA380-8 NEUVACOD (Neurovascular Unit and Cognitive Disorders) Pole Biologie Sante Poitiers France

Alzheimer＇s and Parkinson＇s diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposits are amyloid peptide and tau for Alzheimer＇s disease, α-synuclein and synphilin-1 for Parkinson＇s disease. Drugs currently proposed to treat these pathologies do not prevent neurodegenerative processes and are mainly symptomatic therapies. Molecules inducing inhibition of aggregation or disaggregation of these proteins could have beneficial effects, especially if they have other beneficial effects for these diseases. Thus, several natural polyphenols, which have antioxidative, anti-inflammatory and neuroprotective properties, have been largely studied, for their effects on protein aggregates found in these diseases, notably in vitro. In this article, we propose to review the significant papers concerning the role of polyphenols on aggregation and disaggregation of amyloid peptide, tau, α-synuclein, synphilin-1, suggesting that these compounds could be useful in the treatments in Alzheimer＇s and Parkinson＇s diseases.

关键词： natural polyphenols protein aggregates Alzheimer's disease amyloid peptide amyloid plaques hyperphosphorylated tau Parkinson's disease a-synuclein synphilin-I

Early-onset colorectal cancer:A sporadic or inherited disease?

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World Journal of Gastroenterology 2014年第35期20卷 12420-12430页

作者： Vittoria Stigliano Lupe Sanchez-Mete aline Martayan Marcello Anti Division of Gastroenterology and Digestive Endoscopy Regina Elena National Cancer Institute Division of Clinical Pathology Regina Elena National Cancer Institute

Colorectal cancer is the third most common cancer diagnosed worldwide. Although epidemiology data show a marked variability around the world, its overall incidence rate shows a slow but steady decrease, mainly in developed countries. Conversely, early-onset colorectal cancer appears to display an opposite trend with an overall prevalence in United States and European Union ranging from 3.0% and 8.6%. Colorectal cancer has a substantial proportion of familial cases. In particular, early age at onset is especially suggestive of hereditary predisposition. The clinicopathological and molecular features of colorectal cancer cases show a marked heterogeneity not only between early- and late-onset cases but also within the early-onset group. Two distinct subtypes of early-onset colorectal cancers can be identified: a “sporadic” subtype, usually without family history, and an inherited subtype arising in the context of well defined hereditary syndromes. The pathogenesis of the early-onset disease is substantially well characterized in the inherited subtype, which is mainly associated to the Lynch syndrome and occasionally to other rare mendelian diseases, whereas in the “sporadic” subtype the origin of the disease may be attributed to the presence of various common/rare genetic variants, so far largely unidentified, displaying variable penetrance. These variants are thought to act cumulatively to increase the risk of colorectal cancer, and presumably to also anticipate its onset. Efforts are ongoing in the attempt to unravel the intricate genetic basis of this “sporadic” early-onset disease. A better knowledge of molecular entities and pathways may impact on family-tailored prevention and clinical management strategies.

关键词： Early-onset colorectal cancer Epidemiology Hereditary syndrome Lynch syndrome MUTYH-associated polyposis