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Aqueous Extract of Ceiba pentandra Stimulates the Production of Fetal Hemoglobin in Sickle Cell Patients

Journal of Biosciences and Medicines 2024年第8期12卷 295-306页

作者： Marie Miezi Nsimba Magain Barihuta Mihatano Blaise Maya Mbamu aline diza lubongo Thoms Nzaji Kolombo Josué Matadi Mukengeshaie José Nzunzu Lami Laboratoire de Recherche Bio-Organique Dpartement de Chimie Mdicinale et Pharmacognosie Facult des Sciences Pharmaceutiques Universit de Kinshasa Kinshasa Democratic Republic of the Congo Laboratoire dAnalyse Biologique Hpital Biamba Marie Mutombo Kinshasa Democratic Republic of the Congo Centre de Phytothrapie Moderne NIECA Commune de Ngaba Kinshasa Democratic Republic of the Congo Traumatology Service Department of Surgery Kinshasa University Hospital University of Kinshasa Kinshasa Democratic Republic of the Congo

Subsequent studies have demonstrated the reversed activity of the aqueous extract of Ceiba pentandra on the deformity of sickled red blood cells in hypoxia conditions. The observation which related to an in vitro study had given rise to hopes as to the management of sickle cell disease (SCD) by the use of this plant species. In this paper, the authors aimed to investigate the effect of the aqueous extract of C. pentandra on the production of fetal hemoglobin in SCD patients. The work carried out hemoglobin electrophoresis, for a period of six months, on blood samples from SCD patients who voluntarily undergone routine treatment, based on the medicinal recipe prepared from the bark of the trunk and branches of C. pentandra, in a hospital center of herbal medicines located in Kinshasa. The medicinal recipe called BEAT-SS is a patented product of the hospital center named Centre de Phytothérapie Moderne NIECA. Blood samples from patients under treatment were taken to evaluate the behavior of different forms of hemoglobin (hemoglobin S, hemoglobin F and hemoglobin A2). Agarose gel electrophoresis with integrated reading was used for the separation of the different forms of hemoglobin, as well as their dosage on each sample of sickle blood. A reduction in the proportion of hemoglobin S and an increase in the proportion of fetal hemoglobin were found in all sickle cell patients during the treatment period. This observation could affirm that the management of sickle cell patients using the recipe prepared from the aqueous extract of C. pentandra could increase the level of fetal hemoglobin in these patients.

关键词： Sickle Cell Disease Hemoglobin S Fetal Hemoglobin Ceiba pentandra

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