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Atrial fibrillation in patients with gastroesophageal reflux disease: A comprehensive review

World Journal of Gastroenterology 2014年第28期20卷 9592-9599页

作者： Crina Roman Stanislas Bruley des Varannes lucian Muresan alina picos.dan l dumitras.u Division of Internal Medicine Second Medical Clinic"Iuliu Hatieganu" University of Medicine and Pharmacy Institut des Maladies de l’Appareil Digestif University HospitalHotel Dieu44093 Nantes Cedex 01France Department of Cardiology Rehabilitation Hospital"Iuliu Hatieganu" University of Medicine and Pharmacy Faculty of Dentistry "Iuliu Hatieganu" University of Medicine and Pharmacy

AIM:To analyze the potential relationship between gastroesophageal reflux disease(GERD)and the development of atrial fibrillation(AF).METHODS:using the key words"atrial fibrillation and gastroesophageal reflux","atrial fibrillation and esophagitis,peptic","atrial fibrillation and hernia,hiatal"the PubMed,EMBASE,Cochrane library,OVIDSP,WIlEY databases were screened for relevant publications on GERD and AF in adults between January 1972-December *** written in languages other than English or French,studies not performed in humans,reviews,case reports,abstracts,conference presentations,letters to the editor,editorials,comments and opinions were not taken into *** treating the subject of radiofrequency ablation of AF and the consecutive development of GERD were also ***:Two thousand one hundred sixty-one titles were found of which 8 articles met the inclusion *** presence of AF in patients with GERD was reported to be between 0.62%-14%,higher compared to those without *** data provided by these observational studies showed that patients with GERD,especially those with more severe GERD-related symptoms,had an increased risk of developing AF compared with those without GERD,but a causal relationship between GERD and AF could not be established based on these *** mechanisms of AF as a consequence of GERD remain largely unknown,with inflammation and vagal stimulation playing a possible role in the development of these *** with proton pomp inhibitors may improve symptoms related to AF and facilitate conversion to sinus ***:Although links between AF and GERD exist,large randomized clinical studies are required for a better understanding of the relationship between these two entities.

关键词： Gastroesophageal reflux disease Esophagitis Atrial

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