检索结果-南通市图书馆

Review of screening for pancreatic cancer in high risk individuals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第19期17卷 2365-2371页

作者： alina stoita Ian D Penman David B Williams Department of Gastroenterology St Vincent's Hospital 390 Victoria StreetDarlinghurst2010NSWAustralia Centre for Liver and Digestive Disorders Royal Infirmary of Edinburgh51 Little France CrescentEdinburghEH16 4SAUnited Kingdom

Pancreatic cancer is difficult to diagnose at an early stage and is associated with a very poor *** percent of pancreatic cancers result from genetic susceptibility and/or familial *** from families with multiple affected first-degree relatives and those with a known cancer-causing genetic mutation have been shown to be at much higher risk of developing pancreatic *** efforts have focused on detecting disease at an earlier stage to improve survival in these high-risk *** article reviews high-risk groups,screening methods,and current screening programs and their results.

关键词： Pancreatic cancer Familial cancer Cancer screening Risk factors Endoscopic ultrasound Hereditary cancer

Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第26期27卷 4045-4087页

作者： Robert S O'Neill alina stoita Department of Gastroenterology St Vincent's Hospital SydneySydney 2010Australia St George and Sutherland Clinical School Faculty of MedicineUniversity of New South WalesSydney 2010Australia St Vincent’s Clinical School Faculty of MedicineUniversity of New South WalesSydney 2010Australia

Pancreatic cancer(PC)is a leading cause of cancer related mortality on a global *** disease itself is associated with a dismal prognosis,partly due to its silent nature resulting in patients presenting with advanced disease at the time of *** combat this,there has been an explosion in the last decade of potential candidate biomarkers in the research setting in the hope that a diagnostic biomarker may provide a glimmer of hope in what is otherwise quite a substantial clinical ***,serum carbohydrate antigen 19-9 is utilized in the diagnostic work-up of patients diagnosed with PC however this biomarker lacks the sensitivity and specificity associated with a gold-standard *** the search for a biomarker that is both sensitive and specific for the diagnosis of PC,there has been a paradigm shift towards a focus on liquid biopsy and the use of diagnostic panels which has subsequently proved to have efficacy in the diagnosis of ***,promising developments in the field of early detection on PC using diagnostic biomarkers include the detection of microRNA(miRNA)in serum and circulating tumour *** these modalities,although in their infancy and yet to be widely accepted into routine clinical practice,possess merit in the early detection of *** reviewed over 300 biomarkers with the aim to provide an in-depth summary of the current state-of-play regarding diagnostic biomarkers in PC(serum,urinary,salivary,faecal,pancreatic juice and biliary fluid).

关键词： Pancreatic cancer Cancer Biomarkers Diagnostic Review

Macrophage inhibitory cytokine-1/growth differentiation factor-15 in premalignant and neoplastic tumours in a high-risk pancreatic cancer cohort

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第14期26卷 1660-1673页

作者： Robert Sean O’Neill Sam Emmanuel David Williams alina stoita Department of Gastroenterology St Vincent’s HospitalSydney 2010Australia St Vincent’s Clinical School Faculty of MedicineUniversity of New South WalesSydney 2010Australia

BACKGROUND Pancreatic cancer(PC)is a leading cause of cancer related mortality worldwide,with poor survival due to late ***,biomarkers have limited use in early diagnosis of *** inhibitory cytokine-1 or growth differentiation factor-15(MIC-1/GDF15)has been implicated as a potential serum biomarker in PC and other *** To determine the role of MIC-1/GDF15 in detecting pre-malignant pancreatic lesions and neoplastic tumours in an asymptomatic high-risk cohort part of Australian Pancreatic Cancer Screening *** A feasibility prospective single centre cohort study was *** recruited for yearly surveillance with endoscopic ultrasound(EUS)had serial fasting blood samples collected before EUS for MIC-1/GDF15,C-reactive protein and carbohydrate antigen *** were stratified into five groups based on EUS findings:Normal;pancreatic cysts,branch-duct intraductal papillary mucinous neoplasm;diffuse non-specific abnormalities;and neoplastic ***-1/GDF15 serum levels were quantified using *** in whom EUS demonstrated abnormalities but not malignancy were closely followed up with magnetic resonance imaging(MRI)or computed *** One hundred twenty participants were prospectively recruited from ***-seven participants(39.2%)had an abnormal EUS and five participants(4.2%)were diagnosed with neoplastic tumours,three by EUS(two pancreatic and one liver)and two by MRI/computed tomography(breast cancer,bladder cancer),which were performed for follow up of abnormal *** serum MIC-1/GDF15 was a significant predictor of neoplastic tumours on receiver operator characteristic curve analysis[area under curve(AUC)=0.814,P=0.023].Baseline serum MIC-1/GDF15 had moderate predictive capacity for branch-duct intraductal papillary mucinous neoplasm(AUC=0.644)and neoplastic tumours noted on EUS(AUC=0.793),however this was not significant(P=0.188 and 0.081 respectively).Seria

关键词： Growth differentiation factor 15 Cytokines Pancreatic neoplasms Digestive system neoplasms Pancreatic diseases Biomarkers Diagnostic screening programs

Clinical predictors for sessile serrated polyposis syndrome:A case control study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2017年第9期9卷 464-470页

作者： Yang Wu Alexander Mullin alina stoita Department of Gastroenterology and Hepatology St Vincent’s HospitalUniversity of NSW Alexander Mullin University of Notre Dame

AIM To compared individuals with serrated polyposis syndrome (SPS) to those with sessile serrated adenoma (SSA) and adenomas in the setting of endoscopists with high adenoma detection rates at a secondary and tertiary academic *** Retrospectively we collated the clinical,endoscopic and histological features of all patients with SPS at St Vincent's public and private hospital in the last 3 *** were identified by searching through 2 pathology *** explored included smoking status,symptoms,and family history of concurrent colorectal cancer,number and location of *** with SPS were matched to two cohorts (1) patients with SSA not meeting World Health Organization (WHO) criteria for SPS over 3 years; and (2) patients with exclusively *** control cases were also matched according to gender and *** detection rates ranged from 25% to 40%.RESULTS Forty patients with SPS were identified and matched with 40 patients in each control *** total 15452 colonoscopies were performed over the study period which amounts to a prevalence of 1: 384 patients (0.26%) with *** patients (35%) required more than 1 year to accumulate enough polyps to reach WHO criteria for *** diagnosis of SPS was largely incidental and 5% SPS patients were diagnosed with colorectal cancer over 3 *** chance of detecting a meta-synchronous adenoma was similar in those with SPS(42%) and those with SSA(55%),P = *** majority of patients(75%) meeting criteria for SPS were *** mean age of those with SPS (45 years) was significantly lower than both cohorts with SSA(57 years) and adenomas(63 years),P = *** univariate analysis cigarette exposure,firstdegree family history of colorectal cancer and a high BMI weren't significantly more associated with SPS compared to patients with SSA or patients with ***,patients with SPS (97%) and patients with SSAs not meeting SPS criteria(98%) were significantly

关键词： Serrated lesions Colonoscopy Colorectal polyps Polyposis syndrome Colorectal cancer