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Dual Functional Diblock Amino Acid Copolymer Displaying Synergistic Effect with Curcumin against MRSA and Encapsulation of Curcumin

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Chinese Journal of Chemistry 2023年第23期41卷 3333-3338页

作者： Yueming Wu Yuan Chen Haowen Yu alideertu dong Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237 China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237 China Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityHohhotInner Mongolia010021 China

The intensive use of antibiotics intensifies the development of bacterial resistance,which has become a serious problem ***-resistant Staphylococcus aureus(MRSA)has resulted in significant morbidity and ***,it is an urgent need to develop new antimicrobial drugs and administration ***,we report a dual functional diblock copolymer PLL20-b-PBLG20,which was prepared by superfast and water-insensitive polymerization on N-carboxyanhydrides(NCA)initiated by tetraalkylammonium *** addition to direct antimicrobial activity,PLL20-b-PBLG20 also exerts a synergistic bactericidal effect against MRSA with curcumin,a plant extract with antibacterial ***,PLL20-b-PBLG20 successfully encapsulates curcumin to form nanoparticles via *** combination of dual functional PLL20-b-PBLG20 and curcumin holds promise in combating MRSA infections.

关键词： Amino acid polymer Antimicrobial Synergy Encapsulation MRSA

Glycopolymer N-halamine-modified biochars with high specificity for Escherichia coli eradication

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Chinese Journal of Chemical Engineering 2021年第10期34卷 229-236页

作者： Qinggele Borjihan Quanfu Yao Huihui Qu Haixia Wu Ying Liu alideertu dong College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityHohhot 010021China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China College of Chemistry and Environment Hohhot Minzu CollegeHohhot 010051China

Antibiotic-resistant bacteria contamination in environments imposes great threats to human life *** research aims to develop novel targeted antibacterial biochars for achieving high selectivity to kill pathogenic Escherichia coli(***).The glycopolymer N-halamine-modified biochars(i.e.,BCPMA-Cl)were synthesized by the modification of biochars with poly[2-(methacrylamido)glucopyranose-coacrylamide](P(MAG-co-AM),followed by chlorination *** on the results of FTIR,turbidity,XPS,and UV–vis,BCPMA-Cl was successfully synthesized and demonstrated to be able to eliminate Staphylococcus aureus(***)and ***,BCPMA-Cl possessed extremely potent to specific-killing 10^(4) CFU·ml^(-1) of *** with lower hemolytic activity(<5%).Additionally,the antibacterial mechanisms of BCPMA-Cl against bacteria were contact-killing and release-killing contributed by active chlorine(i.e.,Cl^(+)).Therefore,this work provided a cost-effective and facile approach for preparation of functional biochars used for bacteria-specific therapeutic applications via livestock pollutants as well as showing a promising strategy to avoid bacterial resistance.

关键词： Biochars N-halamine Glycopolymer Antibacterial coating Specific killing

Recovery and in-situ reduction of precious metals by graphdiyne and graphdiyne oxide for antibacterial use

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Rare Metals 2024年第4期43卷 1747-1757页

作者： Ming-Ji Jiang Ya-Na Zhang Ling-Shen Meng Jing Kang Yong-Jun Li alideertu dong College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot010021China Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityHohhot010021China Department of Chemistry University of ZurichCH-8057ZurichSwitzerland Laboratory of Organic Solids and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing100190China

Based on the in-situ self-reduction and chemical stability,graphdiyne(GDY)and graphdiyne oxide(GDYO)are used as trapping agents to investigate the ability for recovering Au^(3+),Ag^+,and Pd^(2+)under different pH values and interfering *** strong acidity at pH=1,these two agents demonstrate high select recovery towards the three precious metal ions,which could be insitu reduced to nanoparticles(NPs).In addition,superparamagnetic Fe_(3)O_(4)NPs are deposited on the surfaces of GDY and *** magnetic responses enable GDYFe_(3)O_(4)to recover precious metals conveniently and efficiently by the aid of an external magnetic *** study also confirms the antibacterial activity of the as-recovered NPs deposited on GDY and GDYO against Escherichia coli and Staphylococcus aureus(1×10^(5)colony-forming unit(CFU)·mL^(-1)),and the antibacterial rates are 100%.This strategy of recovering precious metals and subsequently reusing to combat pathogens will be of great significance for environmental remediation and biomedical applications.

关键词： Graphdiyne In-situ reduction Recovery Precious metals Antibacterial

Cow dung-derived biochars engineered as antibacterial agents for bacterial decontamination

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Journal of Environmental Sciences 2021年第7期33卷 33-43页

作者： Quanfu Yao Qinggele Borjihan Huihui Qu Yixuan Guo Ziying Zhao Long Qiao Ting Li alideertu dong Ying Liu College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China College of Chemistry and Environment Hohhot Minzu CollegeHohhot 010051China College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityHohhot 010021China

Disposal of the pollutants arising from farming cattle and other livestock threatens the environment and public safety in diverse ***,we report on the synthesis of engineered biochars using cow dung as raw material,and investigating these biochars as antibacterial agents for water *** coating the biochars with N-halamine polymer and loading them with active chlorine (i.e.,Cl+),we were able to regulate them on demand by tuning the polymer coating and bleaching *** obtained N-halamine-modified biochars were found to be extremely potent against Escherichia coli and Staphylococcus *** also investigated the possibility of using these N-halamine-modified biochars for bacterial decontamination in real-world *** findings indicated that a homemade filter column packed with N-halamine-modified biochars removed pathogenic bacteria from mining sewage,dairy sewage,domestic sewage,and artificial *** proposed strategy could indicate a new way for utilizing livestock pollutants to create on-demand decontaminants.

关键词： Cow dung Biochars Polymer coating Antibacterial agent Bacterial decontamination

Electrospun N-halamine/ZnO-based platform eradicates bacteria through multimodal antimicrobial mechanism of action

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Rare Metals 2023年第1期42卷 222-233页

作者： Hui-Hui Qu Cong Wang Yi-Xuan Guo Zi-Ying Zhao Long Qiao Jie-Bing Yang Hai-Xia Wu Quan-Shun Li alideertu dong College of Chemistry and Chemical Engineering Engineering Research Center of Dairy Quality and Safety Control TechnologyMinistry of EducationInner Mongolia UniversityHohhot010021China Center of Experimental Instrument School of Food Science and TechnologyDalian Polytechnic UniversityDalian116034China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun130012China

The emergence and prevalence of antibiotic-resistant bacteria demands powerful antibacterial tactics to combat infectious *** combinational therapy based on synergistic hybrid antibacterial materials is a promising approach to realize effective sterilization through the rational integration of distinct bactericides into one compact *** this work,we constructed a microfiber-based antibacterial platform(PAM-Cl/ZnO MFs)by electrospinning N-halamine polymers(PAM-Cl)loaded with zinc oxide(ZnO)*** as-designed PAM-Cl/ZnO MFs inherited the intrinsic antibacterial effects of both PAM-Cl microfibers(PAM-Cl MFs)and ZnO microfibers(ZnO MFs),and the material exhibited enhanced synergistic antibacterial performance against Staphylococcus aureus(***)and Escherichia coli(***)in *** bactericidal effect was multimodal and included contact killing based on the N-Cl bond of N-halamine,multiple-release killing,such as reactive oxygen species(ROS)under light irritation,and Zn^(2+)and Cl^(+)acting as antibacterial ***,PAM-Cl/Zno MFs worked on inactivate bacteria even under harsh temperatures and atmospheric ***,PAM-Cl/ZnO MFs exhibited good biocompatibility and performed outstanding acceleration of wound healing with in vivo mouse skin defect models using *** work advances the design of antibacterial hybrid materials with the potency to eradicate bacteria in biological systems in multiple settings through the superiority of multimodal synergistic therapy.

关键词： N-halamine ZnO nanoparticles Electrospinning Synergistic antibacterial therapy Various scenarios

Promotion of reactive oxygen species activated by nanosilver surface engineering for resistant bacteria-infected skin tissue therapy

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Rare Metals 2023年第12期42卷 4167-4183页

作者： Pei-Pei Li Yu Zhang Chao Wang Shu-Jie Wang Wen-Qing Yan Dou-Xin Xiao Jing Kang De-Zhi Yang Hai-Xia Wu alideertu dong College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityHohhot 010021China International Mongolia Hospital of Inner Mongolia Hohhot 010065China

Nanosilver has been regarded as a promising alternative to traditional antibiotics for fighting pathogenassociated infections due to its efficacy toward a broad spectrum of ***,bacterial resistance to nanosilver has emerged *** this contribution,a surface engineering strategy based on N-halamine chemistry to address bacterial resistance to nanosilver was *** 1,3-dichloro-5,5-dimethylhydantoin(DCDMH)as an N-halamine source,AgCI nanodots were deposited on the surface of Ag nano wires(Ag NWs)via in situ redox reaction to prepare AgCl-on-Ag *** in vitro and in vivo tests,AgCl-on-Ag NWs effectively inactivated two antibiotic-resistant bacteria,ampicillinresistant Escherichia coli(AREC)and methicillin-resistant Staphylococcus aureus(MRSA)with the minimum bactericidal concentration(MBC)as low as 10μg·ml~(-1)and exhibited good biosafety against normal *** experimental and theoretical tests demonstrated that AgCl-onAg NWs worked on AREC and MAS A by generating high level of reactive oxygen species under visible light irradiation,coupled with the sustained Ag ion ***,the antibacterial mechanism of AgCl-on-Ag NWs against MRSA was verified at the gene level by transcriptome analysis(RNA sequencing).Moreover,the fullthickness defect model verified that AgCl-on-Ag NWs reduced inflammatory cell infiltration and dramatically accelerated wound *** work provides a synergistic mechanism based on nanosilver surface engineering to eradicate the resistant bacteria that can alleviate drug resistance and develop an innovative approach for the treatment of bacterial infections.

关键词： Surface engineering Nanosilver N-halamine Reactive oxygen species(ROS) Antibiotic resistance

N-卤胺类高分子与纳米抗菌材料的制备及应用

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化学进展 2017年第2期29卷 318-328页

作者：李平董阿力德尔图孙梓嘉高歌吉林大学化学学院长春130021 内蒙古大学化学与化工学院呼和浩特010021

在诸多的抗菌剂中,N-卤胺类抗菌剂作为新型抗菌剂,具有高效、持久、广谱、可再生、无毒和对环境无污染等优点,是一种绿色环保高效的抗菌剂。因此,对N-卤胺类抗菌剂的研究受到广大学者的高度重视。本文综述了高分子N-卤胺和纳米N-卤胺抗... 详细信息

在诸多的抗菌剂中,N-卤胺类抗菌剂作为新型抗菌剂,具有高效、持久、广谱、可再生、无毒和对环境无污染等优点,是一种绿色环保高效的抗菌剂。因此,对N-卤胺类抗菌剂的研究受到广大学者的高度重视。本文综述了高分子N-卤胺和纳米N-卤胺抗菌材料的合成途径以及应用。高分子N-卤胺材料的合成主要包括三种方法:由单体聚合得到的高分子N-卤胺;N-卤胺前驱体接枝在其他高分子材料表面而形成的接枝聚合物;以及共混、静电纺丝、包覆等其他手段。对于N-卤胺抗菌材料而言,接触面积对其抗菌活性至关重要,纳米尺寸的N-卤胺抗菌材料具有非常大的比表面积,因而显示出更加优异的抗菌性能。本文着重介绍了纳米N-卤胺抗菌材料的研究进展和发展方向,并在分析N-卤胺基抗菌材料研究现状的基础上,对其开发和应用前景进行了展望。

关键词： N-卤胺抗菌材料纳米粒子

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文献检索在科研能力培养方面的重要性探索

广州化工 2014年第23期42卷 199-200,213页

作者：董阿力德尔图内蒙古大学化学化工学院内蒙古呼和浩特010021

文献检索是科研工作者培养情报意识和从大量的文献资料中获取知识和情报的一门科学方法。文献检索在科研工作者培养科研能力方面有着重要的作用。笔者针对文献检索在培养科研能力的重要性,围绕培养科研分类能力、科研想象能力、科研分... 详细信息

文献检索是科研工作者培养情报意识和从大量的文献资料中获取知识和情报的一门科学方法。文献检索在科研工作者培养科研能力方面有着重要的作用。笔者针对文献检索在培养科研能力的重要性,围绕培养科研分类能力、科研想象能力、科研分析综合能力、科研探究能力等四个方面进行了全面系统探索。

关键词：文献检索科研能力重要性

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短瓣金莲花指标成分的红外光谱快速分析

光谱学与光谱分析 2019年第11期39卷 3624-3628页

作者：耿淑琴樊肇胜刘豪曾胜张艳玲董阿力德尔图周群孙素琴内蒙古大学化学化工学院内蒙古呼和浩特010021 清华大学化学系北京100084

将现代红外光谱分析技术与化学计量学方法相结合,建立利用红外光谱对短瓣金莲花药材的指标成分进行快速定量分析的方法。以高效液相色谱法获得短瓣金莲花指标成分(荭草苷、牡荆苷)的含量作为参考数据,以傅里叶变换红外光谱技术获取其红... 详细信息

将现代红外光谱分析技术与化学计量学方法相结合,建立利用红外光谱对短瓣金莲花药材的指标成分进行快速定量分析的方法。以高效液相色谱法获得短瓣金莲花指标成分(荭草苷、牡荆苷)的含量作为参考数据,以傅里叶变换红外光谱技术获取其红外光谱图,在此基础上利用化学计量学方法将指标成分与红外光谱图数据关联,构建指标成分的快速预测模型。以不同比例甲醇-水作为溶剂,采用室温浸提、加热回流、超声辅助工艺提取获得36个短瓣金莲花药材提取物。利用高效液相色谱法测试短瓣金莲花提取物的荭草苷和牡荆苷含量,并以傅里叶变换红外光谱仪辅以水平衰减全反射附件测试各样品的红外光谱图。分别选取29个提取物样品作为检验集,其余为校正集,采用TQ Analyst EZ Edition软件进行建模。以交叉验证相关系数(R2)和交叉验证误差均方根(RMSEC)为指标选择光谱预处理方法、定量分析方法和建模波段,用预测误差均方根(RMSEP)考核模型的预测效果。通过筛选得到优化的光谱预处理方法为标准正态分布校正(SNV)和二阶导数(13点平滑),定量分析方法为偏最小二乘(PLS)方法,荭草苷和牡荆苷的最佳波段分别为2 050~650和1 900~650cm^-1。以PLS法构建的荭草苷和牡荆苷模型的相关系数分别为0.919 8和0.970 8,模型预测结果的相对偏差分别在-2.0%~3.2%和-3.4%~4.7%之间。鉴于红外光谱技术所具有的测试迅速、微观宏观指纹特性、定性定量皆可分析、对环境无污染等特点,利用红外光谱法可对中药提取物的指标成分进行快速、准确、环保、高效的分析,为中药的质量控制提供了新的思路和解决方案。

关键词：红外光谱快速分析短瓣金莲花荭草苷牡荆苷