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IDO1 in cancer: a Gemini of immune checkpoints

Cellular & Molecular Immunology 2018年第5期15卷 447-457页

作者： Lijie Zhai Erik Ladomersky alicia lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright Department of Neurological Surgery Northwestern University Department of Pediatrics Northwestern University Division of Hematology Oncology and Stem Cell TransplantationNorthwestern University Ann&Robert H.Lurie Children’s Hospital of Chicago Northwestern University Department of Medicine-Hematology/Oncology Northwestern University Department of Microbiology-Immunology Northwestern University Department of MedicineDivision of Hematology and Oncology Northwestern UniversityBrain Tumor InstituteNorthwestern University Robert H.Lurie Comprehensive Cancer Center of Northwestern University Northwestern UniversityChicagoIL 60611USA

Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as ***,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human *** studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject *** the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously *** to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive *** gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer ***,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。

关键词： glioblastoma glioma IDO immunosuppression kynurenine immunotherapy melanoma Treg

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THE IMPLICIT CONVEX FEASIBILITY PROBLEM AND ITS APPLICATION TO ADAPTIVE IMAGE DENOISING

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Journal of Computational Mathematics 2016年第6期34卷 610-625页

作者： Yair Censor Aviv Gibali Frank lenzen Christoph Schnorr Department of Mathematics University of Haifa Mr. Carmel 3498838 Haifa Israel Department of Mathematics ORT Braude College 2161002 Karmiel Israel Heidelberg Collaboratory for Image Processing Mathematikon INF 205 University of Heidelberg 69120 Heidelberg Germany

The implicit convex feasibility problem attempts to find a point in the intersection of a finite family of convex sets, some of which are not explicitly determined but may vary. We develop simultaneous and sequential projection methods capable of handling such problems and demonstrate their applicability to image denoising in a specific medical imaging situation. By allowing the variable sets to undergo scaling, shifting and rotation, this work generalizes pre^ious results -vherein the implicit convex feasibility problem was used for cooperative wireless sensor network positioning where sets are balls and their centers were implicit.

关键词： Implicit convex feasibility Split feasibility projection methods Variable sets,Proximity function Image denoising.

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Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis

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Journal of Geriatric Cardiology 2018年第4期15卷 261-267页

作者： Marjo JAG De Ronde-Tillmans Tom AJ de Jager Jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWJ. Utens Francesco US Mattace-Raso MaRie J lenzen Peter PT de Jaegere Erasmus Medical Center Department of Cardiology Thorax Center Rotterdam the Netherlands Erasmus Medical Center Section of Geriatrics Department of Internal Medicine Rotterdam the Netherlands Erasmus Medical Center Department of Child and Adolescent Psychiatry/Psychology Sophia Children 's Hospital Rotterdam the Netherlands The Netherlands Research Institute of Child Development and Education University of Amsterdam the Netherlands

Background Transcatheter aortic valve implantation （TAVI） has become the standard treatment for patients with severe symptomatic aortic stenosis （AS） considered at very high risk for surgical aortic valve replacement. The purpose of this sub-study was to evaluate long-term （〉 4 years） health-related quality of life （QoL） in octogenarians who underwent TAVI. Methods A single center observational registry in twenty patients who underwent frame analysis assessment ≥ 4 years after TAVI. Health-related QoL was evaluated, using the Short Form-36 （SF-36）, the EuroQoL-5D （EQ-5D） and the visual analogue score （EQ-VAS） questionnaires. Results The mean SF-36 subscale scores at follow-up were physical functioning 40.8 ± 26.3, role physical functioning 67.7 ± 34.9, vitality 54.6 ± 21.6, general health 52.1 ± 20.4, social functioning 63.8 ± 37.7, role emotional functioning 70.2 ± 36.0, mental health 73.2 ± 23.3 and bodily pain 80.9 ± 22.9. The mean EQ-VAS score 〉 4 years after TAVI was 64.7 ± 15.1. With respect to functional class, 80% of the patients were in NYHA class I/II at follow-up compared to 15% prior to TAVI. Conclusions This sub-study reports a significant improvement in functional class （NYHA） in a selected group of very elderly patients 〉 4 years after TAVI. Furthermore, all patients showed a satisfactory QoL despite their age and multiple comorbidities. In addition, our study reveals a lower QoL when compared with the general age matched Dutch population.

关键词： Octogenarians Quality of life Transcatheter aortic valve implantation

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Successful treatment of cervical esophageal leakage by endoscopic-vacuum assisted closure therapy

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World Journal of Gastrointestinal Endoscopy 2013年第7期5卷 340-345页

作者： Henrike lenzen Ahmed A Negm Thomas J Erichsen Michael P Manns Jochen Wedemeyer Tim O Lankisch Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School30625 Hannover Germany Department of Internal Medicine Robert Koch Hospital Gehrden30989 Gehrden Germany

AIM: To evaluate the efficacy and safety of endoscopic-vacuum assisted closure (E-VAC) therapy in the treatment of cervical esophageal leakage. METHODS: Between May and November 2012, three male patients who developed post-operative cervical esophageal leakage were treated with E-VAC therapy. One patient had undergone surgical excision of a pharyngo-cervical liposarcoma with partial esophageal resection, and the other two patients had received surgical treatment for symptomatic Zenker's diverticulum. Following endoscopic verification of the leakage, a trimmed polyurethane sponge was fixed to the distal end of a nasogastric silicone tube and endoscopically positioned into the wound cavity, and with decreasing cavity size the sponge was positioned intraluminally to cover the leak. Continuous suction was applied, and the vacuum drainage system was changed twice a ***: The initial E-VAC placement was technically successful for all three patients, and complete closure of the esophageal leak was achieved without any procedure-related complications. In all three patients, the insufficiencies were located either above or slightly below the upper esophageal sphincter. The median duration of the E-VAC drainage was 29 d (range: 19-49 d), with a median of seven sponge exchanges (range: 5-12 sponge exchanges). In addition, the E-VAC therapy reduced inflammatory markers to within normal range for all three patients. Two of the patients were immediately fitted with a percutaneous enteral gastric feeding tube with jejunal extension, and the third patient received parenteral feeding. All three patients showed normal swallow function and no evidence of stricture after completion of the E-VAC therapy. CONCLUSION: E-VAC therapy for cervical esophageal leakage was well tolerated by patients. This safe and effective procedure may significantly reduce morbidity and mortality following cervical esophageal leakage.

关键词： Endoscopic-vacuum assisted closure therapy Vacuum therapy Negative pressure wound therapy Cervical esophageal leakage Anastomotic leakage

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商品和服务消费在家庭温室气体计算表中的重要性

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AMBIO－人类环境杂志 2001年第7期30卷 439-442页

作者： Manfred lenzen 鲁春霞澳大利亚悉尼大学

尽管生活方式,尤其是商品和服务消费,对于温室气体排放的全球性不公平和不可持续性具有关键作用,但这些问题在有关的情报和教育资料如温室气体计算表中常常没有给予充分的表述。通常的结论是,对于气候变化负有责任的是个人,而且只限于... 详细信息

尽管生活方式,尤其是商品和服务消费,对于温室气体排放的全球性不公平和不可持续性具有关键作用,但这些问题在有关的情报和教育资料如温室气体计算表中常常没有给予充分的表述。通常的结论是,对于气候变化负有责任的是个人,而且只限于读者周围的环境,如家庭和私人汽车,而商品和服务的消费却几乎一直被忽略。结果是,有关减少个人温室气体排放的建议都集中在次要的电力和燃料的使用方面,没有把减少商品和服务消费这个更重要的问题作为减轻气候变化的一个有效途径。本文以最近发表的家庭温室气体排放调查表为例,阐述上述缺点。同时也提出了一个温室气体综合计算表的实例。

关键词：服务消费温室气体计算表重要性商品消费

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混合动力商用车的潜力

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汽车与新动力 2012年第5期 11-13页

作者： Beidl C Schmitt M Kluin M lenzen B 范明强

与轿车不同,商用车极少装用混合动力装置。此外,目前商用车所应用的柴油机在质量、成本和效率方面还存在问题。概述了德国Darmstadt工业大学就混合动力应用于商用车的相关研究。

关键词：混合动力节油潜力商用车

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已知或新检出糖尿病(而非糖调节受损)对冠心病患者的1年预后有负面影响:来自欧洲心脏调查糖尿病和心脏专题研究

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世界核心医学期刊文摘(心脏病学分册) 2007年第6期 35-36页

作者： lenzen M Ryden L hrvik J M.L.Simoons 马超 Thoraxcenter Department of CardiologyErasmus University Medical CenterPOBox 20403000 CARotterdamNetherlands

目的:尽管已知糖尿病是心血管疾病的主要致病因素,也是冠心病(CAD)患者不良预后的独立预测因素,但关于新诊断为糖尿病或糖代谢受损(IGR)的CAD患

关键词：糖尿病患者预测因素 CA 代谢病糖代谢 IGR 检出心脏空腹血糖专题研究专项研究预后

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促进高级研究的制度性战略

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国家教育行政学院学报 2006年第9期 46-50页

作者：迪埃特.伦森德国柏林自由大学

柏林自由大学是德国一流的研究型大学。为应对高等教育国际化、德国人口减少和人才外流的挑战,满足国家对高层次人才的需要,高等教育必须实现制度性战略转型。德国柏林自由大学进行了促进高级研究的制度性战略改革,构建起一个创新型的... 详细信息

柏林自由大学是德国一流的研究型大学。为应对高等教育国际化、德国人口减少和人才外流的挑战,满足国家对高层次人才的需要,高等教育必须实现制度性战略转型。德国柏林自由大学进行了促进高级研究的制度性战略改革,构建起一个创新型的网络体系。其中,集群发展中心、研究生教育中心和国际交流中心是这一网络体系的核心构架。

关键词：人才培养集群发展中心研究生教育中心国际交流中心

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已确诊冠心病患者的治疗及预后:关于冠状动脉血运重建的欧洲心脏调查

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世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 41-42页

作者： lenzen M. J. Boersma E. Bertrand M. E. W. Wijns 刘少伟 Cardiovascular Centre OLV Hospital 164 Moorselbaan B 9300 Aalst Belgium

Aims: The purpose of the Euro Heart Survey Programme of the European Society of Cardiology is to evaluate to which extent clinical practice endorses existing guidelines as well as to identify differences in population profiles, patient management, and outcome across Europe. The current survey focuses on the invasive diagnosis and treatment of patients with established coronary artery disease(CAD). Methods and results: Between November 2001 and March 2002, 7769 consecutive patients undergoing invasive evaluation at 130 hospitals(31 countries) were screened for the presence of one or more coronary stenosis >50%in diameter. Patient demographics and comorbidity, clinical presentation, invasive parameters, treatment options, and procedural techniques were prospectively entered in an electronic database(550 variables+29 per diseased coronary segment). Major adverse cardiac events(MACE) were evaluated at 30 days and 1 year. Out of 5619 patients with angiographically proven coronary stenosis(72%of screened population), 53%presented with stable angina while ST elevation myocardial infarction(STEMI) was the indication for coronary angiography in 16%and non-ST segment elevation myocardial infarction or unstable angina in 30%. Only medical therapy was continued in 21%, whereas mechanical revascularization was performed in the remainder[percutaneous coronary intervention(PCI) in 58%and coronary artery bypass grafting(CABG) in 21%]. Patients referred for PCI were younger,were more active, had a lower risk profile, and had less comorbid conditions. CABG was performed mostly in patients with left main lesions(21%), two-(25%), or three-vessel disease(67%) with 4.1 diseased segments, on average. Single-vessel PCI was performed in 82%of patients with either single-(45%), two-(33%), or three-vessel disease(21%). Stents were used in 75%of attempted lesions,with a large variation between sites. Direct PCI for STEMI was performed in 410 cases, representing 7%of the entire workload in the

关键词：欧洲心脏介入诊断不稳定型心绞痛药物洗脱支架裸金属支架血运重建三支血管病变心脏不良事件他汀类药物搭桥手术

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原发性硬化性胆管炎病人的钆塞酸二钠增强功能MRI研究

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国际医学放射学杂志 2016年第3期 335-336页

作者： H.Hinrichs J.B.Hinrichs M.Gutberlet H.lenzen H.J.Raatschen F.Wacker 祁丽 Department of Diagnostic and Interventional Radiology Hannover Medical School

摘要目的探讨钆塞酸二钠增强肝脏T1mapping MRI的可变翻转角在原发硬化性胆管炎(PSC)病人中的应用价值,评估全肝和肝段肝功能,并确定其与疾病的严重程度的相关性。方法本前瞻性研究共纳入61例(女19例,男42例,平均年龄41岁)PSC病人。在... 详细信息

摘要目的探讨钆塞酸二钠增强肝脏T1mapping MRI的可变翻转角在原发硬化性胆管炎(PSC)病人中的应用价值,评估全肝和肝段肝功能,并确定其与疾病的严重程度的相关性。方法本前瞻性研究共纳入61例(女19例,男42例,平均年龄41岁)PSC病人。在对比剂注入前、注入后16 min(HP1)及132 min(HP2)后分别用3D GRE序列行T1mapping

关键词：钆塞酸二钠原发性硬化性胆管炎 MRI 病人

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