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组织工程化人工神经实验研究

中国创伤骨科杂志 2000年第4期2卷 290-292页

作者：沈尊理 berger Alfred HIERNER Robert LOHMEYER Joern ALLMELING Christina WALTER F.Gerhard 上海市第一人民医院整形外科上海市200080 德国汉诺威医学院整形手重建外科德国汉诺威医学院神经病理研究所

目的研究组织工程化人工神经修复大鼠2.5cm长坐骨神经缺损的效果。方法 21只2月龄Lewis lw雌性大鼠随机分成三个神经移植组,每组7只。A组:种植同源雪旺细胞并具有内部支架结构的胶原神经管,即组织工程化人工神经。b组:无雪旺细胞但具... 详细信息

目的研究组织工程化人工神经修复大鼠2.5cm长坐骨神经缺损的效果。方法 21只2月龄Lewis lw雌性大鼠随机分成三个神经移植组,每组7只。A组:种植同源雪旺细胞并具有内部支架结构的胶原神经管,即组织工程化人工神经。b组:无雪旺细胞但具有内部支架结构的胶原神经管。C组:自体神经移植组。术后六个月,进行系列神经电生理监测,神经肌肉组织学观察,S-100和神经微丝蛋白(Neurofilament)免疫组化染色,轴突计数等检查。结果在A组和C组移植神经上均能诱发出波幅明显的神经肌肉复合动作电位(CMAP),再生轴突已通过移植神经全长,远端肌肉轻度萎缩。而b组中没有或仅记录到极小波幅的CMAP,移植神经远端结缔纤维组织增生,再生轴突罕见,所支配肌肉明显萎缩。结论初步结果显示:组织工程化人工神经可用来修复大鼠长段神经缺损。

关键词：组织工程神经移植雪旺氏细胞培养神经管

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Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?

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World Journal of Gastroenterology 2007年第26期13卷 3605-3609页

作者： Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas borschitz Stefan biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R berger Theodor Junginger Peter R Galle Carl C Schimanski Department of General and Abdominal Surgery Johannes Gutenberg University of Mainz MainzGermany First Department of Internal Medicine Johannes Gutenberg University of Mainz MainzGermany Institute of Pathology Johannes Gutenberg University of MainzMainzGermany Third Department of Internal Medicine Johannes Gutenberg University of Mainz MainzGermany Unit of toxicology and chemotherapy German Cancer Research CenterGermany

AIM： To define the （co-）expression pattern of target receptor-tyrosine-kinases （RTK） in human gastric adenocarcinoma. METHODS： The （co-）expression pattern of VEGFR1-3, PDGFR（α/β and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition, IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS： The majority of samples revealed a VEGFR1 （98%）, VEGFR2 （80%）, VEGFR3 （67%）, PDGFRα （82%） and PDGFRβ （82%） expression, whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells, accompanied by an additional nuclear staining for VEGFR3, EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes, which also depicted a PDGFRα expression. CONCLUSION： Our results reveal a high rate ofreceptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy.

关键词： VEGFR EGFR PDGFR Cancer Adeno-carcinoma Gastric Stomach

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膝关节单髁置换10年以上的随访结果

骨科动态 2005年第3期1卷 104-109页

作者： RICHARD A. berger R. MICHAEL MENEGHINI JOSHUA J. JACObS MITCHELL b. SHEINKOP CRAIG J. DELLA VALLE AARON G. ROSENbERG JORGE O. GALANTE 李晓华（译）赵良瑜（译） Investigatiou performed at the Department of Orthopaedic Surgery Rush Medical College Rush-Presbyterian-St. Luke＇s Medical Center Chicago Illinois 上海第二军医大学附属长征医院骨科 200003

背景：当前，膝关节单髁置换再次引起人们的兴趣。本篇报道阐述了一种目前仍在应用的单髁置换假体的10年以上的随访结果。方法：对连续的51例患者的62侧组配式骨水泥型Miller—Galante单髁置换假体进行临床和影像学研究。所有患者均有... 详细信息

背景：当前，膝关节单髁置换再次引起人们的兴趣。本篇报道阐述了一种目前仍在应用的单髁置换假体的10年以上的随访结果。方法：对连续的51例患者的62侧组配式骨水泥型Miller—Galante单髁置换假体进行临床和影像学研究。所有患者均有孤立的单髁疾患，而无髌股关节症状尤失随访病例。13例（13膝）在10年随访期内死亡，余38例（49膝）随访至少10年，平均随访期为12年。结果：末次随访时，专门外科医院膝关节评分从术前的平均55分提高到平均92分。38膝（80％）为优，6膝（12％）为良，4膝（8％）为可。39膝（80％）屈曲至少可达120。。2例患者（2膝）虽单髁假体固定良好，但由于髌股关节炎进展，分别在术后第7年和第11年进行全膝置换翻修术。末次随访时影像学检查．所有假体无松动也无假体周围骨溶解的迹象。在影像学上观察9膝（18％）到对侧问隔有进行性关节间隙狭窄，有7膝（14％）为髌股关节间隙进行性狭窄。Kaplan—Meier分析发现，以翻修或放射学松动为终点，假体的10年生存率为98．0％±2％，13年生存率为97．5％±4.3％。以无菌性松动为终点，13年生存率为100％。结论：经过10年以上随访，这种骨水泥型组配式单髁假体具有良好的临床和影像学结果。虽然假体10年存留率良好，但影像学上可见其他间隔的进行性骨关节炎症状有缓慢进展。掌握好适应证和手术技术．这种单髁假体具有良好的结果，并开始第二个十年应用．

关键词：膝关节单髁置换随访结果关节间隙狭窄影像学研究进行性狭窄无菌性松动单髁假体假体周围骨溶解 3年生存率

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad b. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti b.S. Acharya C. Adam bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat b. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob b. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire b.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. babal H. bachacou K. bachas A. bachiu F. backman A. badea P. bagnaia M. bahmani A.J. bailey V.R. bailey J.T. baines L. baines O.K. baker E. bakos D. bakshi Gupta V. balakrishnan R. balasubramanian E.M. baldin P. balek E. ballabene F. balli L.M. baltes W.K. balunas J. balz E. banas M. bandieramonte A. bandyopadhyay S. bansal L. barak M. barakat E.L. barberio D. barberis M. barbero M.Z. barel K.N. barends T. barillari M-S. barisits T. barklow P. baron D.A. baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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宗教美国，世俗欧洲？

Information Measures of Wages and Employment: Application to Senegal

作者： (美)彼得·伯格(Peter berger) (英)格瑞斯·戴维(Grace Davie) (英)埃菲·霍卡斯(Effie Fokas)

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Applied Mathematics 2016年第3期7卷 177-182页

作者： Charles b. Moss Samba Mbaye James F. Oehmke Food and Resource Economics Department University of Florida Gainesville FL USA Department of Economics and Management Scienes Universite Gaston Berger de Saint Louis Saint Louis Senegal United States Agency for International Development Washington DC USA

This paper develops an information theoretic estimator of wage and employment shifts that provides quantification of and inference about type of employment (full time, part time, seasonal, unemployed) and industry share of employment. It is applied to determine the effects of two United States Agency for International Development (USAID) projects on employment in villages in the Tambacounda and Kedougou provinces in Senegal. The projects support the development of local forest-based production and processing industries. The results demonstrate statistically significant and positive effects on employment and the industry composition of employment.

关键词： Information Theory Agribusiness Development Agro-Forestry Forest Resources Poverty Reduction

对心室预激的心电生理进行无创性单次搏动成像

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 56-56页

作者： berger T. Fischer G. Pfeifer b. 刘少伟 Department of Internal Medicine Division of CardiologyMedical University InnsbruckInnsbruckAustria Dr.

目的:本研究旨在确定与标准的有创性电解剖标测法相比。

关键词：心电生理预激综合征标测高分辨率心电图导管射频消融导管室消融靶点起源部位离散度无创性

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淋巴细胞表面的一种热休克蛋白bE2的分离与鉴定

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中国病理生理杂志 2000年第10期16卷 200-200页

作者：董子明,赵明耀,杨洪艳,姚珂,张义国,Carole berger,王念慈河南医科大学病理生理学教研室!河南郑州450052 河南医科大学病理生理学教研室!河南郑州450052 河南医科大学病理生理学教研室!河南郑州450052 河南医科大学病理生理学教研室!河南郑州450052 河南医科大学病理生理学教研室!河南郑州450052 美国耶鲁大学皮肤系NewHavenCT06521U.

目的:bE2是皮肤T细胞淋巴瘤(CTCL)T细胞白血病的恶性淋巴细胞、艾滋病(AIDS)患者的部分淋巴细胞以及Eb病毒转化的b淋巴细胞(EbV-b)所表达的细胞表面的一种单聚体蛋白质,分子量为78 ***等用HTLV-1+的成人T细胞白血病(ATL)患者的淋巴细胞... 详细信息

目的:bE2是皮肤T细胞淋巴瘤(CTCL)T细胞白血病的恶性淋巴细胞、艾滋病(AIDS)患者的部分淋巴细胞以及Eb病毒转化的b淋巴细胞(EbV-b)所表达的细胞表面的一种单聚体蛋白质,分子量为78 ***等用HTLV-1+的成人T细胞白血病(ATL)患者的淋巴细胞免疫小鼠,制备抗bE2的单克隆抗体.该单抗可以识别在CTCL和ATL的恶性T细胞,EbV-b细胞,慢性b淋巴细胞白血病的淋巴细胞及AIDS的部分淋巴细胞所表达的一种78 kD的单链膜蛋白.休止状态的淋巴细胞受丝裂原等刺激后,其正常的T细胞也可呈bE2阳性.正常T细胞为阴性,而CTCL超过一半为阳性,因而可作为CTCL的诊断和预后评估指标.bE2在细胞表达的意义尚未确定,为弄清CTCL淋巴细胞及激活的正常淋巴细胞所表达的bE2的性质,本文从bEV-b细胞中分离出bE2分子,测定其氨基酸序列.方法和结果:细胞因蛋白裂解液裂解后,用单向、双向电泳分离、纯化、测定氨基酸序列.其大部分序列与78 kD的热休克蛋白(HSP)同源.提示bE2可能系HSP家族的一个成员,并可能为MHC限制性抗原递呈蛋白和肽合成、转运和装配起作用,HSP分子也能直接作为细胞介导的免疫应答的靶分子.bE2免疫球蛋白重链结合蛋白(bIP)一样能结合ATP,说明二者有相似性,然而识别胞浆的70 kD和78 kD的HSP的多抗或单抗在bE2阳性的CTCL细胞和EbV-b细胞表面却为阴性,我们对二者进行肽谱分析,表明有一定差异,提示二者是不同的分子或构型不同的分子.结论:bE2可能是存在于细胞中的热休克蛋白,并可能在恶性或转化的淋巴细胞表面表达,估计在肿瘤免疫中有一定潜在的意义.

关键词：热休克蛋白细胞表面 bE2

Knowledge and Attitudes of Health Care Providers and the Population about Rabies in Sokone Health District, Senegal

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Open Journal of Preventive Medicine 2020年第4期10卷 63-71页

作者： Khadim Niang Jean A. D. Tine Ahmadou b. Ndao Fatoumata b. Diongue Amadou I. Diallo Adama Faye Papa Ndiaye Anta Tal-Dia Public Health Department Gaston Berger University (UGB) Saint-Louis Senegal Institut de Santé et Développement Cheikh Anta Diop University Dakar Senegal Chief Medical Officer of Sokone Health District Fatick Region Senegal.

Rabies is still a deadly disease, but it is 100% preventable through vaccination. In 2016, Senegal notified 1214 cases of dog bites. In the same year, the district of Sokone recorded 50 cases of dog bites, of which 31.2% of the cases were notified in the region of Fatick. The objective of this study is to assess the level of knowledge, attitudes and practices of communities and healthcare providers when faced with a case of exposure to rabies in Sokone health district. This quantitative estimation study is of a descriptive cross-sectional type, which took place during the third quarter of 2017. It targeted the community and health care providers in the Sokone health district. Three-stage cluster sampling was carried out in the community. The recruitment of healthcare providers has been comprehensive. A questionnaire was administered to the community in the form of individual interviews and another questionnaire was sent to health care providers in the form of self-administration. Knowledge, attitude and practice rating grids were developed for the two categories of interviewees. Data entry and analysis was done with Epi Info 3.5.3 software and R 3.3.1. Out of 813 community members surveyed, 6.8% had already been bitten by an animal. A good level of knowledge about rabies was found in 22.4% of the community members. The attitude to a bite was correct for 94.1%. Of the 38 healthcare providers surveyed, only 5.6% had a good understanding of rabies. No provider knew the indications for rabies vaccination and the post-exposure vaccination schedule. In the Sokone health district, communities knew little about rabies. Healthcare providers who are supposed to inform and supervise them in the fight against rabies know less about it. Strengthening the skills of healthcare staff in dealing with bites exposing them to rabies is of urgency in the Sokone health district.

关键词： Rabies Zoonosis Neglected Tropical Disease bites Senegal