检索结果-南通市图书馆

Conformational dynamics as an intrinsic determinant of prion protein misfolding and neurotoxicity

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2095-2096页

作者： Alessandro Cembran Pedro fernandez-Funez Department of Chemistry and Biochemistry University of Minnesota DuluthDuluthMNUSA Department of Biomedical Sciences University of Minnesota Medical SchoolDuluth CampusDuluthMNUSA

The prion protein(PrP) is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal *** diseases are rare but deserve special attention because of their unique f... 详细信息

关键词： folding intrinsic dynamics

Medical Risks and Rewards--The search for effective cancer-fighting technology involves some unknown risks

在线全文

学校读者我要写书评

暂无评论

空中英语教室（高级版．彭蒙惠英语） 2024年第9期 28-29,47页

作者： meg Wingerter 不详

Aprocess of taking patients'own cells and reprogramming them to fight cancer has been a last-ditch option for blood cancer patients when nothing else worked,but a new study underway in Aurora,[Colorado,]is trying to d... 详细信息

关键词： cancer Medical fighting

Unveiling sinus venosus atrial septal defect and partial anomalous pulmonary venous return in an elderly patient

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2024年第4期21卷 462-464页

作者： Cristina M Font Anamarys Blanco fernandez Dinesh Kadariya Department of Medicine Division of CardiologyUniversity of Florida College of MedicineJacksonvilleFloridaUSA

Sinus venosus defect(SVD) accounts for 4%–11% of all atrial septal defects(ASD) and may present with dyspnea, heart failure(HF), palpitations, or angina.^[1] The malformation typically involves an interatrial communication due to a deficiency in the common wall connecting the right pulmonary veins and the superior vena cava(SVC) and often accompanies anomalous pulmonary venous connection of some or all of the pulmonary veins.

关键词： atrial septal venous

A review of data-driven whole-life state of health prediction for lithium-ion batteries:Data preprocessing, aging characteristics, algorithms, and future challenges

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第10期97卷 630-649页

作者： Yanxin Xie Shunli Wang Gexiang Zhang Paul Takyi-Aninakwa Carlos fernandez Frede Blaabjerg School of Information Engineering Southwest University of Science and Technology College of Electric Power Inner Mongolia University of Technology School of Pharmacy and Life Sciences Robert Gordon University Department of Energy Technology Aalborg University

Lithium-ion batteries are the preferred green energy storage method and are equipped with intelligent battery management systems(BMSs) that efficiently manage the *** not only ensures the safety performance of the batteries but also significantly improves their efficiency and reduces their damage *** their whole life cycle,lithium-ion batteries undergo aging and performance degradation due to diverse external environments and irregular degradation of internal *** degradation is reflected in the state of health(SOH) ***,this review offers the first comprehensive analysis of battery SOH estimation strategies across the entire lifecycle over the past five years,highlighting common research focuses rooted in data-driven *** delves into various dimensions such as dataset integration and preprocessing,health feature parameter extraction,and the construction of SOH estimation *** approaches unearth hidden insights within data,addressing the inherent tension between computational complexity and estimation *** enha nce support for in-vehicle implementation,cloud computing,and the echelon technologies of battery recycling,remanufacturing,and reuse,as well as to offer insights into these technologies,a segmented management approach will be introduced in the *** will encompass source domain data processing,multi-feature factor reconfiguration,hybrid drive modeling,parameter correction mechanisms,and fulltime health *** on the best SOH estimation outcomes,health strategies tailored to different stages can be devised in the future,leading to the establishment of a comprehensive SOH assessment *** will mitigate cross-domain distribution disparities and facilitate adaptation to a broader array of dynamic operation *** article reviews the current research landscape from four perspectives and discusses the challenges that lie *** and practitioners can ga

关键词： Aging mechanism Battery management system Data-driven approach Lithium-ion batteries State of health Whole life cycle

Psychiatric outcomes in outpatients affected by long COVID:A link between mental health and persistence of olfactory complaint

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第4期14卷 507-512页

作者： Victoria Metelkina-fernandez Louise-Emilie Dumas Clair Vandersteen David Chirio Auriane Gros Arnaud fernandez Florence Askenazy Valeria Manera Department of Psychiatry Nice University HospitalNice 06000France Department of Child and Adolescent Psychiatry UniversitéCôte d’AzurNice 06200France ENT Head and Neck InstituteNice 06100France Department of Infectiology Nice University HospitalNice 06200France Department of Orthophony UniversitéCôte d’AzurNice 06100France Cobtek UniversitéCôte d’AzurNice 06100France

BACKGROUND Anosmia was one of the main symptoms of coronavirus disease 2019(COVID-19).A psychiatric history(i.e.,depression)may be an independent contributor to the risk of COVID-19 diagnosis,and COVID-19 survivors appear to have an increased risk of neuropsychiatric sequelae(bidirectional association).AIM To compare the rate of psychiatric disorder among post-COVID patients without anosmia vs patients with persistent olfactory *** We conducted a prospective case control study from March 2020 to May *** recruited at the ENT department of Nice University Hospital had a subjective olfactory complaint(visual analogue scale)for over 6 wk and a molecular or CT-proven severe acute respiratory syndrome coronavirus 2 diagnosis confirmed by ***-COVID patients without persistent olfactory disorders were recruited at the university hospital infectiology *** medical histories were collected by a psychiatrist during the *** Thirty-four patients with post-COVID-19 olfactory complaints were included in the first group of the *** percent of the patients were female(n=17).The group’s mean age was 40.5±12.9 *** control group included 32 participants,of which 34.4%were female(n=11),and had a mean age of 61.2±12.2 *** rate of psychiatric disorder among post-COVID patients with olfactory complaints was significatively higher(41.7%)than among patients without(18.8%)(χ2=5.9,P=0.015).CONCLUSION The presence of a psychiatric history may constitute a potential risk factor for the development of long COVID due to persistent *** therefore seems important to establish reinforced health monitoring after a COVID 19 infection in at-risk *** prospective,translational,and collaborative studies are needed to extrapolate these results to the general population.

关键词： COVID-19 Anosmia Psychiatry Stress Neuroplasticity Psychiatric history

Diabetic cardiomyopathy:Emerging therapeutic options

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第8期15卷 1677-1682页

作者： Cornelius James fernandez Sahana Shetty Joseph M Pappachan Department of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Endocrinology Kasturba Medical CollegeManipal Academy of Higher EducationManipal 576104KarnatakaIndia Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Diabetic cardiomyopathy(DbCM)is a common but underrecognized complication of patients with diabetes mellitus(DM).Although the pathobiology of other cardiac complications of diabetes such as ischemic heart disease and cardiac autonomic neuropathy are mostly known with reasonable therapeutic options,the mechanisms and management options for DbCM are still not fully *** its early stages,DbCM presents with diastolic dysfunction followed by heart failure(HF)with preserved ejection fraction that can progress to systolic dysfunction and HF with reduced ejection fraction in its advanced stages unless appropriately *** from prompt control of DM with lifestyle changes and antidiabetic medications,disease-modifying therapy for DbCM includes prompt control of hypertension and dyslipidemia inherent to patients with DM as in other forms of heart diseases and the use of treatments with proven efficacy in HF.A basic study by Zhang et al,in a recent issue of the World Journal of Diabetes elaborates the potential pathophysiological alterations and the therapeutic role of teneligliptin in diabetic mouse models with *** this preliminary basic study might help to improve our understanding of DbCM and offer a potential new management option for patients with the disease,the positive results from such animal models might not always translate to clinical practice as the pathobiology of DbCM in humans could be ***,such experimental studies can encourage more scientific efforts to find a better solution to treat patients with this enigmatic disease.

关键词： Diabetic cardiomyopathy Diabetic cardiomyopathy Heart failure Pathobiology Teneligliptin

Diabetes and tuberculosis:An emerging dual threat to healthcare

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第7期15卷 1409-1416页

作者： Sahana Shetty Joseph M Pappachan Cornelius James fernandez Department of Endocrinology Kasturba Medical CollegeManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom

Tuberculosis(TB)remains a huge global healthcare challenge even in the 21^(st) century though the prevalence has dropped in developed countries in recent *** mellitus(DM)is an important risk factor for the development and perpetuation of TB owing to the immune dysfunction in patients with *** coexistence of both diseases in the same individual also aggravates disease severity,complications,and chance of treatment failure because of gross immune alterations posed by DM as well as *** complex cellular and humoral immunological factors are involved in the dangerous interaction between TB and DM,some of which remain unknown even *** is highly important to identify the risk factors for TB in patients with DM,and vice versa,to ensure early diagnosis and management to prevent complications from this ominous *** their research study published in the recent issue of the World Journal of Diabetes,Shi et al elaborate on the factors associated with the development of TB in a large cohort of DM patients from *** such research output from different regions of the world is expected to improve our knowledge to fight the health devastation posed by TB in patients with diabetes.

关键词： Tuberculosis Diabetes mellitus Immune dysfunction Treatment failure Multi-drug resistant tuberculosis

Templated synthesis of transition metal phosphide electrocatalysts for oxygen and hydrogen evolution reactions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第2期89卷 646-669,I0014页

作者： Rose Anne Acedera alicia Theresse Dumlao DJ Donn Matienzo Maricor Divinagracia Julie Anne del Rosario Paraggua Po-Ya Abel Chuang Joey Ocon Laboratory of Electrochemical Engineering(LEE) Department of Chemical EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines Mechanical Engineering University of CaliforniaMercedCA 95343USA Energy Engineering Program College of EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines

Transition metal phosphides(TMPs)have been regarded as alternative hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalysts owing to their comparable activity to those of noble metal-based *** have been produced in various morphologies,including hollow and porous nanostructures,which are features deemed desirable for electrocatalytic *** synthesis routes are often responsible for such *** paper reviews the latest advances and existing challenges in the synthesis of TMP-based OER and HER catalysts through templated methods.A comprehensive review of the structure-property-performance of TMP-based HER and OER catalysts prepared using different templates is *** discussion proceeds according to application,first by HER and further divided among the types of templates used-from hard templates,sacrificial templates,and soft templates to the emerging dynamic hydrogen bubble *** catalysts are then reviewed and grouped according to their ***,prospective research directions for the synthesis of hollow and porous TMP-based catalysts,such as improvements on both activity and stability of TMPs,design of environmentally benign templates and processes,and analysis of the reaction mechanism through advanced material characterization techniques and theoretical calculations,are suggested.

关键词： OER HER Transition metal phosphide Templated synthesis Electrocatalysts

Non-pharmacological interventions for diabetic peripheral neuropathy:Are we winning the battle?

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第4期15卷 579-585页

作者： Dania Blaibel Cornelius James fernandez Joseph M Pappachan Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Department of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom

Despite the advent of relatively reliable modalities of diagnosing diabetic peripheral neuropathy(DPN),such as nerve conduction studies,there is still a knowledge gap about the pathophysiology,and thus limited available in-terventions for symptom control and curtailing disease *** pharma-cologic aspect of management is mainly centred on pain control,however,there are several important aspects of DPN such as loss of vibration sense,pressure sense,and proprioception which are associated with risks to lower limb health,which pharmacotherapy does not ***,published evidence suggests non-pharmacologic interventions such as glycaemic control through dietary modification and exercise need to be combined with other measures such as psychotherapy,to reach a desired,however modest *** is emerging as an important treatment modality for several chronic medical conditions including neuropathic and other pain *** their study published in the World Journal of Diabetes on the potential of acupuncture to reduce DPN symptoms and enhance nerve conduction parameters,Hoerder et al have been able to demonstrate that acupuncture improves sensory function and that this effect is likely sustained two months after treatment *** previous studies also support these findings,larger multi-center randomized control trials including a sham-controlled arm accounting for a placebo effect are ***,given the satisfactory safety profile and the positive results found in these studies,it is likely that acupuncture may become an important aspect of the repertoire of effective DPN management.

关键词： Diabetic peripheral neuropathy Diabetes mellitus Pharmacotherapy Acupuncture Neuropathic pain Nonpharmacological intervention