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Comparison of Apigenin,Quercetin and Kaempferol Accumulation and Total Flavonoid Content in Leaves,Embryogenic Cultures and Cell Suspension Cultures of Parsley(Petroselinum crispum)

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国际实验植物学杂志(英文) 2023年第10期92卷 2807-2823页

作者： Laura Isabel Arias-Rodríguez Martha alicia Rodríguez-Mendiola Carlos Arias-Castro Federico Antonio Gutiérrez Miceli Diana Reséndez Pérez María Celina Luján hidalgo Juan JoséVillalobos Maldonado Norma Alejandra Mancilla Margalli Analytical Laboratory National Technological Institute of MexicoTuxtla Gutierrez CampusTuxtla GutierrezMexico Plant Biotechnology Laboratory Instrumental Analysis LaboratoryPlant Biochemistry LaboratoryNational Technological Institute of MexicoTlajomulco de ZunigaMexico Department of Cellular Biology and Genetics Faculty of Biological SciencesAutonomous University of Nuevo LeonSan Nicolas delos GarzaMexico

In recent years,there has been a growing interest in exploring alternative treatments for bone *** tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential promoters of bone *** our study,we specifically investigated the extract of Petroselinum crispum,a plant known for its abundance of osteogenic flavonoids such as apigenin,quercetin,and *** objective was to compare the total flavonoid content(TFC)and their accumulation in different *** obtained hydrolyzed aqueous extracts from the leaves of parsley plants(grown for 12 weeks in the field),weekly embryogenic cultures,and suspension cell *** TFC,measured in mg quercetin equivalent per gram of dry weight(QE mg/g dw),was found to be 53.81±0.97 for 52 g dw of leaves(1 kg plant fw),31.10±1.52 for 420 g dw of embryogenic cultures,and 11.80±0.76 for 210 g dw of cell ***,only the leaves and embryogenic cultures showed significant accumulation of osteogenic flavonoids,with apigenin levels of 1.8±0.3 and 0.32±0.02 mg/g dw,and kaempferol levels of 1.0±0.18 and 0.2±0.01 mg/g dw,*** findings indicate that embryogenic cultures have the potential to produce up to 40%more apigenin in 12 weeks compared to 1 kg of parsley plant,thanks to their superior biomass reproductive *** results present a promising biotechnological approach for generating extracts enriched with bioactive compounds,which can be further utilized in in vitro osteogenic testing.

关键词： Parsley(Petroselinum crispum)cultures osteogenic flavonoids bone regeneration aqueous extracts

Preface to the Focused Issue on High-Order Numerical Methods for Evolutionary PDEs

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Communications on Applied Mathematics and Computation 2023年第2期5卷 529-531页

作者： Arturo hidalgo Michael Dumbser Eleuterio F.Toro Departamento de Ingeniería Geológica y Minera Escuela Técnica Superior de Ingenieros de Minas y EnergíaCenter for Computational SimulationUniversidad Politécnica de MadridRíos Rosas2128003 MadridSpain Department of Civil Environmental and Mechanical EngineeringUniversity of TrentoVia Mesiano 7738123 TrentoItaly

The underlying fields of this special issue of CAMC include mathematical modeling through evolutionary partial differential equations(PDEs),advanced high-order non-lin-ear numerical methods for their approximation and applications in various engineering branches,in physics,biology and medicine,to name but a *** special interest are math-ematical models based on systems of hyperbolic balance laws,including stiff source terms.

关键词： hyperbolic stiff approximation

3D Bioprinting with Live Cells

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Engineered Regeneration 2022年第3期3卷 292-309页

作者： alicia Persaud Alexander Maus Lia Strait Donghui Zhu Department of Biomedical Engineering Stony Brook UniversityUSA

In recent years,the shortage of available organs for transplant patients has grown exponentially across the ***,the healthcare industry is in dire need of artificial *** recent research studies and tissue engineering groups have decided to utilize 3D bioprinting to produce these artificial *** synthetic organ printing is made possible by advancements in the materials required for the constructs,the printing method-ologies used to produce them,and the final physical structures’varying *** cutting-edge research and technology related to 3D and 4D live cell bioprinting have recently allowed researchers to produce multiple types of artificial organs and *** tissues can be utilized for drug screening and organ replacement *** article provides an extensive review of all the pertinent 3D live cell bioprinting ***,we describe scaffolding methods and their comparison with the traditional ***,we explain the 3D bioprinting technology,its evolution,and its multiple ***,we describe the pros and cons of each bioprinting ***,we have discussed the critical bioink properties and their impact on the formation of 3D bioprinting *** addition,we also describe the mechanical properties of ***,we have thoroughly discussed the various types of hydrogels and their *** kind of hydrogel is utilized in specific applications,and we have presented a comprehensive list of its advantages and ***,we have discussed various applications of 3D bioprinting *** have considered a case study of human or-gans and elaborated on how bioprinters can revolutionize the organ replacement ***,we evaluated the possibility of 4D printing in the future organ industry,incorporating temporal factors into the bioprinting process.

关键词： Bioprinting Three-dimensional Scaffolding Live cell Hydrogels 4D bioprinting Applications

Improving the prognosis before and after liver transplantation:Is muscle a game changer?

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World Journal of Gastroenterology 2022年第40期28卷 5807-5817页

作者： Alexis Goffaux alicia Delorme Géraldine Dahlqvist Nicolas Lanthier Laboratory of Hepato-Gastroenterology Institut de Recherche Expérimentale et CliniqueUniversitécatholique de LouvainBrussels 1200Belgium Service d’Hépato-Gastroentérologie Cliniques universitaires Saint-LucUniversitécatholique de LouvainBrussels 1200Belgium

Liver transplantation(LT)is currently the only curative treatment option for selected patients with end stage liver disease or hepatocellular *** waiting list-mortality,post-transplant morbidity and mortality and refining the selection of the patients remain our current central *** this field,different concepts dealing with nutrition and the muscle such as sarcopenia,malnutrition,frailty or myosteatosis have emerged as possible game *** more than a decade,many prospective studies have demonstrated that sarcopenia and frailty are major predictive factors of mortality in the waiting list but also after *** is also a well-known risk factor for morbidity and *** composition is a newer concept giving insight on muscle quality which has also been shown to be linked to poorer *** of these terms has a precise definition as well as pathophysiological *** bidirectional liver-muscle axis makes sense in this *** the best,easy to use in clinical practice tools to assess muscle quality,quantity,and function in this specific population and developing quality prospective studies to identify interventional strategies that could improve these parameters as well as evaluate the effect on mortality are among the important challenges of today.

关键词： Muscle Liver Transplantation Sarcopenia Myosteatosis Frailty

Explainable Rules and Heuristics in AI Algorithm Recommendation Approaches——A Systematic Literature Review and Mapping Study

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1023-1051页

作者： Francisco JoséGarcía-Penlvo Andrea Vázquez-Ingelmo alicia García-Holgado GRIAL Research Group Computer Science DepartmentUniversity of SalamancaSalamanca37008Spain

The exponential use of artificial intelligence(AI)to solve and automated complex tasks has catapulted its popularity generating some challenges that need to be *** AI is a powerfulmeans to discover interesting patterns and obtain predictive models,the use of these algorithms comes with a great responsibility,as an incomplete or unbalanced set of training data or an unproper interpretation of the models’outcomes could result in misleading conclusions that ultimately could become very *** these reasons,it is important to rely on expert knowledge when applying these ***,not every user can count on this specific expertise;non-AIexpert users could also benefit from applying these powerful algorithms to their domain problems,but they need basic guidelines to obtain themost out of AI *** goal of this work is to present a systematic review of the literature to analyze studies whose outcomes are explainable rules and heuristics to select suitable AI algorithms given a set of input *** systematic review follows the methodology proposed by Kitchenham and other authors in the field of software *** a result,9 papers that tackle AI algorithmrecommendation through tangible and traceable rules and heuristics were *** reduced number of retrieved papers suggests a lack of reporting explicit rules and heuristics when testing the suitability and performance of AI algorithms.

关键词： SLR systematic literature review artificial intelligence machine learning algorithm recommendation heuristics explainability

Exploring Alternatives to Create Digital Twins from and for Process Simulation

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Journal of Computer Science Research 2024年第1期6卷 16-30页

作者： Jaime Barbero-Sánchez alicia Megía-Ortega Víctor R.Ferro Jose-Luis Valverde Department of Chemical Engineering University of Castilla La ManchaAvda.Camilo JoséCela 12Ciudad Real13071Spain Department of Chemical Engineering Autonomous University of MadridCantoblancoMadrid28049Spain

In this work,Digital Twins based on Neural Networks for the steady state production of styrene were ***,both the Aspen Technology AI Model Builder(alternative 1)and a homemade MS Excel VBA code connected to Aspen HYSYS and Aspen Plus(alternative 2)were used with this same *** raw data used for generating the Digital Twins were obtained from process simulations using Aspen HYSYS and/or Aspen Plus,which were connected through a recycle-like stream via automation for solving the entire simulation *** HYSYS was used for solving the pre-heating,reaction,and stabilization sections of the process whereas Aspen Plus ensured the computing of the separation and purification *** alternatives led to an excellent prediction showing the capability of creating Digital Twins from and for process simulation.

关键词： Digital Twin Aspen Hybrid Model Builder Aspen HYSYS Aspen Plus Automation MS Excel-VBA

Determination of altitudes of the three main Ecuadorian summits through GNSS positioning

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Geodesy and Geodynamics 2022年第4期13卷 343-351页

作者： Maria Jose Merizalde Mora Cesar Alberto Leiva Gonzalez Dennys Alexander Enriquez hidalgo Theofilos Toulkeridis Universidad de Las Fuerzas Armadas ESPE SangolquiEcuador Instituto Geografico Militar IGM QuitoEcuador Universidad de Especialidades Turisticas UDET QuitoEcuador

Determining the altitude of mountains is one of the most fundamental challenges for ***,the main objective of the study is to determine the altitudes of the three main summits in Ecuador through GNSS positioning,referring to the official vertical datum of Ecuador and the geo-potential surface(W_(o)).The three peaks are active volcanoes named Chimborazo,Cotopaxi and Cayambe,all of which are known to be over 5700 m above sea *** GNSS was performed on the summit of the volcanoes,and the GPS leveling method was applied on nearby *** these summits,the correction of the potential difference between the mean sea level and W_(o) was *** altitudes referred to the mean sea level were compared with other registered heights,and the results are more accurate than previous geodetic missions.

关键词： Altitude Volcanoes GNSS GPS leveling Geopotential

A novel semantic segmentation approach based on U-Net,WU-Net,and U-Net++deep learning for predicting areas sensitive to pluvial flood at tropical area

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International Journal of Digital Earth 2023年第1期16卷 3661-3679页

作者： Laura Melgar-García Francisco Martínez-álvarez Dieu Tien Bui alicia Troncoso Data Science&Big Data Lab Pablo de Olavide UniversitySevilleSpain GIS Group Department of Business and ITUniversity of South-Eastern NorwayGullbringvegen 36B?i Telemark3800Norway

Floods remain one of the most devastating weather-induced disastersworldwide, resulting in numerous fatalities each year and severelyimpacting socio-economic development and the ***, the ability to predict flood-prone areas in advance is crucialfor effective risk management. The objective of this research is to assessand compare three convolutional neural networks, U-Net, WU-Net, andU-Net++, for spatial prediction of pluvial flood with a case study at atropical area in the north of Vietnam. They are relative new convolutionalgorithms developed based on U-shaped architectures. For this task, ageospatial database with 796 historical flood locations and 12 floodindicators was prepared. For training the models, the binary crossentropywas employed as the loss function, while the Adaptive momentestimation (ADAM) algorithm was used for the optimization of themodel parameters, whereas, F1-score and classification accuracy (Acc)were used to assess the performance of the models. The results unequivocally highlight the high performance of the three models,achieving an impressive accuracy rate of 96.01%. The flood susceptibility maps derived from this research possess considerable utility for local authorities, providing valuable insights and informationto enhance decision-making processes and facilitate the implementation of effective risk management strategies.

关键词： Flash-flood assessment convolutional networks climate change GIS

Effect of heat treatment on the mechanical and biocorrosion behaviour of two Mg-Zn-Ca alloys

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Journal of Magnesium and Alloys 2022年第2期10卷 581-595页

作者： N.Pulido-González P.hidalgo-Manrique S.García-Rodríguez B.Torres J.Rams Departamento de Matemática Aplicada Ciencia e Ingeniería de Materiales y Tecnología ElectrónicaESCETUniversidad Rey Juan CarlosC/Tulipán s/nMóstolesMadrid28933Spain

The effect of heat treatment on the mechanical and biocorrosion behaviour of the Mg-1 wt.%Zn-1 wt.%Ca(ZX11)and Mg-3 wt.%Zn-0.4 wt.%Ca(ZX30)alloys was *** this purpose,three-point bending tests as well as electrochemical and immersion tests in Hank’s solution were performed on both alloys in four different thermal conditions:as-cast,solution-treated,peak-aged and *** examinations revealed that the as-cast ZX11 and ZX30 alloys exhibit a microstructure composed ofα-Mg grains separated by large Mg_(2)Ca and Ca_(2)Mg_(6)Zn_(3) particles and by large Ca_(2)Mg_(6)Zn_(3) particles,*** solution treatment,the Ca_(2)Mg_(6)Zn_(3) precipitates at the grain boundaries(GBs)are fully dissolved in the ZX11 alloy,but mainly redistributed to form a more connected configuration in the ZX30 alloy,showing a poor age-hardening ***,after solution-treatment,galvanic corrosion and corrosion rate decreases in the former,but increases in the *** peak-aged condition displays the highest corrosion rate for both alloys,maybe due to an excessive number density of fine Ca_(2)Mg_(6)Zn_(3) particles acting as cathodic ***,the over-aged condition shows the lowest corrosion rate for the ZX11 alloy and a very similar one to that of the as-cast sample for the ZX30 *** ZX11 alloy shows generally better biocorrosion behaviour than the ZX30 alloy to its lower content in the Ca_(2)Mg_(6)Zn_(3) phase and thus reduced galvanic *** Mg_(2)Ca phase present in the studied ZX11 alloy has been proved to exhibit an increased corrosion potential,which has been related to an observed enrichment with Zn.

关键词： Magnesium alloys Biodegradable implants Heat treatment Microstructure Mechanical properties Corrosion