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Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects

Open Journal of Immunology 2013年第3期3卷 82-92页

作者： V. Wallace McCarlie James K. Hartsfield Jr Janice S. Blum Carlos González-cabezas Judith R. Chin George J. Eckert Lorri A. Morford Mark D. Pescovitz Henry Rodriguez Margherita Fontana Richard L. Gregory Center for Oral Health Research Division of Orthodontics Department of Oral Health Science and Department of Microbiology Immunology and Molecular Genetics Colleges of Dentistry and Medicine University of Kentucky Lexington USA Center for Oral Health Research Division of Orthodontics Department of Oral Health Science College of Dentistry University of Kentucky Lexington USA Department of Biostatistics Schools of Medicine and Public Health Indiana University Indianapolis USA Department of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan Ann Arbor USA Department of Microbiology and Immunology School of Medicine Indiana University Indianapolis USA Department of Pediatric Dentistry and Orthodontics School of Dental Medicine East Carolina University Greenville USA Department of Pediatric Dentistry School of Dentistry Indiana University Indianapolis USA Department of Pediatrics College of Medicine University of South Florida Tampa USA Departments of Oral Biology and Preventive and Community Dentistry and Department of Pathology and Laboratory Medicine Schools of Dentistry and Medicine Indiana University Indianapolis USA Departments of Surgery and Microbiology and Immunology School of Medicine Indiana University Indianapolis USA

Bacterial adherence to the acquired dental pellicle, important in dental caries (caries), is mediated by receptor-adhesins such as salivary agglutinin binding to Streptococcus mutans antigen I/II (I/II). Ten selected I/II epitopes were chosen to determine their reactivity to human salivary IgA. Previous studies suggested that a specific HLA biomarker group (HLA-DRB1*04) may have differential influence of immune responses to I/II. However, it was not known whether secretory IgA (SIgA) responses to the selected epitopes from HLA-DRB1*04 positive subjects were different compared to controls, or across other caries-related factors such as total IgA (TIgA). Thirty-two total subjects were matched according to HLA type, gender, ethnicity and age. HLA genotyping, oral bacterial, immunoglobulin and antibody analyses were performed. A large observed difference emerged with regard to the natural immune reservoir of TIgA in HLA-DRB1*04 positive subjects, specifically, a 27.6% reduction compared to controls. In contrast to all other epitopes studied, HLA-DRB1*04 positive subjects also exhibited reduced reactivity to I/II epitope 834-853. HLA-DRB1*04 positive subjects exhibited lower specific SIgA activity/TIgA to 834-853 and also a lower specific reactivity to 834-853/whole cell S. mutans UA159. Furthermore, HLA-DRB1*04 positive subjects exhibited lower responses to I/II in its entirety. The large observed difference in TIgA and the 834-853 reactivity pattern across multiple measures suggest potentially important connections pertaining to the link between HLA-DRB1*04 and caries.

关键词： Dental Caries Streptococcus mutans I/II IgA Immunomodulation Immunogenetics HLA-II DRB1 DRB1*04

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Potentiality of Vermicompost Humic Acids in Banana in Vitro Micropropagation Clone： Enano Guantanamero

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Journal of Environmental Science and Engineering(A) 2013年第11期2卷 677-685页

作者： Marcia B. Moya Fernandez Luis Eduardo Cosio-Vargas Daniel cabezas Montero Andres Calderin Garcia Dany Marrero Lopez Sandra Perez Alvarez Deperment of Plant Protection Agrarian University of Havana (Fructuoso Rodriguez Perez) Mayabeque 32 700 Cuba INIFAP (Nacional Research Center of Forest Agrarian and Livestock) Uruapan 60150 Mexico Havana Biofabric Mayabeque 32700 Cuba

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