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Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1307-1323页

作者： Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca alicia guadalupe oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza Department of Medical Oncology Hospital Professor Doutor Fernando Fonseca EPEAmadora 2720-276Portugal Department of Medical Oncology Centro Hospitalar Barreiro-Montijo EPEBarreiro 2830-003Portugal Department of Medical Oncology Hospital do Espírito Santo deÉvora EPEÉvora 7000-811Portugal Department of Medical Oncology Centro Hospitalar Universitário do Algarve EPEAlgarve 8000-386Portugal Department of Medical Oncology Hospital São Francisco XavierCentro Hospitalar Lisboa Ocidental EPELisboa 1449-005Portugal Department of Medical Oncology Hospital Santo António dos CapuchosCentro Hospital Lisboa Central EPELisboa 1169-050Portugal Department of Medical Oncology Hospital BeatrizÂngeloLoures 2674-514Portugal Department of Medical Oncology Centro Hospitalar de Trás-os-Montes e Alto Douro EPEVila Real 5000-508Portugal Department of Medical Oncology Hospital da Senhora da Oliveira EPEGuimarães 4835-044Portugal Department of Medical Oncology Hospital Garcia de Orta EPEAlmada 2805-267Portugal Department of Medical Oncology Hospital da LuzLisboa 1500-650Portugal Department of Medical Oncology Hospital Distrital de Santarém EPESantarém 2005-177Portugal

BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive *** To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC *** This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese *** were compared through non-parametric Mann-Whitney *** operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent *** This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of *** Higher NLR is correlated with longer survival *** LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT a

关键词： Gastric cancer Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel Neutrophil-to-lymphocyte Lymphocyte-to-monocyte Platelet-to-lymphocyte Tumor regression grade

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Effects of biological soil crusts and drought on emergence and survival of a Patagonian perennial grass in the Monte of Argentina

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Journal of Arid Land 2014年第6期6卷 735-741页

作者： Flavia Alejra FUNK Alejro LOYDI guadalupe PETER Center for Renewable Natural Resources of the Semi-arid Zone National Scientific and Technical Research Council (CONICET)Bahía Blanca 8000Argentina Río Negro National University Viedma 8500Argentina

Biological soil crusts are widely distributed in arid and semiarid regions. They have an important eco- logical role, especially by modifying physical and chemical properties of soils. Biological crusts may also modify seed germination and seedling establishment. The effects vary widely according to the type of crust and the vas- cular plant species. The objective of this study was to determine the effect of moss-dominated biological soil crusts on the emergence, biomass and survival of Poa ligularis Nees ex Steud. under different irrigation regimes. We col- lected seeds of P. ligularis and biological soil crusts composed of two species of mosses： Syntrichia princeps （De Not.） Mitt and Ceratodon purpureus （Hedw.） Brid. from an area in the Monte of Argentina. The result showed that seedling emergence of P. ligularis was higher in treatments with bare soil than in soil covered by crusts, and also in those with watering to field capacity. Mean emergence time was higher in treatments with bare soil and watering to field capacity. Seedling biomass also showed significant differences between treatments. These results suggest that biological soil crusts dominated by mosses do not promote P. ligularis emergence, although they would not affect its survival.

关键词： drought field capacity recruitment microsites mosses semiarid region Poa ligularis

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Is Tetranychus urticae suitable prey for development and reproduction of nafve Coleomegilla maculata？

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Insect Science 2014年第1期21卷 83-92页

作者： Eric W. Riddick Zhixin Wu M~ guadalupe Rojas National Biological Control Laboratory Agricultural Research Service USDA 59 Lee Road Stoneville MS 38776 USA

The lady beetle Coleomegilla maculata De Geer is an omnivorous predator that could help suppress aphid and spider mite populations on plants in greenhouses, plantscapes or interiorscapes. We are assessing the nutritional requirements and feeding behavior of C. maculata on target prey （spider mites） and factitious （unnatural） food. Our ultimate goal is to develop an efficacious diet to mass produce C. maculata. In this study, we tested the hypothesis that Tetranychus urticae Koch （two-spotted spider mite） is not suitable prey for development and reproduction of naive C. maculata （i.e., with no prior exposure to T. urticae）. Our objectives were to （i） provide baseline data on the effects of consuming T. urticae on C. maculata life history, （ii） to compare the effects of consuming all stages of T. urticae versus eggs ofMusca domestica L. （common housefly）, and （iii） to determine if the consumption of plant products was beneficial. We used C. maculata from a colony reared only on Ephestia kuehniella Zeller （Mediterranean flour moth） eggs. In experiments, C. maculata larvae were reared from the first instar to adult stage with prey/food in replicated arenas; adult females were paired with a single male with prey/food. The results showed that naive C. maculata readily attacked and consumed T. urticae. Nevertheless, T. urticae was less suitable than M. domestica eggs for C. maculata development and reproduction. Applying a synthetic pollen-Chlorella alga powder （SPCA） in arenas containing T. urticae appeared to boost C. maculata female development and reproduction.

关键词： behavior biocontrol CoccineUidae nutrition rearing

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Rehabilitation of Semi-Arid Grasslands through the Perennialization of Lots by Implementing Perennial Forage Exotic Grass

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2115-2125页

作者： Delfina Arancio Sidoti Juan Manuel Zeberio guadalupe Peter Universidad Nacional de Río Negro Sede AtlánticaCEANPaViedma8500Argentina Consejo Nacional de Investigaciones Científicas y Técnicas CONICETCABABuenos Aires1425Argentina Chacra Experimental Patagones Ministerio de Desarrollo Agrario de la Provincia de Buenos AiresCarmen de Patagones8504Argentina

Argentina is the country with the highest proportion of arid and semi-arid ecosystems in Latin *** the rangelands of Southwestern Buenos Aires(Patagones Department),there is a clear advancement of the agricultural frontier to the detriment of the native forest in this *** to rainfall variation and seed acquisition,Thinopyrum ponticum is cultivated as a forage perennial crop in this *** objective was to evaluate the performance of *** as a facilitating crop for the medium-term rehabilitation of natural grasslands in semi-arid *** working hypotheses were that:1)native perennial grass cover increases over the years and 2)diversity and specific richness of the vegetation are enhanced by the duration of Tall Wheatgrass *** were collected from commercial plots where *** was shown:recent implantation(5–8 years,RI);medium implantation(13–15 years,MI);and old implantation(20–22 years,OI).Thirty-four species were identified and classified into seven functional groups:Annual grasses,annual herbs,perennial herbs,exotic perennial herbs,perennial forage grasses,exotic perennial forage grasses,perennial forage exotic grasses,and nonforage perennial *** ponticum’s total cover was between RI and *** cover,species richness,and Shannon-Weaver diversity index showed no differences among *** forage grasses exhibited higher cover values in sites with greater implantation age and annual grasses showed the opposite *** results indicated that *** does not invade the sampled plots and enhances the colonization of the planted plots by perennial forage native ***,even though the herbaceous cover had been recovered,the woody layer which could provide environmental services and specific values for conservation was not.

关键词： Wheatgrass clearing vegetation monte Thinopyrum ponticum

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Ocular trauma in an urban Spanish population:epidemiology and visual outcome

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1327-1333页

作者： Marta Belmonte-Grau guadalupe Garrido-Ceca Paula Marticorena-álvarez Department of Ophthalmology Hospital Universitario de La PrincesaMadrid 28006Spain Universidad Autónoma de Madrid Medicine UniversityMadrid 28006Spain

AIM:To describe epidemiological aspects,clinical findings,and visual results in eye trauma patients requiring urgent surgery at a tertiary ***:Retrospective review of adult patients requiring urgent surgery for trauma to the eyeball from January 2010 and April *** was collected relative to age,gender,mechanism of the injury,type of wound,initial and final visual acuity,number and type of surgeries carried *** were classed according to the Birmingham Eye Trauma Terminology(BETT)and the Ocular Trauma Score(OTS)***:The survey included 92 *** age was 54.76±22.18 *** most frequent cause was domestic accidents(44.6%),followed by aggression(22.80%)and occupational accidents(17.4%).Trauma from aggression was more frequent in men(P=0.006)and accidents in the home more common in women(P=0.011).Patients over 65 y presented an odds ratio(OR)of 10.71 for suffering a domestic *** between 15-45 and 46-65 y were at higher risk of trauma from aggression(OR=17.52 and OR=10.94,respectively).As for the type of injury,63.04%were open-globe lesions,Zone II being the most frequently affected(27.2%).In Logistic regression analysis,old age(P=0.05)and retinal involvement(P=0.001)were found to be associated with higher rate of unfavourable visual ***:The epidemiological aspects of eye trauma are highly dependent on the area of population *** accidents are more relevant than workplace accidents in older urban areas with high socioeconomic status.A better knowledge of the epidemiological characteristics is useful for implementing specific prevention measures and appropriate treatment strategies.

关键词： ocular trauma epidemiology domestic accident

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Refractive index measurement of dielectric samples using highly focused radially polarized light(Invited Paper)

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Chinese Optics Letters 2017年第3期15卷 12-15页

作者： guadalupe López-Morales Victor-Manuel Rico-Botero Rafael Espinosa-Luna Qiwen Zhan GIPYS Laboratory Centro de Investigaciones en Optica A. C. León Gto 37150 México Department of Electro-Optics and Photonics University of Dayton Dayton OH 45469 USA

In this Letter, a refractive index measurement of a dielectric sample using highly focused radially polarized light is reported. Through imaging analysis of the optical field at the pupil plane of a high numerical aperture （NA） objective lens reflected by the sample under study, the Brewster angle is found. Employing a high NA objective lens allows the measurement of multiple angles of incidence from 0° to 64° in a single shot. The refractive index of the sample is estimated using the measured Brewster angle. The experimental results are compared with the theoretical images computed with the Fresnel theory, and a good agreement is obtained.

关键词： high Refractive index measurement of dielectric samples using highly focused radially polarized light

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Cadmium sorption by sodium and thiourea-modified zeolite-rich tuffs

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Journal of Environmental Sciences 2017年第2期29卷 39-48页

作者： Perfecto Barragán P M.guadalupe Macedo M Maria T.Olguín Instituto Tecnologico de Toluca Laboratorio de Investigacion en Ingenieria Ambiental.Av.Tecnologico S/NColonia Ex-Rancho La VirgenMetepecEstado de Meico CP.52140Mexico Instituto National de Investigaciones Nucleares Departamento de QuimicaA.P.18-1027Col.EseandonDelegacion Miguel Hidalgo C.P.11801Mexico

In the present investigation, two zeolite-rich tuffs from Guaymas and El Cajon（State of Sonora）, which were conditioned with a sodium chloride solution and subsequently modified with a thiourea solution, were chosen to evaluate the removal of Cd from aqueous systems. The zeolitic materials were characterized by scanning electron microscopy and X-ray diffraction. The surface area was also determined. The experiments were performed in a batch system, and the influences of p H, contact time between phases, and the concentration of Cd in the solution on the adsorption by sodium or thiourea-modified zeolite-rich tuff were investigated. It was found that the efficiency of Cd ion removal from aqueous solutions is influenced by the p H of the aqueous systems. The Cd adsorption kinetic data were well fitted to a pseudo-second-order model in all cases. The Langmuir and Langmuir–Freundlich isotherms adequately described the Cd sorption behavior by the zeolite from El Cajon pretreated with Na Cl and the zeolite from Guaymas modified with thiourea, respectively.

关键词： Cadmium Zeolite-rich-tuff Sorption Kinetics Isotherms

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Intraexaminer repeatability and agreement in stereoacuity measurements made in young adults

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 374-381页

作者： Beatriz Antona Ana Barrio Isabel Sanchez Enrique Gonzalez guadalupe Gonzalez Department of Optics II (Optometry and Vision) Faculty of Optics and Optometry Complutense University of Madrid

AIM: To determine the repeatability and agreement of stereoacuity measurements made using some of the most widely used clinical tests: Frisby, TNO, Randot and ***: Stereoacuity was measured in two different sessions separated by a time interval of at least 24 h but no longer than 1wk in 74 subjects of mean age 20.6y using the four methods. The study participants were divided into two groups: subjects with normal binocular vision and subjects with abnormal binocular ***: Best repeatability was shown by the Frisby and Titmus [coefficient of repeatability(COR): ±13 and±12s arc respectively] in the subjects with normal binocular vision though a clear ceiling effect was *** the subjects with abnormal binocular vision, best repeatability was shown by the Frisby(COR: ±69s arc)and Randot(COR: ±72s arc). In both groups, the TNO test showed poorest agreement with the other ***:Therepeatabilityofstereoacuitymeasures was low in subjects with poor binocular vision yet fairly good in subjects with normal binocular vision with the exception of the TNO test. The reduced agreement detected between the tests indicates they cannot be used interchangeably.

关键词： stereoacuity repeatability agreement tereopsis

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Electrochemical reduction of Cr(Ⅵ)in the presence of sodium alginate and its application in water purification

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Journal of Environmental Sciences 2021年第3期33卷 304-312页

作者： Bryan Butter Paola Santander guadalupe del CPizarro Diego POyarzún Federico Tasca Julio Sánchez Facultad de Química y Biología Universidad de Santiago de ChileUSACHCasilla 40Correo 33SantiagoChile Departamento de Química Universidad Tecnológica MetropolitanaJ.P.Alessandri 1242SantiagoChile Laboratorio de Nanotecnología Recursos Naturales y Sistemas ComplejosFacultad de Ciencias NaturalesUniversidad de AtacamaCopayapu 485CopiapóChile

Chromium(Cr)is used in many manufacturing processes,and its release into natural waters is a major environmental problem *** concentrations of Cr(Ⅵ)are toxic to human health and living organisms due to the carcinogenic and mutagenic nature of this *** work examined the conversion of Cr(Ⅵ)to Cr(Ⅲ)via electrochemical reduction using gold electrode in an acidic sodium alginate(SA)solution and subsequent removal of the produced Cr(Ⅲ)-SA by the polymer-enhanced ultrafiltration(PEUF)technique.A solution of SA in nitric acid was used both as an electrolytic medium during the voltammetric measurements and bulk electrolysis and as an extracting agent during the PEUF *** electroanalysis of Cr(Ⅵ)was performed by linear sweep voltammetry in the presence of acidic SA solution to study its voltammetric behavior as a function of the Cr(Ⅵ)concentration,pH,presence of Cr(Ⅲ),SA concentration and scan *** addition,the quantitative reduction of Cr(Ⅵ)to Cr(Ⅲ)was studied through the bulk electrolysis *** results showed efficient reduction with well-defined peaks at approximately 0.3 V ***/AgCl,using a gold working *** the pH increased,the reduction signal strongly decreased until its *** optimum SA concentration was 10 mmol/L,and it was observed that the presence of Cr(Ⅲ)did not interfere in the Cr(Ⅵ)*** the quantitative reduction by bulk electrolysis in the presence of acidic SA solution,it was possible to reduce all Cr(Ⅵ)to Cr(Ⅲ)followed by its removal via PEUF.

关键词： Alginate solution Chromium Electroanalytical chemistry Ultrafiltration Water purification

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A technical and socioeconomic approach to estimate forest residues as a feedstock for bioenergy in northern Mexico

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Forest Ecosystems 2019年第4期6卷 312-322页

作者： guadalupe Carrasco-Diaz Gustavo Perez-Verdin Jonathan Escobar-Flores Marco Antonio Marquez-Linares Instituto Politecnico Nacional CIIDIR Dgo.

Background: Forest residues can be a feasible alternative for converting energy into fuels, electricity, or *** to other second-generation bioenergy sources, they do not compete for food, are relatively cheap,abundant in forest-rich areas, and more importantly their energy balance is close to zero. Biomass estimations can help design energy strategies to reduce fossil fuels dependency. Because of the land property distribution in Mexico,biomass estimations should consider not only the physical availability, but also the willingness of landowners to extract such raw ***: This study presents a methodological approach for evaluating the potential use of forest residues as a feedstock to generate bioenergy in northern Mexico. Remote sensing and field forest inventory were used to estimate the quantity and distribution of forest residues. In addition, a discrete choice analysis evaluated landowners’ preferences towards bioenergy development, including the most important factors that influence their willingness to extract their products and the expected *** and conclusions: Considering both physical and socio-economic aspects, results showed that about59,000 metric tons per year could be available in the study area. The vast majority of landowners surveyed are willing to extract forest residues, as long as they are presented with extraction plans with the highest income. However, many showed concerns about the environmental impacts this activity can have on soils,plants, and fauna. These results can help evaluate the potential of these resources for bioenergy development.

关键词： Bioenergy Choice experiments Forest landowners Forest residues Remote sensing

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