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A New Implant for Transfemoral Amputation: Improved Gait and Comfort

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Open Journal of Orthopedics 2021年第6期11卷 199-205页

作者： mathieu Assal Halah Kutaish Richard Stern alice Bonnefoy-mazure Antoine Acker Axel Gamulin Stephane Stephane Gorki Carmona Alain Lacraz Foot & Ankle Surgery Center Centre Assal Hirslanden Clinique La Colline Geneva Switzerland Faculty of medicine Geneva University Geneva Switzerland Willy Taillard Laboratory of Kinesiology Geneva University Hospitals and Geneva University Geneva Switzerland Division of Orthopaedic Surgery and Traumatology University Hospitals of Geneva Geneva Switzerland

Introduction: Transfemoral amputation results in a prosthesis which bears weight on the ischium. Gait disturbance, lack of an end-bearing stump and discomfort in the groin from the socket even while sitting, are important issues. Methods: This is a pilot report of an ongoing randomized blind clinical trial of a new intramedullary implant post transfemoral amputation. Here, we describe a single case illustrating the surgical technique and clinical outcome of a dysfunctional post-traumatic transfemoral amputation addressed with this implant. Clinical gait analysis, SF-12 and VAS were assessed pre- and post-intervention at 6 months of follow-up. Results: An improved stump control is accomplished by means of myoplasty and myodesis through an end-cap. Stride width improved from 0.21 m pre-op to 0.13 m post-op, and more symmetrical stride length (△0.21 m pre-op vs. △0.06 m post-op) was noted, indicating improved gait quality and stability. Gait velocity increased (0.51 ± 0.04 m/s pre-op vs. 0.64 ± 0.02 m/s post-op). Conclusion: This technique reveals improvements in gait parameters in a transfemoral amputee treated with a new procedure. Improved prosthesis control, sitting comfort, greater hip range of motion, better gait stability, and enhanced walking abilities were noted.

关键词： Above Knee Amputation Transfemoral Amputation Gritti-Stokes Weight-Bearing end-Cap

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Quantum monty Hall Problem under Decoherence

作者： (美)詹姆斯·亨德勒(James Hendler) (美)爱丽丝 m.穆维西尔(alice m.mul.e.ill)

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Communications in Theoretical Physics 2010年第7期54卷 47-54页

作者： Salman Khan m.Ramzan m.K.Khan Department of Physics Quaid-i-Azam University

We study the effect of decoherence on quantum monty Hall problem under the influence of amplitude damping, depolarizing, and dephasing channels. It is shown that under the effect of decoherence, there is a Nash equilibrium of the game in case of depolarizing channel for alice＇s quantum strategy. Whereas in case of dephasing noise, the game is not influenced by the quantum channel. For amplitude damping channel, Bob＇s payoffs are found symmetrical about a decoherence of 50% and the maximum occurs at this value of decoherence for his classical strategy. However, it is worth-mentioning that in case of depolarizing channel, Bob＇s classical strategy remains always dominant against any choice of alice＇s strategy.

关键词： quantum monty Hall problem decoherence entanglement payoffs

Personalising exacerbation prediction strategies in chronic obstructive pulmonary disease

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World Journal of Respirology 2020年第2期10卷 11-16页

作者： Paul R ellis alice m Turner Institute of Applied Health Research University of BirminghamBirmingham B152TTUnited Kingdom

Chronic obstructive pulmonary disease(COPD)is one of the leading causes of mortality and morbidity *** of the most important features of this disease is exacerbations where a patient’s respiratory symptoms episodically *** accounted for over 140000 hospital admissions in 2012 in the United Kingdom with considerably more exacerbations being treated in primary *** significant research in this area in recent years,treatment of acute exacerbations in the community remains limited to oral glucocorticoids,antibiotics and *** of the issues with unpicking the complexity of exacerbations is trying to find out the exact underlying cause and mechanism that leads to symptoms and lung *** symptoms are initially guided by symptoms alone though multiple causes of exacerbations have common *** includes viral and bacterial infections and episodes relating to environmental triggers such as pollen and *** is also evidence that cardiovascular factors can contribute to symptoms of breathlessness that can mimic COPD *** this editorial we discuss recent advances in the use of precision medicine to more accurately treat exacerbations of *** includes identification of phenotypes that could help rationalise treatment and more importantly identify novel drug *** also consider the future role of precision medicine in preventing exacerbations and identifying COPD patients that are at increased risk of developing them.

关键词： Chronic obstructive pulmonary disease exacerbations Phenotypes endotypes Precision medicine Clinical

A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export

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A neuroligin-4 missense mutation associated with autism impa...

新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究（英文）

中国神经科学学会第十届全国学术会议

作者： Chen Zhang Jeff m milunsky Stephanie Newton Jaewon Ko Geping Zhao Tom A maher Helen Tager-Flusberg marc F Bolhger alice S Carter Antony A Boucard Craig m Powell Thomas C Sudhof Department of molecular and Cellular Physiology Stanford University Departments of Neuroscience The University of Texas Southwestern Medical Center Center for Human Genetics Boston University School of Medicine Department of Pediatrics/Genetics and Genomics Boston University School of Medicine Human Development Program Boston University School of Medicine Departments of Neurology The University of Texas Southwestern Medical Center Departments of Psychiatry The University of Texas Southwestern Medical Center Howard Hughes medical Institute Stanford University Departments of molecular Genetics The University of Texas Southwestern Medical Center Departments of Howard Hughes medical Institute The University of Texas Southwestern Medical Center

Neuroligins（NLs） are postsynaptic cell-adhesion molecules essential for normal synapse *** in neuroligin-4（NL4）（gene symbol:NLGN4） have been reported in some patients with autism spectrum disorder（ASD）and other neurodevelopmental ***,the low frequency of NL4 mutations and the limited information about the affected patients and the functional consequences of their mutations cast doubt on the causal role of NLA mutations in these ***,we describe two brothers with classical ASD who carry a single amino-acid substitution in NL4（R87W）.This substitution was absent from the brothers’ asymptomatic parents,suggesting that it arose in the maternal germ line.R87 is conserved in all NL isoforms,and the R87W substitution is not observed in control *** the protein level,the R87W substitution impaired glycosylation processing of NL4 expressed in HeK293 and COS cells,destabilized NL4,caused NL4 retention in the endoplasmic reticulum in non-neuronal cells and neurons,and blocked NLA transport to the cell *** a result,the R87Wsubstitution inactivated the synapse-formation activity of NLA and abolished the functional effect ofNLA on synapse *** together,these observations suggest that a point mutation in NLA can cause ASD by a loss-of-function mechanism.

关键词： neuroligins synapse autism spectrum disorder

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康复学报 2015年第1期25卷 26-33页

作者： meredith T L YeUNG Alan W P WONG Katherine S L HUANG alice Y m JONeS 新加坡理工大学学术项目部门新加坡中央医院理疗治疗部门格里菲斯大学联合健康科学学院

目的:6 min步行距离(6mWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6mWD的最小临床重要差异(mCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6... 详细信息

目的:6 min步行距离(6mWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6mWD的最小临床重要差异(mCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6mWD的最小临床重要差异。方法:采用"锚定"法和"分布"法对新加坡中央医院肺康复计划登记处的资料进行了分析。"锚定"法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6mWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过"分布"法确定6mWD的mCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6mWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由"分布"法确定6mWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6mWD的最小临床重要差异的估计值。

关键词：肺康复 6mWD 最小临床重要差异

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厨房制造徐州某餐厅

室内设计与装修 2009年第6期 36-41页

作者： Horace Pan Alan Tse Vivian Chan alice

厨房制造（made in Kitchen）是一家才开业不久的餐厅，位于徐州市个非常热闹的街区。整个餐厅共1114m^2，分为两层。原本的建筑中并没有将上下两层直接连接起来的楼梯，因此需要设计师在餐厅的内部设计出个垂直的楼梯，以联通上下两层... 详细信息

厨房制造（made in Kitchen）是一家才开业不久的餐厅，位于徐州市个非常热闹的街区。整个餐厅共1114m^2，分为两层。原本的建筑中并没有将上下两层直接连接起来的楼梯，因此需要设计师在餐厅的内部设计出个垂直的楼梯，以联通上下两层，这是设计重点之。

关键词：徐州市餐厅制造厨房内部设计室内空间隔音效果设计师

2007年ACC／AHA非心脏手术围手术期心血管评估与管理指南：实施概要

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麻醉与镇痛 2010年第6期6卷 1-28页

作者： Lee A Fleisher Joshua A Beckman Kenneth A Brown Hugh Calkins elliott Chaikof Kirsten e Fleischmann William K Freeman James B Froehlich edward K Kasper Judy R Kersten Barbara Riegel John F Robb Sidney C Smith alice K Jacobs Cynthia D Adams Jeffrey L Anderson elliott m Antman Christopher e Buller mark A Creager Steven m ettinger David P Faxon Valentin Fuster Jonathan L Halperin Loren F Hiratzka Sharon A Hunt Bruce W Lytle Rick Nishimura Joseph P Ornato Richard L Page Lynn G Tarkington Clyde W Yancy

美国心脏病学院镁国心脏协会工作组有关实践指南的一份报告（编写委员会对2002年非心脏手术围手术期心血管评估指南的修改）

关键词：非心脏手术管理指南血管评估围手术期 ACC/AHA 美国心脏病学院实践指南心脏协会

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美应削减赤字，避免经济二次触底

世界知识 2011年第23期 6-6页

作者：徐永智 alice m．Rivlin

美国经济复苏速度与年初相比已经大幅放缓，目前应特剐警惕美议会削减赤字的谈判破裂且欧洲财政危机急速恶化的情况，这将导致美经济二次触底。目前德法希望维持欧盟，因此尽管需要时间，希腊危机仍将被控制。尽管欧盟制定了财政规则，... 详细信息

美国经济复苏速度与年初相比已经大幅放缓，目前应特剐警惕美议会削减赤字的谈判破裂且欧洲财政危机急速恶化的情况，这将导致美经济二次触底。目前德法希望维持欧盟，因此尽管需要时间，希腊危机仍将被控制。尽管欧盟制定了财政规则，但是在混乱情况下要求每个国家都遵守相当困难。

关键词：经济复苏赤字财政危机欧盟