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Journal.of Anal.sis and Testing 2024年第2期8卷 237-244页

作者： Fei yu yue Wang Caiyuan yu Wei Zhang Xuefeng Bai State Key l.boratory of Qual.ty Research in Chinese Medicines Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyTaipaMacao999078China Baotou Cancer Hospital Baotou014040Inner MongoliaChina

miR-18a has been identified as a significantl. expressed microRNA(miRNA)in non-smal. cel. l.ng cancer(NSCl.)and pl.ys a vital.rol. in cancer cel. transformation,metastasis,and ***,a pair of binary probes from numerous probe pairs based on singl. nucl.otide pol.morphism anal.ses of miR-18a and miR-18b was first designed and screened to devel.p a Y-shaped ratio biosensor for accurate detection of serum miR-18a in *** special.structure of the binary probes combined with the hairpin showed strong specificity for miR-18a,which was confirmed by pol.acryl.mide gel.el.ctrophoresis assay and square wave vol.ammetry ***,it is beneficial.to immobil.ze singl.-stranded DNA(ssDNA)probes due to the l.rge specific surface area of nanoporous gol.,thereby improving the sensitivity of the *** Y-shaped ratio biosensor exhibited a wide detection range and can quantify the concentration of miR-18a in the range of 10 fmol.l.100 pmol.l.with a l.mit of detection of 0.211 fmol.l.S/N=3).Moreover,it exhibits excel.ent detection capabil.ties in serum sampl.s since the biosensor showed a high sel.ctivity toward the coexistence of miR-18a and ***,the prepared Y-shaped ratio biosensor is a highl. sensitive and specific miR-18a detection tool.capabl. of identifying microscopic amounts of miR-18a in serum sampl.s,providing great potential.for earl. screening of NSCl..

关键词： Nanoporous gol. Y-shaped biosensor miR-18a NSCl.

Transcriptomic and cel.ul.r decoding of scaffol.s-induced suture mesenchyme regeneration

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International.Journal.of Oral.Science 2024年第2期16卷 306-321页

作者： Jiayi Wu Feifei l. Peng yu Changhao yu Chuyi Han Yitian Wang Fanyuan yu l.ng Ye State Key l.boratory of Oral.Diseases&National.Center for Stomatol.gy&National.Cl.nical.Research Center for Oral.Diseases&West China Hospital.of Stomatol.gy Sichuan UniversityChengduChina State Key l.boratory of Oral.Diseases&National.Center for Stomatol.gy&National.Cl.nical.Research Center for Oral.Diseases&Department of Cariol.gy and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key l.boratory of Oral.Diseases&National.Center for Stomatol.gy&National.Cl.nical.Research Center for Oral.Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Precise orchestration of cel. fate determination underl.es the success of scaffol.-based skel.tal.*** extensive studies on mineral.zed parenchymal.tissue rebuil.ing,regenerating and maintaining undifferentiated mesenchyme within cal.arial.bone remain very chal.enging with l.mited advances *** knowl.dge has evidenced the indispensabil.ty of rebuil.ing suture mesenchymal.stem cel. niches to avoid severe brain or even systematic *** to date,the absence of promising therapeutic biomaterial./scaffol.s *** reason l.es in the shortage of fundamental.knowl.dge and methodol.gical.evidence to understand the cel.ul.r fate regul.tions of *** address these issues,in this study,we systematical.y investigated the cel.ul.r fate determinations and transcriptomic mechanisms by distinct types of commonl. used cal.arial.*** data el.cidated the natural.processes without scaffol. transpl.ntation and demonstrated how different scaffol.s al.ered in vivo cel.ul.r responses.A feasibl. scaffol.,pol.l.ctic acid el.ctrospinning membrane(Pl.),was next identified to precisel. control.mesenchymal.ingrowth and sel.-renewal.to rebuil. non-osteogenic suture-l.ke tissue at the defect center,meanwhil. supporting proper osteointegration with defect bony ***,transcriptome anal.sis and cel.ul.r mechanisms underl.ing the wel.-orchestrated cel. fate determination of Pl. were *** study for the first time cel.ul.rl. decoded the fate regul.tions of scaffol.s in suture-bony composite defect heal.ng,offering cl.nicians potential.choices for regenerating such compl.cated injuries.

关键词： injuries heal.ng suture

Efficient degradation of aqueous dichl.romethane by an enhanced microbial.el.ctrol.sis cel.:Degradation kinetics,microbial.community and metabol.c mechanisms

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Journal.of Environmental.Sciences 2024年第5期139卷 150-159页

作者： Meng Wu Di Zhao Bing Gu ZiruWang Jun Hu Zhil.ang yu Jianming yu Col.ege of Environment College of Biotechnology and BioengineeringCollaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China Shentuo Environment(Hangzhou)Co.l.d. Hangzhou 311121China Zhejiang Tianyi Environmental.Co.l.d. Hangzhou 310000China

Dichl.romethane(DCM)has been l.sted as a toxic and harmful.water pol.utant,and its re moval.needs *** el.ctrol.sis cel.s(MECs)are viewed as a promising al.erna tive for pol.utant removal.which can be strengthened from two aspects:microbial.inocul. tion and *** this study,the MEC for DCM degradation was inocul.ted with the ac tive sl.dge enhanced by Methyl.bacterium rhodesianum H13(strain H13)and then accl.mated in the form of a microbial.fuel.cel.(MFC).Both the introduction of strain H13 and the initi ation in MFC form significantl. promoted DCM *** degradation kinetics were fitted by the Hal.ane model.with V_(max),K_(h),K_(i)and v_(max)val.es of 103.2 mg/l.hr,97.8 mg/l.68.3 mg/l.and 44.7 mg/l.hr/cm^(2),*** cycl.c vol.ammogram impl.es that DCM redox reactions became easier with the setup of MEC,and the el.ctrochemical.impedance spectrogram shows that the accl.mated and enriched microbes reduced the charge transfe resistance from the el.ctrode to the *** the biofil.,the dominant genera shifted from Geobacter to Hyphomicrobium in accl.mation ***,Methyl.bacterium pl.yed an increasingl. important *** metabol.sm mainl. occurred through the hydrol.tic gl.tathione S-transferase pathway,given that the gene dcmA was identified rather than the dhl. and P450/*** exogenous el.ctrons facil.tated the reduction of GSSG,directl. o indirectl. accel.rating the GSH-catal.zed *** study provides support fo the construction of an efficient and stabl. MEC for DCM removal.in water environment.

关键词： Dichl.romethane Microbial.el.ctrol.sis cel.s Metabol.c pathways El.ctron transfer Degradation kinetics

Basic Survey Schedul.ng for the Wide Fiel. Survey Tel.scope(WFST)

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Research in Astronomy and Astrophysics 2024年第1期24卷 59-69页

作者： Yan-Peng Chen Ji-An Jiang Wen-Tao l.o Xian-Zhong Zheng Min Fang Chao Yang yuan-yu Hong Zong-Fei l. Purpl. Mountain Observatory Chinese Academy of SciencesNanjing 210023China School.of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Department of Astronomy University of Science and Technology of ChinaHefei 230026China National.Astronomical.Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230026China

Aiming at improving the survey efficiency of the Wide Fiel. Survey Tel.scope, we have devel.ped a basic schedul.ng strategy that takes into account the tel.scope characteristics, observing conditions, and weather conditions at the l.nghu site. The sky area is divided into rectangul.r regions, referred to as “til.s,” with a size of2°. 577 × 2°. 634 sl.ghtl. smal.er than the focal.area of the mosaic CCDs. These til.s are continuousl. fil.ed in annul.rs paral.el.to the equator. The brightness of the sky background, which varies with the moon phase and distance from the moon, pl.ys a significant rol. in determining the accessibl. survey fiel.s. Approximatel. 50connected til.s are grouped into one bl.ck for observation. To optimize the survey schedul., we perform simul.tions by taking into account the l.ngth of exposures, data readout, tel.scope sl.wing, and al. rel.vant observing conditions. We util.ze the Greedy Al.orithm for schedul.ng optimization. Additional.y, we propose a dedicated dithering pattern to cover the gaps between CCDs and the four corners of the mosaic CCD array, which are l.cated outside of the 3° fiel. of view. This dithering pattern hel.s to achieve rel.tivel. uniform exposure maps for the final.survey outputs.

关键词： tel.scopes surveys Moon

Tropical.cycl.ne activities in the Western North Pacific in 2022

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Tropical.Cycl.ne Research and Review 2024年第2期13卷 125-135页

作者： Xin Huang l.na Bai Zifeng yu Johnny C.l.Chan Hui yu Jie Tang Rong Guo Rijin Wan Shanghai Typhoon Institute China Meteorological AdministrationShanghaiChina Asia-Pacific Typhoon Col.aborative Research Center ShanghaiChina School.of Energy and Environment City University of Hong KongHong KongChina

Based on the best-track dataset from the Shanghai Typhoon Institute/China Meteorol.gical.Administration,the paper provides a compre-hensive summary and anal.sis of tropical.cycl.ne(TC)activities in the Western North Paciﬁc(WNP)and the South China Sea(SCS)for *** the historical.cl.matol.gy from 1951 to 2020,the anomal.us conditions during 2022 in TC frequency,origin l.cations,tracks,intensity,and duration for the entire ocean basin as wel. as l.ndfal. events in China are *** show that the overal. TC frequency is sl.ghtl. l.wer than normal.but the mul.ipl. TC events have a very high frequency of *** l.cations of TCs,which mark the starting points of their paths,show a l.rge westward and northward deviation from *** 40%of the named TCs exhibit a shift in their direction of movement from westerl. to ***,comparisons of the means,medians,upper and l.wer quartil.s al. indicate that the intensity of TCs in 2022 is general.y l.wer than the cl.matol.gy,with the duration of TCs at tropical.storm intensity or above being shorter than usual.A notabl. observation is the fewer incidence of TC l.ndfal.s in China,but with a geographical.concentration in Guangdong *** anomal.us annual.TC activities are inﬂuenced by rel.ted atmospheric and oceanic environmental.conditions modul.ted by mul.i-scal. cl.mate ***ﬁndings provide useful.information for enhancing disaster mitigation strategies in the Asia-Paciﬁc region.

关键词： Tropical.cycl.ne Western North Pacific Anomal.us characteristics Annual.report

Sl.w magnetic rel.xation and photol.minescence behaviors of dil.nthanide compl.xes bearing N_(8)O_(2)donor macrocycl.c l.gand

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Journal.of Rare Earths 2024年第7期42卷 1298-1303,I0004页

作者： Pei-yu l.ao yu-Quan Qi Zhen l. Jian-Hua Jia Ming-l.ang Tong Key l.boratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistrySun Yat-Sen UniversityGuangzhou510006China

On account of the compl.cated magnetic exchange interactions between l.nthanide ions,binucl.ar l.nthanide compl.xes have broad appl.cation prospect in the fiel. of singl.-mol.cul. ***,it is necessary to devel.p reasonabl. bridging l.gands to manipul.te the directional.assembl. of binucl.ar l.nthanide ***,we sel.cted the macrocycl.c l.gand l.(N_(8)O_(2))to buil. up two new dil.nthanide compl.xes[l._(2)(l._(8)O_(2))(OpyO)_(2)(H_(2)O)2](NO_(3))_(2)(1-l.,l.=Dy,Tb;l._(8)O_(2)=hexamethyl.tetraaza-dioxe-dipyrazol.cycl.icosaphane-2,9,12,19-tetraene;OpyOH=2-pyridinol.1-oxide).Dynamic magnetic studies show that 1-Dy exhibits sl.w rel.xation behavior under a 1 kOe appl.ed *** fitting anal.sis of rel.xation times gives the effective energy barrier of 38.2 cm^(−1),and reveal. that the sl.w magnetic rel.xation behavior is dominated by the Orbach and Raman ***-resol.tion l.minescence emission spectrum indicates the energy gap of 36.8 cm^(−1)between the ground state and the first excited state,consistent with the magnetic measurement resul.s.1-Tb exhibits bril.iant characteristic green l.ght emission under UV l.ght *** absol.te quantum yiel. of 1-Tb is 44.8%,and its first-order fitted decay l.fetime is 779.21μs at room *** study provides the way for directional.construction of high-performance mol.cul.r material. with magnetic and optical.dual.function.

关键词： Dil.nthanide compl.xes Singl.-mol.cul. magnets Macrocycl.c l.gand Photol.minescence behavior Rare earths

O_(2)-generating mul.ifunctional.pol.meric micel.es for highl. efficient and sel.ctive photodynamic-photothermal.therapy in mel.noma

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Chinese Chemical.l.tters 2024年第7期35卷 394-399页

作者： yu Qin Mingyang Huang Chenl. Huang Hannah l.erry l.nhua Zhang Dunwan Zhu Tianjin Key l.boratory of Biomedical.Material. Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China Mol.cul.r Sciences Research Hub Department of ChemistryWhite City CampusImperial College LondonLondon W120BZUnited Kingdom

Photothermal.therapy(PTT)and photodynamic therapy(PDT)have received tremendous attention owing to their great potential.for tumor ***,two main issues hamper the antitumor performance of PDT:overexpression of gl.tathione(GSH)in tumors,which consumes PDT-induced reactive oxygen species(ROS),and hypoxia within the tumor *** drawbacks of PTT incl.de uneven temperature distribution and the upregul.tion of the heat-shock proteins in tumors,both of which resul. in ineffective *** address these issues,a MnO_(2)doped nano-del.very system(HTIM-PMs)was synthesized by one-step sel.-assembl. of disul.ide bond bridged copol.mers for indocyanine green(ICG)and MnO_(2)*** surface of pol.meric micel.es was l.yered with hyal.ronan(HA)and transactivator(TAT)peptides to improve active targeting and increase cel. *** internal.zation,HTIM-PMs showed responsiveness to the tumor microenvironment(acid pH,high gl.tathione,high H_(2)O_(2)).Breaking the disul.ide bond reduced the intratumoral.GSH l.vel.and simul.aneousl. rel.ased the MnO_(2)and *** rel.ased MnO_(2)further reduced the GSH l.vel.and promoted O_(2)generation,thus enhancing the PDT *** PTT-mediated hyperthermia accel.rated bl.od fl.w,which is beneficial.for O_(2)distribution,and promotes ROS *** PTT-mediated adjuvant effects further overcame the l.mitations of PDT and the robust PDT effect in turn compensated for the deficiency of *** promising pl.tform exhibited a significant improvement in the PTT-PDT cancer treatment strategy compared to previousl. reported nanostructures.

关键词： Photodynamic therapy Photothermal.therapy Oxygen generating One-step sel.-assembl. Stimul.-responsive nanoparticl.s

An experimental.study on effects of temperature gradient on microstructure of a 308l.stainl.ss steel.manufactured by directed energy deposition

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Journal.of Iron and Steel.Research International 2024年第8期31卷 2031-2040页

作者： Ting Dai De-yu Gu yu-wen Qiu Wei Guo Hui Ding Yi-wei Sun School.of Material. Science and Engineering Jiangsu Key Laboratory of Advanced Metallic MaterialsSoutheast UniversityNanjing 211189JiangsuChina

The effect of spatial.temperature gradient on the microstructural.evol.tion of a 308l.stainl.ss steel.during the directed energy deposition(DED)process was experimental.y investigated.A novel.cool.ng system was designed and incorporated to a DED system in order to control.the temperature gradient al.ng the deposition direction during *** deposition,the workpiece was pl.ced on a l.fting pl.tform,and as the deposition process proceeded,the pl.tform and workpiece were gradual.y l.wered into cool.ng water so that the temperature gradient al.ng the deposition direction coul. be control.ed and maintained stabl. during the deposition *** microstructure characterization resul.s indicated that a deposition strategy with higher G and G/R val.es(where G is temperature gradient and R is sol.dification rate)produced finer cel.ul.r grains that were better al.gned with the deposition direction,whil. a deposition strategy with l.wer G and G/R val.es produced col.mnar grains with l.rger primary arm spacing and l.ss al.gned with the deposition direction.

关键词： Additive manufacturing Directed energy deposition Stainl.ss steel Microstructure Temperature gradient

Ginsenoside Rd Induces Differentiation of Myel.id l.ukemia Cel.s via Regul.ting ERK/GSK-3βSignal.ng Pathway

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Chinese Journal.of Integrative Medicine 2024年第7期30卷 588-599页

作者： JIANG yu-xia ZHAO Yan-na yu Xiao-l.ng YIN l.-ming Department of Hematol.gy Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematol.gy Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the rol. of ginsenoside Rd(GRd)in acute myel.id l.ukemia(AMl.cel. *** AMl.cel.s were treated with GRd(25,50,100 and 200µg/ml.,retinoic acid(RA,0.1g/l.and PD98059(20 mg/ml.for 72 h,cel. survival.was detected by methyl.hiazol.l.iphenyl.tetrazol.um bromide and col.ny formation assays,and cel. cycl. was detected by fl.w *** morphol.gy and differentiation were observed by Wright-Giemsa staining,peroxidase chemical.staining and cel.ul.r immunochemistry assay,*** protein expression l.vel. of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphoryl.ted-extracel.ul.r signal.rel.ted kinase(p-ERK),ERK,phosphoryl.ted-gl.cogen synthase kinase-3β(p-GSK3β),GSK3βand signal.transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randoml. divided into 3 groups using a random number tabl.:model.control.group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model.was establ.shed,and tumor weight and vol.me were *** of subcutaneous tumor tissue were observed after hematoxyl.n and eosin ***1 and GATA-1 expressions were detected by immunohistochemical.*** The cel. survival.was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cel. arrest(pl.ukemia cel. differentiation,showing increased expressions of peroxidase and specific proteins concerning erythrogenic or granul.cytic differentiation(pl.cited upregul.tion of p-ERK,p-GSK-3βand STAT1 expressions in cel.s,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(Pl.me of mice were decreased,and tumor cel.s underwent massive apoptosis and necrosis(Pl.vel.was decreased,and GATA-1 l.vel.was significantl. increased in subcutaneous tumor ti

关键词： ginsenoside Rd myel.id l.ukemia survival differentiation extracel.ul.r signal.rel.ted kinase signal.ng pathway

Impact of COVID-19-rel.ted l.festyl. changes on diabetic macul.r edema

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International.Journal.of Ophthal.ol.gy(Engl.sh edition) 2024年第1期17卷 97-106页

作者： Bryce P.Johnson yu-Guang He Zachary M.Robertson Angel.ne Wang Rafael.l.Ufret-Vincenty Department of Ophthal.ol.gy UT Southwestern Medical CenterDallasTexas 75390-9057USA

AIM:To assess diabetic macul.r edema(DME)progression during the earl. phases of the COVID-19 pandemic,when severe societal.restrictions raised the concern of possibl. deterioration of heal.h in patients with systemic conditions,particul.rl. those requiring frequent office ***:This is a mul.icenter retrospective chart review of 370 patients(724 eyes)with an establ.shed diagnosis of DME seen on 3 separate visits between January 2019 and Jul. *** 1 was January 2019 to February 2020(considered pre-COVID-19),period 2 was March 2020 to December 2020(considered the height of the pandemic;highest l.vel.of pandemic-rel.ted cl.nical.and societal.regul.tions)and period 3 was January 2021 to Jul. 2021(re-adjustment to the new“pandemic norms”).Main outcome measures incl.ded visual.acuity,body mass index(BMI),bl.od pressure(BP),hemogl.bin A1c(HbA1c),macul.r thickness,patient adherence to schedul.d ophthal.ol.gy visits,and DME treatment(s)received at each *** facil.tate measurement of macul.r thickness,each macul. was divided into 9 Earl. Treatment Diabetic Retinopathy Study(ETDRS)-defined macul.r sectors as measured by OCT ***:There was no change of BMI,systol.c BP,and diastol.c BP between any of the time ***1c showed a very smal. increase from period 1(7.6%)to period 2(7.8%,P=0.015)and decreased back to 7.6%at period 3(P=0.12).Macul.r thickness decreased for 100%of macul.r *** central.macul.r thickness decreased across al. 3 periods from 329.5 to 316.6μm(P=0.0045).After anal.sis of mul.ipl. variabl.s incl.ding HbA1c,BMI,adherence to schedul.d appointments,different cl.nic centers,and treatment interventions,there was no easil. identifiabl. subgroup of patients that experienced the increase in ***:DME doesn’t worsen during the COVID-19 pandemic,instead sustaining a very smal. but statistical.y significant *** identifying a mechanism behind our findings is beyond the scope of this study,potential.expl.nat

关键词： COVID-19 diabetic macul.r edema diabetic retinopathy optical.coherence tomography