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Synaptic alterations as a common phase in neurological and neurodevelopmental diseases: JNK is a key mediator in synaptic changes

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Neural Regeneration Research 2023年第3期18卷 531-532页

作者： Clara alice Musi Carlo Bonadonna Tiziana Borsello Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilanoItaly Mario Negri Insitute for Pharmacolgical Research-IRCCS MilanoItaly

Brain synapses play a key role in neuronal communication:this“conversation”is at the basis of all brain activities and synaptic dysfunction leads to brain *** study the modulators of this crucial synaptic function and we here present the evidence supporting the c-Jun N-terminal kinase(JNK)pathway as a pivotal actor in this scenario.

关键词： alterations diseases neurological

On a Class of Non-local Operators in Conformal Geometry

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Chinese Annals of Mathematics,Series B 2017年第1期38卷 215-234页

作者： Sun Yung alice CHANG Ray A.YANG Mathematics Department Princeton UniversityFine HallWashington RoadPrinceton New Jersey 08544-1000USA

In this expository article, the authors discuss the connection between the study of non-local operators on Euclidean space to the study of fractional GJMS operators in conformal geometry. The emphasis is on the study of a class of fourth order operators and their third order boundary operators. These third order operators are generalizations of the Dirichlet-to-Neumann operator.

关键词： High order fractional GJMS operator Generalized boundary Yamabe problem Sobolov trace extension

Modeling chemical releases from building materials: The search for extended validity domain and parsimony

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Building Simulation 2021年第4期14卷 1277-1293页

作者： Lei Huang alice Micolier Henri P.Gavin Olivier Jolliet Department of Environmental Health Sciences School of Public HealthUniversity of MichiganAnn ArborMIUSA I2M CNRSUMR 5295351 Cours de la LibérationUniversity of Bordeaux33400TalenceFrance Department of Civil and Environmental Engineering Duke UniversityDurhanNCUSA

This study aims to systematically evaluate and extend the validity domains of multiple mechanistic models of chemical emissions from building materials. We compare the validity domain of the analytical solution with four numerical solutions for a single layer material with one convective surface and a wide range of chemical properties, material thicknesses, and simulation time. We also develop a parsimonious simplified model, ensuring the widest possible validity domain with minimum simulation time. For diffusion coefficients lower than 10−15 m^(2)/s, accuracy of the analytical solution requires at least 5000 positive roots. The numerical method using uneven discretization and finite difference approximation for the boundary conditions is the best numerical solution. The parsimonious combined D- and K-limited model achieves similar accuracy as the best numerical solution except slight overestimates at the interface between the D- and K-limited zones, while having simpler computations and much shorter simulation time. These models show good agreement against experimental data. This study demonstrates that the complex analytical solution can be well approximated by a simpler model with a wide validity domain, enabling the high-throughput screenings of a large number of chemical-product combinations.

关键词： emission models building materials organic chemicals analytical solution numerical and simplified solutions high-throughput assessment

Numerical Approximation of Oscillatory Solutions of Hyperbolic-Elliptic Systems of Conservation Laws by Multiresolution Schemes

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Advances in Applied Mathematics and Mechanics 2009年第5期1卷 581-614页

作者： Stefan Berres Raimund Burger alice Kozakevicius Departamento de Ciencias Matematicas y Fısicas Universidad Catolica de TemucoTemucoChile CI2MA and Departamento de Ingenier´ıa Matem´atica Facultad de Ciencias Fısicas y Matem´aticasUniversidad de Concepci´onCasilla 160-CConcepci´onChile Departamento de Matematica-CCNE Universidade Federal de Santa MariaAv.Roraima1000Campus Universit´arioSanta MariaRSCEP 97105-900Brazil

The generic structure of solutions of initial value problems of hyperbolic-elliptic systems,also called mixed systems,of conservation laws is not yet fully *** reason for the absence of a core well-posedness theory for these equations is the sensitivity of their solutions to the structure of a parabolic regularization when attempting to single out an admissible solution by the vanishing viscosity *** is,however,theoretical and numerical evidence for the appearance of solutions that exhibit persistent oscillations,so-called oscillatory waves,which are(in general,measure-valued)solutions that emerge from Riemann data or slightly perturbed constant data chosen from the interior of the elliptic *** capture these solutions,usually a fine computational grid is *** this work,a version of the multiresolution method applied to a WENO scheme for systems of conservation laws is proposed as a simulation tool for the efficient computation of solutions of oscillatory wave *** hyperbolic-elliptic 2×2 systems of conservation laws considered are a prototype system for three-phase flow in porous media and a system modeling the separation of a heavy-buoyant bidisperse *** the latter case,varying one scalar parameter produces elliptic regions of different shapes and numbers of points of tangency with the borders of the phase space,giving rise to different kinds of oscillation waves.

关键词： Hyperbolic-elliptic system conservation law oscillation wave numerical simulation multiresolution method sedimentation model

Considerations for pediatric burn sedation and analgesia

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Burns & Trauma 2017年第4期5卷 218-228页

作者： alice Fagin Tina L. Palmieri Arkansas Children's Hospital 1 Children's Way Little Rock AR 72202 USA Shriners Hospitals for Children Northern California and University of California Davis 2425 Stockton Blvd Suite 718 Sacramento CA USA

Burn patients experience anxiety and pain in the course of their injury, treatment, and recovery. Hence, treatment of anxiety and pain is paramount after burn injury. Children, in particular, pose challenges in anxiety and pain management due to their unique physiologic, psychologic, and anatomic status. Burn injuries further complicate pain management and sedation as such injuries can have effects on medication response and elimination. Burn injuries further complicate pain management and sedation as such injuries can have effects on medication response and elimination. The purpose of this review is to describe the challenges associated with management of anxiety, pain, and sedation in burned children and to describe the different options for treatment of anxiety and pain in burned children.

关键词： Pediatric Sedation Burns

Nonlinear constrained optimization using the flexible tolerance method hybridized with different unconstrained methods

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Chinese Journal of Chemical Engineering 2017年第4期25卷 442-452页

作者： alice Medeiros Lima Antonio Jose Goncalves Cruz Wu Hong Kwong Chemical Engineering Graduate Program Federal University of Sdo CarlosRodovia Washington Luizkm 235-5P310Sao CarlosSP 13565-905Brazil Department of Chemical Engineering Federal University of Sao CarlosRodovia Washington Luizkm 235-SP 310Silo CarlosSP 13565-905Brazil

This paper proposes the use of the flexible tolerance method(FTM) modified with scaling of variables and hybridized with different unconstrained optimization methods to solve real constrained optimization *** benchmark problems used to analyze the performance of the methods were taken from G-Suite *** original method(FTM) and other four proposed methods:(i) FTM with scaling of variables(FTMS),(ii) FTMS hybridized with BFGS(FTMS-BFGS),(iii) FTMS hybridized with modified Powell's method(FTMS-Powell)and(iv) FTMS hybridized with PSO(FTMS-PSO), were implemented. The success rates of the methods were 80%,100%, 75%, 95% and 85%, for FTM, FTMS, FTMS-BFGS, FTMS-Powell and FTMS-PSO, respectively. Numerical experiments including real constrained problems indicated that FTMS gave the best performance, followed by FTMSPowell and FTMS-PSO. Despite the inferior performance compared to FTMS and FTMS-Powell, the FTMS-PSO method presented some advantages since good different initial points could be obtained, which allow exploring different routes through the solution space and to escape from local optima. The proposed methods proved to be an effective way of improving the performance of the original FTM.

关键词： Flexible tolerance method Modified Powell’s method BFGS PSO Scaling Hybridization

An improved flexible tolerance method for solving nonlinear constrained optimization problems:Application in mass integration

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Chinese Journal of Chemical Engineering 2017年第5期25卷 617-631页

作者： alice Medeiros Lima Wu Hong Kwong Antonio José Goncalves Cruz Chemical Engineering Graduate Program Federal University of Sao Carlos Department of Chemical Engineering Department of Chemical Engineering Federal University of Sao Carlos

This paper proposes the use of the flexible tolerance method(FTM) modified with adaptive Nelder–Mead parameters and barrier to solve constrained optimization problems. The problems used to analyze the performance of the methods were taken from G-Suite functions, and the methods with the best performance were applied in mass integration problems. Four methods were proposed:(1) flexible tolerance method(FTM) using adaptive parameters(FTMA),(2) flexible tolerance method with scaling(FTMS) and with adaptive parameters(FTMAS),(3) FTMS including the barrier modification(MFTMS) and(4) MFTMS hybridized with PSO(MFTMS-PSO). The success rates of these methods were 100%(MFTMS), 85%(MFTMS-PSO), 40%(FTMAS) and 30%(FTMA).Numerical experiments indicated that the MFTMS could efficiently and reliably improve the accuracy of global optima. In mass integration, the method was able, from current process situation, to reach the optimum process configuration that includes integration issues, which was not possible using FTM in its standard formulation. The hybridization of FTMS with PSO(without barrier), FTMS-PSO, was also able to solve mass integration problems efficiently.

关键词： Flexible tolerance method Adaptive parameters Scaling Constrained optimization Barrier PSO Mass integration

Fecal microbial transplant for the treatment of pediatric inflammatory bowel disease

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World Journal of Gastroenterology 2016年第47期22卷 10304-10315页

作者： alice Yuxin Wang Jelena Popov Nikhil Pai Michael G DeG roote School of Medicine McM aster University Department of Pediatrics Division of Pediatric Gastroenterology Mc Master Children’s Hospital McM aster University Mc Master Integrative Neuroscience Discovery and Study Graduate Program Mc Master University

The role of fecal microbial transplant(FMT) in the treatment of pediatric gastrointestinal disease has become increasingly popular among pediatric practitioners, patients, and parents. The success of FMT for the treatment of recurrent Clostridium difficile infection(RCDI) has bolstered interest in its potential application to other disease states, such as inflammatory bowel disease(IBD). FMT has particular interest in pediatrics, given the concerns of patients and parents about rates of adverse events with existing therapeutic options, and the greater cumulative medication burden associated with childhoodonset disease. Published literature on the use of FMT in pediatrics is sparse. Only 45 pediatric patients treated for RCDI have been reported, and only 27 pediatric patients with pediatric IBD. The pediatric microbiome may uniquely respond to microbial-based therapies. This review will provide a comprehensive overview of fecal microbial transplant and its potential role in the treatment of pediatric inflammatory bowel disease. We will discuss the microbiome in pediatric inflammatory bowel disease, existing adult and pediatric literature on the use of FMT in IBD treatment, and pediatric FMT trials that are currently recruiting patients. This review will also discuss features of the microbiome that may be associated with host response in fecal transplant, and potential challenges and opportunities for the future of FMT in pediatric IBD treatment.

关键词： Inflammatory bowel disease Microbiome Microbiota fecal microbial transplant Pediatric Crohn’s disease Ulcerative colitis

Realization of the first sub-shot-noise wide field microscope

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Light(Science & Applications) 2017年第1期6卷 737-743页

作者： Nigam Samantaray Ivano Ruo-Berchera alice Meda Marco Genovese INRIM Strada delle Cacce 91I-10135 TorinoItaly Politecnico di Torino Corso Duca degli Abruzzi24I-10129 TorinoItaly INFN Via P.Giuria 1I-10125 TorinoItaly

Recently,several proof of principle experiments have demonstrated the advantages of quantum technologies over classical *** present challenge is to surpass the limits of proof of principle demonstrations to approach real *** letter presents such an achievement in the field of quantum enhanced *** particular,we describe the realization of a sub-shot-noise wide field microscope based on spatially multi-mode non-classical photon number correlations in twin *** microscope produces realtime images of 8000 pixels at full resolution,for a 500μm2 field of view,with noise reduced to 80%of the shot noise level(for each pixel),which is suitable for absorption imaging of complex *** fast post-elaboration,specifically applying a quantum enhanced median filter,the noise can be further reduced(to o30%of the shot noise level)by setting a trade-off with the resolution,thus achieving the best sensitivity per incident photon reported in absorption microscopy.

关键词： imaging microscopy parametric down conversion sub-shot-noise