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Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients

World Journal of Gastroenterology 2019年第10期25卷 1266-1277页

作者： alice jane foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F Brant Kevan Jacobson Division of Gastroenterology Hepatology and NutritionBritish Columbia Children’s Hospital Pediatrics B.C.Children’s Hospital Research Institute Pediatrics British Columbia children’s HospitalUniversity of British Columbia Department of Statistics University of British Columbia Department of Cellular and Physiological Sciences Faculty of Medicine

BACKGROUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease *** In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease *** In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 *** 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CONCLUSION Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population.

关键词： Fecal calprotectin Disease relapse Biomarker Crohn’s disease Children

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Risk factors for hepatocellular carcinoma associated with hepatitis C genotype 3 infection:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1596-1612页

作者： Hamzah Z Farooq Michael James jane Abbott Patrick Oyibo Pip Divall Naheed Choudhry Graham R foster Blizard Institute Queen Mary University of LondonLondon E12ATUnited Kingdom School of Health and Psychological Sciences University of LondonLondon EC1V 0HBUnited Kingdom University Hospitals of Leicester Library University Hospitals of Leicester NHS TrustLeicester LE39QPUnited Kingdom

BACKGROUND Hepatitis C virus(HCV)is a blood-borne virus which globally affects around 79 million people and is associated with high morbidity and *** infection leads to cirrhosis in a large proportion of patients and often causes hepatocellular carcinoma(HCC)in people with *** the 6 HCV genotypes(G1-G6),genotype-3 accounts for 17.9%of *** genotype-3 responds least well to directly-acting antivirals and patients with genotype-3 infection are at increased risk of HCC even if they do not have *** To systematically review and critically appraise all risk factors for HCC secondary to HCV-G3 in all ***,we studied possible risk factors for HCC due to HCV-G3 in the literature from 1946 to *** This systematic review aimed to synthesise existing and published studies of risk factors for HCC secondary to HCV genotype-3 and evaluate their strengths and *** searched Web of Science,Medline,EMBASE,and CENTRAL for publications reporting risk factors for HCC due to HCV genotype-3 in all settings,*** Four thousand one hundred and forty-four records were identified from the four databases with 260 records removed as *** thousand eight hundred and eighty-four records were screened with 3514 *** hundred and seventy-one full-texts were assessed for eligibility with seven studies included for *** the seven studies,three studies were retrospective case-control trials,two retrospective cohort studies,one a prospective cohort study and one a cross-sectional study *** were based in hospital settings with four in Pakistan,two in South Korea and one in the United *** total number of participants were 9621 of which 167 developed HCC(1.7%).All seven studies found cirrhosis to be a risk factor for HCC secondary to HCV genotype-3 followed by higher age(five-studies),with two studies each showing male sex,high alpha feto-protein,directly-acting antivirals trea

关键词： Hepatocellular carcinoma Hepatitis C Genotype 3 Systematic review Blood-borne viruses Liver cancer

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The Animals of China in the Eighteenth-Century British Imagination

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Fudan Journal of the Humanities and Social Sciences 2015年第2期8卷 167-177页

作者： jane Spencer College of Humanities University of Exeter Queen's Building The Queen's DriveExeter EX4 4QH UK

In eighteenth-century Britain, knowledge about animals from around the world was rapidly increasing. This paper focuses on what the British knew and imagined about the animals of China from reading the works of European travellers and natural historians. Whereas the animals of Africa and America served to foster a growing sense of European mastery of less civilized parts of the world through trade and possession, those of China were understood as embedded in a highly advanced civilization and therefore as sources of knowledge about that civilization. This paper examines the way in which British understandings of China were mediated through accounts of Chinese animals and of human–animal relations in China. Looking at works of popular natural history and at Oliver Goldsmith’s fictional letters of a "Chinese philosopher" in The Citizen of the World (1762), I argue that the animals of China bore several messages about their country. Focusing on the particular examples of the golden pheasant, the horse, the cormorant, and the cat, I suggest that British writing about Chinese animals served as a way of expressing mixed feelings about the value of advanced civilizations, whether Chinese or European.

关键词：人与动物英国人中国知识文明历史学家自然史世界欧洲

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Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease

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World Journal of Gastroenterology 2016年第8期22卷 2611-2620页

作者： alice L Bennett David Moore Peter A Bampton Robert V Bryant jane M Andrews Department of Gastroenterology Royal Adelaide Hospital North Terrace Adelaide SA 5000 Australia Department of Gastroenterology Flinders Medical Centre Flinders Drive Bedford Park SA 5042 Australia School of Medicine University of Adelaide Adelaide SA 5000 Australia Department of Gastroenterology Women's and Children's Hospital Adelaide SA 5006 Australia School of Medicine Flinders University Adelaide SA 5001 Australia

AIM: To describe the disease and psychosocialoutcomes of an inflammatory bowel disease(IBD) transition cohort and their ***: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition process. RESULTS: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance(35%), there was a very low usage(5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority(54%) felt they were not strongly prepared. A high rate(78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex(8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices(of the options offered) was a shared clinic appointment with all key stakeholders. CONCLUSION: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans.

关键词： Transition care Crohn’s disease Ulcerative colitis Chronic illness Inflammatory bowel disease Patien

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“透明”的建筑英国斯劳兰黎学院

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室内设计与装修 2010年第4期 68-73页

作者： alice foster+Partners

由foster＋Partners事务所设计、ARBIB基金会赞助的兰黎学院于2009年11正式投入使用。该学院以全新的办学理念挑战传统教育方式,开设了多项与众不同的课程,如辩论术、博物馆展陈、板球和划船等,惠及1150名年龄在11岁至18岁之间的学生。... 详细信息

由foster＋Partners事务所设计、ARBIB基金会赞助的兰黎学院于2009年11正式投入使用。该学院以全新的办学理念挑战传统教育方式,开设了多项与众不同的课程,如辩论术、博物馆展陈、板球和划船等,惠及1150名年龄在11岁至18岁之间的学生。除了课程设置外,

关键词：学院建筑英国课程设置教育方式办学理念事务所基金会

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青少年艾滋病毒感染者全球研究议程

青少年艾滋病毒感染者全球研究议程

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作者： alice Armstrong Jason M.Nagata Marissa Vicari Cadi Irvine Lucie Cluver Annette H.Sohn jane Ferguson Georgina Caswell Lucy Wanjiku Njenga Rachel Baggaley Martina Penazzato 张雅琴 Department of HIV and Global Hepatitis Programme World Health Organization Division of Adolescent and Young Adult Medicine Department of Pediatrics University of CaliforniaSan Francisc(UCSF) Department of Psychiatry and Mental Health University of Cape Town

【背景】尽管人们对青少年HIV的研究兴趣越来越大,但与青少年HIV感染者(ALHIV)的需求相比,目前介入研究的速度仍然很低。需要更有力的证据为创新和有针对性的干预措施提供信息,以弥补研究差距,为政策提供信息,并改善青少年的成果。世卫... 详细信息

【背景】尽管人们对青少年HIV的研究兴趣越来越大,但与青少年HIV感染者(ALHIV)的需求相比,目前介入研究的速度仍然很低。需要更有力的证据为创新和有针对性的干预措施提供信息,以弥补研究差距,为政策提供信息,并改善青少年的成果。世卫组织和CIPHER开展了一项全球研究优先次序的工作,以便在资源减少的情况下集中精力进行优先研究。【方法】采用儿童健康与营养研究倡议(CHNRI)方法。结果由一个专家组进行审查,并确定了检测、治疗和服务提供、现有政策、已发表文献和正在进行的研究的5个优先主题。【结果】共有来自67个国家的323人提交了986个研究问题。关于艾滋病毒检测,优先主题包括战略和干预措施,以改善获得、接受和与护理的联系,以及自我检测,特别是对关键人群。在治疗方面,优先事项包括监测和改善依从性的战略、新型药物输送系统、预防和管理共感染、最佳药物序列以及短期和长期结果。在服务提供方面,优先事项包括整个层级的服务提供模式、提高护理和性健康和生殖健康保留率的战略、对怀孕的ALHIV的支持以及提供心理社会支持。【结论】这一优先研究议程有助于集中今后对ALHIV的研究,并有助于填补关键的知识空白。关键的利益相关者、捐赠者、项目经理和研究人员都应该支持这些优先问题和主题,共同推动青少年艾滋病研究议程向前发展。

关键词：青少年艾滋病毒研究议程艾滋病毒检测艾滋病毒治疗艾滋病毒服务提供

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平凡的简

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新东方英语（中英文版） 2016年第8期 42-43页

作者： Liz foster 张玲

我相信自己跟许多爱书之人一样,回首走过的人生之路时,发现自己总能记起某些特定的书,它们助我成为现在的我;我也总能想起书中某些特定的人物,他们在我读完书许多年后依然与我如影随形。这些人物中,不可能没有简·爱。当我12岁第一次遇... 详细信息

我相信自己跟许多爱书之人一样,回首走过的人生之路时,发现自己总能记起某些特定的书,它们助我成为现在的我;我也总能想起书中某些特定的人物,他们在我读完书许多年后依然与我如影随形。这些人物中,不可能没有简·爱。当我12岁第一次遇到简这个人物时,让我印象最深的是简身上的一种特质,

关键词：相信自己人生之路简·爱爱书罗彻斯特 Charlotte 夏洛蒂·勃朗特 Rochester intelligent 罗切斯特

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创意新生代——2018伦敦New Designers展览

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现代装饰 2018年第5期 96-103页

作者： alice Funge Angie Packer Azmy Anything Anna Manfield Alex O'Connor Silver Bronwen Grieves Dominika Kupcova Laura-jane Atkinson Leszek Sikon Vlajeda Clarke Verity Howard Vanessa Stopforth Yeshen Venema 范嘉苑 ATYPICAL COCO.G

New Designers 2018展览将于今年的6月27日至7月7日在伊斯灵顿商业设计中心举办。作为已有33年历史的＂New Designers＂是英国最前沿的设计展览之一,每年都有许多英国的设计新星从中崭露头角。今年夏天,New Designers将会精心挑选3000... 详细信息

New Designers 2018展览将于今年的6月27日至7月7日在伊斯灵顿商业设计中心举办。作为已有33年历史的＂New Designers＂是英国最前沿的设计展览之一,每年都有许多英国的设计新星从中崭露头角。今年夏天,New Designers将会精心挑选3000多位年轻的在读设计师的作品呈现给观众,有大部分是从未面世的毕业生作品。展会旨在挖掘新生代的优秀设计师,让大众了解新生代设计师的想法与理念,通过创意的碰撞让灵感迸发。

关键词：新生代展览创意伦敦设计中心设计师毕业生英国

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人类与自然耦合系统

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AMBIO－人类环境杂志 2007年第B12期36卷 602-611页

作者：刘建国 Thomas Dietz Stephen R.Carpenter Carl Folke Marina Alberti Charles L.Redman Stephen H.Schneider Elinor Ostrom alice N.Pell jane Lubchenco William W.Taylor 欧阳志云 Peter Deadman Timothy Kratz William Provencher 张淑敏密歇根州立大学美国威斯康星大学瑞典皇家科学院贝耶学院华盛顿大学亚利桑那州立大学斯坦福大学亚利桑那州立大学制度多样性研究中心康奈尔大学的康奈尔国际食品农业与发展学院俄勒冈州立大学密歇根州立大学鱼类和野生动植物系中国科学院生态环境研究中心国家城市和区域生态重点实验室沃特卢大学地理系威斯康星州大学的威斯康星大学鳟鱼湖站威斯康星大学

人类与自然系统不断地相互作用促使人类与自然耦合系统(CHANS)的形成与发展。近期的研究揭示了人类与自然耦合系统在组织、空间以及时间上耦合的复杂性。这些耦合在相互作用方面从直接演化到更间接;在联结方面从邻近演化到更远距离;在... 详细信息

人类与自然系统不断地相互作用促使人类与自然耦合系统(CHANS)的形成与发展。近期的研究揭示了人类与自然耦合系统在组织、空间以及时间上耦合的复杂性。这些耦合在相互作用方面从直接演化到更间接;在联结方面从邻近演化到更远距离;在尺度上,从局部演化到全球;在模式和过程上,从简单演化到复杂。解开如相互影响和突发属性的复杂性,能够导致新的科学发现,并且对于开发生态和社会经济可持续性的有效政策是非常重要的。以解决关于人类与自然耦合系统的基本问题和迎接社会的空前挑战为目的的,真正整合不同学科的机会正显现出来。

关键词：耦合系统自然系统人类相互作用社会经济科学发现可持续性复杂性

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建设恢复力和适应性以对付北极的变化

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AMBIO－人类环境杂志 2006年第4期35卷 198-202页

作者： F.Stuart Chapin Ⅲ Michael Hoel Steven R.Carpenter jane Lubchenco Brian Walker Terry V.Callaghan Carl Folke Simon A.Levin Karl-Gran Mler Christer Nilsson Scott Barrett Fikret Berkes Anne-Sophie Crépin Kjell Danell Thomas Rosswall David Starrett Anastasios Xepapadeas Sergey A.Zimov 陈卓天 Institute of Arctic Biology University of Alaska Department of Economics University of Oslo Center for Limnology University of Wisconsin Department of Zoology Oregon State University CSIRO Sustainable Ecosystems Abisko Scientific Research Station Department of Systems Ecology and Centre for Transdisciplinary Environmental Research Stockholm University Department of Ecology and Evolutionary Biology Princeton University The Beijer Institute Landscape Ecology Group Department of Ecology and Environmental Science Ume University School of Advanced International Studies Johns Hopkins University Natural Resources Institute University of Manitoba Department of Animal Ecology Swedish University of Agricultural Sciences International Council for Science Department of Economics Stanford University Department of Economics University Crete Northeast Science Station Pacific Institute for GeographyFar-East BranchRussian Academy of SciencesRepublic Sakha(Yakutia)

人类行为引起的空前的全球变化挑战着社会支撑我们这颗行星保持自身优点的能力。这就要求对变化进行主动的管理以培养地球的恢复力——维持在变化的情况下对社会很重要的一些属性,和适应性——发展新的社会生态构造以便在新的条件下有... 详细信息

人类行为引起的空前的全球变化挑战着社会支撑我们这颗行星保持自身优点的能力。这就要求对变化进行主动的管理以培养地球的恢复力——维持在变化的情况下对社会很重要的一些属性,和适应性——发展新的社会生态构造以便在新的条件下有效地发挥作用。北极的广大地区仍然完整地保留着原型的生态及社会过程及反馈,这为我们为变化预先做出计划提供了可能是最后一个实验的机会。如果该策略的可行性在北极可以被证实,我们对于变化的动态所得到的进一步的理解就可以实施到那些被人类较大地改变了的地区中。现在执行管理北极变化的政策的条件可能很理想,因为近来的研究提供了极其重要的科学知识,合适的国际机制也已各就各位,而且,如果北极地区的国家选择这样做的话,他们具备实行必要改变的财力。

关键词：北极地区适应性恢复力社会生态人类行为全球变化社会过程科学知识

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