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Personalizing medicine for metastatic colorectal cancer:Current developments

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World Journal of Gastroenterology 2014年第30期20卷 10425-10431页

作者： rea Marin Marques alice Turner Ramon rade de Mello Centro Hospitalar do Médio Ave Unidade de Santo Tirso4780-371 Santo Tirso4200-072 PortoPortugal School of Medicine University of Otago2 Riccarton AveChristchurch Central8011 ChristchurchNew Zealand Department of Medical Oncology Portuguese Oncology Institute (IPO PORTO)4200-072 PortoPortugal Department of Biomedical Sciences and Medicine School of MedicineUniversity of Algarve8005-139 FaroPortugal

Metastatic colorectal cancer(mCRC)is still one of the tumor types with the highest incidence and *** 2012,colorectal cancer was the second most prevalence cancer among males(9%)and the third among females(8%).In this disease,early diagnosis is important to improve treatment ***,at the time of diagnosis,about one quarter of patients already have metastases,and overall survival of these patients at 5-years survival is very *** of these poor statistics,the development of new drugs against specific targets,including the pathway of angiogenesis,has witnessed a remarkable ***,targets therapies through epidermal growth factor and its receptor and also KRAS pathways modulation acquired a main role whether in association with standard chemotherapy and *** the current knowledge in the field of molecular biology,including genetic mutations and polymorphisms,we know better why patients respond so differently to the same ***,in the future we can develop increasingly personalized treatments to the patient and not the *** review aims to summarize some molecular pathways and their relation to tumor growth,as well as novel targeted developing drugs and recently approved for mCRC.

关键词： Metastatic colorectal cancer Angiogenesis Vascular endothelial growth factor Epidermal growth factor Target therapy

Recent Trends in Physical Activity among Chinese Children Based on Their Demographic and Social Characteristics

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Biomedical and Environmental Sciences 2021年第5期34卷 404-409页

作者： YANG Xiu LEUNG alice Waiyi ZHAI Yi ZHAO Wen Hua Chinese Center for Disease Control and Prevention Beijing 102206China National Institution for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Chinese University of Hong Kong Hong Kong 999077China Beijing Tian Tan Hospital Capital Medical UniversityBeijing 100070China

Aimed to explore the trends in physical activity among Chinese children,data of 4,341 children aged6-17 years who participated in at least one round of"China Health and Nutrition Survey"from 2004 to2015 were *** measures mixed models were applied to test the trends in physical activity,which were further analyzed after applying stratification on gender,age,urbanization level,residential area and region.

关键词： ed. applying children

Immunomodulatory properties of dental tissue-derived mesenchymal stem cells: Implication in disease and tissue regeneration

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World Journal of Stem Cells 2019年第9期11卷 604-617页

作者： Oleh Andrukhov Christian Behm alice Blufstein Xiaohui Rausch-Fan Division of Conservative Dentistry and Periodontology University Clinic of Dentistry Medical University of Vienna

Mesenchymal stem cells(MSCs)are considered as an attractive tool for tissue regeneration and possess a strong immunomodulatory *** tissuederived MSCs can be isolated from different sources,such as the dental pulp,periodontal ligament,deciduous teeth,apical papilla,dental follicles and *** to numerous in vitro studies,the effect of dental MSCs on immune cells might depend on several factors,such as the experimental setting,MSC tissue source and type of immune cell *** studies have shown that the immunomodulatory activity of dental MSCs is strongly upregulated by activated immune *** exert mostly immunosuppressive effects,leading to the dampening of immune cell ***,the reciprocal interaction between dental MSCs and immune cells represents an elegant mechanism that potentially contributes to tissue homeostasis and inflammatory disease *** the immunomodulatory potential of dental MSCs has been extensively investigated in vitro,its role in vivo remains obscure.A few studies have reported that the MSCs isolated from inflamed dental tissues have a compromised immunomodulatory ***,the expression of some immunomodulatory proteins is enhanced in periodontal disease and even shows some correlation with disease ***-based immunomodulation may play an essential role in the regeneration of different dental ***,immunomodulation-based strategies may be a very promising tool in regenerative dentistry.

关键词： Mesenchymal stem cells Dental tissue Immunomodulation Peripheral blood mononuclear cells Oral diseases Tissue regeneration

The Effect of Teachers' Attitudes on Primary School Pupils' Evaluation of Teacher Efficacy:a Study of Malawian Rural Government Schools

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The Effect of Teachers' Attitudes on Primary School Pupils' ...

作者： Mtendere alice Kishindo 华中师范大学

学位级别：硕士

迄今为止,已有相当多的研究涉及到了生活取向测验、学生测验评价、学生成绩责任测验和教师的自我效能感。然而,类似的研究在马拉维还比较少见。本研究认为,除了学生家庭的不良经济条件外,教师也能促进或阻碍学生的学业成绩,而教师的这... 详细信息

迄今为止,已有相当多的研究涉及到了生活取向测验、学生测验评价、学生成绩责任测验和教师的自我效能感。然而,类似的研究在马拉维还比较少见。本研究认为,除了学生家庭的不良经济条件外,教师也能促进或阻碍学生的学业成绩,而教师的这种作用又取决于影响教师在教室中的语言表达的内、外部因素。本文是少数调查马拉维教师态度的研究之一。本研究的目的是检验自我效能感、生活取向和农村地区的学生成绩责任感是否能够预测学生对教师有效性的评价;本文的另一个目的是检测不同班级和小组之间可能存在的差异。以期根据研究结果为马拉维的教育部门提供建议。本文采用了定量研究方法,共有400名被试参与了研究,他们来自马拉维首都利隆圭区附近的农村。根据班杜拉(Albert Bandura)的认知理论及伍尔福克和霍伊(Woolfolk&Hoy)的教师效能感理论,本研究第一个假设是,不同年级教师的自我效能感有显著差异;第二个假设是,学生对教师有效性的评价与教师的自我效能感和责任感显著相关;最后一个假设是教师的生活取向、自我效能感和责任感能够预测学生对教师有效性的评价。本研究的研究工具为：生活取向测验、学生测验评价、学生成绩责任测验和教师自我效能感测验。本研究使用统计软件ANOVA对不同小组和班级之间的生活取向、自我效能感和责任感之间的差异进行了检验。本研究也考察了生活取向、教师自我效能感、教师责任感以及学生效果评价之间的相关关系。另外,本研究利用回归分析对教师生活取向、教师自我效能感和责任感对学生效果评价的预测作用进行了检验。结果表明,教师态度对学生成绩有显著影响。ANOVA分析表明,不同年纪和小组的被试之间的生活取向、学生成就责任感和教师自我效能感之间没有显著差异。相关分析表明教师的自我效能感与学生对教师有效性的评价显著相关。回归分析显示生活取向、教师自我效能感和学生成绩责任感能解释学生对教师有效性的评价。最后,文章讨论了本研究的局限性和未来的研究方向,并指出了研究的理论和实践意义。

关键词：生活取向教师自我效能感责任感小学生农村

Survey： Use of Acupuncture for the Treatment of Acute Low Back Pain by Physicians and Physiotherapists in Ontario

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Journal of Acupuncture and Tuina Science 2010年第6期8卷 331-335页

作者： Kien Vinh Trinh alice Sy DeGroote School of Medicine Office of MD Admissions McMaster University Ontario L8N 3Z5 Canada Faculty of Health Sciences McMaster University Ontario L8N 3Z5 Canada

Objective： To determine the prevalence of the use of acupuncture treatment for acute low back pain （LBP） among acupuncture practitioners, and investigate acupuncture practitioners＇ perceptions on the effectiveness of this treatment modality and the costs associated with its use in Canada. Methods： A questionnaire designed to achieve our objectives was distributed to all 285 members in the Ontario chapter of the Acupuncture Foundation of Canada （AFC） in September of 1996. Only responses from physicians and physiotherapists were included in the analysis. Results： Of the 281 eligible physicians and physiotherapists, 197 completed the survey （response rate of 70.1%）. 45.0% of the respondents were physicians and 55.0% of them were physiotherapists. 87.0% of the respondents had used acupuncture for the treatment of acute LBP in the past, 66.0% of them were using it at the time of the survey and 87.0% said they would continue to use it in the future. 83.0% of the respondents perceived acupuncture to be effective for acute LBP and 60.0% of them believed that treating acute LBP with acupuncture will prevent the development of chronic LBE The average cost per treatment was $28 and the average time of treatments thought to be necessary to treat acute LBP was 5.7. Conclusions： The results showed that the majority of the respondents had a positive and favorable outlook towards using acupuncture for the treatment of acute LBP. They frequently used acupuncture for treating this condition in their practice and an overwhelming majority perceived acupuncture to be effective for treating acute LBP. In addition, over half of the respondents believed that acupuncture treatment would prevent the progression of acute LBE Although the acupuncture practitioners surveyed in this study perceived acupuncture to be an effective treatment for acute LBP, quantitative data from high quality research are needed to validate these perceptions.

关键词： Low Back Pain: Acuouncture Theranv: Ouestionnaires

Establishment of customized mouse stem cell lines by sequential nuclear transfer

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Cell Research 2007年第1期17卷 80-87页

作者： alice Jouneau FRE 2857 Biologie du Développement et Reproduction UMR 1198 ENVA CNRS F-78350 INRA Chinese Academv of Sciences Jouy en Josas Beijing 100080 France State Key Laboratory of Reproductive BiologyJoint laboratory of biology of embryonic cells of mammalians(LABIOCEM) Institute of Zoology China

Therapeutic cloning,whereby embryonic stem cells (ESCs) are derived from nuclear transfer (NT) embryos,mayplay a major role in the new era of regenerative *** this study we established forty nuclear transfer-ESC (NT-ESC) lines that were derived from NT embryos of different donor cell types or *** found that NT-ESCs werecapable of forming embryoid bodies,In addition,NT-ESCs expressed pluripotency stem cell markers in vitro and coulddifferentiate into embryonic tissues in *** embryos from early passage R1 donor cells were able to form full termdeveloped pups,whereas those from late passage R1 ES donor cells lost the potential for reprogramming that is essentialfor live *** subsequently established sequential NT-R1-ESC lines that were developed from NT blastocyst of latepassage R1 ESC ***,these NT-R1-ESC lines,when used as nuclear transfer donors at their early passages,failed to result in live *** indicates that the therapeutic cloning process using sequential NT-ESCs may not rescuethe developmental deficiencies that resided in previous donor generations.

关键词： nuclear transfer therapeutic cloning embryonic stem cells

Women receive more inpatient resections and ablations for hepatocellular carcinoma than men

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World Journal of Hepatology 2017年第36期9卷 1346-1351页

作者： Lindsay Sobotka alice Hinton Lanla Conteh Department of Internal Medicine the Ohio State University Wexner Medical Center Division of Biostatistics College of Public Health the Ohio State University Section of Hepatology Division of Gastroenterology Hepatology and Nutrition the Hepatocellular Carcinoma Multidisciplinary Clinic the James Comprehensive Cancer Center the Ohio State University Wexner Medical Center

AIM To evaluate disparities in the treatment of hepatocellular carcinoma(HCC) based on *** A retrospective database analysis using the Nationwide Inpatient Sample(NIS) was performed between 2010 and 2013. Adult patients with a primary diagnosis of hepatocellular carcinoma determined by International Classification of Disease 9(ICD-9) codes were included. Univariate analysis and multivariate logistic regressions were performed to analyze differences in treatment, mortality, features of decompensation, and metastatic disease based on the patient's *** The analysis included 62582 patients with 45908 men and 16674 women. Women were less likely to present with decompensated liver disease(OR = 0.84, P < 0.001) and had less risk of inpatient mortality when compared to men(OR = 0.75, P < 0.001). Women were more likely to receive inpatient resection(OR = 1.31, P < 0.001) or an ablation(OR = 1.22, P = 0.028) than men. There was no significant difference between men and women in regard to liver transplantation and transcatheter arterial chemoembolization(TACE).CONCLUSION Gender impacts treatment for hepatocellular carcinoma. Women are more likely to undergo an ablation or resection then men. Gender disparities in transplantation have resolved.

关键词： Hepatocellular carcinoma Gender disparities Liver transplantation Liver resection Ablation

Modelling the Impacts of Climate Change on Agricultural Crops in Zimbabwe

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Modelling the Impacts of Climate Change on Agricultural Crop...

作者： Tyan alice Makanda 浙江师范大学

学位级别：硕士

Climate in general plays a significant role on planet *** determines the natural distribution of species as well as how their facets will change over *** change is a serious global issue affecting countries at different *** on climate change and variability have indicated a probably alteration in the geographically suitable land areas for crop *** such,many African countries will be affected given their great dependence on agriculture and Zimbabwe is no *** crops' geographical or climate suitability is very essential for avoiding yield losses due to unfavorable growth environments in the changing climatic circumstances yet in Zimbabwe information on change in crop suitability due to climate change is ***,the objective in this study is to model the current and future potential distribution of rain-fed food and cash crops that are cultivated in Zimbabwe namely groundnuts,maize,millet,sorghum,soybean,cotton and *** study seeks to determine how current crop suitability will shift under the changing climate in the 2050 *** study used Maximum Entropy model(Maxent)which is a correlative machine learning model with the ability to generate correlation between values of explanatory variables and recognized occurrence points of *** variables for two Shared Socioeconomic pathways(SSP)2.4-5 and 5.8-5 from three General Circulation Models(ACCESS-CM2,IPSL-CM6A-LR and MRI-ESM2-0)were selected for predicting potential future distribution.A total of 22 environmental variables were used in the study including 19 bioclimatic *** other contributing variables are soil texture,organic carbon and land use–land *** other contributing variables are soil texture,organic carbon and land use–land *** jackknife performance,based on the Area Under Curve(AUC)values was used as evaluation of the *** value of 0.638,0.669,0.664,0.679,0.698,0,745 and 0.718 were obtained for maiz

关键词： Climate change Agricultural crop Zimbabwe Maxent modeling

Multiplexing technology for in vitro diagnosis of pathogens： the key contribution of phosphorus dendrimers

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Science China Materials 2018年第11期61卷 1454-1461页

作者： Jean Pierre Majoral Jean Marie Francois Richard Fabre alice Senescau Serge Mignani Anne-Marie Caminade Laboratoire de Chimie de Coordination du CNRS 31077 Toulouse Cedex 4France LCC-CNRS Universit6 de Toulouse CNRSToulouseFrance Dendris 31670 LabegeFrance LISBP UMR CNRS 5504 INRA 79231077 Toulouse Cedex 04France Universite Paris Descartes PRES Sorbonne Paris Cite CNRS-UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicolgique75006 ParisFrance

After the microbiology based on Pasteur's method and polymerase chain reaction(PCR), the diagnosis company named Dendris has proposed a third-generation of diagnosis enabling the search of a broad range of pathogens with strong sensitivity and specificity. This extraordinary profile was possible thanks to the use of phosphorus dendrimers for which various techniques of deposition on a given support were investigated and described and analyzed in this report.

关键词： phosphorus dendrimers diagnosis DNA arrays multiplexing technology