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A perspective on age-related changes in cell environment and risk of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 719-720页

作者： alice Y.Liu Department of Cell Biology and Neuroscience Rutgers State University of New JerseyPiscatawayNJUSA

“Age-related neurodegenerative disease”underscores human age as the primary risk factor for disease development:Alzheimer’s,Parkinson’s,and Huntington’s disease(HD)as *** for the age-dependent delay in disease manifestation,in particular for autosomal dominant forms of the disease,and the underlying cause(s)of specific neuron dysfunction and death to manifest as memory loss,anxiety,depression,and agitation in disease subjects remain *** are interested in understanding age-related changes in cell environment that can modulate the structure,function,aggregation.

关键词： Huntington Alzheimer death

Long-term monitoring of cycles in Clethrionomys rutilus in the Yukon boreal forest

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Integrative Zoology 2024年第1期19卷 27-36页

作者： Charles J.KREBS alice J.KENNEY B.Scott GILBERT Rudy BOONSTRA Department of Zoology University of British ColumbiaVancouverBritish ColumbiaCanada Renewable Resources Management Program Yukon UniversityWhitehorseYukonCanada Department of Biological Sciences University of Toronto ScarboroughTorontoOntarioCanada

Baseline studies of small rodent populations in undisturbed ecosystems are *** report here 50 years of mon-itoring and experimentation in Yukon of a dominant rodent species in the North American boreal forest,the red-backed vole Clethrionomys *** voles breed in summer,weigh 20–25 g,and reach a maximum density of 20 to 25 per *** populations have shown consistent 3–4-year cycles for the last 50 years with the only change being that peak densities averaged 8/ha until 2000 and 18/ha since that *** the last 25 years,we have measured food resources,predator numbers,and winter weather,and for 1-year social interactions,to estimate their contribution to changes in the rate of summer increase and the rate of overwinter *** these potential limiting factors could contribute to changes in density,and we measured their relative contributions statistically with multiple *** rate of winter decline in density was related to both food supply and winter *** rate of summer increase was related to summer berry crops and white spruce cone *** measure of predator numbers was related to winter or summer changes in vole *** was a large signal of climate change effects in these *** is no density dependence in summer population growth and only a weak one in winter population *** of our results provide a clear understanding of what generates 3–4-year cycles in these voles,and the major missing piece may be an understanding of social interactions at high density.

关键词： boreal forest climate change density dependence population cycles predation winter severity

Discussing menstrual health in family medicine

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family Medicine and Community Health 2024年第2期12卷 23-26页

作者： Allison R Casola alice Renaud Ashwini Kamath Mulki Thomas Jefferson University Sidney Kimmel Medical College PhiladelphiaPennsylvaniaUSA Lehigh Valley Health Network AllentownPennsylvaniaUSA Valley Health Partners family Health Center AllentownPennsylvaniaUSA

MENSTRUAL HEALTH Menstrual health is a general biological marker for many cisgender women,transgender men and non-binary *** more than half of the population being people who menstruate,stigma,lack of conversation and pressing social needs around menstrual health persists throughout medicine.1 Discussions around menstruation and menstrual management can be difficult for individuals,whether it is with friends or family,or in the healthcare setting.1 Patients who have never discussed menstruation with a clinician may not know what is healthy,assume that an abnormal experience is normal and may endure periods that negatively affect their life,career or well-being.2–5 Menstruation plays a vital role in overall well-being and contributes significantly to an individual’s quality of *** their scope of care,family medicine clinicians are poised to identify red-flag menstrual symptoms in their routine visits with patients,reducing time to diagnosis of menstrual *** urge family medicine clinicians to have renewed conversations surrounding menstrual health with their *** purpose of this report is to supply a brief overview of the importance of menstrual communication in primary care and serve as a resource to enhance menstrual communication between patient and clinician,with the ultimate goal of decreasing menstrual stigma and promoting improved menstrual health and experiences for patients.

关键词： routine men spite

A Theoretically Grounded Question Answering Data Set for Evaluating Machine Common Sense

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Data Intelligence 2024年第1期6卷 1-28页

作者： Henrique Santos Ke Shen alice M.Mulvehill Mayank Kejriwal Deborah L.McGuinness Rensselaer Polytechnic Institute Troy NY Information Sciences Institute Marina del Rey CA

Achieving machine common sense has been a longstanding problem within Artificial *** far,benchmark data sets that are grounded in a theory of common sense and can be used to conduct rigorous,semantic evaluations of common sense reasoning(CSR)systems have been *** expectation of the AI community is that neuro-symbolic reasoners can help bridge this gap towards more dependable systems with common *** propose a novel benchmark,called Theoretically Grounded common sense Reasoning(TG-CSR),modeled as a set of question answering instances,with each instance grounded in a semantic category of common sense,such as space,time,and *** benchmark is few-shot i.e.,only a few training and validation examples are provided in the public release to avoid the possibility of *** from recent evaluations suggest that TG-CSR is challenging even for state-of-the-art statistical *** to its semantic rigor,this benchmark can be used to evaluate the common sense reasoning capabilities of neuro-symbolic systems.

关键词： reasoning Intelligence instance

Literature Review of the Prevalence of Hypertension at Gulu University, Gulu City, Acholi Subregion, Northern Uganda

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World Journal of Cardiovascular Diseases 2024年第9期14卷 588-602页

作者： Lamwaka alice Veronica Mboowa John Bosco Department of Pharmacy Faculty of Medicine Gulu University Gulu City Uganda

Hypertension is a big problem worldwide. The purpose of this study is to examine the prevalence, knowledge, attitude, and practice about hypertension at Gulu University, Gulu city, Gulu district, Acholi subregion, Northern Uganda. A literature search on hypertension was done. It showed that, in Uganda, a representative number of 17,777 adult patients’ data were analyzed from January 2014 to february 2024. The epidemiological data on awareness of hypertension was found to be at 8%. Of this, 18.3% of the people with hypertension had it under control. The results of the findings were promising. Hypertension is an important public health challenge in Uganda particularly in Northern Uganda where Gulu University falls. In comparison with the two regions of Central Uganda and Northern Uganda, there was a significant number of populations that were not aware of their condition. Those diagnosed were on treatment but the treatment was not adhered to due to stock outs of medicines. Therefore, Measures are required to prevent hypertension, improve awareness, treatment and control within the community, especially at Gulu University where research has never been done.

关键词： Prevalence Hypertension Blood Pressure Knowledge Attitude Practices Cross Sectional Studies

Assessment of Groundwater Stability Using Corrosion and Scaling Tendency Indices on Selected Springs in the Manga Region in Nyamira County, Kenya

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Open Journal of Microphysics 2024年第3期14卷 79-88页

作者： Calford Odhiambo Otieno alice Makonjo Wekesa Physics Department Kisii University Kisii Kenya

We present the result of groundwater stability assessment on three major springs in the Manga region in Nyamira County found in Kenya in 2018. These springs are Kiangoso (SP1), Kerongo (SP2) and Tetema (SP3). The corrosion and scaling tendency indices were obtained using the Langelier saturation index (LSI), Ryznar stability index (RSI), and Puckorius scaling index (PSI). The LSI values obtained for SP1, SP2, and SP3 are −3.93, −4.71, and −4.17, respectively, while using RSI, the values obtained for SP1, SP2, and SP3 are 14.15, 14.53, and 13.74, respectively. Using PSI, the values of SP1, SP2, and SP3 are 5.58, 5.45, and 5.58, respectively. from the interpretation of the indices, the groundwater from the three springs in the Manga region using LSI and RSI showed intolerable corrosion;hence, it is unlikely to scale as obtained from PSI.

关键词： Langelier Saturation Index Ryznar Stability Index Puckorius Scaling Index

Harnessing marine microbiomes to develop a sustainable,all-Atlantic bioeconomy

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mLife 2024年第2期3卷 163-166页

作者： Cristiane Thompson alice C.Ortmann Henk Bolhuis Thulani Makhalanyane fabiano Thompson Institute of Biology Federal University of Rio de Janeiro(UFRJ)Rio de JaneiroBrazil fisheries and Oceans Canada Bedford Institute of OceanographyDartmouthNova ScotiaCanada Department of Marine Microbiology and Biogeochemistry Royal Netherlands Institute for Sea Research(NIOZ)The Netherlands Department of Microbiology School of Data Science and Computational ThinkingStellenbosch UniversityStellenboschSouth Africa

Marine microbiomes are integral to the functioning of a healthy ocean and have the potential to be key contributors toward an all-Atlantic sustainable blue bioeconomy(figure 1).New compounds may be developed based on these *** Atlantic Ocean is a biodiversity *** All-Atlantic Ocean Research and Innovation Alliance(AAORIA)Declaration,signed in 2022 in Washington,DC,is a promising mechanism to move forward marine microbiome science,technology,and innovation.

关键词： Atlantic marine ocean

Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study

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Journal of Sport and Health Science 2024年第2期13卷 222-232页

作者： Xinyi Jin Yilin Chen Hongliang feng Mingqing Zhou Joey W.Y.Chang Yaping Liu alice Pik Shan Kong Xiao Tan Yun-Kwok Wing Yannis Yan Liang Jihui Zhang Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention Guangdong Cardiovascular InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China School of Medicine South China University of TechnologyGuangzhou 510641China Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510180China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510282China Guangdong Mental Health Center Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510120China Li Chiu Kong family Sleep Assessment Unit Department of PsychiatryFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Medical Sciences Uppsala UniversityUppsala 75185Sweden Department of Big Data in Health Science Zhejiang University School of Public HealthHangzhou 310058China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou 510260China

Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a population-based prospective cohort ***:Altogether,88,000 participants(mean age=62.2±7.9 years,mean±SD)were included from the UK *** duration(short:8 h/day)and PA of different intensities were measured using a wrist-won accelerometer over a 7-day period between 2013 and *** was classified according to the median or World Health Organization-recommendation:total volume of PA(high,low),moderate-to-vigorous PA(MVPA)(recommended,not recommended),and light-intensity PA(high,low).Incidence of type 2diabetes was ascertained using hospital records or death ***:During a median follow-up of 7.0 years,1615 incident type 2 diabetes cases were *** with normal sleep duration,short(hazard ratio(HR)=1.21,95%confidence interval(95%CI):1.03-1.41)but not long sleep duration(HR=1.01,95%CI:0.89-1.15)was associated with excessive type 2 diabetes *** increased risk among short sleepers seems to be protected against by *** with normal sleepers with high or recommended PA,short sleepers with low volume of PA(HR=1.81,95%CI:1.46-2.25),not recommended(below the World Health Organization-recommended level of)MVPA(HR=1.92,95%CI:1.55-2.36),or low light-intensity PA(HR=1.49,95%CI:1.13-1.90)had a higher risk of type 2 diabetes,while short sleepers with a high volume of PA(HR=1.14,95%CI:0.88-1.49),recommended MVPA(HR=1.02,95%CI:0.71-1.48),or high light-intensity PA(HR=1.14,95%CI:0.92-1.41)did ***:Accelerometer-measured short but not long sleep duration was associated with a higher risk of incident type 2 diabetes.A higher level of PA,regardless of intensity,potentially ameliorates this excessive risk.

关键词： Light physical activity Sleep duration Triaxial accelerometer Type 2 diabetes UK Biobank

Adopting the margin of stability for space–time landslide prediction–A data-driven approach for generating spatial dynamic thresholds

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Geoscience frontiers 2024年第5期15卷 75-92页

作者： Stefan Steger Mateo Moreno alice Crespi Stefano Luigi Gariano Maria Teresa Brunetti Massimo Melillo Silvia Peruccacci francesco Marra Lotte de Vugt Thomas Zieher Martin Rutzinger Volkmar Mair Massimiliano Pittore GeoSphere Austria ViennaAustria Center for Climate Change and Transformation Eurac ResearchBolzanoItaly faculty of Geo-information Science and Earth Observation(ITC) University of TwenteEnschedethe Netherlands Research Institute for Geo-Hydrological Protection National Research Council(CNR-IRPI)PerugiaItaly Department of Geosciences University of PaduaPaduaItaly Institute of Atmospheric Sciences and Climate National Research Council(CNR-ISAC)BolognaItaly Department of Geography University of InnsbruckInnsbruckAustria Department of Natural Hazards Austrian Research Centre for Forests(BFW)InnsbruckAustria Office for Geology and Building Materials Testing Autonomous Province of Bolzano-South TyrolCardanoItaly

Shallow landslide initiation typically results from an interplay of dynamic triggering and preparatory conditions along with static predisposition *** data-driven methods for assessing landslide susceptibility or for establishing rainfall-triggering thresholds are prevalent,integrating spatiotemporal information for dynamic large-area landslide prediction remains a *** main aim of this research is to generate a dynamic spatial landslide initiation model that operates at a daily scale and explicitly counteracts potential errors in the available landslide *** previous studies focusing on space–time landslide modelling,it places a strong emphasis on reducing the propagation of landslide data errors into the modelling results,while ensuring interpretable *** introduces also other noteworthy innovations,such as visualizing the final predictions as dynamic spatial thresholds linked to true positive rates and false alarm rates and by using animations for highlighting its application potential for hindcasting and *** initial step involves the creation of a spatio-temporally representative sample of landslide presence and absence observations for the study area of South Tyrol,Italy(7400 km2)within well-investigated *** setup entails integrating landslide controls that operate on various temporal scales through a binomial Generalized Additive Mixed *** relationships are then interpreted based on variable importance and partial effect plots,while predictive performance is evaluated through various crossvalidation *** and user-defined probability cutpoints are used to establish quantitative thresholds that reflect both,the true positive rate(correctly predicted landslides)and the false positive rate(precipitation periods misclassified as landslide-inducing conditions).The resulting dynamic maps directly visualize landslide threshold *** model demonstrates high predictive performanc

关键词： Early warning Space-time model Rainfall thresholds Landslide susceptibility,Generalized Additive Mixed Model forecasting