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Current guidelines for the management of celiac disease:A systematic review with comparative analysis

World Journal of Gastroenterology 2022年第1期28卷 154-175页

作者： Alberto Raiteri Alessandro Granito alice giamperoli Teresa Catenaro Giulia Negrini Francesco Tovoli Division of Internal Medicine Hepatobiliary and Immunoallergic DiseasesIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy

BACKGROUND Wheat and other gluten-containing grains are widely consumed,providing approximately 50%of the caloric intake in both industrialised and developing *** widespread diffusion of gluten-containing diets has rapidly led to a sharp increase in celiac disease *** condition was thought to be very rare outside Europe and relatively ignored by health professionals and the global ***,in recent years,the discovery of important diagnostic and pathogenic milestones has led to the emergence of celiac disease(CD)from obscurity to global *** modifications have prompted experts worldwide to identify effective strategies for the diagnosis and follow-up of *** scientific societies,mainly from Europe and America,have proposed guidelines based on CD's most recent *** To identify the most recent scientific guidelines on CD,aiming to find and critically analyse the main *** We performed a database search on PubMed selecting papers published between January 2010 and January 2021 in the English *** was lastly accessed on 1 March *** We distinguished guidelines from 7 different scientific societies whose reputation is worldwide recognized and representative of the clinical practice in different geographical *** were noted in the possibility of a no-biopsy diagnosis,HLA testing,follow-up protocols,and *** We found a relatively high concordance between the guidelines for *** modifications have occurred in the last years,especially about the possibility of a no-biopsy diagnosis in *** modifications are expected in the next future and will probably involve the extension of the non-invasive diagnosis to the adult population and the follow-up modalities.

关键词： Celiac disease Gluten Gluten-free diet Gluten sensitivity Clinical guidelines Non-invasive diagnosis Histopathological findings Serological markers Genetics

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