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Leaves Aqueous Extr.ct of <i>Boer.avia coccinea</i>Induces Antinociceptive Effect but Incr.ases Nitr.c Oxide Pr.duction in Macr.phages

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Jour.al of Biosciences and Medicines 2020年第10期8卷 90-103页

作者： Basile N. Piegang Douglas A. M. Ngangoum Sor.lle M. Ngassam Pius P. Tseuguem Bibiane A. Wandji Desir. F. T. Bomba aliance r. fokoua Télesphor. B. Nguelefack r.sear.h Unit of Neur.-Inflammator. and Car.iovascular.Phar.acology Laboratory of Animal Physiology and Phytopharmacology Faculty of Science University of Dschang Dschang Cameroon Institut Univer.itair. du Golf de Guinée (IUG) Institut Supérieur des Sciences Appliquées (ISA) Douala Cameroun

Pain tr.atment is one of the most challenging situations of the moder. medicine. To over.ome the actual limitations, new str.tegies should be developed and phytother.py r.pr.sents a pr.mising alter.ative. Boer.avia coccinea is a medicinal plant used for.the tr.atment of pain. The pr.sent wor. was under.aken to evaluate the antinociceptive effects of cr.de aqueous extr.ct of the leaves of Boer.avia coccinea (AE) on acute pain and examine its mechanism of action. The analgesic effect of AE was evaluated at doses 50, 100, 200 and 400 mg/kg using the for.alin-induced nociception in mice. The specific analgesic effect of AE was ver.fied by testing its effect of AE on the sleep induced by diazepam. The anti-inflammator. effects of AE wer. also tested in vivo (100 and 200 mg/kg) on CFA-induced inflammation and in vitr. (1 to 300 μg/ml) on the pr.duction of NO by non-activated or.activated (LPS, 1 μg/l) macr.phages. The effect of AE in non-stimulated macr.phages was evaluated in absence and in pr.sence of L-NAME (100 μg/ml) or.dexathetasone (30 μg/ml). AE administer.d or.lly significantly (p r.genic and inflammator. phases of the for.alin pain with a maximum inhibition per.entage of 81% at the 1st phase and 90% at the 2nd phase, but did not show any anti-inflammator. effect. AE at 50 mg/kg incr.ased the latency to sleep and r.duced sleep dur.tion. AE dr.stically (p r.ased the NO pr.duction by non-activated or.activated macr.phages by up to 5654%. L-NAME and dexamethasone potentiated the activation effect of AE on NO pr.duction. In conclusion, AE possess potent antinociceptive effect that is not r.lated to any anti-inflammator. activity. Instead, this extr.ct incr.ases the nitr.c oxide pr.duction by an unknown mechanism.

关键词： Boer.avia coccinea Aqueous Extr.ct Analgesic Macr.phage Nitr.c Oxide

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