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Journal of mountain Science 2021年第5期18卷 1235-1245页

作者： Emad A.FARAHAT aliaa m.refaat Botany and microbiology Department Faculty of ScienceHelwan UniversityCairo 11795Egypt Botany Department Faculty of ScienceAin Shams UniversityCairo 11566Egypt

Climate change will affect the geographic distribution and richness of species at different spatial and temporal *** applied maximum entropy(maxEnt)modeling to predict the potential influence of climatic change on the current and future distribution of the important mountainous tree species moringa peregrina(Forssk.)*** maxent model performed better than random models for the species with the training and test AUC(Area Under the receiver-operating characteristic Curve)values of 0.96 and 0.90,*** test and response curves showed that the distribution of the species negatively correlates with higher altitudes and precipitation in October and ***,it positively correlates with the total annual precipitation and precipitation in *** current and future climatic conditions,our model predicted habitat gains for *** towards the coastal northern and southern limits of its *** potentially suitable habitats,under future climate projections,are currently characterized by elevations ofm *** total annual precipitation of 80-225 mm/*** and high potential habitat suitability will increase by 5.6%-6%and 2.1%-2.3%,under RCP2.6 and RCP4.5 scenario,*** results indicated that the habitat suitability of *** would increase with increasing climate warming,particularly under RCP2.6 *** recommend sustainable conservation and cultivation of moringa peregrina in its current habitats along the Red Sea mountains.

关键词： Climate change Conservation max Ent mountains moringa peregrina Arid lands

An Energy-Efficient Wireless Power Transmission-Based Forest Fire Detection System

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Computers, materials & Continua 2022年第7期72卷 441-459页

作者： Arwa A.mashat Niayesh Gharaei aliaa m.Alabdali Faculty of Computing&Information Technology King Abdulaziz UniversityRabigh21911Saudi Arabia

Compared with the traditional techniques of forest fires detection,wireless sensor network(WSN)is a very promising green technology in detecting efficiently the ***,the power constraint of sensor nodes is one of the main design limitations of WSNs,which leads to limited operation time of nodes and late fire *** the past years,wireless power transfer(WPT)technology has been known as a proper solution to prolong the operation time of sensor *** WPT-based mechanisms,wireless mobile chargers(WmC)are utilized to recharge the batteries of sensor nodes ***,the energy of WmC is provided using energy-harvesting or energy-scavenging techniques with employing huge,and expensive ***,the high price of energy-harvesting devices hinders the use of this technology in large and dense networks,as such networks require multiple WmCs to improve the quality of service to the sensor *** solve this problem,multiple power banks can be employed instead of utilizing ***,the long waiting time of critical sensor nodes located outside the charging range of the energy transmitters is another limitation of the previous ***,the sensor nodes are equipped with radio frequency(RF)technology,which allows them to exchange energy ***,critical sensor nodes located outside the charging range of the WmC can easily receive energy from neighboring ***,in this paper,an energy-efficient and cost-effective wireless power transmission(ECWPT)scheme is presented to improve the network lifetime and performance in forest fire detection-based *** results exhibit that ECWPT scheme achieves improved network performance in terms of computational time(12.6%);network throughput(60.7%);data delivery ratio(20.9%);and network overhead(35%)as compared to previous related *** conclusion,the proposed scheme significantly improves network energy efficiency for WSN.

关键词： Forest fire detection rechargeable wireless sensor networks wireless mobile charger power constraint sustainable network lifetime

microalbuminuria in hepatitis C-genotype 4:Effect of pegylated interferon and ribavirin

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World Journal of Gastroenterology 2010年第10期16卷 1226-1231页

作者： moutaz Derbala Fatma m Shebl Awad Rashid aliaa Amer Abdulbari Bener Department of Gastroenterology and Hepa-tology Hamad Medical Corporation Department of medicine Weill Cornell Medical College in Qatar Infections & Immunoepidemiology Branch Division of Cancer Epidemiology and GeneticsNational Cancer Institute Epidemiology Branch National Liver Institute Department of Nephrology Hamad Medical Corporation Department of Laboratory medicine and Histo-pathology Hematology SectionHamad Medical Corporation Department of medical Statistics and Epidemiology Hamad Medical Corporation

AIm:To study the relation between hepatitis C virus (HCV) genotype 4 and microalbuminuria and renal impairment in relation to hepatic histology, and viremia in the absence of cryoglobulinemia, and to examine the effect of treatment on ***: Three hundred subjects, including 233 HCV genotype-4 infected patients, were tested for cryoglobulinemia, microalbuminuria, albumin creatinine ratio (ACR), urea, creatinine, and estimated glomerular filtration rate (eGFR). The parameters were measured again in the HCV patients after 48 wk of treatment with pegylated interferon and ***: Significantly higher levels of microalbumin- uria were detected in HCV-positive patients compared to HCV-negative controls (median 9.5 vs 5.9, respectively, Kruskal-Wallis P=0.017). Log microalbuminuria was significantly correlated with hepatic inflammation (r=0.13, P=0.036) and f ibrosis (r=0.12, P=0.061), but not with viral load (r=-0.03, P=0.610), or alanine transaminase (r=-0.03, P=0.617). Diabetes mellitus neither significantly moderated (χ2=0.13, P=0.720), nor mediated (Sobel test P=0.49) the HCV effect. HCV status was signifi cantly associated with log microalbu-minuria (χ2=4.97, P=0.026), adjusting for age, gender, diabetes, cryoglobulinemia, urea and creatinine. A positive HCV status was not significantly associated with low eGFR (mL/min every 1.73 m2) [odds ratio (OR): 0.5, 95% confidence interval (CI):0.2-1.4], nor with high ACR (OR: 1.7, 95% CI:0.7-4.1). End-of-treatment response (ETR) was achieved in 51.9% of patients. Individuals with ETR had significantly lower microalbuminuria post-treatment (χ2=8.19, P=0.004).CONCLUSION: HCV affected the development of microalbuminuria independent of diabetes or cryoglobulinemia. Combination therapy of pegylated interferon-ribavirin had a positive effect in reducing microalbuminuria.

关键词： Hepatitis C virus Genotype Kidney diseases Albuminuria Proteinuria Peginterferon α-2a Ribavirin

Cytotoxic Effect of Soy Bean Saponin against Colon Cancer

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Journal of Biosciences and medicines 2019年第7期7卷 70-86页

作者： mai m. El-Keiy aliaa m. Radwan Tarek m. mohamed Biochemistry Division Chemistry Department Faculty of Science Tanta University Tanta Gharbia Egypt

Saponin is an important class of natural products that can be presented in many plants, it has a diverse range of properties, which include pharmacological and medicinal properties, antimicrobial, insecticidal, and anticancer activities. The aim of this study was to extract the saponin from different Egyptian legumes sources and evaluate the antitumor activity of partially purified saponin extracted from soybean in mouse colon cancer cells in vitro and compare its activity with cisplatin as reference chemotherapeutic drug. In this study saponin extracted from soybean and partially purified using silica gel column chromatography and then characterized by using IR and HPLC techniques. Antitumor activity of partially purified saponin was evaluated by using mTT assay, caspase-9 activity and apoptotic effect by flow cytometric analysis. Our results showed that the high saponin was present in soybean with concentration 94.8 mg/g dry weight. The partially purified soybean saponin inhibited the proliferation of colon cancer cell line in a dose-dependent manner with IC50 43.4 μg/ml after 48 hrs treatment. The proliferation inhibitory effect of soybean saponin was associated with its apoptosis-inducing effect by activation of caspase-9 and increasing the percent of apoptotic cells to 91.02% when compared with negative control after analysis by flow cytometry. In conclusion, soybean saponin had antitumor activity against mouse colon cancer cell line and its mechanism was mediated through apoptotic effect.

关键词： Saponin Soybean Colon Cancer Antitumor Activity Apoptosis

Aspartate transaminase to platelet ratio index in hepatitis C virus and Schistosomiasis coinfection

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World Journal of Gastroenterology 2015年第46期21卷 13132-13139页

作者： moutaz Derbala mohammed Elshiekh Elbadri aliaa mohamed Amer Saad Al Kaabi Khaleel Hassan Sultan Yasser medhat Kamel Eman Hassan Satti Elsayed Tony Yervant Avades Prem Chandra Fatma m Shebl Gastroenterology and Hepatology Hamad Medical CorporationHamad General Hospital Gastroenterology and Hepatology Theodor Bilharz Research Institute medical Department Weill Cornell Medical College Laboratory medicine and pathology Hematology SectionHamad Medical CorporationHamad General Hospital General medicine Medical EducationHamad Medical CorporationHamad General Hospital Department of Laboratory medicine and Pathology Hamad Medical CorporationHamad General Hospital medical Research Center Hamad Medical CorporationHamad General Hospital Chronic Disease Epidemiology DepartmentYale School of Public Health

AIm: To assess the diagnostic accuracy,of aminotransferase-to-platelet ratio index(APRI) alone and with antischistosomal antibody(Ab) in patients with hepatitis C virus(HCV) and schistosomiasis coinfection. mETHODS: This retrospective study included medical records of three hundred and eighty three Egyptianmen patients who had undergone percutaneous liver biopsy between January 2006 to April 2014 in tertiary care hospital in Qatar for diagnosis or monitoring purpose were selected. Data of patients > 18 years of age were included in the study. The values of HCV RNA titer and antischistosomal antibody titer were also taken into consideration. Patients were excluded from the study if they had any other concomitant chronic liver disease,including; history of previous antiviral or interferon therapy,immunosuppressive,therapy,chronic hepatitis B infection,human immunodeficiency virus co-infection,autoimmune hepatitis,decompensated liver disease,hepatocellular carcinoma,prior liver transplantation,and if no data about the liver biopsy present. RESULTS: median age of patients was 46 years. About 7.1% had no fibrosis,whereas 30.4%,37.5%,20.4%,and 4.6% had fibrosis of stage Ⅰ,Ⅱ,Ⅲ,and Ⅳ respectively. In bivariate analysis,APRI score,levels of AST,platelet count and age of patient showed statistically significant association with liver fibrosis(P mal antibody titer(P = 0.52) and HCV RNA titer(P = 0.79) failed to show a significant association. The respective AUC values for no fibrosis,significant fibrosis,severe fibrosis and cirrhosis of APRI score were 63%,73.2%,81.1% and 88.9% respectively. This showed good sensitivity and specificity of APRI alone for grading of liver fibrosis. But the inclusion of anti-Schistosoma antibody did not improve the prediction of fibrosis stage. CONCLUSION: The study results suggest that noninvasive biochemical markers like APRI are sensitive and specific in diagnosing the degree of fibrosis and cirrhosis in patient

关键词： Hepatitis C Schistosomiasis Aspartate transaminase

Planning Target Volume margin in Linac-Based Stereotactic Radiosurgery for Brain metastases

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Journal of Cancer Therapy 2024年第7期15卷 265-272页

作者： Hany S. Attallah Radwa m. Hamed Khaled m. EL-Shahat aliaa mahmoud mahmoud Abdallah Ibraheem Haggag Emad moustafa Adel Yassin Department of Radiation Oncology International Medical Center (IMC) Cairo Egypt Department of Radiation Oncology Armed Forces Medical Collogue (AFCM) Cairo Egypt Department of medical Physics Al Azhar University Cairo Egypt Department of medical Physics International Medical Center (IMC) Cairo Egypt Department of medical Physics Department of Clinical Oncology Faculty of Medicine Zagazig University Zagazig Egypt

Background: The treatment of brain metastases with radiotherapy has shifted to the use of Stereotactic Radio-surgery (SRS). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. material and methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.

关键词： SRS Brain metastases PTV

Radiotherapy to the Left Breast with 3DCRT, ImRT or VmAT: International medical Center Experience

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Journal of Cancer Therapy 2021年第3期12卷 107-115页

作者： Hany S. Attallah Radwa m. Hamed Haytham A. Abdelkader mahmoud m. Abdallah aliaa mahmoud Ibraheem Haggag Bassam E. makram Ahmed m. El-Saeed Department of Radiation Oncology Inattentional Medical Center Cairo Egypt Department of Radiation Oncology Helwan University Cairo Egypt

Radiation therapy after conservative breast surgery is an integral part of the treatment of early breast cancer. The aim of radiotherapy is to achieve the best coverage of the Planning Target Volume (PTV), while reducing the dose to the Organs at Risk (OAR). Such goals are not always achievable with the conformal three dimensions plans (3DCRT). Recently, radiation oncologist uses Intensity Modulated Radiotherapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) for irradiating the breast. In this study, we compared 3DCRT, IMRT and VMAT for left breast cancer patients in terms of PTV coverage, OAR. Wemily:"">mi

关键词： Left Breast Radiotherapy 3DCRT ImRT VmAT Large Breast Nodal Irradiation Boost