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Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations

World Journal of Stem Cells 2023年第5期15卷 302-322页

作者： Żaneta kałuzińska-kołat Damian kołat katarzyna kośla Elżbieta Płuciennik Andrzej k Bednarek Department of Experimental Surgery Medical University of LodzLodz 90-136LodzkiePoland Department of Molecular Carcinogenesis Medical University of LodzLodz 90-752LodzkiePoland Department of Functional Genomics Medical University of LodzLodz 90-752LodzkiePoland

Literature data on glioblastoma ongoingly underline the link between metabolism and cancer stemness,the latter is one responsible for potentiating the resistance to treatment,inter alia due to increased *** recent years,glioblastoma stemness research has bashfully introduced a key aspect of cytoskeletal rearrangements,whereas the impact of the cytoskeleton on invasiveness is well *** non-stem glioblastoma cells are less invasive than glioblastoma stem cells(GSCs),these cells also acquire stemness with greater ease if characterized as invasive cells and not tumor core *** suggests that glioblastoma stemness should be further investigated for any phenomena related to the cytoskeleton and metabolism,as they may provide new invasion-related ***,we proved that interplay between metabolism and cytoskeleton existed in *** searching for cytoskeleton-related processes in which the investigated genes might have been involved,not only did we stumble across the relation to metabolism but also reported genes that were found to be implicated in ***,dedicated research on these genes in GSCs seems justifiable and might reveal novel directions and/or biomarkers that could be utilized in the ***,we review the previously identified cytoskeleton/metabolism-related genes through the prism of glioblastoma stemness.

关键词： Glioblastoma Stemness Cytoskeleton Metabolism Biomarkers Therapy

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早产儿足月时的脑结构异常

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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 60-61页

作者： Inder T. E. Warfield S. k. Wang H. 俞晓梅(译) - PEDIATRICS 2005 115/2 (286-294) 不详

***-term studies of the outcome of very prematurely born infants have clearly documented that the majority of such infants have significant moto r,cognitive,and behavioral ***,there is a limited understanding of the nature of the cerebral abnormality underlying these adverse neurologic o *** overall aim of this study was to define quantitatively the alt erations in cerebral tissue volumes at term equivalent in a large longitudinal c ohort study of very low birth weight premature infants in comparison to term-bo rn infants by using advanced volumetric 3-dimensional magnetic resonance imagin g(MRI)*** also aimed to define any relationship of such perinatal l esions as white matter(WM)-injury or other potentially adverse factors to the quantitative structural ***,we wished to identify the rel ationship of the structural alterations to short-term neurodevelopmental outcom *** November 1998 to December 2000,119 consecutive premature infan ts admitted to the neonatal intensive care units at Christchurch Women’s Hospit al(Christchurch,New Zealand)and the Royal Women’s Hospital(Melbourne,Austr alia)were recruited(88%of eligible)after informed parental consent to underg o an MRI scan at term ***-one term-born infants across both sit es were recruited *** advanced 3-dimensional tissue segmentat ion with 3-dimensional reconstruction was undertaken to estimate volumes of cer ebral tissues:gray matter(GM;cortical and deep nuclear structures),WM(myelinated and unmyelinated),and cerebrospinal fluid(CSF).*** comp arison to the term-born infants,the premature infants at term demonstrated pro minent reductions in cerebral cortical GM volume(premature infants [mean ±SD]:178 ±41 mL;term infants:227 ±26 mL)and in deep nuclear GM volume(prematur e infants:10.8 ±4.1 mL;term infants:13.8 ±5.2 mL)and an increase in CSF vo lume(premature infants:45.6 ±22.1 mL;term infants:28.9

关键词：极低出生体重早产儿脑结构异常足月新生儿重症监护病房三维重建不良转归结构改变妇产医院磁共振成像 MRI扫描

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