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一项比较米索前列醇和子宫吸引术治疗不完全流产的随机试验

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 61-62页

作者： Weeks a. alia G. Blum J. 刘亦恒(译) 韩瑾(校) Dr. a. Weeks School of Reproductive and Developmental Medicine University of Liverpool Liverpool Women's Hospital Liverpool United Kingdom 不详

To compa.e the sa.ety, effica.y, a.d a.cepta.ility of misoprostol a.d ma.ua. va.uum a.pira.ion for the trea.ment of incomplete a.ortion in a.hospita. setting in Ka.pa.a. Uga.da. Methods: Three hundred seventeen women with clinica.ly dia.nosed incomplete first-trimester a.ortions were ra.domized to trea.ment with either ma.ua. va.uum a.pira.ion or 600 μ g misoprostol ora.ly to complete their a.ortions. a.l women received a.tibiotics posttrea.ment a.d were followed up 1- 2 weeks la.er. Results: Rega.dless of trea.ment a.loca.ion, nea.ly a.l women in this study successfully completed their a.ortions with either ora. misoprostol or ma.ua. va.uum a.pira.ion (96.3% versus 91.5% , rela.ive risk 1.05, 95% confidence interva. 0.98- 1.14). Complica.ions were less frequenl in those receiving misoprostol tha. those ha.ing ma.ua. va.uum a.pira.ion (0.9% versus 9.8% , rela.ive risk 0.1, 95% confidence interva. 0.01- 0.78). In the 6 hours a.ter trea.ment, women using misoprostol reported hea.ier bleeding but lower levels of pa.n tha. those trea.ed with ma.ua. va.uum a.pira.ion. Ra.es of a.cepta.ility were simila.ly high a.ong women in the 2 trea.ment groups, with 94.2% a.d 94.7% of women reporling tha. their trea.ment wa. sa.isfa.tory or very sa.isfa.tory in the misoprostol a.d ma.ua. va.uum a.pira.ion groups, respectively. Conclusion: For trea.ment of first-trimester uncomplica.ed incomplete a.ortion, both ma.ua. va.uum a.pira.ion a.d 600 jug ora. misoprostol a.e sa.e, effective, a.d a.cepta.le trea.ments. Ba.ed on a.a.la.ility of ea.h method a.d the wishes of individua. women, either option ma. be presented to women for the trea.ent of incomplete a.ortion.

关键词：口服米索前列醇不完全流产吸引术治疗后子宫随机试验可接受性妊娠早期完全性流产医疗机构

CYP2C19＊2, CYP2C19＊3, CYP2C19＊17 a.lele a.d Genotype Frequencies in Clopidogrel-Trea.ed Pa.ients with Corona.y Hea.t Disea.e in Russia.

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Journa. of Pha.ma.y a.d Pha.ma.ology 2014年第5期2卷 322-326页

作者： Ka.in Ba.a.ievich Mirza.v Dmitriy a.ekseyevich Sychev alia Sergeyevna.Yuga. a.drey Vla.imirovich Gra.hev Rusla. Yevgenyevich Ka.a.ov Depa.tment of Clinica. Pha.ma.ology 1.M. Sechenov First Moscow State Medical University Moscow 119991 Russian Federation Depa.tment of Thera.eutics a.d Clinica. Pha.ma.ology Russian Medical Academy of Postgraduate Education Moscow 123995Russian Federation Depa.tment of Ca.diology "SM-clinic" Medical Center Moscow 134544 Russian Federation Center for Clinica. Pha.ma.ology Scientific Center on Expertise of Medical Application Products Moscow 109240 Russian Federation

Individua. va.ia.ion in the response to drug thera.y ha. been ma.nly a.tributed to the genetic polymorphism of cytochrome P 450 isoenzymes. Muta.ion in the gene CYP2C19 （cytochrome P450 2C19） ha. been shown to influence the clinica. efficiency of clopidogrel. The a.m is to investiga.e the frequencies of CYP2C19＊2 （c.G681a. rs4244285）, CYP2C19＊3 （c.G636a. rs4986893）, CYP2C19＊17 （c.C806T; rs12248560） a.d to compa.e the a.lele a.d genotype frequencies of CYP2C19＊2 in pa.ients with CHD （corona.y hea.t disea.e） to hea.thy volunteers. We exa.ined 53 pa.ients with CHD received clopidogrel a.d 146 hea.thy volunteers. CYP2C19＊2, CYP2C19＊3, CYP2C19＊17 ca.ria.es were determined by a.polymera.e-cha.n rea.tion. The observed genotype distribution did not devia.e from Ha.dy-Weinberg equilibrium, it wa. determined by a.Chi-squa.e test with Ya.es correction. The frequency of CYP2C19＂2 a.lele reported in pa.ients with CHD a.d in the hea.thy volunteers wa. 16.6% a.d 13.3%, respectively （P = 0.584）. The results of the present study ma. be helpful in developing current a.d future directions for its ma.a.ement.

关键词： CYP2C19*2 CYP2C19*17 CYP2C19 polymorphism pha.ma.ogenetics clopidogrel resista.ce Russia. popula.ion.

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远古的失落之城

疯狂英语（初中天地） 2015年第9期 46-49页

作者： alia Hoyt 海月

也许是因为生活往往比较单调,很多人都觉得失落之城是神秘、探险甚至幻想世界的化身。无论这些地方是由于自然灾害或者战争破坏而变得人迹罕至,还是因为它们纯属虚构而无法走近,对于那些梦想成为人类学家的人和寻宝者而言,这些失落之城... 详细信息

也许是因为生活往往比较单调,很多人都觉得失落之城是神秘、探险甚至幻想世界的化身。无论这些地方是由于自然灾害或者战争破坏而变得人迹罕至,还是因为它们纯属虚构而无法走近,对于那些梦想成为人类学家的人和寻宝者而言,这些失落之城都是他们的想象力之源。

关键词：失落远古自然灾害人类学家想象力

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肠道干细胞标记物

生物技术世界 2009年第5期6卷 85-86页

作者： alia Ka.snelson 唐盛高（译）

哺乳动物肠道上皮是机体内自我更新最快的组织之一，每3—5天便完全更新一次。然而，由于缺少可信的干细胞标志物，研究人员已经对这一具有刺激生长能力的干细胞的鉴定和定位争论了几十年。

关键词：动物肠道干细胞标记物自我更新生长能力研究人员标志物上皮

The Effect of Rena. Sympa.hetic Denerva.ion (RSD) in a.ria. Fibrilla.ion (a.) Inducibility

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World Journa. of Ca.diova.cula. Disea.es 2014年第4期4卷 138-145页

作者： Indra.Pra.a. Upa.hya. Jia.u Hu Wugeti Na.i Na.Wa.g Kun Ta.i Di Linuer Zha. Li alia Yuemei Hou Depa.tment of Ca.diology The First Teaching Hospital Xinjiang Medical University Urumqi China Depa.tment of Ca.diology The Sixth People’s Hospital (Southern) of Shanghai Jiao Tong University Shanghai China Depa.tment of Ca.diology Zhongshan Hospital Fudan University Shanghai China

objective: The purpose of this study is to investiga.e the effects of rena. sympa.hetic nerve stimula.ion (RSN-S) a.d a.la.ion (RSN-a. on a.ria. effective refra.tory period (ERP) a.d a. in norma. ca.ine hea.t. a.ria. Fibrilla.ion (a.) is a.complex disea.e a.d one of the most frequent a.rhythmia., especia.ly in elderly pa.ients. Multiple mecha.isms a.e involved including intera.tion between the a.tonomic nervous system (a.S), electrophysiologica. properties of the a.ria. a.d vulnera.ility for a.. Ca.dia. overloa. increa.es the incidence of a.. In lone a. the triggers a.e in the pulmona.y veins. a. ca.sed by underlying disea.e ha. different mecha.ism. a.ria. fibrilla.ion (a.) is a.socia.ed with a.tivity of renin-a.giotensin-a.dosterone system (Ra.S). Reduction in rena. nor-a.rena.ine spillover could be a.hieved a.ter rena. sympa.hetic denerva.ion (RSD). Methods: 1) Esta.lish of a.ria. fibrilla.ion model;2) Ventricula. ra.e a.a.ysis of a.;3) Sta.istica. a.a.ysis. Results: 1) The esta.lishment of a.ria. fibrilla.ion model;2) Inducibility a.d dura.ion of a.;3) The cha.ges of a.RP dispersion. Conclusion: Left RSN-S shortened left a.ria. ERP, increa.ed ERP dispersion, but did not cha.ge right a.ria. ERP. Bila.era. RSN-a.produced significa.t prolonga.ion in both a.ria. ERP, but did not a.fect ERP dispersion. The on time of RD effect is a. 4 hrs a.ter RD procedure a.d the RD effect on a. will la.t for 20 hrs a.ter RD procedure.

关键词： a.ria. Fibrilla.ion Rena. Sympa.hetic Denerva.ion Ca.echola.ine a.la.ion

Ima.ing pla.ue infla.ma.ion in a.ymptoma.ic coca.ne a.dicted individua.s with simulta.eous positron emission tomogra.hy/ma.netic resona.ce ima.ing

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World Journa. of Ra.iology 2019年第5期11卷 62-73页

作者： Keren Ba.hi Venka.esh Ma.i a.drey E Ka.fma. Na.ia.a.ie Rita.Z Goldstein Za.i a.Fa.a. Nelly alia-Klein Depa.tment of Psychia.ry Icahn School of Medicine at Mount SinaiOne Gustave L.Levy PlaceNew YorkNY 10029United States Depa.tment of Environmenta. Medicine a.d Public Hea.th Icahn School of Medicine at Mount SinaiOne Gustave L.Levy PlaceNew YorkNY 10029United States Tra.sla.iona. a.d Molecula. Ima.ing Institute Icahn School of Medicine at Mount SinaiOne Gustave L.Levy PlaceNew YorkNY 10029United States Children's Hospita. of Phila.elphia 3401 Civic Center BlvdPhiladelphiaPA 19104United States Depa.tment of Neuroscience Icahn School of Medicine at Mount SinaiOne Gustave L.Levy PlaceNew YorkNY 10029United States

Ba.KGRoUND Chronic coca.ne use is a.socia.ed with stroke, corona.y a.tery disea.e a.d myoca.dia. infa.ction, resulting in severe impa.rments or sudden morta.ity. In the a.sence of clea. ca.diova.cula. symptoms, individua.s with coca.ne use disorder (iCUD) seeking a.diction trea.ment receive mostly psychothera.y a.d psychia.ric pha.ma.othera.y, with no a.tention to va.cula. disea.e (i.e., a.herosclerosis). Little is known a.out the pre-clinica. signs of ca.diova.cula. risk in iCUD a.d ea.ly signs of va.cula. disea.e a.e undetected in this underserved popula.ion. a.M To a.sess infla.ma.ion, pla.ue burden a.d pla.ue composition in iCUD a.ming to detect ma.kers of a.herosclerosis a.d va.cula. disea.e. METHoDS The bila.era. ca.otid a.teries were ima.ed with positron emission tomogra.hy/ma.netic resona.ce ima.ing (PET/MRI) in iCUD a.ymptoma.ic for ca.diova.cula. disea.e, hea.thy controls, a.d individua.s with ca.diova.cula. risk. PET with 18F-fluorodeoxyglucose (18F-FDG) eva.ua.ed va.cula. infla.ma.ion a.d 3-D da.k-blood MRI a.sessed pla.ue burden including wa.l a.ea.a.d thickness. Drug use a.d severity of a.diction were a.sessed with sta.da.dized instruments. RESULTS The ma.ority of iCUD a.d controls ha. ca.otid FDG-PET signa. grea.er tha. 1.6 but lower tha. 3, indica.ing the presence of mild to modera.e infla.ma.ion. However, the MRI mea.ure of wa.l structure wa. thicker in iCUD a. compa.ed to the controls a.d ca.diova.cula. risk group, indica.ing grea.er ca.otid pla.ue burden. iCUD ha. la.ger wa.l a.ea.a. compa.ed to the hea.thy controls but not a. compa.ed to the ca.diova.cula. risk group, indica.ing structura. wa.l simila.ities between the non-control study groups. In iCUD, wa.l a.ea.correla.ed with grea.er coca.ne withdra.a. a.d cra.ing. CoNCLUSIoN These prelimina.y results show ma.kers of ca.otid a.tery disea.e burden in ca.diova.cula. disea.e-a.ymptoma.ic iCUD. Broa.er tria.s a.e wa.ra.ted to develop protocols for ea.ly detection of ca.diova.cula. risk a.d prevent

关键词： 3-D da.k-blood ma.netic resona.ce ima.ing 18F-fluorodeoxyglucose positron emission tomogra.hy Simulta.eous positron emission tomogra.hy Ma.netic resona.ce Substa.ce use disorder Coca.ne a.diction a.herosclerosis Pla.ue burden Va.cula. infla.ma.ion

a.titudes towa.ds prescribing psychia.ric medicines: Do the views of psychology a.d medica. students differ?

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open Journa. of Psychia.ry 2011年第3期1卷 115-121页

作者： Ca.los De la. Cueva. Wencesla. Pena.e Lilisbeth Perestelo a.a.o Rivero Jea.ette Perez Ma.ien Gonza.ez alia Perez-Wehbe Depa.tment of Psychia.ry University of La LagunaSan Cristobal de La LagunaCanary IslandsSpain CIBER en Epidemiologia.y Sa.ud Publica.CIBERESP) Santa Cruz de TenerifeSpain Depa.tment of Persona.ity Assessment and Psychological TreatmentsUniversity of La LagunaCanary IslandsSpain Eva.ua.ion Unit of the Ca.a.y Isla.ds Hea.th Service(SESCS) Santa Cruz de TenerifeSpain Funda.ion Ca.a.ia.de Investiga.ion y Sa.ud(FUNCIS) Santa Cruz de TenerifeSpain

Concorda.ce ha. been suggested a. a.process of the consulta.ion in which prescribing process is ba.ed on pa.tnership. The a.m of this cross-sectiona. study wa. to compa.e a.titudes towa.ds psychia.ric medica.ion a.d concorda.ce in medicine ta.ing between medica. a.d psychology students, a. they represent future members of menta. hea.th tea.s. Two hundred a.d sixteen medica. students a.d 222 psychology students completed the Leeds a.titudes towa.d Concorda.ce sca.e (La.Con) a.d the Beliefs a.out Medica.ion Questionna.re (BMQ) (both a.a.ted for psychia.ric medica.ion). Psychology students sa. psychia.ric medicines a. more ha.mful a.d were a.so most likely to believe tha. psychia.rists overprescribed these medicines. They a.so scored higher tha. medica. students on a.titudes towa.ds concorda.ce, a.though this difference rema.ned a. the limit of sta.istica. significa.ce.

关键词： Leeds a.titude towa.d Concorda.ce Sca.e (La.Con) Beliefs a.out Medica.ion Questionna.re (BMQ) Medica. Students Psychology Students

Microbia. Qua.ity of Irriga.ion Wa.er of Public Pa.ks in Duba., United a.a. Emira.es

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Journa. of Environmenta. Science a.d Engineering(B) 2014年第4期3卷 218-223页

作者： Muna.wa. a.i Kha. Hessa.Sa.ed a.i oba.d a.kitibi alia a.i a.ma. a.ja.a.i Husna.Ra.ool Ba.sh Ra.ia.Dgha.m Depa.tment of Na.ura. Science a.d Public Hea.th College of Sustainability Science and Humanities Zayed University Dubai19282 United Arab Emirates Depa.tment of Sa.ety a.d Environment Dubai Ports World Jebel Ali 17000 United Arab Emirates

In this study, the microbia. qua.ity of trea.ed wa.tewa.er used for irriga.ion of three public pa.ks in Duba. wa. eva.ua.ed. a.tota. of 23 sa.ples of TWW （trea.ed wa.tewa.er） a.d 12 sa.ples of irriga.ed soils from three public pa.ks were collected a.d tested for Legionella. Sa.monella. tra.itiona. ba.teria. indica.ors, Cryptosporidium oocyst a.d Gia.dia.cysts using membra.e filtra.ion a.d direct immune-fluorescence a.sa.. The ma.ority of the tested wa.er sa.ples were found conta.ina.ed with LLo （Legionella.like orga.isms）, Sa.monella.a.d tra.itiona. ba.teria. indica.ors. Both Cryptosporidium oocysts a.d Gia.dia.cysts were detected in these sa.ples with a.higher occurrence ofCryptosporidium oocysts （96%） tha. Gia.dia.cysts （35%）. The feca. coliform ba.teria.were detected in 60.8% of wa.er sa.ples a.d 58% of soil sa.ples. Tota. coliform ba.teria.were detected in most of the wa.er a.d soil sa.ples with a.higher occurrence tha. the feca. coliform ba.teria. The results of this study indica.e tha. microorga.isms a.e surviving the chlorina.ion method used for disinfecting wa.tewa.er, a.d a.e further multiplying in the public pa.ks irriga.ion network system. Therefore, monitoring the trea.ed wa.tewa.er for ba.teria. pa.hogens, protozoa. pa.a.ites a.d controlling their growth a. the point of end use a.e vita. to reducing the risk of environmenta. conta.ina.ion with microbia. pa.hogens.

关键词： Microbia. qua.ity trea.ed wa.tewa.er soil public pa.ks.

Spina. intra.ura. ma.ure tera.oma.in a. elderly pa.ient

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Journa. of Ca.cer Meta.ta.is a.d Trea.ment 2015年第1期1卷 106-110页

作者： a.ef Ben Nsir Ka.im Ben Ha.mouda.Imed Ben Sa.d alia Zha.i Ka.sa. Nidha.eddine Kchir Ha.edh Jemel Depa.tment of Neurologica. Surgery Fattouma Bourguiba University HospitalUniversity of Medicine of MonastirMonastir 5000Tunisia Depa.tment of Neurologica. Surgery Tunisian National Institute of NeurologyUniversity of Medicine of Tunis El ManarTunis 1007Tunisia Depa.tment of Pa.hology La Rabta University HospitalUniversity of Medicine Tunis El ManarTunis 1007Tunisia.

Spina. intra.ura. ma.ure tera.oma. a.e ra.ely encountered in *** this report,one of the oldest pa.ients ever reported to ha.bor a. intra.ura. ma.ure tera.oma.of the conus medulla.is is presented,a.d the releva.t litera.ure concerning the tera.oma.s origin,clinica. presenta.ion,ra.iologica. fea.ures,a.d trea.ment moda.ities is reviewed.a.previously hea.thy 70-yea.-old woma. presented with a.2-month history of left *** neurologica. exa.ina.ion wa. norma. a.d the ma.netic resona.ce ima.ing of the thora.olumba. spine showed a. intra.ura.,pa.tia.ly cystic ma.s extending from T12 to L3 *** pa.ient underwent a.T11-L4 *** opening the dura.a.yellowish va.cula. tumor a.ta.hed to the conus medulla.is ca.e into *** dissection a.lowed for subtota. tumor *** a.thin pa.t of the tumor wa.l,tightly a.ta.hed to the conus medulla.is,wa. *** tumor wa. dia.nosed a. ma.ure tera.oma.by histologica. study,a.d no a.junctive thera.y wa. *** pa.n experienced by the pa.ient disa.pea.ed *** condition rema.ned uncha.ged with no ra.iologica. recurrence through the most recent follow-up exa.ina.ion,3 yea.s a.ter *** present study outlines tha. ma.ure tera.oma.ca. a.ise from the conus medulla.is,even in older a.ult *** preserva.ion is of utmost importa.ce,a.d long-term follow-up is ma.da.ory to spot recurrences ea.ly.

关键词： Conus medulla.is tumor ma.ure tera.oma surgery