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Diagnostic and Prognostic Value of Nuclear Factor Kappa-B in Diffuse Large B Cell Lymphoma in Egyptian Patients with Hepatitis C Virus Genotype 4

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American Journal of Molecular Biology 2019年第3期9卷 121-143页

作者： Nabil El Halawani Manal El Sordi Mona Aiad Bassma El Sabaa alia hashim Internal Medicine Department Faculty of Medicine Alexandria University Alexandria Egypt Clinical Pathology Department Faculty of Medicine Alexandria University Alexandria Egypt Pathology Department Faculty of Medicine Alexandria University Alexandria Egypt

Background: Members of the NFκB [p65] family have potential diagnostic and prognostic role in various inflammatory diseases and Lymphomas. Aim: We studied NFκB [p65] in paraffin blocks of hepatitis-C-virus [HCV] positive genotype-4 and HCV negative diffuse large B-cell lymphoma [DLBCL] patients, aiming at identification of its differential expression and prognosis in DLBCL and its subtypes;GCB and ABC. This is to establish its relation to HCV infection and its role in lymphogenesis. Besides assessing the role of new directly acting antiviral drugs [Sofusbuvir/Ledipasvir] concomitantly administered to [CHOP] combination in HCV positive DLBCL. Subjects and Methods: NFκB [p65] expression was assessed using Anti-NFκB [p65] antibody semi-quantitative technique in 30 newly diagnosed DLBCL patients [HCV positive [n = 15], HCV negative [n = 15]. Results: NFκB [p65] expression was higher in the HCV positive DLBCL patients than their HCV negative counterpart, with a positive correlation with the viral load [r = 0.536, p = 0.088]. NFκB [p65] expression was significantly more frequently detected in the ABC subtype than GCB subtype [p = 0.04]. Patients who expressed NFκB [p65] had higher incidence of extranodal involvement, advanced stages, higher LDH levels and IPI score. Besides, the expression of NFκB [P65] revealed an inferior overall response [OR] [p = 0.044]. Higher complete response rates to CHOP concomitantly with antiviral [ledipasvir/sofosbuvir] were encountered in the HCV positive group. In HCV positive group, NFκB [P65] displayed a positive relationship with the viral load and liver enzymes [p = 0.04], besides an inverse relation with serum albumin. This raises the possibility that NFκB [p65] expression is suggestive of the hepatic necro-inflammation in HCV patients. The ABC group presented more in advanced stages than GCB. Higher frequency of the ABC subgroup exhibited intermediate to high viral load, while it was less in the GCB. A statistically significant differe

关键词： Diffuse Large B-Cell Lymphoma NF-κB Hepatitis C Virus Germinal Center-B Activated B-Cell-Like Antiviral Therapy

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Toxicity effects of water extracts of Holothuria atra Jaeger in mice

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Asian Pacific Journal of Tropical Biomedicine 2014年第8期4卷 614-617页

作者： Ridzwan Bin hashim Nurul alia Azizan Zaitunnatakin Zamli Farah Hanis Zulkipli Nurzafirah Mazlan Osama Yousef Althunibat Department of Biomedical Science Faculty of Allied Health SciencesInternational Islamic University Malaysia Kuantan CampusJalan Sultan Ahmad ShahBandar Indera Mahkota 1025200 KuantanPahangMalaysia Faculty of Pharmacy Alzaytoonah University of JordanAmmanJordan

Objective:To determine lethal median dose(LD_(50)) and histopalhological toxicity of water extract of Hololhuria atra(H,atra) in ***:The behavioral changes,mortality and histopathology examination on liver were assessed in mice 14 d after the administration(i.p.) of *** water *** doses 110,20,30,50.100.150 and 200 mg/kg) of *** were *** control group was treated with normal saline,Results:In the acute study in mice,the water extracts of H,atra caused dose-dependent general behavior adverse affects and *** main behavioral sign of toxicity was hypoactivity,noticed immediately after administration of the extract which was more obvious at the higher doses and persisted until *** increased with increasing doses,the calculated LD_(50)was 41 mg/kg in *** liver toxicity was confirmed by histopalhological examination,which indicated the presence of abnormal hepatocytes with a distorted shape and undefined cell lining as well as enlarged nuclei in low doses *** doses groups indicated a more prominent distortion of the polyhedral hepatocytes with undefined cell lining,massive cytoplasm,*** and karyolytie nuclei(necrosis of hepatocytes).Control group showed polyhedral hepatocytes with defined cell lining arranged in cords and normal round nuclei,with granular ***:Because of the relatively low LD_(50) value in the acute study in mice,it may be concluded that the *** water extract is toxic.

关键词： Holothuria atra Water extract Lethal median dose Animal toxicity

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