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Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Trichomeriaceae, a new sooty mould family of Chaetothyriales

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Fungal Diversity 2012年第5期56卷 63-76页

作者： Putarak Chomnunti D.J.Bhat E.B.Gareth Jones Ekachai Chukeatirote ali.h.bahkali Kevin D.hyde International Fungal Research and Development Centre The Research Institute of Resource InsectsChinese Academy of ForestryBailongsiKunmingYunnanPeople’s Republic of China 650224 Institute of Excellence in Fungal Research School of ScienceMae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute of Ocean and Earth Sciences(IOES) C308Institute of Postgraduate Studies BuildingUniversity of Malaya50603Kuala LumpurMalaysia College of Science Botany and Microbiology DepartmentKing Saud UniversityRiyadh 1145Saudi Arabia

Trichomerium is a genus of foliar epiphytes with the appearance of sooty moulds,mostly occurring on the surface of living leaves and apparently gaining their nutrients from insect *** have ascostromata with setae and develop on a loosely interwoven mycelial mass of dark brown hyphae,while asci have a bitunicate appearance with hyaline *** this study,we made 16 collections of Trichomerium from *** were isolated,and the LSU and ITS rDNA gene regions *** analysis indicated that the Trichomerium species form a monophyletic clade within Chaetothyriales and warrant the introduction of a new family *** support for the Chaetothyriales is 100%and clearly separates Trichomeriaceae from Capnodiales which are morphologically very similar.A detailed account of Trichomerium is provided and we describe and illustrate three new species based on morphological and molecular *** propose that *** is adopted as the generic type of Trichomerium because it has been impossible to obtain the holotype specimen of *** and also no molecular data exists in worldwide databases for this species or genus.

关键词： Foliar epiphytes Phylogeny Sooty moulds Trichomerium

Classification of marine Ascomycota,Basidiomycota,Blastocladiomycota and Chytridiomycota

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Fungal Diversity 2015年第4期73卷 1-72页

作者： E.B.Gareth Jones Satinee Suetrong Jariya Sakayaroj ali.h.bahkali Mohamed A.Abdel-Wahab Teun Boekhout Ka-Lai Pang Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Fungal Biodiversity Laboratory BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoe Khlong LuangPathum Thani 12120Thailand Department of Botany Faculty of ScienceSohag UniversitySohagEgypt CBS Fungal Biodiversity Centre(KNAW) Uppsalalaan 83584CT UtrechtThe Netherlands Institute of Marine Biology and Center of Excellence for the Oceans Taiwan Ocean University2 Pei-Ning RoadKeelung 20224TaiwanRepublic of China

This paper lists the accepted names and classification of marine fungi,updating the scheme presented in *** classification includes 1,112 species(in 472 genera):Ascomycota 805(in 352 genera),Basidiomycota 21 species(in 17 genera),Chytridiomycota and related phyla 26 species(in 13 genera),Zygomycota three(in two genera),Blastocladiomycota one species(one genus),asexual morphs of filamentous fungi 43(in 26 genera);and marine yeasts:Ascomycota 138 species(in 35 genera),Basidiomycota 75 species(in 26 genera).These fungi belong to 129 families and 65 *** halosphaeriaceae remains the largest family of marine fungi with 141 species in 59 genera,while the most specious genera are Aspergillus(47 species),Penicillium(39 species)and the yeast genus Candida(64 species).The review includes details of recent higher order nomenclature changes,and accounts of new families,genera and species described over the past 5 years.

关键词： Fungal classification Marine fungi Molecular phylogeny New taxa Praelongicaulis gen nov Tirisporellales Torpedosporales ordo nov

Numerical Shock Viscosity for Impact Analysis Using ALE Formulation

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Computer Modeling in Engineering & Sciences 2018年第10期117卷 91-107页

作者： Souli Mhamed Paul Du Bois Essam Al-bahkali Universitéde Lille1 Unitéde Mécanique de Lille UMR CNRS 8107France Consulting Engineer Troy MichiganUSA Mechanical Engineering Department King Saud UniversityP.O.Box 80011421 RiyadhSaudi Arabia

When the simulation takes account of dissipative mechanisms,*** conduction and viscosity,the shocks become smeared out to produce thin layers of rapidly and continuously varying energy,density,pressure and velocity rather than discrete surfaces of mathematical *** the mid twentieth century,Von Neumann and Richtmyer suggested the use of a viscous pressure term(bulk viscosity)in the equilibrium equations for ideal gases in order to examine the shock while avoiding numerical oscillations at the shock *** the bulk viscosity is included in the conservation equations,the comprehensive physics present a continuous solution satisfying the Rankine-hugoniot ***,the published literature includes few engineering and research studies presenting the novel equilibrium equations in which the incorporation of bulk viscosity generates a continuous solution in keeping with conservation *** present work is aimed at demonstrating that the artificial bulk viscosity defined by Von Neumann and Richtmyer is also applicable to fluids described by a density-linear equation of state,that the novel equations present a continuous solution,and that a shock layer of the same order as the computational grid is *** the method has been employed and mathematically proven for onedimensional flow,it would seem to be just as relevant to the analysis of more complex flow dynamics and fluid structure interactions via an application of the Arbitrary Lagrangian Eulerian(ALE)formulation.

关键词： Shock wave fluid structure interaction ALE

Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor hayat Rafay ali Syed hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental health Institute of hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

Some stromatic pyrenomycetous fungi from northern ***,Camillea and hypoxylon(Xylariaceae)

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Fungal Diversity 2012年第4期55卷 65-76页

作者： L.N.Vasilyeva S.L.Stephenson K.D.hyde A.h.bahkali Institute of Biology and Soil Science Far East Branch of the Russian Academy of SciencesVladivostok 690022Russia University of Arkansas FayettevilleAR 72701USA Institute of Excellence in Fungal Research Mae Fah Lung UniversityChiang Rai 57100Thailand School of Science Mae Fah Lung UniversityChiang Rai 57100Thailand Botany and Microbiology Department College of ScienceKing Saud UniversityRiyadh 11442Saudi Arabia

Fourteen species of stromatic pyrenomycetous fungi(family Xylariaceae)collected in northern Thailand are *** of these(Biscogniauxia lithocarpi,Camillea malaysiensis ***,hypoxylon juventuterubrum,***,***,and ***)are described as taxa new to *** of these taxa are provided,and they are compared with similar taxa known from the Western hemisphere.

关键词： Ascomycota SE Asia Taxonomy Xylariales

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Meliolales

Fungal Diversity 2015年第5期74卷 91-141页

作者： Sinang hongsanan Qing Tian Derek Peršoh Xiang-Yu Zeng Kevin D.hyde Putarak Chomnunti Saranyaphat Boonmee ali.h.bahkali Ting-Chi Wen Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Institute of Excellence in Fungal Research Chiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Ruhr-Universität Bochum GeobotanyUniversitätsstraße 15044780 BochumGermany Botany and Microbiology Department College of ScienceKing Saud UniversityRiyadhKSA 11442Saudi Arabia The Engineering and Research Center of Southwest Bio-Pharmaceutical Resource Ministry of EducationGuizhou UniversityGuiyang 550025China

The order Meliolales comprises the families Armatellaceae and *** are black mildews that grow on the surface of host plants,often regarded as minor plant *** this study,types or specimens of 17 genera of Armatellaceae and Meliolaceae were borrowed from herbaria and *** is accepted in Armatellaceae and Amazonia,Appendiculella,Asteridiella,Cryptomeliola,Endomeliola,Irenopsis and Meliola are accepted in the family *** is synonymized under ***,Ectendomeliola,haraea,hypasteridium,Leptascospora,Metasteridium,Ophiociliomyces,Ophioirenina,Ophiomeliola,Parasteridium,Pauahia,Pleomeliola,Pleomerium,Prataprajella,Ticomyces,Urupe and Xenostigme are excluded from Meliolaceae,and are treated as doubtful genera or placed in ascomycetes genera incertae *** type species of each genus is re-described and illustrated with *** are provided and comparisons *** new species of Meliola and one new species of Irenopsis are also introduced with molecular data and we provide the most populated phylogenetic tree of Meliolomycetidae to *** thailandicum was found on Dimocarpus longan(Sapindales)and Acacia auriculiformis(Fabales)and confirmed to be the same species in the molecular *** has important implications as the several hundred Meliola species are recognized based on host *** the same species being recorded from two unrelated hosts sheds doubt on Meliola species being host-specific.

关键词： Armatella Armatellaceae Ascomycota Black mildews Meliola Meliolaceae Meliolomycetidae Sordariomycetes Morphology Type Species Taxonomy

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

heat shock protein family B(small)member 8(hSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of hSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,hSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,hSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,hSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which hSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of hSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting hSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment hSPB8 neuroinflammation neuromuscular diseases therapy