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中西医结合学报 2012年第12期10卷 1470-1475页

作者： Toktam Mohammadpour Mahmoud Hosseini reza Karami Hamid reza Sadeghnia ali reza ebrahimzadeh bideskan Lili Enayatfard Neuroscience Research Center and Department of Physiology School of Medicine Mashhad University of Medical Sciences Pharmacological Research Center of Medicinal plants Mashhad University of Medical Sciences Department of Anatomy School of Medicine Mashhad University of Medical Sciences

目的:研究黄豆提取物对经戊四唑(pentylenetrazole,PTZ)诱发癫发作的女性荷尔蒙缺失雌性大鼠与正常雌性大鼠的不同作用,以及因性别差异引起的植物雌性激素对行为的影响。方法:雄性Wistar大鼠被随机分为雄性生理盐水组,雄性低、中、高剂... 详细信息

目的:研究黄豆提取物对经戊四唑(pentylenetrazole,PTZ)诱发癫发作的女性荷尔蒙缺失雌性大鼠与正常雌性大鼠的不同作用,以及因性别差异引起的植物雌性激素对行为的影响。方法:雄性Wistar大鼠被随机分为雄性生理盐水组,雄性低、中、高剂量黄豆提取物治疗组,每组8只;雌性Wistar大鼠随机分为假手术生理盐水组,假手术低、中、高剂量黄豆提取物治疗组,去卵巢生理盐水组,去卵巢低、中、高剂量黄豆提取物治疗组,每组8只。去卵巢大鼠在氯胺酮麻醉下行卵巢切除术。分别给予各组大鼠生理盐水及不同剂量黄豆提取物治疗2周后腹腔内注射戊四唑。将大鼠放置在树脂玻璃笼内,记录最小阵挛性癫发作(minial clonic seizure,MCS)潜伏期和强直性阵挛性癫发作(generalized tonic-clonic seizure,GTCS)潜伏期。结果:与雄性生理盐水组大鼠比较,雄性低、中剂量黄豆提取物治疗组的MSC和GTCS潜伏期显著缩短(P<0.05或P<0.01)。雌性假手术大鼠在给予黄豆提取物治疗后,其MSC和GTCS潜伏期没有显著改变。与去卵巢生理盐水组比较,去卵巢低、高剂量黄豆提取物治疗组的MSC和GTCS潜伏期明显缩短(P<0.05或P<0.01)。结论:黄豆的植物雌激素能影响由PTZ诱发的癫发作的轻重程度,但其影响程度与卵巢激素水平有关。机制还有待进一步研究。

关键词：黄豆癫癎发作卵巢切除术大鼠

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大豆提取物抗戊四唑所致卵巢切除大鼠痉挛的作用(英文)

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中西医结合学报 2011年第6期9卷 611-618页

作者： ali reza ebrahimzadeh bideskan Mahmoud Hosseini Toktam Mohammadpour reza Karami Mehdi Khodamoradi Habibollah Nemati Karimooy Hassan Alavi Department of Anatomy School of MedicineMashhad University of Medical SciencesMashhadIran Neuroscience Research Center and Department of Physiology School of MedicineMashhad University of Medical SciencesMashhadIran Pharmacological Research Center of Medicinal Plants Mashhad University of Medical SciencesMashhadIran Neuroscience Research Center and Department of Anatomy School of MedicineMashhad University of Medical SciencesMashhadIran

目的:研究大豆提取物抗戊四唑所致卵巢切除大鼠痉挛的作用。方法:雌性Wistar大鼠随机分为4组(n=15),分别为假手术组、卵巢切除组、低剂量大豆提取物组和高剂量大豆提取物组。假手术组大鼠行假手术,其余3组大鼠行卵巢切除术。每组大鼠再... 详细信息

目的:研究大豆提取物抗戊四唑所致卵巢切除大鼠痉挛的作用。方法:雌性Wistar大鼠随机分为4组(n=15),分别为假手术组、卵巢切除组、低剂量大豆提取物组和高剂量大豆提取物组。假手术组大鼠行假手术,其余3组大鼠行卵巢切除术。每组大鼠再随机分为2个亚组,其中一个亚组(n=7)每日予低剂量戊四唑(40mg/kg)腹腔内注射,连续14d;另一亚组(n=8)予一次高剂量戊四唑(90mg/kg)腹腔内注射。在戊四唑注射前30min,低剂量大豆提取物(20mg/kg)及高剂量大豆提取物(60mg/kg)组分别腹腔内注射大豆提取物,假手术组及卵巢切除组注射生理盐水。上述步骤完成后,将大鼠置于树脂玻璃箱中观察60min。结果:重复低剂量注射戊四唑14d,卵巢切除组大鼠的痉挛评分在第3、5、8、10、11、12及13天低于假手术组(P<0.05或P<0.01),而低剂量大豆提取物组和高剂量大豆提取物组大鼠的痉挛评分高于卵巢切除组(P<0.05或P<0.01)。一次性高剂量注射戊四唑后,与假手术组相比,卵巢切除组大鼠阵发性强直性抽搐潜伏期延长,而最小阵发性痉挛潜伏期无明显变化;与卵巢切除组相比,低剂量及高剂量的大豆提取物显著缩短了大鼠阵发性强直性抽搐及最小阵发性痉挛的潜伏期(P<0.01)。结论:雌激素能够影响戊四唑所致大鼠痉挛的严重程度,而大豆中所含的植物雌激素也具有类似作用,这种作用还有待更多的研究予以证实。

关键词：大豆植物雌激素类植物提取物发作戊四唑大鼠

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Identification of a novel nonsense mutation in kyphoscoliosis peptidase gene in an Iranian patient with myofibrillar myopathy

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Genes & Diseases 2018年第4期5卷 331-334页

作者： reza ebrahimzadeh-Vesal Atieh Teymoori ali Mohammad Dourandish Mohsen Azimi-Nezhad Department of Basic Medical Sciences Neyshabur University of Medical SciencesNeyshaburIran Department of Medical Genetics School of MedicineGolestan University of Medical SciencesGorganIran Medical Genetics Counseling Center NeyshaburIran Department of Medical Genetics School of MedicineMashhad University of Medical SciencesMashhadIran

Myofibrillar myopathies(MFMs)are rare genetic and slowly progressive neuromuscular *** pathogenic mutations have been reported in MFM-related genes including DES,CRYAB,MYOT,LDB3 or ZASP,FLNC,BAG3,FHL1 and *** MFMs is commonly inherited in an autosomal dominant manner,the inheritance pattern and novel mutated genes are not thoroughly elucidated in some ***,we report discovery of a novel nonsense mutation in a 29-year-old Iranian male patient with motor disorders and deformity in his lower *** parents are second *** Motor Sensory Neuropathy as initial genetic diagnosis was ruled *** exome sequencing using NGS on Illumina Hi-Seq4000 platform was performed to identify the disease and possible mutated gene(s).Our data analysis identified a homozygous nonsense unreported c.C415T(p.R139X)variant on kyphoscoliosis peptidase(KY)gene(NM_178554:exon4).Sanger sequencing of this mutation has been performed for his other related family *** and segregation analysis was confirmed the NGS results and autosomal recessive inheritance pattern of the disease.

关键词： Kyphoscoliosis peptidase gene Myofibrillar myopathy Next generation sequencing Novel mutation Rare genetic neuromuscular disorders

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Deep learning:Applications,architectures,models,tools,and frameworks:A comprehensive survey

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 581-606页

作者： Mehdi Gheisari Fereshteh ebrahimzadeh Mohamadtaghi Rahimi Mahdieh Moazzamigodarzi Yang Liu Pijush Kanti Dutta Pramanik Mohammad ali Heravi Abolfazl Mehbodniya Mustafa Ghaderzadeh Mohammad reza Feylizadeh Saeed Kosari School of Computer Science and Technology Harbin Institute of Technology(Shenzhen)ShenzhenChina Department of Cognitive Computing Institute of Computer Science and EngineeringSaveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennaiIndia Department of Computer Science Islamic Azad UniversityTehranIran Computer Engineering Department Bu‐Ali Sina UniversityHamedanIran Department of Mathematics and Statistics Iran University of Science and TechnologyTehranIran Department of Mathematics and Statistics University of Northern British ColumbiaBCCanada Peng Cheng Laboratory ShenzhenChina Deprtment of Technology Jodhpur Institute of Engineering&TechnologyJodhpurIndia Department of Computer Engineering Sadjad University of TechnologyMashhadIran Department of Electronics and Communications Engineering Kuwait College of Science and TechnologyDoha DistrictKuwait Department of Artificial Intelligence Smart University of Medical SciencesTehranIran Department of Industrial Engineering Shiraz BranchIslamic Azad UniversityShirazIran Institute of Computing Science and Technology Guangzhou UniversityGuangzhouChina

Deep Learning(DL)is a subfield of machine learning that significantly impacts extracting new *** using DL,the extraction of advanced data representations and knowledge can be made *** effective DL techniques help to find more hidden *** learning has a promising future due to its great performance and *** need to understand the fundamentals and the state‐of‐the‐art of DL to leverage it effectively.A survey on DL ways,advantages,drawbacks,architectures,and methods to have a straightforward and clear understanding of it from different views is explained in the ***,the existing related methods are compared with each other,and the application of DL is described in some applications,such as medical image analysis,handwriting recognition,and so on.

关键词： data mining data privacy deep learning

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Prevalence of antibiotic resistance in Helicobacter pylori : A recent literature review

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World Journal of Methodology 2015年第3期5卷 164-174页

作者： reza Ghotaslou Hamed ebrahimzadeh Leylabadlo Yalda Mohammadzadeh Asl Research Center of Infectious and Tropical Diseases Tabriz University of Medical Sciences Department of Microbiology School of Medicine Tabriz University of Medical Sciences

AIM: To review previous studies(the last 6 years) about the Helicobacter pylori(H. pylori) antibiotic resistance in order to evaluate the trend in antibiotic resistance. METHODS: In this study, the Pub Med, MEDLINE, Science Direct, Google Scholar and Scielo manuscripts were reviewed from 2009 to 2014. RESULTS: On the whole rates of H. pylori antibiotic resistance were 47.22%(30.5%-75.02%) for metronidazole, 19.74%(5.46%-30.8%) for clarithromycin, 18.94%(14.19%-25.28%) for levofloxacin, and 14.67%(2%-40.87%) for amoxicillin, 11.70%(0%-50%) for tetracycline, 11.5%(0%-23%) for furazolidon and 6.75%(1%-12.45%) for rifabutin. The frequency of tetracycline, metronidazole and amoxicillin resistance was higher in Africa, while clarithromycin and levofloxacin resistance was higher in North America and Asian, respectively. CONCLUSION: The most sensitive drug is rifabutin and the lowest sensitive drug is metronidazole in the world. The worldwide H. pylori antibiotic resistance to clarithromycin and levofloxacin has increased during the last 6 years. The present systematic review show alarming results and a novel plan is needed for eradication therapy of H. pylori infections.

关键词： Antibiotic resistance Helicobacter pylori Worldwide

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