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Novel biallelic loss-of-function mutations in CFAP43 cause multiple morphological abnormalities of the sperm flagellum in Pakistani families

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Asian Journal of Andrology 2021年第6期23卷 627-632页

作者： Ihsan Khan Basit Shah Sobia Dil Nadeem Ullah Jian-Teng Zhou Da-Ren Zhao Yuan-Wei Zhang Xiao-Hua Jiang Ranjha Khan Asad Khan haider ali Muhammad Zubair Wasim Shah Huan Zhang Qing-Hua Shi First Affiliated Hospital of USTC Hefei National Laboratory for Physical Sciences at Microscalethe CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineCAS Center for Excellence in Molecular Cell ScienceCollaborative Innovation Center of Genetics and DevelopmentUniversity of Science and Technology of ChinaHefei 230027China

Multiple morphological abnormalities of the sperm flagella(MMAF)is a specific type of asthenoteratozoospermia,presenting with multiple morphological anomalies in spermatozoa,such as absent,bent,coiled,short,or irregular caliber *** genetic studies revealed pathogenic mutations in genes encoding cilia and flagella-associated proteins(CFAPs;e.g.,CFAP43,CFAP44,CFAP65,CFAP69,CFAP70,and CFAP251)responsible for the MMAF phenotype in infertile men from different ethnic ***,none of them have been identified in infertile Pakistani males with *** the current study,two Pakistani families with MMAF patients were ***-exome sequencing(WES)of patients and their parents was *** analysis reflected novel biallelic loss-of-function mutations in CFAP43 in both families(Family 1:ENST00000357060.3,***300Lysfs*22 and ***526Serfs*43 in a compound heterozygous state;Family 2:ENST00000357060.3,***526Serfs*43 in a homozygous state).Sanger sequencing further confirmed that these mutations were segregated recessively in the families with the MMAF *** reverse-transcriptase polymerase chain reaction(qRT-PCR)was carried out to detect the effect of the mutation on mRNA of the affected *** research demonstrated that biallelic loss-of-function mutations in CFAP43 accounted for the majority of all CFAP43-mutant MMAF *** the best of our knowledge,this is the first study to report CFAP43 biallelic loss-of-function mutations in a Pakistani population with the MMAF *** study will help researchers and clinicians to understand the genetic etiology of MMAF better.

关键词： cilia and flagella-associated proteins male infertility multiple morphological abnormalities of the sperm flagella whole-exome sequencing

Implementation &Comparative Analysis of 10, 18 &24 Level Diode Clamped Inverters Using “Trust Region Dog Leg” Method

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Circuits and Systems 2015年第3期6卷 70-80页

作者： haider ali Mohamed Z. H. Qawaqzeh Muhammad Abbas Takialddin Al Smadi CIIT Abbottabad Pakistan Faculty of Engineering Al-Balqa’ Applied University Amman Jordan Department of Communications and Electronics Engineering College of Engineering Jerash University Jerash Jordan

Multilevel inverters are used in many industrial applications because of good power quality, minimum losses and less harmonics contents. Multilevel inverters require no series connected synchronized switching devices, transformer and complex filters. In this paper 10, 18, 24 diode clamped multi-level inverters (DCMLI) are implemented using trust region dog leg optimization method to find the optimized values of switching angles (θ). It decreases the total harmonic distortion (THD) of the output voltages and to reduce the complexity of external filter required. The multi-level inverters are implemented in MATLAB Simulation and results are compared in terms of harmonics, system complexity and efficiency.

关键词： DCMLI THD Switching Angles IGBTs Trust Region Dog Leg

Mid-term outcomes of a kinematically designed cruciate retaining total knee arthroplasty

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World Journal of Orthopedics 2024年第2期15卷 118-128页

作者： Jonathan L Katzman Akram A Habibi Muhammad A haider Casey Cardillo Ivan Fernandez-Madrid Morteza Meftah Ran Schwarzkopf Department of Orthopedic Surgery Division of Adult Reconstructive SurgeryNYU Langone Orthopedic HospitalNYU Langone HealthNew YorkNY 10010United States

BACKGROUND Advances in implant material and design have allowed for improvements in total knee arthroplasty(TKA)outcomes.A cruciate retaining(CR)TKA provides the least constraint of TKA designs by preserving the native posterior cruciate *** research exists that has examined clinical outcomes or patient reported outcome measures(PROMs)of a large cohort of patients undergoing a CR TKA utilizing a kinematically designed *** was hypothesized that the studied CR Knee System would demonstrate favorable outcomes and a clinically significant improvement in pain and functional *** To assess both short-term and mid-term clinical outcomes and PROMs of a novel CR TKA *** A retrospective,multi-surgeon study identified 255 knees undergoing a TKA utilizing a kinematically designed CR Knee System(JOURNEY™II CR;Smith and Nephew,Inc.,Memphis,TN)at an urban,academic medical institution between March 2015 and July 2021 with a minimum of two-years of clinical follow-up with an orthopedic *** demographics,surgical information,clinical outcomes,and PROMs data were collected via query of electronic medical *** PROMs collected in the present study included the Knee Injury and Osteoarthritis Outcome Score for Joint Replacement(KOOS JR)and Patient-Reported Outcomes Measurement Information System(PROMIS■)*** significance of improvements in mean PROM scores from preoperative scores to scores collected at six months and two-years postoperatively was analyzed using Independent Samples *** Of the 255 patients,65.5%were female,43.8%were White,and patients had an average age of 60.6 *** osteoarthritis(96.9%)was the most common primary *** mean surgical time was 105.3 minutes and mean length of stay was 2.1 d with most patients discharged home(92.5%).There were 18 emergency department(ED)visits within 90 d of surgery resulting in a 90 d ED visit rate of 7.1%,including a 2.4%orthopedic-related ED visit ra

关键词： Total knee arthroplasty Cruciate retaining Kinematic design Survivorship Bearing material Prosthetic design Clinical outcomes Patient-reported outcome measures

Numerical Study on the Effects of Contraction Ratio in a Two-Phase Flow Injection Nozzle

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Open Journal of Fluid Dynamics 2016年第1期6卷 1-10页

作者： haider ali Kyung Won Kim Jae Sik Kim Jong Yun Choi Cheol Woo Park School of Mechanical Engineering Kyungpook National University Daegu Korea Podomaul Co. Ltd. 1190 Kumchang-Ro Daechang-Myon Yeongcheon-Si Korea B.C.M. Co. Ltd. 81 Yeomsaekgongdancheon-Ro Seo-Gu Daegu Korea

The Euler-Euler numerical method was used to investigate the effects of contraction ratio on twophase flow mixing with mass transfer in the flow injection nozzle. The geometric shape of the nozzle was modified to improve carbonation efficiency. A gas inlet hole was created to increase the flow mixing of CO2 with water. A nozzle throat was also introduced to increase the gas dissolution by increasing flow rates. Various contraction ratios of nozzle throat, inlet gas and liquid velocities, and gas bubble sizes were employed to determine their effects on gas hold-up, gas concentration, and mass transfer coefficient. Results revealed that the flow injection nozzle with high contraction ratios improved carbonation because of high gas hold-up. Gas concentration was directly related to contraction ratio and gas flow velocities. Carbonation reduced when high liquid velocities and large gas bubbles were employed because of inefficient flow mixing. This study indicated that flow injection nozzle with large contraction ratios were suitable for carbonation because of their ability to increase gas hold-up, gas concentration, and mass transfer coefficient.

关键词： Flow Injection Nozzle Nozzle Throat Contraction Ratio Gas-Liquid Flow Mass Transfer

Environmental impact of energy imports:Natural resources income and natural gas production profitability in the Asia-Pacific Economic Cooperation Countries

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Geoscience Frontiers 2024年第2期15卷 125-139页

作者： Aimin Pan Si Xu Syed Anees haider Zaidi School of Business Hunan University of Science and TechnologyXiangtanChina School of Tourism and Economic Management Nanchang Normal UniversityNanchangChina Faculty of Economic Sciences University of WarsawPoland

Environmental degradation is a pressing global concern,with the energy sector being one of the major contributors to this *** environmental impact of energy imports,particularly regarding natural resources income and natural gas production profitability,cannot be *** must assess the environmental consequences of their energy choices and take steps to minimize their *** transitioning to cleaner and more sustainable energy sources,countries can ensure a better future for the environment and their *** study examines the impact of energy imports and natural resources income on environmental degradation in the Asia-Pacific Economic Cooperation(APEC)countries from 1990 to 2020,using revenue minus the production cost of natural gas and electricity production from renewable sources as moderating ***-run estimates are derived using the Generalized Method of Moments and robust least *** findings elucidate that importing energy from countries specializing in renewable energy can help reduce reliance on fossil *** diversification of energy sources decreases the overall carbon footprint and contributes to a cleaner *** gas production often involves infrastructure construction,such as drilling rigs and pipelines,which can disrupt natural habitats and wildlife *** destruction of ecosystems can have long-term consequences on biodiversity and ecological *** environmental impact of energy imports,particularly related to natural resource income and natural gas production profitability,requires BRICS countries to take proactive *** nations can address the environmental challenges associated with their energy demands by implementing policies prioritizing sustainable resource management,carbon pricing,stringent regulation,and investment in research and *** doing so,they can balance economic growth and environmental sustainability,ensuring a greener future for the BRICS

关键词： Energy imports Environmental degradation Natural resources income Renewable energy APEC countries

Recent Developments in Authentication Schemes Used in Machine-Type Communication Devices in Machine-to-Machine Communication: Issues and Challenges

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Computers, Materials & Continua 2024年第4期79卷 93-115页

作者： Shafi Ullah Sibghat Ullah Bazai Mohammad Imran Qazi Mudassar Ilyas Abid Mehmood Muhammad Asim Saleem Muhmmad Aasim Rafique Arsalan haider Ilyas Khan Sajid Iqbal Yonis Gulzar Kauser Hameed Department of Computer Engineering Balochistan University of Information TechnologyEngineering and Management SciencesQuetta87300Pakistan Department of Information Technology Balochistan University of Information TechnologyEngineeringand Management SciencesQuetta87300Pakistan Department of Information Systems College of Computer Sciences and Information TechnologyKing Faisal UniversityHofuf in Al-Ahsa31982Saudi Arabia Department of Management Information Systems College of Business AdministrationKing Faisal UniversityHofuf in Al-Ahsa31982Saudi Arabia Department of Software Engineering College of ComputingRiphah International UniversityFaisalabad44000Pakistan Department of Electrical Engineering Balochistan University of Information Technology Engineeringand Management SciencesQuetta87300Pakistan Department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-Majmaah11952Saudi Arabia

Machine-to-machine (M2M) communication plays a fundamental role in autonomous IoT (Internet of Things)-based infrastructure, a vital part of the fourth industrial revolution. Machine-type communication devices(MTCDs) regularly share extensive data without human intervention while making all types of decisions. Thesedecisions may involve controlling sensitive ventilation systems maintaining uniform temperature, live heartbeatmonitoring, and several different alert systems. Many of these devices simultaneously share data to form anautomated system. The data shared between machine-type communication devices (MTCDs) is prone to risk dueto limited computational power, internal memory, and energy capacity. Therefore, securing the data and devicesbecomes challenging due to factors such as dynamic operational environments, remoteness, harsh conditions,and areas where human physical access is difficult. One of the crucial parts of securing MTCDs and data isauthentication, where each devicemust be verified before data transmission. SeveralM2Mauthentication schemeshave been proposed in the literature, however, the literature lacks a comprehensive overview of current M2Mauthentication techniques and the challenges associated with them. To utilize a suitable authentication schemefor specific scenarios, it is important to understand the challenges associated with it. Therefore, this article fillsthis gap by reviewing the state-of-the-art research on authentication schemes in MTCDs specifically concerningapplication categories, security provisions, and performance efficiency.

关键词： Authentication cyber security internet of things machine-type communication devices machine-to-machine communication

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植酸酶的多种益处

国外畜牧学（猪与禽） 2010年第3期30卷 18-19页

作者：苏良科 Syed ali Raza haider Prix药业(私营)有限公司

从提升饲料价值至改善环境(图1),植酸酶的价值是无容置疑的。

关键词：植酸酶饲料价值矿物质家禽饲料

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基于VAR的齿轮早期故障监测研究

兵器装备工程学报 2018年第4期39卷 126-130页

作者：大海蔡景胡维南京航空航天大学南京211106

针对齿轮传统监测难以及时发现早期故障的不足,开展了基于VAR的齿轮早期故障监测研究。采用时域同步平均方法,消除齿轮状态监测振动信号中的背景噪音;利用齿轮健康时段的振动监测数据,建立了VAR模型,得到残差值,通过监测残差是否发生突... 详细信息

针对齿轮传统监测难以及时发现早期故障的不足,开展了基于VAR的齿轮早期故障监测研究。采用时域同步平均方法,消除齿轮状态监测振动信号中的背景噪音;利用齿轮健康时段的振动监测数据,建立了VAR模型,得到残差值,通过监测残差是否发生突变的方法判断故障有否发生。最后采用齿轮振动试验数据对判断结果进行验证,结果表明可以有效监测齿轮箱的早期故障。

关键词： VAR 状态监测早期故障

Is it necessary to stop glucagon-like peptide-1 receptor agonists prior to endoscopic procedure? A retrospective study

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World Journal of Gastroenterology 2024年第26期30卷 3221-3228页

作者： haider Ghazanfar Nismat Javed Abeer Qasim Franklin Sosa Faryal Altaf Shazia Khan Jaydeep Mahasamudram Abhilasha Jyala Sameer Datta Kandhi Dongmin Shin Nikhitha Mantri Haozhe Sun Siddarth Hanumanthu Harish Patel Jasbir Makker Bhavna Balar Anil Dev Sridhar Chilimuri Division of Gastroenterology Department of Internal MedicineBronxCare Health SystemIcahn School of Medicine at Mount SinaiBronxNY 10457United States Department of Internal Medicine BronxCare Health SystemIcahn School of Medicine at Mount SinaiBronxNY 10457United States

BACKGROUND Glucagon-like peptide-1 receptor agonists(GLP-1 RA)are effective in diabetes and obesity,reducing hyperglycemia by increasing insulin release and delaying gastric ***,they can cause gastroparesis,raising concerns about aspiration during *** guidelines advise discontinuing GLP-1 RA before surgery to reduce the risk of pulmonary *** To evaluate the effect of GLP-1 RAs on gastric residual contents during endosco-pic *** A retrospective chart review at BronxCare Health System,New York,from January 2019 to October 2023,assessed gastric residue and aspiration in GLP-1 RA patients undergoing endoscopic *** groups were compared based on dietary status before the *** included demographics,symptoms of gastroparesis,opiate use,hemoglobin A1c,GLP-1 agonist indication,endo-scopic details,and aspiration *** SPSS was used for analysis,cal-culating means,standard deviations,and applying Pearson’s chi-square and t-tests for associations,with P<0.05 as being *** During the study,306 patients were included,with 41.2%on a clear liquid/low residue diet and 58.8%on a regular diet before *** patients(63.1%)were male,with a mean age of 60±12 *** majority(85.6%)were on GLP-1 RAs for diabetes,and 10.1%reported digestive symptoms before *** those on a clear liquid diet,1.5%had residual food at endoscopy compared to 10%on a regular diet,which was statistically significant(P=0.03).Out of 31 patients with digestive symptoms,13%had residual food,all from the regular diet group(P=0.130).No complications were reported during or after the *** The study reflects a significant rise in GLP-1 RA use for diabetes and obesity.A 24-hour liquid diet seems safe for endoscopic procedures without *** with upper gastrointestinal symptoms might have a higher residual food risk,though not statistically *** research is needed

关键词： Glucagon-like peptide-1 agonists Gastroparesis Endoscopic procedures Residual food Complications