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Single nucleotide polymorphism within chromosome 8q24 is associated with prostate cancer development in Saudi Arabia

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Asian Journal of Urology 2024年第1期11卷 26-32页

作者： Awad Elsid Osman Sahar Alharbi Atif ali Ahmed Asim ali Elbagir Pathology and Clinical Laboratory Management Department(PCLM) King Fahad Medical CityRiyadhSaudi Arabia Department of Pathology and Laboratory Medicine University of Missouri at Children's Mercy HospitalKansas CityMOUSA

Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in Saudi males is low but is probably familial or genetically ***: To identify any possible association of SNP with PCa development in Saudi patients, we investigated a group of SNPs in Saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients’ groups and healthy control group. A total of thirteen SNPs were genotyped using TaqMan® minor groove binder polymerase chain reaction ***: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequency in PCa patients than controls (p< 0.05). The rs16901979 CA genotype was found at significantly greater frequency in PCa patients than in healthy controls (43% vs. 14%, odds ratio=4.6, p=0.0001) and benign hyperplasia group (43% vs. 25%, odds ratio=2.2, p=0.009).Conclusion: Our study has highlighted the association of rs16901979 SNP with PCa in Saudi males. Such findings have important implications in the PCa diagnosis and in screening unaffected family members of Saudi patients.

关键词： Prostatecancer Saudi Singlenucleotide polymorphism Allele

A review on reinforcement learning-based highway autonomous vehicle control

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Green Energy and Intelligent Transportation 2024年第4期3卷 72-90页

作者： ali Irshayyid Jun Chen Guojiang Xiong Oakland University USA Guizhou UniversityChina

Autonomous driving is an active area of research in artificial intelligence and *** advances in deep reinforcement learning(DRL)show promise for training autonomous vehicles to handle complex real-world driving *** paper reviews recent advancement on the application of DRL to highway lane change,ramp merge,and platoon *** particular,similarities,differences,limitations,and best practices regarding the DRL formulations,DRL training algorithms,simulations,and metrics are reviewed and *** paper starts by reviewing different traffic scenarios that are discussed by the literature,followed by a thorough review on the DRL technology such as the state representation methods that capture interactive dynamics critical for safe and efficient merging and the reward formulations that manage key metrics like safety,efficiency,comfort,and *** from this review can guide future research toward realizing the potential of DRL for automated driving in complex traffic under uncertainty.

关键词： Autonomous vehicles Connected and automated vehicles Deep reinforcement learning Platoon

Hydrodynamic Assessment of A New Nature-Based Armour Unit on Rubble Mound Breakwater for Coastal Protection

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China Ocean Engineering 2024年第3期38卷 439-452页

作者： Ehsan SAFA alireza MOJTAHEDI Abdolmajid MOHAMMADIAN Mohamad ali Lotfollahi YAGHIN Department of Water Resources Engineering Faculty of Civil EngineeringUniversity of TabrizTabriz ***Iran Faculty of Civil Engineering University of OttawaOttawa K1H 8M5Canada

This research proposes a novel nature-based design of a new concrete armour unit for the cover layer of a rubblemoundbreakwater. Armour units are versatile with respect to shape, orientation, surface condition details, and ***, a detailed analysis is required to investigate the exact state of their hydraulic interactions and structuralresponses. In this regard, the performance results of several traditional armour units, including the Antifer cube,Tetrapod, X-block and natural stone, are considered for the first step of this study. Then, the related observed resultsare compared with those obtained for a newly designed (artificial coral) armour unit. The research methodology utilizesthe common wave flume test procedure. Furthermore, several verified numerical models in OpenFOAM code areused to gain the extra required data. The proposed armour is configured to provide an effective shore protection as anenvironmental-friendly coastal structure. Thus it is designed with a main trunk including deep grooves to imitate thetypical geometry of a coral type configuration, so as to attain desirable performance. The observed results and ananalytic hierarchy process (AHP) concept are used to compare the hydraulic performance of the studied traditionaland newly proposed (artificial coral) armour units. The results indicate that the artificial coral armour unit demonstratesacceptable performance. The widely used traditional armour units might be replaced by newer designs for betterwave energy dissipation, and more importantly, for fewer adverse effects on the marine environment.

关键词： rubble mound breakwater hydraulic interaction armour unit analytic hierarchy process numerical model

Securing Cloud-Encrypted Data:Detecting Ransomware-as-a-Service(RaaS)Attacks through Deep Learning Ensemble

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Computers, Materials & Continua 2024年第4期79卷 857-873页

作者： Amardeep Singh Hamad ali Abosaq Saad Arif Zohaib Mushtaq Muhammad Irfan Ghulam Abbas Arshad ali Alanoud Al Mazroa School of Computer Information Sciences University of CumberlandsWilliamsburgKentucky40769USA Computer Science Department College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl-Ahsa31982Saudi Arabia Department of Electrical Electronics and Computer SystemsCollege of Engineering and TechnologyUniversity of SargodhaSargodha40100Pakistan Electrical Engineering Department College of EngineeringNajran UniversityNajran61441Saudi Arabia Department of Electrical Engineering The University of LahoreLahore54000Pakistan Faculty of Computer and Information Systems Islamic University of MadinahMadinah42351Saudi Arabia Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

Data security assurance is crucial due to the increasing prevalence of cloud computing and its widespread use across different industries,especially in light of the growing number of cybersecurity threats.A major and everpresent threat is Ransomware-as-a-Service(RaaS)assaults,which enable even individuals with minimal technical knowledge to conduct ransomware *** study provides a new approach for RaaS attack detection which uses an ensemble of deep learning *** this purpose,the network intrusion detection dataset“UNSWNB15”from the Intelligent Security Group of the University of New South Wales,Australia is *** the initial phase,the rectified linear unit-,scaled exponential linear unit-,and exponential linear unit-based three separate Multi-Layer Perceptron(MLP)models are ***,using the combined predictive power of these three MLPs,the RansoDetect Fusion ensemble model is introduced in the suggested *** proposed ensemble technique outperforms previous studieswith impressive performance metrics results,including 98.79%accuracy and recall,98.85%precision,and 98.80%*** empirical results of this study validate the ensemble model’s ability to improve cybersecurity defenses by showing that it outperforms individual *** expanding the field of cybersecurity strategy,this research highlights the significance of combined deep learning models in strengthening intrusion detection systems against sophisticated cyber threats.

关键词： Cloud encryption RaaS ensemble threat detection deep learning cybersecurity

Evolution of light deflection and shadow from a gauge-potential-like AdS black hole under the influence of a non-magnetic plasma medium

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Communications in Theoretical Physics 2024年第9期76卷 83-94页

作者： Riasat ali Xia Tiecheng Muhammad Awais Rimsha Babar Department of Mathematics Shanghai University and Newtouch Center for Mathematics of Shanghai UniversityShanghai-200444China Department of Mathematics University of Engineering and Technology Lahore-54890Pakistan Department of Mathematics GC University Faisalabad Layyah CampusLayyah-31200Pakistan

We investigate the light deflection in the weak field approximation from the accelerating charged AdS black *** this purpose,we apply the Gauss–Bonnet theorem to calculate the light deflection in the weak field area and use the Gibbons–Werner approach to analyze the optical geometry of the accelerating charged AdS black hole in the non-magnetic plasma absence/presence of a non-magnetic *** also represent the graphical behavior of the light deflection angle *** impact *** also compute the light deflection angle using Keeton and Petters approximations under the impact of accelerating charged AdS black hole ***,by using the ray-tracing approach,we determine the shadow in the nonmagnetic plasma presence and also demonstrate that graphical shadow has an impact on the gauge potential,non-magnetic plasma frequencies and charge.

关键词： accelerating charged Ad S black hole Gibbons-Werner approach deflection angle ray-tracing approach shadow

Impacts of multiple demand-side management strategies on microgrids planning:a literature survey

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Clean Energy 2024年第1期8卷 36-54页

作者： Rasha Elazab Ahmed T.Abdelnaby A.A.ali Electrical Power and Machines Department Faculty of Engineering at Helwan UniversityCairoEgypt

Demand-side management(DSM)schemes play a crucial role in managing renewable energy generation and load fluctuations by uti-lizing demand-response programmes(DRPs).This paper aims to provide a detailed overview of DRPs that help microgrid operators to keep costs and reliability within acceptable ***,this review paper provides a detailed economic load model for DRPs based on initial load,demand-response(DR)incentive,DR penalty and elasticity *** article also aims to guide researchers in identifying research gaps in DSM applications in microgrids by comparing various DSM schemes from different countries and regions in terms of DSM strategies,objective functions and optimization ***,this study analyses the impact of DRPs on microgrid configuration from the perspective of utilities and customers,considering technical and economic performance *** a result,it can be concluded that none of the studied cases provides models or guidelines for choosing appropriate DSM schemes that consider different consumer interests or load-type ***,a few researchers have addressed the features of a modern price-based DR strategy,renewable generation-based dynamic pricing DR,which offers higher customer satisfaction than traditional DRPs.

关键词： demand-side management optimal sizing demand-response strategies renewable generation-based dynamic pricing

Development of anti-corrosive coating on AZ31 Mg alloy modified by MOF/LDH/PEO hybrids

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Journal of Magnesium and Alloys 2024年第2期12卷 586-607页

作者： Muhammad ali Khan Ananda Repycha Safira Mohammad Aadil Mosab Kaseem Corrosion and Electrochemistry Laboratory Department of Nanotechnology and Advanced Materials EngineeringSejong UniversitySeoul 05006Republic of Korea

The self-assembly of hybrid inorganic-organic materials on stationary platforms plays a critical role in improving their structural stability and wide *** this work,a novel two-step hydrothermal approach is proposed for synthesizing stable and advanced hybrid coatings on metal-oxide platforms through the surface modification of layered double hydroxide(LDH)films using novel metal-organic frameworks(MOFs).Initially,Mg-Al LDH nanocontainers,grown on a magnesium oxide layer produced through plasma electrolytic oxidation(PEO)of AZ31 Mg alloy substrate,were intercalated with cobalt via an oxidation route,providing the metallic coordination center for the MOF *** the subsequent step,a pioneering technique is introduced,utilizing tryptophan as the organic linker for the first time at a pH of *** self-assembly of cobalt-tryptophan complex,driven by the strong bonding between electrophilic sites of monomers and nucleophilic sites,facilitated the formation of a MOF network having a cloud-like structure on the surface of MgAl LDH's *** resulting MOF-LDH encapsulation containers demonstrate exceptional electrochemical stability when exposed to a 3.5 wt.%NaCl solution,surpassing the performance of PEO and pure LDH *** enhanced stability is attributed to the development of a dense top layer and a stable composition within the self-assembled MOF,effectively sealing flaws and preventing the infiltration of corrosive ions into the underlying metallic *** formation mechanism of MOFs on LDH galleries is investigated using density functional theory calculations.

关键词： Mg alloy Layered double hydroxide Metal-organic frameworks Corrosion DFT

Fully polarized Compton scattering in plane waves and its polarization transfer

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Matter and Radiation at Extremes 2024年第3期9卷 45-56页

作者： Suo Tang Yu Xin Meng Wen Mamat ali Bake Baisong Xie College of Physics and Optoelectronic Engineering Ocean University of ChinaQingdaoShandong 266100China Department of Physics Hubei UniversityWuhan 430062China Xinjiang Key Laboratory of Solid State Physics and Devices School of Physics Science and TechnologyXinjiang UniversityUrumqi 830017China Key Laboratory of Beam Technology of the Ministry of Education and College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China

Fully polarized Compton scattering from a beam of spin-polarized electrons is investigated in plane-wave backgrounds in a broad intensity region from the perturbative to the nonperturbative *** the perturbative regime,polarized linear Compton scattering is considered for investigating polarization transfer from a single laser photon to a scattered photon,and in the high-intensity region,the polarized locally monochromatic approximation and locally constant field approximation are established and are employed to study polarization transfer from an incoming electron to a scattered *** numerical results suggest an appreciable improvement of about 10%in the scattering probability in the intermediate-intensity region if the electron’s longitudinal spin is parallel to the laser *** longitudinal spin of the incoming electron can be transferred to the scattered photon with an efficiency that increases with laser intensity and collisional *** collision between an optical laser with frequency1 eV and a 10 GeV electron,this polarization transfer efficiency can increase from about 20%in the perturbative regime to about 50%in the nonperturbative regime for scattered photons with relatively high energy.

关键词： polarized scattered transfer

CRISPR,CAR-T,and NK:Current applications and future perspectives

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Genes & Diseases 2024年第4期11卷 246-257页

作者： Mohadeseh Khoshandam Hossein Soltaninejad Amir ali Hamidieh Saman Hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom branch***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14965/161Iran Department of stem cells technology and Tissue Regeneration Faculty of Interdisciplinary Science and TechnologiesTarbiat Modares UniversityTehran 15614Iran Pediatric Cell Therapy and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran University of Medical SciencesTehran ***Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 15614Iran

Chimeric antigen receptor T(CAR-T)cell therapy represents a breakthrough in personalized cancer *** this regard,synthetic receptors comprised of antigen recognition domains,signaling,and stimulatory domains are used to reprogram T-cells to target tum or cells and destroy *** the success of this approach in refractory B-cell malignancies,the optimal potency of CAR T-cell therapy for many other cancers,particularly solid tumors,has not been *** killer cells are powerful cytotoxic lymphocytes specialized in recognizing and dispensing the tumor cells in coordination with other anti-tumor immunity *** on these studies,many investigations are focused on the accurate designing of CAR T-cells with clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system or other novel gene editing tools that can induce hereditary changes with or without the presence of a double-stranded break into the *** methodologies can be specifically focused on negative controllers of T-cells,induce modifications to a particular gene,and produce reproducible,safe,and powerful allogeneic CAR T-cells for on-demand cancer *** improvement of the CRISPR/Cas9 innovation offers an adaptable and proficient gene-editing capability in activating different pathways to help natural killer cells interact with novel CARs to particularly target tumor *** achievements and future challenges of combining next-generation CRISPR-Cas9 gene editing tools to optimize CAR T-cell and natural killer cell treatment for future clinical trials toward the foundation of modern cancer treatments have been assessed inthis review.

关键词： Cancer CAR T-cell CRISPR Gene editing Immunotherapy NK cell