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New approaches to increase intestinal length: Methods used for intestinal regeneration and bioengineering

World Journal of Transplantation 2016年第1期6卷 1-9页

作者： ali shirafkan Mauro Montalbano Joshua Mc Guire Cristiana Rastellini Luca Cicalese Texas Transplant Center Department of Surgery University of Texas Medical Branch

Inadequate absorptive surface area poses a great challenge to the patients suffering a variety of in-testinal diseases causing short bowel syndrome. To date, these patients are managed with total parenteral nutrition or intestinal transplantation. However, these carry significant morbidity and mortality. Currently, by emergence of tissue engineering, anticipations to utilize an alternative method to increase the intestinal absorptive surface area are increasing. In this paper, we will review the improvements made over time in attempting elongating the intestine with surgical techniques as well as using intestinal bioengineering. Performing sequential intestinal lengthening was the preliminary method applied in humans. However, these methods did not reach widespread use and has limited outcome. Subsequent experimental methods were developed utilizing scaffolds to regenerate intestinal tissue and organoids unit from the intestinal epithelium. Stem cells also have been studied and applied in all types of tissue engineering. Biomaterials were utilized as a structural support for naive cells to produce bio-engineered tissue that can achieve a near-normal anatomical structure. A promising novel approach is the elongation of the intestine with an acellular biologic scaffold to generate a neoformed intestinal tissue that showed, for the first time, evidence of absorption in vivo. In the large intestine, studies are more focused on regeneration and engineering of sphincters and will be briefly reviewed. From the review of the existing literature, it can be concluded that significant progress has been achieved in these experimental methods but that these now need to be fully translated into a pre-clinical and clinical experimentation to become a future viable therapeutic option.

关键词： Bioengineered intestine Tissue engineered Scaffolds Organoids Stem cells Intestinal elongation techniques

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Single-Step Combined Laparoscopic Management of Hepatocellular Carcinoma with Simultaneous Radio Frequency Ablation and Trans-Arterial Embolization in Unresactable Lesions

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Journal of Cancer Therapy 2016年第13期7卷 979-985页

作者： Lukman Cheraghvandi Michael Silva Charlie Cheng Mauro Montalbano ali shirafkan Cristiana Rastellini Luca Cicalese Department of Surgery University of Texas Medical Branch Galveston TX USA

Hepatocellular carcinoma (HCC) is a cancer with increasing incidence in the USA and high mortality rate. HCC is often difficult to treat due to underlying comorbidities such as cirrhosis. However, the application of loco-regional thermal ablation using radio frequency (RF) and trans-arterial embolization with chemotherapy (TACE) or without (TAE) has shown promising results in the treatment of patients not amenable to surgical resection or liver transplantation. Conventionally, RF and TAE are performed in two separated sessions or two steps and often RF ablation is performed percutaneously. However, no consensus has been reached regarding the ideal interval between the two treatments. In this article, we discuss the feasibility and benefits of a single-step TAE in combination with laparoscopic RF ablation in one operative session. We also present a case where this procedure has been successfully performed demonstrating its feasibility. We suggest that the use of laparoscopic RF ablation in the same surgical session as TAE is feasible and potentially offers several advantages over the two-step process that is usually performed with embolization followed by percutaneous RF with a long time interval. In this article we discuss such advantages.

关键词： Single Step Single Session Hepatocellular Carcinoma Laparoscopic Radiofrequency Ablation Trans-Arterial Embolization

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The efficacy of a Persian herbal formulation on functional bloating: A double-blind randomized controlled trial

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Journal of Integrative Medicine 2019年第5期17卷 344-350页

作者： Zienab Mahmoudpour Javad Shokri Mohammad Kamalinejad Neda Meftah Soraya Khafri Seyyed ali Mozaffarpur Hoda shirafkan Student Research Committee Babol University o f Medical SciencesBabol 47745-47176Iran Department of Persian Medicine School of Persian MedicineBabol University of Medical SciencesBabol 47745-47176Iran Department of Internal Medicine Babol University of Medical SciencesBabol 47745-47176Iran School of Pharmacy Shahid Beheshti University of Medical SciencesTehran 19968-35113Iran Biostatistics and Epidemiology Department Medicine FacultyBabol University of Medical SciencesBabol 47745-47176Iran Traditional Medicine and History of Medical Sciences Research Center Health Research InstituteBabol University of Medical SciencesBabol 47745-47176Iran Department of Biostatistics Faculty of HealthMazandaran University of Medical SciencesSari 48471-16548Iran

Background: Bloating is a common gastrointestinal complaint which is difficult to ***: This study investigated the efficacy and compliance of a formulation called KAASER comprised of Trachyspermum ammi(L.) Sprague seed, Zingiber officinale Roscoe. rhizome and Piper nigrum L. berry in the treatment of functional ***, setting, participants and intervention: A total of 106 patients with functional bloating, between20 and 50 years of age, participated in this double-blind randomized controlled trial. Patients were divided into 3 parallel groups that received 500 mg of placebo, dimethicone or KAASER, three times a day for 2 *** outcome measures: The frequency and severity of bloating were primary outcomes, while the frequencies of eructation, defecation, borborygmus and early satiation were secondary outcomes. All parameters were evaluated at the beginning(week 0), and also weeks 2, 4 and 10 of the study, through self-report checklists with a scoring ***: Among the 84 patients who completed the study, the frequency and severity of bloating(P < 0.001), the frequencies of eructation, defecation and borborygmus(P = 0.03) were significantly improved in the group receiving KAASER(36 patients) compared with the dimethicone(35 patients)and placebo(35 patients) groups, during the 3 phases of follow-up. These significant differences persisted through the 2 and 8 weeks of follow-ups after cessation of medication(week 4 and 10). In early satiation,no significant differences were observed among the 3 ***: The results showed that KAASER can be effectively used to treat patients suffering from bloating. Bloating, eructation, defecation and borborygmus in the KAASER group remained significantly improved after 2 and 8 weeks of cessation of medication, making this mechanism an interesting area for further *** registration: Registration trial IRCT2015100324327 N on Iranian Registry of Clinical Trials.

关键词： Gastrointestinal diseases Flatulence Plants Traditional medicine Persian medicine

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伊朗传统医学中的消化系统用药

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亚太传统医药 2018年第4期14卷 1-2页

作者： Zeinab Mahmoudpour Hoda shirafkan Morteza Mojahedi Narjes Gorji Seyyed ali Mozaffarpur 巴博尔医科大学伊朗医学系德黑兰医科大学巴博尔大学医学历史系巴博尔医科大学传统医学史系巴博尔大学健康研究中心

功能性胃肠疾病约占胃肠科就诊疾病的40%左右,但治疗方法却很有限。伊朗传统医学是传统医学和替代医学的一个重要分支,其注重采用改善生活方式和利用自然产物的方法调养身心。伊朗医学将消化系统用药称为Jawarishers。Jawarishers通常... 详细信息

功能性胃肠疾病约占胃肠科就诊疾病的40%左右,但治疗方法却很有限。伊朗传统医学是传统医学和替代医学的一个重要分支,其注重采用改善生活方式和利用自然产物的方法调养身心。伊朗医学将消化系统用药称为Jawarishers。Jawarishers通常由多种草药组成,用以促进消化和改善胃肠功能,一些Jawarishers还兼具改善脑、心脏、肝脏功能的作用。通过整理中世纪相关文献,发现很多草药具有改善胃肠功能的作用,其中生姜和黑胡椒是Jawarishers中最常用的两种草药。Jawarishers种类繁多,药理作用多样,现今仍可应用于临床。

关键词：伊朗传统医学消化系统用药胃肠疾病

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