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Gallbladder polyps: Factors affecting surgical decision

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World Journal of Gastroenterology 2013年第28期19卷 4526-4530页

作者： pinar Sarkut Sadik Kilicturgay ali Ozer Ersin Ozturk Tuncay Yilmazlar Department of General Surgery Uludag University School of Medicine Gorukle 16059 Bursa Turke

AIM: To determine the factors affecting the decision to perform surgery, and the efficiency of ultrasonography (USG) in detecting gallbladder polyps (GP). METHODS: Data for 138 patients who underwent cholecystectomy between 1996 and 2012 in our clinic with a diagnosis of GP were retrospectively analyzed. Demographic data, clinical presentation, principal symptoms, ultrasonographic and histopathological findings were evaluated. Patients were evaluated in individual groups according to the age of the patients (older or younger than 50 years old) and polyp size (bigger or smaller than 10 mm) and characteristics of the polyps (pseudopolyp or real polyps). χ 2 tests were used for the statistical evaluation of the data. RESULTS: The median age was 50 (26-85) years and 91 of patients were female. Of 138 patients who underwent cholecystectomy with GP diagnosis, only 99 had a histopathologically defined polyp; 77 of them had pseudopolyps and 22 had true polyps. Twenty-one patients had adenocarcinoma. Of these 21 patients, 11 were male, their median age was 61 (40-85) years and all malignant polyps had diameters > 10 mm (P 10 mm, 22 had true polyps. The sensitivity of USG was 84.6% for polyps with diameters > 10 mm (P alignancy was high in the patients over 50 years old who had single polyps with diameters > 10 mm.

关键词： Gallbladder Polyps Ultrasound Cholecystectomy Malignancy

What is the relationship between frailty and orthostatic hypotension in older adults?

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Journal of Geriatric Cardiology 2019年第3期16卷 272-279页

作者： Suleyman Emre Kocyigit pinar Soysal Esra Ates Bulut ali Ekrem Aydin Ozge Dokuzlar Ahmet Turan Isik Unit for Aging Brain and Dementia Department of Geriatric MedicineFaculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Geriatric Medicine Bezmialem Vakif UniversityFaculty of MedicineIstanbulTurkey

Background Frailty and orthostatic hypotension (OH),which is common in older adults,is associated with morbidity and *** relationship between them remains *** aim of the study is to determine whether there is a relationship between frailty and *** A total of 496 patients who were admitted to the geriatric clinic and underwent comprehensive geriatric assessment were retrospectively *** a cross-sectional and observational study,OH was measured by the Head-up Tilt Table test at 1,3,and 5 min (respectively,OH1,OH3,and OH5) and the frailty was measured by the Fried’s frailty *** The mean age of all patients was 75.4 ± *** prevalence of females was 69.8%.When the frail people were compared with the pre-frail and the robust ones,the frailty was associated with *** was no relationship between the groups in terms of OH1 when the pre-frail group was compared with the robust ***3 were higher in the frail group than in the pre-frail group (P 0.05).Slowness and weakness were associated with OH1 (P < 0.05),whereas the other components of the Fried’s test were *** Frailty may be a risk factor for *** 1^st min measurements of OH should be routinely evaluated in frail older adults to prevent OH-related poor outcomes.

关键词： Frail Orthostatic hypotension Pre-frail Robust

Emotions of Gynecologic Cancer Patients Dealing with Permanent Colostomy:A Qualitative Interview Study

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Journal of Cancer Therapy 2013年第6期4卷 1060-1067页

作者： Gül pinar ali Ayhan Tevfik pinar Department of Nursing Faculty of Health ScienceYildirim Beyazit UniversityAnkaraTurkey Department of Gyne-Oncology Faculty of MedicineBaskent UniversityAnkaraTurkey Department of Public Health Faculty of MedicineKirikkale UniversityAnkaraTurkey

Purpose: This study was conducted to describe emotional state of colostomized patients with gynecologic cancer. Patients and Methods: The study employed a qualitative design from May to October of 2010, in a private university hospitals outpatient gnecologic oncology clinic in Ankara, Turkey. Content analysis with an inductive approach had been used to analyze 32 interviews that served as the data base for this study. Interview form that focused on what gynecologic cancer women felt to living with a colostomy. Results: Findings also reveal that gynecologic cancer patients with colostomy experience many uneasy feelings that affect their emotional state. The content analysis resulted in the development of two thematic units. The first we described as “To experience the consequences of stoma as a gynecologic cancer patients”. The second was “suffering experienced-being challenged the consequences of the stoma”, and the third was “promote self management-normalization of the new condition”. For the psychological support, family and friends’ support has been mentioned as the most important part that can release their anxiety. Conclusions: We concluded that a having stoma was difficult for the women. The emotional state of the women when they get colostomy was typically characterized by fear, and worry about their current process. Body image, self-esteem, social activity, sexuality were the aspects that most affected the patients. Nurses have very important role within holistic approach and empathetic interaction, for determining major problem areas.

关键词： Emotional State Ostomy Qualitative Study

Economic Impact of Clinical Research to Research Centers and Opportunity Cost for the Reimbursement System in Turkey

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Health 2015年第9期7卷 1124-1133页

作者： Güvenc Kockaya Meral Demir pinar Daylan Kockaya Mehtap Tatar ali Yagizüresin Istanbul University IstanbulTurkey Ministry of Health AnkaraTurkey Hacettepe University AnkaraTurkey

Introduction: Clinical research is a key component of drug development with a significant economic value. It has been reported that the development of a new molecule requires 10 - 15 years and costs almost $1.3 billion. Around 75% of the cost is spent on the Phase I-IV clinical research process. This study aimed to show the economic value of clinical research in Turkey. Methods: Clinical trial budgets were estimated from the raw data of the Report of Istanbul Medical Faculty Clinical Research (ITFKAR). In the research, the estimated cost of drugs used in the clinical trials for the Turkish reimbursement agency (SGK) was calculated to show the cost of medicines acquired through clinical research. Results: The total budget for sponsored pharmaceutical research was $107 million in Turkey, and the government saved close to $311,096,130 during 2006-2010, due to not reimbursing the patients for the drugs in the clinical trials. Conclusion: Despite the limitations of the study, the findings are unique for Turkey. The results can lead to revisiting the importance and economic value of clinical trials in Turkey.

关键词： Clinical Research Economic Impact Reimbursement Research Centers Opportunity Cost

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双眼眼部缺损合并非综合征性唇腭裂(英文)

国际眼科杂志 2009年第7期9卷 1243-1244页

作者： pinar Saatci A ylin Yaman Mahmut Kaya Handan Cakmakci Salih Kavukeu ali osman Saatci 大官邸卫生部口腔医院土耳其伊兹密尔 Dokuz Eylul大学眼科教研室 Dokuz Eylul大学放射科教研室 Dokuz Eylul大学儿科教研室

患儿,男,2mo,非综合征性唇腭裂。检查发现患者下方虹膜缺损,玻璃体盖膜,视乳头和脉络膜缺损。核磁共振(MRI)检查显示双侧缺损性小眼球,眼球后囊肿,视神经细。每位唇腭裂患儿需经眼科医师检查以排除可能合并的眼部畸形。

关键词：唇腭裂缺损性小眼球球后囊肿

Post-discharge mortality in the first wave of COVID-19 in Turkey

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Asian Pacific Journal of Tropical Medicine 2022年第11期15卷 479-484页

作者： Fusun Fakili Pelin Duru Cetinkaya Oya Baydar Serap Argun Baris Nurdan Kokturk Seval Kul Oguz Karcioglu pinar Aysert Yildiz Ilim Irmak Yonca Sekibag Emel Azak Sait Mulamahmutoglu Caglar Cuhadaroglu Bugra Kerget Burcu Baran Ketencioglu Hasan Selcuk Ozger Gulcihan Ozkan Zeynep Ture Merve Ercelik Tansu Ulukavak Ciftci Ozlem alici Esra Nurlu Temel Ozlem Ataoglu Neslihan Kose Muge Meltem Tor Gulsah Gunluoglu Sedat Altin Onder Ozturk pinar Yildiz Gulhan Ilknur Basyigit Hasim Boyaci I Kivilcim Oguzulgen Sermin Borekci Bilun Gemicioglu Ismail Hanta Hacer Kuzu Okur Gulseren Sagcan Metin Akgun ali Fuat Kalyoncu Oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalFaculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Halil Sivgin Cubuk State HospitalAnkaraTurkey Department of Infectious Disease Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Pulmonary Medicine Cerrahpasa Faculty of MedicineIstanbul University−CerrahpasaIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineAtaturk UniversityErzurumTurkey Department of Pulmonary Medicine Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Maslak Acibadem HospitalIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Infectious Disease Faculty of MedicineTurkiye Gazetesi Private HospitalIstanbulTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZonguldakTurkey Department of Pulmonary Medicine Universi

Objective:To determine post-discharge mortality and associated factors of the first-wave multicenter Turkish Thoracic Society(TTD)-TURCOVID ***:In this retrospective cohort study,we analyzed the data of 18 of 26 centers included in the first TTD-TURCOVID study,and 1112 cases diagnosed with COVID-19 between 11 March and 31 July 2020 participated in the *** causes of death after COVID-19 discharge were ***:The mean age of the patients was(51.07±16.93)years,with 57.6%male *** the cohort group,89.1%of COVID-19 treatment locations were hospital wards,3.6%were intensive care units(ICUs),and 7.2%were community *** the longterm follow-up,the in-hospital mortality rate was 3.6%(95%CI 2.6-4.8),the post-discharge mortality rate was 2.8%(95%CI 1.9-3.9),and the total mortality was 6.3%(95%CI 5.0-7.8).After discharge,63.3%of mortality overall occurred during the first six *** rates in post-discharge follow-ups were 12.7%(95%CI 8.0-30.6)in cancer patients,10.8%(95%CI 6.3-22.9)in chronic obstructive pulmonary disease patients,11.1%(95%CI 4.4-22.7)in heart failure patients,7.8(95%CI 3.8-14.3)in atherosclerotic heart disease patients,and 2.3%(95%CI 0.8-5.6)in diabetes mellitus *** smokers/ex-smokers,the all-mortality rates were higher than in ***:This multicenter study showed that patients over 65 years of age,males,former/active smoker,ICU stay,lung,heart disease,and malignancy should be followed up for at least the first six months after discharge due to COVID-19.

关键词： COVID-19 Post-discharge Mortality Comorbidity

Torsion of the spermatic cord in adults:a multicenter experience in adults with surgical exploration for acute scrotal pain with suspected testicular torsion

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Asian Journal of Andrology 2022年第6期24卷 575-578页

作者： Van Thi Dang Benjamin Pradere Anne Mauger de Varennes Nadia ali Benali Maxime Vallee William Berchiche Bastien Gondran-Tellier Gaelle Margue Clement Michiels Charles Gaillard Tristan Grevez Florian Bardet Maud Hulin Anthony Manuguerra Ugo pinar Caroline Plassais Margeux Felber William Wandoren Kévin Kaulanjan Ines Dominique Marc Sbizerra Emilien Seizilles de Mazancourt Xavier Matillon Igor Duquesne Maxime Chabenes Victor Gallard Lucas Freton Francois Lannes Zine-Eddine Khene Department of Urology Toulouse University HospitalToulouse 31000France Department of Urology Medical University of ViennaVienna 1090Austria Department of Urology Rennes University HospitalRennes 35000France Department of Urology Poitiers University HospitalPoitiers 86000France Department of Urology Marseille North HospitalMarseille 13000France Department of Urology Bordeaux University HospitalBordeaux 33000France Department of Urology Tours University HospitalTours 37000France Department of Urology Dijon University HospitalDijon 21o00France Department of Urology Reims University HospitalReims 5i000France Department of Urology Nancy University HospitalNancy 54000France Department of Urology Hopitaux Universitaires Pitie-SalpetriereAP-HPParis 75013France Department of Urology Pointe a Pitre University HospitalGuadeloupe 97000France Department of Urology Lyon University HospitalLyon 69000France Department of Urology Cochin HospitalAP-HPParis 75000France Department of Urology Grenoble University HospitalGrenoble 38000France Department of Urology Strasbourg University HospitalStrasbourg 67000France

Acute scrotal pain(AsP)requiring surgical exploration is common in the pediatric population,but little has been reported on this subject with regard to the adult *** aim of this study was to investigate the demographic and clinical characteristics and outcomes of scrotal explorations performed on adult *** over 21 years of age who underwent surgical exploration for ASP with suspected testicular torsion(TT)at 14 French hospitals between January 2005 and December 2019 were included in this *** main outcome measures were demographic characteristics,pathology found during scrotal exploration,and perioperative *** regression was used to perform univariate and multivariate analyses to identify predictors of *** for 1329 men were *** median age was 30(interquartile range[IQR]:25-35;range:21-89)*** the clinical examination,867(65.2%)patients presented with an elevation of the testicle,613(46.1%)patients with scrotal edema or erythema,and 211(15.9%)patients with nausea or *** findings identified TT in only 684(51.5%)patients,epididymo-orchitis in 112(8.4%)patients,a tumor in 16(1.2%)patients,and no causes in 475(35.7%)*** for nonviable testes was required in 101(7.6%)*** multivariate analysis,an elevation of the testicle,erythema/swelling,and the presence of nausea/vomiting were found to be associated with the occurrence of *** torsion is not exclusive to children and adolescents,so must be considered in males of any age with acute scrotal ***,one-third of scrotal explorations in adults did not lead to a diagnosis.

关键词： adults diagnosis exploration scrotal emergencies spermatic cord torsion ultrasonography

The common pentanucleotide polymorphism of the 3’-untranslated region of the leptin receptor gene is associated with obesity in Saudi females

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Health 2013年第2期5卷 285-291页

作者： Maha H. Daghestani Mazin H. Daghestani pinar T. Ozand Ahmed R. Al-Himaidi Mamoon H. Daghestani Nadia A. Aleisa Hana H. Hakami Abdelmoneim Eldali ali N. Al-odaib Biostatistics Epidemiology & Scientific Computing (MBC-03) King Faisal Specialist Hospital and Research Center Riyadh KSA Department of Genetics King Faisal Specialist Hospital and Research Center Riyadh KSA Department of Obstetrics & Gynecology Umm-Al-Qura University Makkah KSA Department of Surgery King Abdulaziz Medical City National Guard Health Affairs Jeddah KSA Department of Zoology Center for Scientific and Medical Female Colleges King Saud University Riyadh KSA Department of Zoology Science College King Saud University Riyadh KSA Duzen Laboratories Istanbul Turkey

Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. Leptin receptor (LEPR) gene has been intensively evaluated in the search of variants that could be related to obesity. The results of most of these studies have been controversial. We investigated the effects of leptin receptor gene 3’-untranslated region (3’-UTR) polymorphism on phenotype, metabolic parameters and anthropometric measurements of obese Saudi females. 122 healthy women aged 19 to 36 years. The subjects were divided into 3 groups according to their body mass index BMI;lean (BMI 18 - 24), overweight (BMI 25 - 29) and obese (BMI ≥ 30). There were 13 homozygotes and 34 heterozygotes for the 3’-UTR insertion allele amongst all 122 women. The results of this study show that the allele frequency of the insertion allele (I) of 3’UTR was significantly higher in overweight (35.3) and obese females (32.2) compared to the frequency in lean females (15.6). The insertion allele was associated with increased BMI in obese groups. The results obtained from this study indicated that in the obese subjects most variable values increased in I/I homozygote but the significant high value recorded among BMI (40.9 ± 7.11 kg/m2, P = 0.042). Our findings indicated that, the obesity in Saudi females is influenced by alteration in the leptin receptor gene 3’-UTR polymorphism.

关键词： Pentanucleotide Polymorphism Leptin Obesity Saudi Females