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Chinese Journal of Chemistry 2007年第12期25卷 1887-1891页

作者： EL-LOUH, ali Khader khalil ABUNADA, Nada Mohamed EL-SHOUBAKI, Mohamed Chemistry Department Faculty of Science Al-Azhar University-Gaza Gaza 76888 Palestine Chemistry Department Faculty of Applied Sciences Al-Aqsa University Gaza Palestine 4051 Israel

2-Thioxo-1,2-dihydropyridine derivatives 2a, 2b were reacted with methyl iodide to give 2-methylthiopyridines 3a, 3b, which were reacted with hydrazine hydrate to produce 3-aminopyrazolo[5,4-b]pyridines 4a, 4b. Compounds 4a, 4b were diazotized to afford the corresponding diazonium salts 5a, 5b, which were reacted with some active methylene compounds 6a-6h to give the corresponding pyrido[2′,3′ ： 3,4]pyrazole[5,1-c][1,2,4]triazines 7-14.

关键词： pyrazolo[3,4-b]pyridine pyrido[2′,3′ : 3,4]pyrazole[5 1-c] [ 1,2,4]triazine 2-arylmethylidene-2-cyanothioacetamine 2-thioxopyridine

Dietary isoflavones,the modulator of breast carcinogenesis:Current landscape and future perspectives

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 186-193页

作者： Javed Iqbal Banzeer Ahsan Abbasi ali Talha khalil Barkat ali Tariq Mahmood Sobia Kanwal Sayed Afzal Shah Wajid ali Department of Plant Sciences Quaid-i-Azam University Department of Eastern Medicine and Surgery Qarshi University UNESCO UNISA Africa chair in nanoscience and nanotechnology Nanosciences African Network(NANOAFNET) Department of Zoology University of GujratSub Campus

Breast cancer is a frightful disease and serious concern in women around the world causing significant health care burden in both developed and developing countries. Extensive research work has shown that breast cancer provides strong resistance to chemical agents, U V radiation,and hormonal treatments. It is generally accepted that cell genetics is not the only main reason for breast cancer and genetic risk factors, for example, mutations in RRCAI and BRCA2 genes constitute 5%-10% of all breast cancer rates. Other related factors include age, gender,race, ethnicity, weight, reproductive factors, exo-and endogenous hormonal exposures, oral contraceptives use, ultraviolet radiation, diet, and night work(circadian disruption). Many studies have revealed that dietary isoflavones regulate breast cancer occurrence, recurrence and prognosis. Dietary isoflavones have long been part of Asian population diet and there is a significant increase as compared to dietary isoflavones intake among other populations. Dietary isoflavones are natural phytoestrogens having both estrogenic and anti-estrogenic potentials on breast cancer cells in culture, animal models and in experimental trials. This literature survey provides a comprehensive overview on the tumor preventive and tumor promoting potentials of dietary isoflavones on breast cancer. In addition, this paper provides a literature review of dietary isoflavones and their effects on up-regulation and down-regulation of different signaling pathways, genes and proteins. Finally, future perspectives of dietary isoflavones and breast cancer researchers are also critically discussed, which will provide a deeper insight regarding the inner molecular mechanisms of action.

关键词： Dietary isoflavones Breast cancer Signaling pathways Natural phytoestrogens

Acupuncture/Electroacupuncture as an Alternative in Current Opioid Crisis

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Chinese Journal of Integrative Medicine 2020年第9期26卷 643-647页

作者： Usman ali Evhy Apryani Muhammad Zaeem Ahsan Rana Muhammad Shoaib khalil AN Ahmad WANG Yong-xiang King's Lab Shanghai Jiao Tong University School of PharmacyShanghai(200240)China

Opioid drugs are the first line of defense in severe pain but the adverse effects associated with opioids are considered as a serious issue ***/electroacupuncture is a type of Chinese medicine therapy which is an effective analgesic therapy,well documented in animals and human *** stimulation could release endogenous opioid peptides causing analgesia in a variety of pain *** can be used as an alternative therapy to control the opioid crisis.

关键词： analgesia Chinese medicine electroacupuncture acupuncture opioid crisis

Plant-derived anticancer agents: A green anticancer approach

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1129-1150页

作者： Javed Iqbal Banzeer Ahsan Abbasi Tariq Mahmood Sobia Kanwal Barkat ali Sayed Afzal Shah ali Talha khalil Department of Plant Sciences Quaid-i-Azam University Islamabad45320Pakistan Department of Zoology University of GujratSub Campus RawalpindiPakistan Department of Eastern Medicine and Surgery Qarshi UniversityLahorePakistan UNESCO UNISA Africa chair in nanoscience and nanotechnology South Africa Nanosciences African Network(NANOAFNET) South Africa

Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless,plants and plant derived products is a revolutionizing field as these are Simple, safer, ecofriendly, low-cost, fast, and less toxic as compared with conventional treatment *** are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates(those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed.

关键词： Cancer Limitations of anticancer drugs Phytochemicals Analogs

Role of dietary phytochemicals in modulation of miRNA expression:Natural swords combating breast cancer

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Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 501-509页

作者： Banzeer Ahsan Abbasi Javed Iqbal Tariq Mahmood ali Talha khalil Barkat ali Sobia Kanwal Sayed Afzal Shah Riaz Ahmad Department of Plant Sciences Quaid-i-Azam University Nanosciences African Network(NANOAFNET) iThemba LABS-National Research Foundation Somerset West Department of Zoology University of GujratSub Campus Department of Eastern Medicine and Surgery Qarshi University UNESCO UNISA Africa Chair in Nanoscience and Nanotechnology College of Graduate StudiesUniversity of South Africa College of Life Sciences Shaanxi Normal University

The National Cancer Institute had projected breast cancer(BC) as one of the topmost prevalent malignancies around the *** many cases,BC becomes resistant to chemotherapy,radiation and hormonal *** BC therapies are associated with adverse side effects,drug resistance and *** research work has shown that these dietary phytochemicals(DPs) may exert therapeutic effects by regulating the miRNA expression.A large number of DPs have been researched as miRNA regulatory agents against BC and some other DPs have not yet been tested against *** have discussed the effects of curcumin,diallyl disulphide,3,3′ diindolylmethane,ellagic acid,genistein,indole-3-carbinol,quercetin,resveratrol,and sulforaphane on regulation of expression of BC miRNAs in a wide range of in vitro and in vivo *** have also shown some of the possible DPs(Oleanolic acid,capsaicin,benzyl isothiocyanate,epigallocatechin gallate,phenethyl isothiocyanate and ursolic acid) that have shown miRNA regulatory activities and have not yet been tested against BC ***,current limitations,challenges,future perspectives of DPs and BC research are also critically discussed.

关键词： Breast cancer miRNAs Dietary phytochemicals In vitro In vivo

Treatment of irritable bowel syndrome with multi-herbal formula: A case report

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Drug Combination Therapy 2021年第3期3卷 32-35页

作者： Atif ali Khan khalil Department of Biological Sciences National University of Medical SciencesRawalpindi 46000Pakistan

Background: Many patients with irritable bowel syndrome (IBS) try the approach of complementary or herbal medicines, as western medications do not treat IBS. The current case report presents the combine effect of four herbal components as a traditional treatment of IBS. Method: The herbal components were purchased from the local market. The components including Lipidium sativum L., Trigonella foenum-graceum L., Myristica fragrance Hoyutt. and Apium graveolens Linn were ground and mixed well (dry weight), and took orally for two days as advised by the local healer. Results: The symptoms included loose bowel movements accompanied by prolonged flatulence abdominal cramping, faecal urgency as well as mucus discharge were improved and remain suppressed for 5 to 6 months afterthe treatment with multi-herbal formula. Conclusion: The current case report showed that the multi-herbal formula might be a promising treatment for IBS-diarrhoea.

关键词： Irritable bowel syndrome(IBS) Diarrhoea Multi-herbal formula Case report

Antifungal, phytotoxic and hemagglutination activity of methanolic extracts of Ocimum basilicum

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Journal of Traditional Chinese Medicine 2016年第6期36卷 794-798页

作者： Kafeel Ahmad ali talha khalil Yusra Ramla Somayya Centre of Biotechnology and Microbiology University of Peshawar

OBJECTIVE: To report some of the pharmacological features of the medicinal plant Ocimum ***: In the current studies, Antifungal activity of crude methanolic fraction of Ocimum basilicum was determined against eight pathogenic fungal strains using tube dilution assay. The methanolic fraction was also investigated for phytotoxic and hemagglutination ***: Of the eight strains investigated only Candida albicans and Curvilaria lunata were found to be least affected by plant extract while the rest were significantly inhibited. Moderate phytotoxic activity was observed against lemna minor. Hemagglutination activity showed absence of phytolectins and hence no agglutination of ***: The crude extract of Ocimum basilicum has significant properties against fungi and phytotoxic substances.

关键词： Plants,toxic Antifungal agents Pathogenicity Ocimum basilicum

Synergistic antibacterial effect of honey and Herba Ocimi Basilici against some bacterial pathogens

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Journal of Traditional Chinese Medicine 2013年第6期33卷 810-814页

作者： ali Talha khalil Imran Khan Kafeel Ahmad Yusra ali Khan Momin Khan Muhammad Jaseem Khan Department of Biotechnology Quaid-i-Azam University Centre of Biotechnology and Microbiology University of Peshawar Institute of Paramedical Sciences Khyber Medical University

OBJECTIVE： To evaluate the antibacterial activity of the combination of different honey brands and methanolic fraction of Herba Ocimi Basilici using agar well diffusion assay. METHODS： The antibacterial activity was deter- mined against thirteen pathogenic bacterial clini- cal isolates including six gram negative （Klebsiella pneumonia, Pseudomonas aeroginosa, Escherichia coli, Salmonella typhi, Salmonella typhimirium, Xanthomonas campestris） and six gram positive strains （Enterococcus faecalis faecalis, Bacillus subti- lis, Staphylococcus aureus, Clostridium perfringens type C, Clostridium perfringens type D, CIostridium chauvoei）. Agar well diffusion method was used while zones of inhibition were measured with verni- er scale. RESULTS： At higher concentration, all the honey brands showed good to significant activity. Thehighest activity was observed for Hamdard brand honey （27.60±0.40） against Enterococcus faecalis. CONCLUSION： These results revealed that combi- nations of plant extracts of Herba Ocimi Basilici with honey can be used for the development of potent and novel antibacterial agents.

关键词： Anti-infective agents Honey Gram-negative bacteria Gram-positive bacteria Well dif-fusion assay

Antibacterial activity of honey in north-west Pakistan against select human pathogens

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Journal of Traditional Chinese Medicine 2014年第1期34卷 86-89页

作者： ali Talha khalil Imran Khan Yusra ali Khan Zabta Khan Shinwari Kafeel Ahmad Jangrez Khan Department of Biotechnology Quaid-i-Azam University Centre of Biotechnology and Microbiology University of Peshawar Department of Biochemistry Quaid-i-Azam University

OBJECTIVE:To investigate the antimicrobial activity of commercially available honey and raw honey samples in Khyber Pakhtunkhwa,Pakistan,against pathogenic bacterial ***:Well diffusion assays were performed to screen pure and diluted honey samples for antibacterial activity against six Gram-negative and six Gram-positive bacterial *** of inhibition were measured and compared with 10 mg ***:When honey samples were diluted to20%-70%,the honey samples showed no activity to mild antibacterial *** highest antibacterial activity was recorded when 90%and pure undiluted honey samples were tested and compared with a control Gentamycin disc(10 mg).CONCLUSION:Commercially processed honey and raw honey samples from north-west of Pakistan possess good antimicrobial potential.

关键词： Anti-bacterial agents Disk diffusion an-timicrobial tests Honey

基于机器学习和双变量统计的滑坡易发性评估 ——以也门乌玛地区为例

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基于机器学习和双变量统计的滑坡易发性评估 ——以也门乌玛地区...

作者： Yasser Mohammed ali ali khalil（亚西尔）东北师范大学

学位级别：硕士

山体滑坡对人类社会和人类活动构成重大风险,常常造成基础设施损坏和人员伤亡。由自然或人类活动引起的山体滑坡在全世界频繁发生,已对全世界的财产和生命造成重大危害。作为热带沙漠气候区国家,也门也经常受山体滑坡灾害影响。也门地... 详细信息

山体滑坡对人类社会和人类活动构成重大风险,常常造成基础设施损坏和人员伤亡。由自然或人类活动引起的山体滑坡在全世界频繁发生,已对全世界的财产和生命造成重大危害。作为热带沙漠气候区国家,也门也经常受山体滑坡灾害影响。也门地形崎岖陡峭、地质构造不稳定、岩石松软易碎、季风期强降雨集中且持续时间长,这些因素共同导致也门山区严重的滑坡问题和相关灾害现象。因此,也门也是世界上最容易发生山体滑坡的国家之一。也门的许多偏远地区的小规模山体滑坡,但除非造成人员伤亡,否则很少有人对其负责。而且小型滑坡造成的经济损失不亚于较大型自然灾害造成的经济损失。尽管也门相关研究者开展了大量的滑坡灾害研究工作,但仍没有可用于产生可靠的滑坡灾害预测的有效方法。针对也门频发的山体滑坡灾害问题,本研究以受山体滑坡灾害威胁严重的也门Utmah地区为研究区。通过调研方法,对该地区的山体滑坡灾害进行了调查,并分析了也门山体滑坡灾害的影响因素和成因,并采用机器学习方法对研究区山体滑坡灾害的易发性进行了评估。本研究选用随机森林(RF)、极端梯度提升(XGBoost)、人工神经网络(ANN)、朴素贝叶斯(NB)和K最近邻(KNN)五种机器学习算法开展对比研究。本研究主要目标是评估和比较相对频率比模型(RFR)和五种机器学习算法(MLA)在也门Utmah地区绘制滑坡易发性(LSM)的有效性。为了创建研究区的山体滑坡地图,研究人员借助高分辨率遥感影像对研究区开展了实地调查。通过对100处滑坡样点进行识别和测绘之后,制作了一份研究区滑坡灾害清单地图。本研究将采样点随机分为训练数据集(70个滑坡)和验证数据集(30个滑坡)。本研究在调研基础上,选取了11个山体滑坡影响因子,并使用频率比(FR)方法对这些因子进行处理为模型的变量参数。最后,本研究对五个机器学习模型使用统计指标进行测试和评估。在本研究中使用了Friedman和Wilcoxon符号秩检验以及受试者工作特征(AUROC)曲线下的面积对研究结果进行评估和验证。基于训练和验证数据集分析,结果表明RF算法(AUROC,0.992)在创建磁化率图方面优于其他模型。XGBoost模型(AUROC,0.991)、NB模型(AUROC,0.970)、ANN模型(AUROC,0.922)、KNN模型(AUROC,0.877)和FR(AUROC,0.674)效果较差。通过研究对比发现,随机森林(RF)模型是在预测山体滑坡效果较好,对研究结果的评估精度较高。该研究也表明机器学习技术对未来开发精确滑坡灾害易发性图方面具有更广的潜在应用。此外,制作的滑坡灾害易发性地图也将对也门当地民众和政府开展滑坡灾害防治、重大决策制定等工作有提供科学支撑。

关键词：滑坡易发性机器学习双变量统计也门