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Performance comparison of training algorithms for the estimation of B?hme abrasion resistance using neural networks

Journal of Mountain Science 2023年第12期20卷 3732-3742页

作者： ali can ozdemir Esma KAHRAMAN Department of Mining Engineering Çukurova UniversityAdana 01250Türkiye

Natural stones used as floor and wall coverings are exposed to many different abrasive forces,so it is essential to choose suitable materials for wear resistance in terms of the life of the *** abrasion resistance of natural stones can be determined in the laboratory by applying the B?hme abrasion resistance(BAR)***,the direct analysis of BAR in the laboratory has disadvantages such as wasting time and energy,experimental errors,and health *** eliminate these disadvantages,the estimation of BAR using artificial neural networks(ANN)was *** natural stone samples were collected from Türkiye,and uniaxial compressive strength(UCS),flexural strength(FS),water absorption rate(WA),unit volume weight(UW),effective porosity(n),and BAR tests were carried *** outputs of these tests were gathered and a data set,consisting of a total of 105 data,was randomly divided into two groups:testing and *** the current study,the success of three different training algorithms of Levenberg-Marquardt(LM),Bayesian regularization(BR),and scaled conjugate gradient(SCG)were compared for BAR prediction of natural *** criteria such as coefficient of determination(R~2),mean square error(MSE),mean square error(RMSE),and mean absolute percentage error(MAPE),which are widely used and adopted in the literature,were used to determine predictive *** findings of the study indicated that ANN is a valid method for estimating the BAR ***,the LM algorithm(R~2=0.9999,MSE=0.0001,RMSE=0.0110,and MAPE=0.0487)in training and the BR algorithm(R~2=0.9896,MSE=0.0589,RMSE=0.2427,and MAPE=1.2327)in testing showed the best prediction *** has been observed that the proposed method is quite practical to *** the artificial neural networks method will provide an advantage in similar laborintensive experimental studies.

关键词： Böhme abrasion resistance Neural networks Levenberg-Marquardt Bayesian regularization Scaled conjugate gradient

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Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan Sezen Omer ozdemir Yeliz Bahar-ozdemir Necati Kaplan Eyüp can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MSCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(Pcant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation Mesenchymal stem cell

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Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas ErdinçCivelek Omer ozdemir Yeliz Bahar-ozdemir Necati Kaplan Eyüp can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional Independence Measure(WeeFIM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(MACS)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant improvements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFIM results(P>0.05).GMFCS and MACS scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSION In light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

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COVID-19 and cardiac complications:Myocarditis and multisystem inflammatory syndrome in children

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World Journal of Cardiology 2024年第5期16卷 260-268页

作者： Muhammed Gunes Oner ozdemir Department of Pediatric Cardiology Research and Training Hospital of SakaryaAdapazarı54100SakaryaTürkiye Department of Pediatric Allergy and Immunology Research and Training Hospital of SakaryaSakarya University Medical FacultyAdapazarı54100SakaryaTürkiye

Coronavirus is an important pathogen causing disease in humans and *** the end of 2019,an investigation into an increase in pneumonia cases in Wuhan,Hubei Province,China,found that the cause was a new *** disease,which spread rapidly across China and caused an outbreak worldwide,resulted in a *** this virus has previously been referred to as 2019-nCoV,which causes coronavirus disease 2019(COVID-19),later it was named severe acute respiratory syndrome coronavirus *** were usually asymptomatic and rarely severely *** April 2020,reports from the United Kingdom indicated that children may have Kawasaki disease or a clinical condition similar to toxic shock *** clinical picture was later defined as multisystem inflammatory syndrome in *** then,similarly affected children as well as cases with other cardiac complications have been reported in other parts of the *** this review,we aimed to evaluate COVID-19 in terms of cardiac involvement by reviewing the literature.

关键词： COVID-19 Cardiac complication Myocarditis Multisystem inflammatory syndrome in children SARS-CoV-2

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Experimental investigation on effective aerosol scavenging using different spray configurations with pre-injection of water mist for Fukushima Daiichi decommissioning

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Nuclear Science and Techniques 2024年第5期35卷 154-172页

作者： Rui-Cong Xu Avadhesh Kumar Sharma Erdal ozdemir Shuichiro Miwa Shunichi Suzuki Department of Nuclear Engineering and Management The University of Tokyo7‑3‑1 HongoBunkyo‑KuTokyo 113‑8656Japan Nuclear Professional School The University of Tokyo2‑2

During the decommissioning of the Fukushima Daiichi nuclear power plant,it is important to consider the retrieval of resolidified debris both in air and underwater *** the subsequent retrieval of debris from the reactor building,the resolidified debris must be cut into smaller pieces using various cutting *** the cutting process,aerosol particles are expected to be generated at the submicron *** has been noted that such aerosols sizing within the Greenfield gap(0.1-1μm)are difficult to remove effectively using traditional spraying ***,to improve the aerosol removal efficiency of the spray system,a new aerosol agglomeration method was recently proposed,which involves injecting water mist to enlarge the sizes of the aerosol particles before removing them using water *** this study,a series of experiments were performed to clarify the proper spray configurations for effective aerosol scavenging and to improve the performance of the water *** experimental results showed that the spray flow rate and droplet characteristics are important factors for the aerosol-scavenging efficiency and performance of the water *** results obtained from this study will be helpful for the optimization of the spray system design for effective aerosol scavenging during the decommissioning of the Fukushima Daiichi plant.

关键词： Fukushima Daiichi decommissioning Aerosol scavenging Multiphase flow Spray system Aerosol-mist agglomeration

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An integrated spatial planning of the mountainous landscapes for ski sports in a case area at the eastern Türkiye

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Journal of Mountain Science 2024年第3期21卷 754-767页

作者： SATIR Onur TOSUN Busra COSKUN OZYOL Funda ozdemir Omer Faruk BERBEROGLU Suha Dept.of Landscape Architecture Van Yuzuncu Yil UniversityVan 65090Türkiye School of Physical Education&Sports Van Yuzuncu Yil UniversityVan 65090Türkiye Van Yuzuncu Yil University Dept.of Architecture&Urban Planning Van 65090Türkiye Dept.of Remote Sensing&GIS Cukurova UniversityAdana 01330Türkiye

Mountainous regions have disadvantages in economic development because of harsh physical and climatic ***,winter tourism activities are one of the key components for supporting economic development in the *** a ski resort area supports direct and indirect employment in a region,and it stops immigration from mountainous regions to other *** research aimed to assess the potential ski areas using a multi criteria evaluation technique in the Van region which is located in the eastern part of Tü*** this context,snow cover duration,sun effect,slope,slope length,elevation,population density,distance from main roads and lake visibility were used as input factors in the decision making *** factor was standardized using a fuzzy technique based on existing well-known ski centers in Tü*** weight of inputs was defined by applying a survey to the professional *** most important factors were detected as transportation opportunities and snow covers whereas,the least important factors were elevation and population ***,lake visibility was very important to make a difference from other existing facilities in the ***,it was included as constraints and lake visible areas were extracted at the final stage of the *** ski areas were mapped in three levels as professional,intermediate and beginner *** of the suitable areas was selected as a sample projection and for the 3D simulation of the ski investment *** costs and benefits were *** was found that a ski tourism area investment can be amortized in 3 years in the region.

关键词： Winter sports and tourism Decision making 3D simulation and modelling Landscape planning GIS

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Inflammation: Complexity and significance of cellular and molecular responses

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Journal of Acute Disease 2024年第1期13卷 3-7页

作者： Serdar ozdemir University of Health Science Umraniye Training and Research HospitalIstanbulTurkey

Inflammation is a multifaceted cellular and molecular response triggered by injury,infection,or various pathological *** as a protective defense mechanism,the inflammatory response involves clinical signs like redness,swelling,pain,and increased body *** cells,notably neutrophils and macrophages,play key roles in orchestrating this *** delicate balance between proinflammatory and anti-inflammatory mediators,including cytokines and chemokines,regulates the inflammatory *** acute inflammation is crucial for tissue repair,chronic inflammation may indicate an imbalance,contributing to conditions like autoimmune *** these mechanisms is vital for developing therapeutic strategies and managing chronic diseases.

关键词： Inflammation C-reactive protein Platelets SCUBE1 Adrenomedullin Calprotectin Pentraxin-3 Immune response Acute phase response Vascular function

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Small and Medium Enterprises and Global Risks: Evidence from Manufacturing SMEs in Turkey

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International Journal of Disaster Risk Science 2020年第1期11卷 59-73页

作者： ali Asgary ali Ihsan ozdemir Hale Ozyürek Disaster and Emergency Management School of Administrative StudiesYork UniversityTorontoON M3J 1P3Canada Business Administration Department Business SchoolAnkara Yildirim Beyazit UniversityEsenboga CampusAnkaraTurkey KOSGEB(Small and Medium Industry Development Organization) AnkaraTurkey

This study investigated how small and medium enterprises(SMEs) in a country perceive major global risks. The aim was to explore how country attributes and circumstances affect SME assessments of the likelihood,impacts, and rankings of global risks, and to find out if SME risk assessment and rankings differ from the global rankings. Data were gathered using an online survey of manufacturing SMEs in Turkey. The results show that global economic risks and geopolitical risks are of major concern for SMEs, and environmental risks are at the bottom of their ranking. Among the economic risks, fiscal crises in key economies and high structural unemployment or underemployment were found to be the highest risks for the SMEs. Failure of regional or global governance, failure of national governance, and interstate conflict with regional consequences were found to be among the top geopolitical risks for the SMEs. The SMEs considered the risk of largescale cyber-attacks and massive incident of data fraud/theft to be relatively higher than other global technological *** social instability and failure of urban planning were among the top societal risks for the SMEs. Although the global environmental and disaster risks were ranked lowest on the list, man-made environmental damage and disasters and major natural hazard-induced disasters were ranked the highest among this group of risks. Overall, the results show that SMEs at a country level, for example Turkey, perceive global risks differently than the major global players.

关键词： Global risks Risk assessment Risk matrix Small and medium enterprises Turkey

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Inflationary effects of oil prices and domestic gasoline prices:Markov-switching-VAR analysis

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Petroleum Science 2015年第2期12卷 355-365页

作者： Selin ozdemir Isil Akgul Department of Econometrics Faculty of EconomicsMarmara University

The purpose of this study is to contribute to the literature by studying the effects of sudden changes both on crude oil import price and domestic gasoline price on inflation for Turkey, an emerging country. Since an inflation targeting regime is being carried out by the Central Bank of Turkey, determination of such effects is becoming more important. Therefore empirical evidence in this paper will serve as guidance for those countries, which have an in- flation targeting regime. Analyses have been done in the period of October 2005-December 2012 by Markovswitching vector autoregressive （MS-VAR） models which are successful in capturing the nonlinear properties of variables. Using MS-VAR analysis, it is found that there are 2 regimes in the analysis period. Furthermore, regime changes can be dated and the turning points of economic cycles can be determined. In addition, it is found that the effect of the changes in crude oil and domestic gasoline prices on consumer prices and core inflation is not the same under different regimes. Moreover, the sudden increase in gasoline price is more important for consumer price infla- tion than crude oil price shocks. Another finding is the presence of a pass-through effect from oil price and ga- soline price to core inflation.

关键词： Crude oil price Domestic gasoline price Consumer price index - Core inflation MS-VAR model

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Mobility of large clusters on a semiconductor surface:Kinetic Monte Carlo simulation results

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Chinese Physics B 2016年第1期25卷 580-584页

作者： M Esen A T Ttizemen M ozdemir Vocational School of Adana Cukurova UniversityAdana O1160Turkey Department of Science and Mathematics Education Faculty of EducationCumhuriyet UniversitySivas 58140Turkey Department of Physics Cukurova UniversityAdana 01330Turkey

The mobility of clusters on a semiconductor surface for various values of cluster size is studied as a function of temperature by kinetic Monte Carlo method. The cluster resides on the surface of a square grid. Kinetic processes such as the diffusion of single particles on the surface, their attachment and detachment to/from clusters, diffusion of particles along cluster edges are considered. The clusters considered in this study consist of 150-6000 atoms per cluster on average. A statistical probability of motion to each direction is assigned to each particle where a particle with four nearest neighbors is assumed to be immobile. The mobility of a cluster is found from the root mean square displacement of the center of mass of the cluster as a function of time. It is found that the diffusion coefficient of clusters goes as D = A（T）Na where N is the average number of particles in the cluster, A（T） is a temperature-dependent constant and a is a parameter with a value of about -0.64 〈 a 〈 -0.75. The value of a is found to be independent of cluster sizes and temperature values （170-220 K） considered in this study. As the diffusion along the perimeter of the cluster becomes prohibitive, the exponent approaches a value of -0.5. The diffusion coefficient is found to change by one order of magnitude as a function of cluster size.

关键词： diffusion constant cluster mobility Monte Carlo method

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