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Protective Effects of Tribulus terrestris,Avena sativa,and White Ginseng Powder on Bone Mineral Density in Hypercholesterolemic Rats

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Journal of Pharmacy and Pharmacology 2019年第6期7卷 286-292页

作者： Mehmet Akdogan Huri Tilla Ilce ali bilgili Basak Hanedan Department of Medical Biochemistry Faculty of MedicineSakarya UniversitySakarya 54050Turkey Department of Nuclear Medicine Faculty of MedicineSakarya UniversitySakarya 54050Turkey Department of Pharmacology and Toxicology Faculty of Veterinary MedicineAnkara UniversityAnkara 06110Turkey Department of Internal Medicine Faculty of Veterinary MedicineAtaturk UniversityErzurum 25240Turkey

This study investigated the effects of the herbal compounds Tribulus terrestris(TT),Avena sativa(AS),white ginseng(WG),and a triple combination(TC)powder on the serum total cholesterol,low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triglyceride,and the tibial bone mineral density(BMD)levels in rats fed a high-cholesterol *** study comprised Group I(normal pellet feed),Group II(pellet feed with 2%cholesterol),Group III(2%cholesterol plus 15%TT),Group IV(2%cholesterol plus 7.5%AS),Group V(2%cholesterol plus 5%WG)and Group VI(2%cholesterol plus 7.5 TT%+3.75%AS,2.5%WG).The serum total cholesterol,LDL-C,HDL-C,triglyceride,and tibial BMD(g/cm2)levels were *** decrease in the serum HDL-C levels in Group II than Group I,and significant increase in the serum LDL-C levels in Group II than Groups I and VI were *** tibial BMD levels were significantly lower in Groups II and IV than Group *** was determined that WG and TC significantly prevented the serum total cholesterol increase;TC significantly prevented the serum LDL-C increase;and TT,WG,and TC were non-significantly effective in the improvement of tibial BMD levels.

关键词： Lipid and lipoproteins Tribulus terrestris Avena sativa white ginseng bone mineral density

Preparation of stable colloidal suspensions of superdisintegrants via wet stirred media milling

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Particuology 2014年第3期12卷 76-82页

作者： Mohammad A.Azad Afolawemi Afolabi Nikita Patel Rajesh Davé Ecevit bilgili Otto H.York Department of Chemical Biologicaland Pharmaceutical EngineeringNew Jersey Institute of TechnologyNewarkNJUSA

Superdisintegrants are cross-linked polymers that can be used as dispersants for fast release of drug nanoparticles from nanocomposite microparticles during in vitro and in vivo dissolution. Currently avail- able superdisintegrant particles have average sizes of approximately 5-130 μm, which are too big for drug nanocomposite applications. Hence, production of stable superdisintegrant suspensions with less than 5 μm particles is desirable. Here, we explore the preparation of colloidal suspensions of anionic and nonionic superdisintegrants using a wet stirred media mill and assess their physical stability. Sodium starch glycolate （SSG） and crospovidone （CP） were selected as representative anionic and nonionic superdisintegrants, and hydroxypropyl cellulose （HPC） and sodium dodecyl sulfate （SDS） were used as a steric stabilizer and a wetting agent/stabilizer, respectively. Particle sizing, scanning electron microscopy, and zeta potential measurements were used to characterize the suspensions. Colloidal superdisintegrant suspensions were prepared reproducibly. The extensive particle breakage was attributed to the swelling-induced softening in water. SSG suspensions were stable even in the absence of stabilizers, whereas CP suspensions required HPC-SDS for minimizing particle aggregation. These findings were explained by the higher absolute （negative） zeta potential of the suspensions of the anionic superdisintegrant （SSG） as compared with those of the nonionic superdisintegrant （CP）.

关键词： Colloidal suspensions Dispersants Physical stability Superdisintegrants Swelling Wet stirred media milling

Modeling surface fuels moisture content in Pinus brutia stands

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Journal of Forestry Research 2019年第2期30卷 577-587页

作者： Ertugrul bilgili Kadir Alperen Coskuner Yetkin Usta Merih Goltas Faculty of Forestry Karadeniz Technical University Faculty of Forestry Istanbul University

Fuel moisture content is an important variable for forest fires because it affects fuel ignition and fire behavior. In order to accurately predict fuel ignition potential, fuel moisture content must be assessed by evaluating fire spread, fireline intensity and fuel *** objective here is to model moisture content of surface fuels in normally stocked Calabrian pine(Pinus brutia Ten.) stands in relation to weather conditions, namely temperature, relative humidity, and wind speed in the Mugla province of Turkey. All surface fuels were categorized according to diameter classes and fuel types. Six fuel categories were defined: these were 0–0.3, 0.3–0.6, and0.6–1 cm diameter classes, and cone, surface litter, and duff. Plastic containers 15 9 20 cm in size with 1 9 1 mm mesh size were used. Samples were taken from 09:00 to19:00 h and weighed every 2 h with 0.01 g precision for10 days in August. At the end of the study, samples were taken to the laboratory, oven-dried at 105 °C for 24 h and weighed to obtain fuel-moisture contents. Weather measurements were taken from a fully automated weather station set up at the study site prior to the study. Correlation and regression analyses were carried out and models were developed to predict fuel moisture contents for desorption and adsorption phase for each fuel type categories. Practical fuel moisture prediction models were developed for dry period. Models were developed that performed well with reasonable accuracy, explaining up to 92 and 95.6%of the variability in fuel-moisture contents for desorption and adsorption phases, respectively. Validation of the models were conducted using an independent data set and known fuel moisture prediction models. The predictive power of the models was satisfactory with mean absolute error values being 1.48 and 1.02 for desorption and adsorption as compared to the 2.05 and 1.60 values for the Van Wagner's hourly litter moisture content prediction model. Results obtained in this stu

关键词： Fire management Forest fires Fuels Fuel moisture

Modeling of Trophospheric Ozone Concentrations Using Genetically Trained Multi-Level Cellular Neural Networks

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Advances in Atmospheric Sciences 2007年第5期24卷 907-914页

作者： H.Kurtulus OZCAN Erdem bilgili Ulku SAHIN O.Nuri UCAN Cuma BAYAT Istanbul University Engineering Faculty Environmental Eng.Dept.34320AvcilarIstanbulTurkey Tuzla Marine Education Center Tuzla IstanbulTurkey Istanbul University Engineering Faculty Electrical-Electronics Eng.Dept.34320AvcilarIstanbulTurkey Beykent University 34500 Buyukcekmece Istanbul

Tropospheric ozone concentrations, which are an important air pollutant, are modeled by the use of an artificial intelligence structure. Data obtained from air pollution measurement stations in the city of Istanbul are utilized in constituting the model. A supervised algorithm for the evaluation of ozone concentration using a genetically trained multi-level cellular neural network （ML-CNN） is introduced, developed, and applied to real data. A genetic algorithm is used in the optimization of CNN templates. The model results and the actual measurement results are compared and statistically evaluated. It is observed that seasonal changes in ozone concentrations are reflected effectively by the concentrations estimated by the multilevel-CNN model structure, with a correlation value of 0.57 ascertained between actual and model results. It is shown that the multilevel-CNN modeling technique is as satisfactory as other modeling techniques in associating the data in a complex medium in air pollution applications.

关键词： genetic algorithm cellular neural networks (CNN) ozone meteorological data

PRODUCTION OF PIGMENT NANOPARTICLES USING A WET STIRRED MILL WITH POLYMERIC MEDIA

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China Particuology 2004年第3期2卷 93-100页

作者： Ecevit bilgili Rhye Hamey Brian Scarlett Particle Engineering Research Center 205 PS&T Building University of Florida Gainesville FL 32611-6135 USAParticle Engineering Research Center 205 PS&T Building University of Florida Gainesville FL 32611-6135 USADepartment of Materials Science and Engineering University of Florida Gainesville FL 32611 USAParticle Engineering Research Center 205 PS&T Building University of Florida Gainesville FL 32611-6135 USA

Pigment nanoparticles with a size range of 10~100 nm were produced from large agglomerates via a stirred media mill operating in the wet-batch mode and using polymeric media. The effects of several operating variables such as the surfactant concentration, polystyrene media loading, and media size on the pigment size distribution of the product were studied. The process dynamics was also investigated. Dynamic light scattering and electron microscopy were used as the characterization techniques. The polymeric grinding media are found to be effective for the production of pigment nanoparticles. The experimental results suggest the existence of an optimum media size and surfactant concentration. A population balance model of the process reveals a transition from first-order breakage kinetics for rela-tively coarse particles to non-first-order kinetics, with a delay period, for the smaller particles. The model implies that large agglomerates split in a first-order fashion whereas the breakage of individual nanoparticles may depend on induced fatigue of the particles.

关键词： nanoparticles stirred media mill pigment polymeric media breakage population balance model

COVID-19 vaccine candidates and vaccine development platforms available worldwide

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Journal of Pharmaceutical Analysis 2021年第6期11卷 675-682页

作者： Nilgun Duman Zahraa ALzaidi Busra Aynekin Duygu Taskin Busra Demirors Abdulbaki Yildirim Izem Olcay Sahin Faik bilgili Eda Tahir Turanli Tommaso Beccari Matteo Bertelli Munis Dundar Department of Medical Genetics Dragos Hospital IstanbulBezmialem Vakif UniversityIstanbul34854Turkey Department of Biotechnology Faculty of Applied ScienceCukurova UniversityAdana01380Turkey Department of Medical Genetics Medical FacultyErciyes UniversityKayseri38030Turkey Department of Economics Faculty of Economics and Administrative SciencesErciyes UniversityKayseri38030Turkey Department of Molecular Biology and Genetics Faculty of ScienceAcibadem University34684IstanbulTurkey Department of Pharmaceutical Sciences University of PerugiaPerugia06123Italy MAGI'S LAB Trentino38068Italy

The pandemic caused by the worldwide spread of the coronavirus,which first appeared in 2019,has been named coronavirus disease 19(COVID-19).More than 4.5 million deaths have been recorded due to the pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),according to the World Health ***-19 Dashboard in September *** from the wildtype,other variations have been successfully transmitted early in the outbreak although they were not discovered until March *** in the SARS-CoV-2 genetic material,such as mutation and recombination,have the ability to modify the viral life span,along with transitivity,cellular tropism,and symptom *** processes are involved in introducing novel vaccines to the population,including vaccine manufacturing,preclinical studies,Food and Drug Administration permission or certification,processing,and ***-19 vaccine candidates have been developed by a number of public and private groups employing a variety of strategies,such as RNA,DNA,protein,and viral vectored *** comprehensive review,which included the most subsequent evidence on unique features of SARS-CoV-2 and the associated morbidity and mortality,was carried out using a systematic search of recent online databases in order to generate useful knowledge about the COVID-19 updated versions and their consequences on the disease symptoms and vaccine development.

关键词： COVID-19 vaccine Vaccine development platform Coronavirus outbreak SARS-CoV-2 variants Treatment

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禽肉加工产品质量控制

中国家禽 2007年第9期29卷 49-50页

作者： S.F.bilgili 陈清

过去的10年里肉鸡业得到了长足的发展，活禽养殖（育种、营养、环境控制和健康程序）、加工工艺（速度和自动化）、产品多样化和全球贸易的发展使得禽类生产比其它肉质资源生产更具有明显的市场优势。消费者越来越迫切地需求方便地购买... 详细信息

过去的10年里肉鸡业得到了长足的发展，活禽养殖（育种、营养、环境控制和健康程序）、加工工艺（速度和自动化）、产品多样化和全球贸易的发展使得禽类生产比其它肉质资源生产更具有明显的市场优势。消费者越来越迫切地需求方便地购买到价廉物美、来源安全的动物性蛋白也促进了这一发展。禽类产品，主要是鸡肉产品，已经在全球很多地区的肉品消费中处于领先地位，

关键词：产品质量控制禽肉加工禽类产品产品多样化动物性蛋白环境控制加工工艺市场优势

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肉鸡体脂肪量与受精力的关系

中国畜牧兽医 1986年第6期 18-19页

作者：苑忠昌 S.F.bilgili

重型品种母鸡体重过大会降低受精力,成年种母鸡体重的差异可能与脂肪存积量有关。但有关体重与体脂.体脂与受精力相关的数据却很少。体重增加则受精力下降这一现象也许

关键词：受精力体脂肪量输卵管子宫附件母鸡体重脂肪含量

A Double-Sided View to Adult Vaccination:The Opinions and Attitudes of Patients and Health Workers

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Health 2018年第12期10卷 1697-1713页

作者： Raziye Sule Gümüstakim Pinar bilgili Murat Cevik Duygu Ayhan Baser Adem Doganer Selda Handan Karahan Saper Zuhal Kanevetci Ergül Ozcelebi Medical Faculty Sutcu Imam UniversityKahramanmarasTurkey Department of Family Medicine Medical SchoolHacettepe UniversityAnkaraTurkey

Objective: Although there are adult vaccination schemes in our country, there are serious deficiencies in the way that doctors direct the patients to this vaccination, but also patients have to make and demand these vaccinations. The aim of our study is to identify the shortcomings in this area and draw a roadmap for what arrangements should be made in terms of physicians and patients in order to increase adult immunization rates in primary care. Method: We conducted a two-phase, multicentered, descriptive clinical trial between October and December 2017. The first phase of the trial was carried out with patients from 3 Family Health Centers in Antalya, Istanbul and Osmaniye. Patients to be interviewed were selected voluntarily among Family Health Center’s applicants. The second phase of the trial was carried out with health workers, who were participated to trial from 26 different provinces of Turkey. In the process, a questionnaire of 19 questions was applied to primary health care workers by the internet. Results: 490 patients were included in the study. There was a significant difference between gender, age, education level and guideline follow-up and vaccination status of patients [p Conclusion: As a result of the studies including our study about adult vaccination, only 10% - 20% of the targeted groups in adults can be vaccinated. However, just like in childhood during adulthood, vaccinations protect individuals from diseases and provide economic benefits. Firstly, the knowledge level of physicians on adult immunization should be updated with in-service trainings, they should first be convinced to vaccinate because they are in risk group and then they should be recommended vaccination to patient to increase the vaccination rates.

关键词： Adult Vaccination Health Workers Patients