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Multidrug resistance Acinetobacter species at the intensive care unit,Aseer Central Hospital,Saudi Arabia:A one year analysis

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 881-885页

作者： ali al bshabshe Martin R.P.Joseph ali al Hussein Waleed Haimour Mohamed E.Hamid Department of Medicine College of MedicineKing Khalid University Department of Microbiology College of MedicineKing Khalid University Intensive Care Unit Aseer Central Hospital Microbiology Laboratories Aseer Central Hospital

Objective:To identify and to determine the antimicrobial susceptibility of Acinetobacter baumannii(***) clinical isolates from ICU at Aseer Central ***:The study was conducted in the Intensive Care Unit,Aseer Central Hospital,Saudi Arabia over 13 months period(2014-2015).Acinetobacter species(n= 105) were isolated from various clinical *** were identified using selected phenotypic criteria and confirmed using the Vitek 2 automated *** system was used to determine the susceptibilities of 21 antimicrobial ***,isolates and drug data were analyzed using the SPSS statistical software package to determine some epidemiological and microbiological ***:Of the 105 stains,*** accounted for 49(46.67%),*** complex,19(18.09%),***/haemolyticus 32(30.47),Acinetobacter haemolyticus 4(3.81%),Acinetobater lwoffii 1(0.95%) and unidentified Acinetobater species 2(1.3%).Of the 105 Acinetobacter strains,103(98.1%) were found multidrug resistant(MDR).*** strain were 100% sensitive to colistin and 74.5% to trimethoprim + *** remaining 19 antimicrobial agents revealed low or no sensitivities:amikacin 16.3%; ampicillin 7.7%; ceftazidime 7.3%.Distribution of similar sensitivities was shown by other Acinetobacter *** number of isolates from males and females indicates no statistical variation(P=0.867) whereas age groups showed significant differences(P= 0.008) as it is clear from the high percentage of infected individuals more than 60 years followed by those aged 20 to 29 years old(19.05%).Upper respiratory tract(30.48%),lower respiratory tract(47.65%) and subcutaneous tissue(9.5%) were the main sources of Acinetobacter *** mean numbers of isolates from these specimens indicate no discrepancy between specimens(P=0.731).Conclusions:Acinetobacterspecies including *** were found MDR(98.1%) according to the current Acinetobacter *** categorization.A

关键词： Acinetobacter spp. ICU Antimicrobials Aseer Central Hospital

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy Chemistry 2025年第1期100卷 125-143页

作者： Md al Raihan C.Adam Dyker Department of Chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Investigation for Uranium Dispersion Adjacent to Cretaceous Phosphatic Outcrops in al-Nassrieh Basin, Southern Palmyrides, Syria

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Journal of Earth Science 2016年第5期27卷 786-795页

作者： Mohamed al-Hilal Ahmad al-ali Department of Geology the Atomic Energy Commission of Syria (AECS)

A detailed radiometric survey including soil gas radon measurements and field gammaray survey, in accordance with geochemical and geological investigations were carried out in alNassrieh Basin（central Syria）, for the purpose of uranium exploration. Thirty-six samples were collected from various lithofacies of the survey area and analyzed by γ-ray spectrometric technique for determining the concentration values of major radioelements. The relationships between the concentrations of equivalent e U, e Th, and their ratios were examined in order to define their trend of variations and evaluate the degree of uranium remobilization and redistribution. although the initial results indicate that uranium enrichment is mostly restricted to the Upper Cretaceous phosphate rocks, a considerable portion of uranium appeared to be leached out of the primary phosphatic source and dispersed in the adjacent recent sediments. Further, notable increases of radon level associated with relatively high values of uranium concentration and gamma count rates were found to be spatially correlated with the transition zone between the marine Paleogene and continental Neogene formations throughout the study basin. This observation demonstrates the importance of the concerned zone as a suitable geological environment for hosting probable uranium mineralization along a chemically reducing interface where surface water of terrestrial and marine origin mingled at depth and away from surficial conditions.

关键词： radiometric survey geochemistry uranium exploration AI-Nassrieh Basin Syria.

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Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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Neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： Sheharyar S.Baig ali N.ali Arshad Majid Sheffield Institute for Translational Neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(VNS)and stroke:Stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive VNS paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,STOP-AUST,and TRAIGE did not show improvements in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

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Decoding molecular mechanisms:brain aging and alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay ali Syed Hammad Qaiser Mohammad Uzair Khalid al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly alzheimer's disease.

关键词： alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using MAX phase Cr2TialC2 saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： Ahmed Shakir al-HITI Hiba HASSAN Department of Electrical Engineering Faculty of Engineering University of Anbar Department of Laser and Optoelectronics Engineering University of Technology-Iraq

We demonstrated a new type of MAX phase material, chromium titanium aluminum carbide（Cr2TialC2） polymer film, to generate a passively Q-switched erbium-doped fiber laser（EDFL）. The film thickness was measured to be around 45 μm, which was fabricated using the embedding method with polyvinyl alcohol（PVA） polymer as hoster. The saturable absorber（SA） film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm, respectively. The Q-switching pulse duration could be varied from 2.46 μs to 770 ns, while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW. The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW, respectively.

关键词： Saturable absorbers

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In flue nee of microwave drying and con venti onal drying methods on the mechanical properties of naproxen sodium drug tablets

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Particuology 2020年第6期18卷 30-40页

作者： Maha al-ali Rajarathinam Parthasarathy Chemical and Environmental Engineering School of EngineeringRM1T UniversityMelbourneVictoria 3001Australia

Tablets are one of the most comm only used solid dosage forms taken by *** preparati on of high-quality tablets requires an understanding of the preparation process and elucidation of how the physical and mechanical properties change as a function of the preparation *** work aims to investigate the impact of microwave irradiation drying and conventional drying methods(including freeze,convective and vacuum drying)on the hardness,tensile strength and friability of tablets made from a multi-component formulation containing naproxen sodium,microcrystalline cellulose,and *** results show that tablets subjected to microwave drying had the secondhighest tensile strength and hardness of 1.296 MPa and 67 N,*** tablets subjected to vacuum drying had the lowest tensile strength and hardness of 1.21 MPa and 64 N,*** friability index values for the tablets derived from the microwave and freeze-drying methods werel%.Microwave drying was observed to be an efficient method to produce naproxen sodium-containing tablets with satisfactory mechanical *** findings confirm that the drying method plays an essential role in the improvement or degradation of the mechanical properties of tablets.

关键词： Microwave drying Naproxen sodium Hardness Friability Tensile strength

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Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura H.al-REKABI A.A.alWAHIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

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Comparative analyses/evaluation of the textural properties of naproxen sodium tablets and powders prepared using microwave and other drying techniques

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Particuology 2020年第3期18卷 197-204页

作者： Maha al-ali Selvakannan Periasamy Rajarathinam Parthasarathy Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3000Australia Applied Chemistry School of ScienceRMIT UniversityMelbourneVictoria 3000Australia

The properties of oral tablets are normally related to the properties of the powders they *** of oral tablets is important for the development of tablets with rapid and safe release of the active *** this study,a new formulation of naproxen sodium was prepared and dried using microwave drying (MWD) and the following conventional drying techniques:freeze-drying (FD),vacuum drying (VD),and convective drying (CD).The reference drug powder (RDP) and dry granules MWG,CDG,VDG,and FDG,which were dried using MWD,CD,VD,and FD,respectively were compressed to form tablets labeled RF-TAB,MW-TAB,CD-TAB,VD-TAB,and FD-TAB,*** dry granules and prepared tablets were characterized using Fourier transform infrared spectrometry,scanning electron microscopy,and X-ray *** study aimed to explore the correlation between the textural characteristics of the tablets and their respective powders for different drying *** the morphologies of the dry particles were irregular,the prepared tablets were smooth and flat with few *** increased the amorphous nature of the granules but decreased their *** crystallinities of all tablets,except those prepared by VD,decreased after *** summary,the characteristics of the prepared tablets were acquired from their respective powders.

关键词： Naproxen sodium Microwave drying Tablet Texture Crystallinity

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