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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Electrocatalytic behaviour of Ni and NiCu alloy modified glassy carbon electrode in electro-oxidation of contraflam

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Journal of Central South University 2017年第8期24卷 1703-1712页

作者： Naeemy ali Mohammadi ali Ehsani ali Aghassi ali Department of Drug and Food Control and Pharmaceutical Qtlality Assurance Research:Centre Faculty of PharmacyTehran University of Medical SciencesP.O.Box 14155-6451TehranIran Nanotechnology Research Centre Faculty of PharmacyTehran University of Medical SciencesP.O.Box 14155-6451TehranIran Department of Chemistry Faculty of ScienceUniversity of QomP.O.Box 37185-359QomIran

The electrocatalytic oxidation of contraflam was investigated in alkaline solution on nickel and nickel–copper alloy modified glassy carbon electrodes(GC/Ni and GC/NiCu). We prepared these electrodes by galvanostatic deposition and the surface morphologies and compositions of electrodes were determined by energy-dispersive X-ray(EDX) and scanning electron microscopy(SEM). Cyclic voltammetry and chronoamperometric methods were employed to characterize the oxidation process and its kinetics. Voltammetric studies exhibit one pair of well-defined redox peaks, which is ascribed to the redox process of the nickel and followed by the greatly enhanced current response of the anodic peak in the presence of contraflam and a decrease in the corresponding cathodic current peak. This indicates that the immobilized redox mediator on the electrode surface was oxidized contraflam via an electrocatalytic mechanism. The catalytic currents increased linearly with the concentration of contraflam in the range of 0.25– 1.5 mmol/L. The anodic peak currents were linearly proportional to the square root of scan rate. This behaviour is the characteristic of a diffusion-controlled process. The determination of contraflam in capsules is applied satisfactorily by modified electrode.

关键词： galvanostatic deposition nickel nickel-copper alloy contraflam modified electrodes cyclic voltammetry oxidation

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Optimal Operation and Size for an Energy Hub with CCHP

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Energy and Power Engineering 2011年第5期3卷 641-649页

作者： ali Mohammad Ranjbar Amir Moshari Hashem Oraee aras Sheikhi 不详

The interest in distributed generation has been increasing in recent years, especially due to technical devel- opment on generation systems that meet environmental and energy policy concerns. One of the most impor- tant distributed energy technologies is Combined Cooling, Heat and Power (CCHP) systems. CCHP is a small and self-contained electric, heating and cooling generation plant that can provide power for households, commercial or industrial facilities. It can reduce power loss and enhance service reliability in distribution systems. The proposed method in this paper determines the optimal size and operation of CCHP, auxiliary boiler and also heat storage unit as elements of an energy hub, for users by an integrated view of electricity and natural gas network. Authors apply cost and benefit analysis in the optimization. To confirm the proposed method, the optimum sizes of these elements are determined for a hotel in Tehran as a case study.

关键词： Combined Cooling Heating And Power (CCHP) Cost And Benefit Analysis Energy Hub Optimal Operation Optimal Size

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NOx emissions of turbofan powered unmanned aerial vehicle for complete flight cycle

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Chinese Journal of Aeronautics 2020年第6期33卷 1683-1691页

作者： ali DINC College of Engineering and Technology American University of the Middle EastKuwait

Unmanned Aerial Vehicles(UAVs) have been getting more and more popular in both civil and military arena. Similar to manned aircraft, their propulsion systems or engines emit harmful gases such as nitrogen oxides. Since UAVs have different mission profiles and operational parameters than manned aircraft, it is worthy to investigate their NOx emissions. Therefore, in this study, NOx emissions of a turbofan powered UAV for complete flight cycle was calculated and optimized within a range of altitude and speed parameters. NOx emissions were calculated based on ICAO ground test data and corrected to any speed and altitude during flight legs using both Boeing Fuel Flow Method 2 and DLR Fuel Flow Method. Total NOx emissions were calculated for complete flight cycles for different altitude and speed parameters. Numerical results were presented graphically and additionally optimization studies were conducted. Optimization studies include determination and comparison of speed and altitude for minimum NOx emissions by the two fuel flow methods and maximum loiter time achievable by UAV.

关键词： Aircraft performance Cycle analysis NOv emissions Optimization Turbofan cnlgine UAV

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Genuine entanglement under squeezed generalized amplitude damping channels with memory

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Chinese Physics B 2024年第2期33卷 158-163页

作者： Mazhar ali Department of Electrical Engineering Faculty of EngineeringIslamic University MadinahMadinah 107Saudi Arabia

We study genuine entanglement among three qubits undergoing a noisy process that includes dissipation, squeezing,and decoherence. We obtain a general solution and analyze the asymptotic quantum states. We find that most of these asymptotic states can be genuinely entangled depending upon the parameters of the channel, memory parameter, and the parameters of the initial states. We study Greenberger–Horne–Zeilinger(GHZ) states and W states, mixed with white noise,and determine the conditions for them to be genuinely entangled at infinity. We find that for these mixtures, it is possible to start with a bi-separable state(with a specific mixture of white noise) and end with genuine entangled states. However, the memory parameter μ must be very high. We find that in contrast to the two-qubit case, none of the three-qubit asymptotic states for n → ∞ are genuinely entangled.

关键词： genuine entanglement squeezed thermal baths multipartite states

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Flow Confinement Effects on the Wake Structure behind a Pitching Airfoil： A Numerical Study Using an Immersed Boundary Method

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Journal of Bionic Engineering 2017年第1期14卷 88-98页

作者： ali Akbar Hosseinjani ali Ashrafizadeh Faculty of Mechanical Engineering K. N. Toosi University of Technology Tehran P.O.B. 19395-1999 Iran

The flow patterns and wake structures behind a pitching airfoil in an un-bounded domain have been studied extensively. In contrast, the flow phenomena associated with a pitching airfoil near a solid boundary have not been adequately studied or reported. This paper aims at filling this research gap by considering the flow confinement effects on the flow pattern around a pitching airfoil. To achieve this goal, the flow fields around a flapping airfoil in un-bounded, bounded and semi-bounded domains are studied and compared. Numerical simulations are carried out at a fixed Reynolds number, Re = 255, and at a fixed oscillation frequency corresponding to St = 0.22. An accurate immersed boundary method is employed to calculate the unsteady flow fields around the airfoil at various flapping amplitudes. It is argued that two flow mechanisms, here called ＂the interaction effect＂ and ＂the induced reverse flow effect＂ are responsible for the variations of the flow field due to the presence of a nearby solid boundary.

关键词： immersed boundary method pitching airfoil vortex street induced momentum aligned vortex

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Effects of different friction stir welding conditions on the microstructure and mechanical properties of copper plates

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International Journal of Minerals,Metallurgy and Materials 2016年第7期23卷 799-809页

作者： ali Alavi Nia ali Shirazi Department of Mechanical Engineering Bu-Ali Sina University

Friction stir welding is a new and innovative welding method used to fuse materials. In this welding method, the heat generated by friction and plastic flow causes significant changes in the microstructure of the material, which leads to local changes in the mechanical properties of the weld. In this study, the effects of various welding parameters such as the rotational and traverse speeds of the tool on the microstructural and mechanical properties of copper plates were investigated; additionally, Charpy tests were performed on copper plates for the first time. Also, the effect of the number of welding passes on the aforementioned properties has not been investigated in previous studies. The results indicated that better welds with superior properties are produced when less heat is transferred to the workpiece during the welding process. It was also found that although the properties of the stir zone improved with an increasing number of weld passes, the properties of its weakest zone, the heat-affected zone, deteriorated.

关键词： copper friction stir welding mechanical properties microstructure

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An extended iterative direct-forcing immersed boundary method in thermo-fluid problems with Dirichlet or Neumann boundary conditions

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Journal of Central South University 2017年第1期24卷 137-154页

作者： ali Akbar Hosseinjani ali Ashrafizadeh Faculty of Mechanical Engineering K.N.Toosi University of TechnologyP.O.B.19395-1999 TehranIran

An iterative direct-forcing immersed boundary method is extended and used to solve convection heat transfer *** pressure,momentum source,and heat source at immersed boundary points are calculated simultaneously to achieve the best *** of convection heat transfer problems with both Dirichlet and Neumann boundary conditions are *** approaches for the implementation of Neumann boundary condition,*** and indirect methods,are introduced and compared in terms of accuracy and computational *** test cases include forced convection on a heated cylinder in an unbounded flow field and mixed convection around a circular body in a lid-driven ***,the proposed method is applied to study the mixed convection around a heated rotating cylinder in a square enclosure with both iso-heat flux and iso-thermal boundary *** results show that the order of accuracy of the indirect method is less than the direct ***,the indirect method takes less computational time both in terms of the implementation of the boundary condition and the post processing time required to compute the heat transfer variables such as the Nusselt *** is concluded that the iterative direct-forcing immersed boundary method is a powerful technique for the solution of convection heat transfer problems with stationary/moving boundaries and various boundary conditions.

关键词： immersed boundary method direct forcing thermo-fluid problems neumann boundary condition

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Effects of Fe_2O_3 Nanoparticles on Water Permeability and Strength Assessments of High Strength Self-Compacting Concrete

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Journal of Materials Science & Technology 2012年第1期28卷 73-82页

作者： ali Khoshakhlagh ali Nazari Gholamreza Khalaj Department of Materials Engineering Science and Research BranchIslamic Azad University Department of Materials Engineering Saveh BranchIslamic Azad University

In this work, compressive, flexural and split tensile strength together with coefficient of water absorption of high performance self-compacting concrete containing different amount of Fe2Os nanoparticles have been investigated. The strength and the water permeability of the specimens have been improved by adding Fe2Os nanoparticles in the cement paste up to 4.0 wt%. Fe203 nanoparticle as a foreign nucleation site could accelerate C-S-H gel formation as a result of increased crystalline Ca（OH）2 amount especially at the early age of hydration and hence increase the strength of the specimens. In addition, Fe203 nanoparticles are able to act as nanofillers and recover the pore structure of the specimens by decreasing harmful pores to improve the water permeability. Several empirical relations have been presented to predict the flexural and the split tensile strength of the specimens by means of the corresponding compressive strength at a certain age of curing. Accelerated peak appearance in conduction calorimetry tests, more weight loss in thermogravimetric analysis and more rapid appearance of peaks related to hydrated products in X-ray diffraction results indicate that Fe203 nanoparticles up to 4 wt% could improve the mechanical and the physical properties of the specimens.

关键词： Water permeability Fe203 nanoparticles Compressive strength Split tensilestrength Flexural strength

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A VERSATILE AND REGIOSELECTIVE SYNTHESIS OF VICINAL AZIDOALCOHOLS USING CROSS-LINKED POLY(4-VINYLPYRIDINE) SUPPORTED AZIDE ION UNDER SOLVENT-FREE CONDITIONS

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Chinese Journal of Polymer Science 2013年第12期31卷 1660-1669页

作者： Mohammad ali Karimi Zarchi ali Tarabsaz Department of Chemistry College of ScienceYazd University

A new polymeric reagent, cross-linked poly（4-vinylpyridine） supported azide ion, [P4-VP]N3, was introduced as polymeric reagents for efficient and regioselective conversion of epoxides to azidohydrins in the presence of cross-linked poly（4-vinylpyridine） supported sulfuric acid, [P4-VP]H2SO4, as a solid proton source and as catalyst under solvent-free conditions. The advantages of this polymeric reagent over some of those reported in the literature are easy work-up procedure and regeneration of the reagent.

关键词： Ring opening of epoxide fl-Azidoalcohols Poly(4-vinytpyridine) Solvent-free conditions Regioselectivity.

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