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大黄素通过调控Wnt/β-catenin信号通路减轻缺血性脑卒中大鼠BCFB

脑与神经疾病杂志 2023年第4期31卷 224-230页

作者：不艾吉尔·艾力米尔古丽·艾麦特卡热也木·卡德尔阿布都扎依尔·买买提徐奕鹏新疆维吾尔自治区人民医院康复科乌鲁木齐830001 新疆维吾尔自治区人民医院神经内科乌鲁木齐830001 新疆维吾尔自治区人民医院医务部乌鲁木齐830001 新疆维吾尔自治区人民医院院前急救120站乌鲁木齐830001

目的本研究旨在探讨大黄素对缺血性脑卒中(CAT)后血-脑脊液屏障(BCFB)的影响及其潜在机制。方法 Sd大鼠随机分为:假手术组、模型组、大黄素低剂量组(20 mg·kg^(-1))、大黄素高剂量组(40 mg·kg^(-1))以及阳性对照组(尼莫地平12 mg·kg... 详细信息

目的本研究旨在探讨大黄素对缺血性脑卒中(CAT)后血-脑脊液屏障(BCFB)的影响及其潜在机制。方法 Sd大鼠随机分为:假手术组、模型组、大黄素低剂量组(20 mg·kg^(-1))、大黄素高剂量组(40 mg·kg^(-1))以及阳性对照组(尼莫地平12 mg·kg^(-1))。构建大鼠大脑中动脉闭塞/再灌注(MCAO/R)模型,通过腹腔注射不同药物进行治疗。对各组大鼠进行神经功能缺损评分;TCC染色检测脑梗死体积;测定脑组织含水量;伊文思蓝(EB)染色检测BCFB通透性;明胶酶谱法评估MMP-9的活性;Western blotting检测基质金属蛋白酶-9 (MMP-9)、闭合蛋白-5 (Claudin-5)和咬合蛋白(Occludin)和磷酸化糖原合成酶激酶(p-GSK-3 β)、β-连环素(β-catenin)蛋白的表达。结果与假手术组相比,模型组大鼠神经功能缺损评分明显增加,脑梗死体积和脑组织含水量均明显增加,脑组织EB含量明显增加,脑组织中Claudin-5、Occludin、p-GSK-3 β、β-catenin蛋白表达明显降低,MMP-9酶活性和蛋白表达明显升高(Pdin-5、Occludin、p-GSK-3 β、β-catenin蛋白表达明显升高,MMP-9酶活性和蛋白表达明显降低(P<0.05)。结论大黄素可通过激活Wnt/β-catenin通路减轻BCFB损伤,对CAT具有神经保护作用。

关键词：大黄素缺血性脑卒中血-脑脊液屏障 Wnt/β-catenin信号通路大鼠

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一个基于深度学习的眼病和肺炎两大类疾病的AI诊断系统

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科学新闻 2019年第2期 33-33页

作者： daniel S.Kermany Michael Goldbaum Wenjia Cai Carolina C.S.Valentim Huiying Liang Sally L.Baxter Alex McKeown Ge Yang Xiaokang Wu Fangbing Yan Justin dong Made K.Prasadha Jacqueline Pei Magdalene Y.L.Ting Jie Zhu Christina Li Sierra Hewett Jason dong Ian Ziyar Alexander Shi Runze Zhang Rui Hou William Shi Xin Fu Yaou duan Viet A.N. Huu Cindy Wen Edward d. Zhang Charlotte L. Zhang Oulan Li Xiaobo Wang Michael A. Singer Xiaodong Sun Jie Xu ali Tafreshi M. Anthony Lewis Huimin Xia 张康美国加州大学圣地亚哥分校人类基因组医学研究所

文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜... 详细信息

文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜OCT(光学相干断层扫描)

关键词： AI 深度学习

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel ahm.d Sebastiano Aiello Muhammad Akram Nawab ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri david Biare Thilo Birkenfeld Sylvie Blin david Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti di Lorenzo daniele Corti Salvatore Costa Flavio dal Corso Christophe de La Taille Jiawei deng Zhi deng Ziyan deng Wilfried depnering Marco diaz Xuefeng ding Yayun ding Bayu dirgantara Sergey dmitrievsky Tadeas dohnal Georgy donchenko Jianmeng dong damien dornic Evgeny doroshkevich Marcos dracos Frédéric druillole Shuxian du Stefano dusini Martin dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measuredelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of delta m^2_(21)reported by solar neutrino experiments and the KamLANd experiment.

关键词： neutrino oscillation solar neutrino JUNO

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