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Acute Morphine Administration Reduces Cell-Mediated Immunity and Induces Reactivation of Latent Herpes Simplex Virus Type 1 in BALB/c Mice

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Cellular & Molecular Immunology 2009年第2期6卷 111-116页

作者： Shafi Mojadadi Abbas jamali Behzad Khansarine jad Hoorieh Soleimanjahi Taravat Bamdad Neuroscience research center Kerman University of Medical Sciences Department of Virology Faculty of medical science Tarbiat Modares University Dept of virology School of medicalsciences Tarbiat Modares University Dept of Microbiology Arak University of Medical Sciences

Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte （CTL） activity in the inhibition of herpes simplex virus type 1 （HSV-1） reactivation, the effect of acute morphine administration on CTL responses was also evaluated. Furthermore, lymphocyte proliferation and IFN-γ production were evaluated for their roles in the induction of the CTL response. The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-γ production. Furthermore, acute morphine administration has been shown to reactivate latent HSV-γ. Previous studies have shown that cellular immune responses have important roles in the inhibition of HSV reactivation. These findings suggest that suppression of a portion of the cellular immune response after acute morphine administration may constitute one part of the mechanism that induces HSV reactivation.

关键词： acute morphine herpes simplex virus-1 reactivation cell-mediated immunity

Spiral Tuning Stub CPW-Fed UWB Slot Offset, Edge Cleft and Edge Slotted Antennas

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Wireless Engineering and Technology 2011年第3期2卷 146-152页

作者： A. A jamali A Gaafar A. A. Abd Elaziz 不详

After the release of the unlicensed Ultra Wideband (UWB) spectrum 3.1 GHz to 10.6 GHz for the commercial purposes by the Federal Communications Commission (FCC), industries and academia pay much attention due to its properties of excellent immunity to multi-path interference, high secured data rate, low power consumption, and simple configuration. The feasible UWB antenna design face some challenges including the ultra wide impedance matching, omni directional radiation pattern, constant gain, high radiation efficiency, low profile, compact antenna size and easy manufacturing. since the CPW fed planar slot antennas have the advantages of wide bandwidth, simple structure, less radiation loss, low cost and easy integration of monolithic microwave integrated circuits (MMIC). In general two parameters affect planar slot antennas impedance bandwidth, the slot width and feed structure. CPW-Fed Slot Antenna with Triangular Tuning Stub, the slot shape could be bow-tie slot, wide rectangular slot, circular slot and hexagonal slot. The impedance tuning can also be performed by using coupling techniques like inductively and capacitively coupled slots, dielectric resonator coupling and other techniques such as using photonic band gap (PGB). Using these techniques, large impedance bandwidth could be obtained but they are quite complicated. Planar slot antennas have two parameters that affect impedance bandwidth, the slot width and the feed structure. The optimum feed structure gives the good impedance matching and the wider slot gives more bandwidth. The proposed antenna in this paper is designed with a compact rectangular slot and a rectangular spiral feeding structure at the interior portion of the feed. The antenna is cleft and slotted at the edge and the effects is studied. The antenna only one of its kinds in structure, small in size and simple design due to less number of design parameters compared with the existing ultra wideband antennas in the literature. The bandwidth,

关键词： UWB CPW Slot Offset Antenna Edge Cleft Antenna Edge Slotted Antenna

Regional Connectivity and Inclusion of New Partners in China-Pakistan Economic Corridor:Prospects and Challenges

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Asian Journal of Middle Eastern and Islamic Studies 2023年第1期17卷 31-48页

作者： Ahmed Bux jamali Hongsong Liu Mehmood Hussain School of International and Public Affairs Shanghai International Studies UniversityChina School of International and Public Affairs Shanghai Jiao Tong UniversityChina Department of International Relations University of Azad Jammu and Kashmir MuzaffarabadPakistan

This paper examines the potential of China-Pakistan Economic Corridor for shared prosperity and economic development through enhanced regional *** argues that CPEC can act as a regional connector for South Asian and Middle Eastern states by bringing enormous economic and trade *** examined the potential utilisation of CPEC as a regional connector in contextualising the Pakistan-China shared consensus for the inclusion of new partners,this paper investigates the areas of regional connectivity cooperation and cross-border linkages with India,Afghanistan,Iran,and Saudi Arabia,and highlights the prospects and challenges to CPEC for mutual collaboration and expanded regionalisation.

关键词： BRI CPEC Gwadar Port Expanded Regionalisation New Partners

Use of Sewage Sludge After Liming as Fertilizer for Maize Growth

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Pedosphere 2008年第2期18卷 203-213页

作者： M.K.jamali T.G.KAZI M.B.ARAIN H.I.AFRIDI A.R.MEMON N.JALBANI A.SHAH National Centre of Excellence in Analytical Chemistry

The use of sewage sludge on agricultural land provides an alternative for its disposal. Therefore, the aim of the present study was to evaluate the feasibility of using industrial sewage sludge produced in Pakistan, as an agricultural fertilizer. The agricultural soil amended with 250 g kg^-1 sewage sludge with or without lime treatment was used for the growth of the common local grain crop, maize （Zea maize）. The mobility of the trace and toxic metals in the sludge samples was assessed by applying a modified BCR sequential extraction procedure. The single extraction procedure was comprised of the application of a mild extractant （CaCl2） and water, for the estimation of the proportion of easily soluble metal fractions. To check the precision of the analytical results, the concentrations of trace and toxic metals in every step of the sequential extraction procedure were summed up and compared with total metal concentrations. The plant-available metal contents, as indicated by the deionized water and 0.01 mol L^-1 CaCl2 solution extraction fractions and the exchangeable fraction of the sequential extraction, decreased significantly （P 〈 0.05） with lime application because of the reduced metal availability at a higher pH, except in the cases of Cd and Cu, whose mobility was slightly increased. Sludge amendment enhanced the dry weight yield of maize and the increase was more obvious for the soil with lime treatment. Liming the sewage sludge reduced the trace and toxic metal contents in the grain tissues, except Cu and Cd, which were below the permissible limits of these metals. The present experiment demonstrates that liming was an important factor in facilitating the growth of maize in sludge-amended soil.

关键词： lime treatment maize metals sequential extraction sewage sludge

H pylori seroprevalence in patients with lung cancer

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World Journal of Gastroenterology 2007年第16期13卷 2349-2351页

作者： Katayoon Najafizadeh Sayeed Falah Tafti Masoud Shiehmorteza Masoud Saloor Masoud jamali Department of Respiratory Medicine National Research Institute of Tuberculosis and Lung Diseases Tehran 19556 Iran

AIM: To assess H pylori seroprevalence in lung cancer and determine whether there is a potential association between lung cancer and H pylori infection. METHODS: The study was conducted on forty consecutive patients with lung cancer, confirmed by pathology (32 men, 8 women; mean age 55.50 ± 11.91 years, range 16-77 years). Forty healthy subjects (25 men, 15 women; mean age 43.08 ± 12.60 years, range 20-79 years) from the patients’ family members were matched to each case subject on the basis of age and socioeconomic status. H pylori infection was detected with a commercially available immunoglobulin G (IgG) enzyme-linked immunosorbent assay (Trinity kit, Biotech co., USA), previously validated in adults (86% sensitivity, 96% specificity) against a gold standard of culture and histology. RESULTS: H pylori seropositivity was present in 52.5% of patients with lung cancer in comparison to 45.0% of healthy control subjects. Although H pylori seropositivity was more frequent in lung cancer patients than in controls, the difference did not reach statistical significance (OR = 1.35, 95% CI = 0.56-3.25; P = 0.65). In addition, there was no significant difference between cases and controls in terms of gastrointestinal symptoms. CONCLUSION: The earlier described association between H pylori infection and lung cancer was not supported in this study. Further studies with larger sample sizes should be undertaken to assess the frequency of H pylori infection in patients with lung cancer and their potential association.

关键词： Lung neoplasm H pylori Helicobacter infections/complications Carcinoma/Non-small cell Carcinoma/Squamous cell Case-control studies

Prevalence of Iron Deficiency Anaemia in School and College Going Students of District Shaheed Benazirabad Sindh Province, Pakistan

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Open Journal of Blood Diseases 2016年第4期6卷 67-78页

作者： Niaz Hussain jamali Hidayatullah Mahesar Muhammad Aqeel Bhutto Department of Community Medicine Peoples University of Medical and Health Sciences for Women Nawabshah Pakistan Department of Physiology University of Sindh Jamshoro Jamshoro Pakistan Institute of Biotechnology and Genetic Engineering University of Sindh Jamshoro Pakistan

The present study aimed to estimate the occurrence of Iron Deficiency anemia (IDA) in school and college going students (aged 11 - 18 years). Anemia is the most public health problem in school age children. It has a wide range of adverse results involving, poor cognitive performance, poor development of infants, preschool and school-aged children. Anemia also causes the impairment of physical capacity, work performance of adolescents and adults, reduction in immune competence and increased morbidity from infections in all age groups. Our study based on 1686 volunteers was randomly selected from different Government High schools and colleges. A Questionnaire was utilized for data collection. BMI was also calculated by dividing weight in kg by the square of height in meters. Hemoglobin (Hb), Hematocrite (Hct), Mean Corpuscular volume (MCV), Mean Corpuscular hemoglobin concentration (MCHC), white blood cell (WBC) and red blood cell was examined using Sysmex kx-21N hemoglobin auto analyzer (Hedwin, 2008). The total percentage of anaemic students (43.1%) and non-anaemic (56.9%) were observed in district Shaheed Benazirabad. The mean Hb level of anaemic students (11.1 ± 4.94) was observed. In males (12.7%) and females (30.4%) anemic was observed. The prevalence of anemia high (16.2%) was observed in the age of 14 - 16 years. The majority of anemic patients (30.2%) belonged to low income group. Area wise prevalence, in rural areas 27.8% and urban areas 15.3% volunteers anaemic was observed. Taluka wise occurrence of anaemia in taluka Sakrand was (14.6%), in taluka Kazi Ahmed (15.0%), in taluka Daur (8.0%) and in taluka Nawabshah was (5.5%). Clinically signs and symptoms showed, pale skin 57.7% and weakness 42.3% were observed in school children.

关键词： Iron Deficiency Anaemia (IDA) Haemglobin (Hb) Red Blood Cell (RBC) White Blood Cell (WBC) Hematocrit (Hct) Body Mass Index (BMI) School Children Pale Skin

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论奥巴马政府对巴基斯坦反恐战略的作用

论奥巴马政府对巴基斯坦反恐战略的作用

作者： Ahmed Bux jamali 吉林大学

学位级别：硕士

本文旨在就奥巴马政府与巴基斯坦的总体反恐合作进行分析和评价,侧重于研究美国在奥巴马执政期间为消除来自巴基斯坦的恐怖主义采取的相关措施及行为。作为国家安全的重大威胁,恐怖主义对于两国的国内和平与稳定都是极具灾难性的。尽管... 详细信息

本文旨在就奥巴马政府与巴基斯坦的总体反恐合作进行分析和评价,侧重于研究美国在奥巴马执政期间为消除来自巴基斯坦的恐怖主义采取的相关措施及行为。作为国家安全的重大威胁,恐怖主义对于两国的国内和平与稳定都是极具灾难性的。尽管在奥巴马执政期间巴基斯坦与美关系经历了大起大落,但就在整个南亚尤其是巴基斯坦遏制恐怖主义这一威胁而言,奥巴马政府的反恐战略是可行的且取得了一定成效。2009年在其上任时,奥巴马政府就在布什政府对巴基斯坦反恐既有政策的基础上制定了新时期对巴基斯坦反恐政策。在处理与巴基斯坦关系时,奥巴马在外交政策上围绕防务和外交展开,“巧实力”概念是奥巴马政府为实现在巴基斯坦战略目标的核心原则。对巴提供军事援助和其他各项援助,帮助进行机构建设及加强经济发展,巴基斯坦在奥巴马这些战略的协助下增强了其在部落地区的安全避难所进行军事行动的能力,这也进一步使得巴基斯坦在政府政策层面建立起关于反恐和军事的制度机制。而对于藏匿于巴基斯坦部落地区的武装恐怖组织来说,经由美国训练的战斗部队、美国提供的武器以及装备都是致命的。也正是因此,许多基地组织及其附属武装组织的高层领导人被美俘虏并送往美国。尽管两国在国内及国际的许多问题上存在一致也存在分歧,但双方都并未在消除巴基斯坦恐怖主义现象这一问题上有所妥协,这正是奥巴马政府长期坚持的反恐和反暴乱战略的成功之处。本文分为以下五个章节:第一章主要介绍和阐述自美国9·11事件以来恐怖主义的动态,包括本文研究背景,文献综述,主要观点和方法概述,已有文献则来源于相关书籍、期刊文章及官方网站等。第二章就9·11事件后的美国与巴基斯坦关系及美国对巴基斯坦外交政策展开讨论。本章第一部分将论述布什政府对巴基斯坦的外交政策。由于美国境内遭到了兴起于阿富汗的基地组织的恐怖袭击,布什政府制定了以美国国家安全为主的全面外交政策,这一外交政策主要通过寻求盟友合作的方式实施。在此意义上,巴基斯坦作为美国在南亚地区的历史性安全伙伴,布什政府与穆沙拉夫总统合作是唯一可行的选择。本章第二部分则分别论述布什总统和奥巴马政府反恐战略的整体连续性及前后变化,也将对两个时期的相关重大外交决策和事件进行比较分析。第三章分析美国在奥巴马政府期间对巴基斯坦外交政策以及奥巴马在任期间所采取的主要决定和行动。奥巴马政府主要通过对巴援助、与巴进行军事防务合作、强化巴基斯坦国内机构来推行其对巴反恐战略。因此,本章重点分析奥巴马政府与巴基斯坦反恐合作的变化趋势和趋向,也对奥巴马采取的一系列举措和策略以及两国在双边关系上的起落进行了阐释。第四章分析美国对巴基斯坦反恐战略所面临的挑战。第一部分分析来自巴基斯坦国内的挑战。巴基斯坦的反恐战略以其军队在国内尤其是在安全避难区域展开军事行动为中心,此外,巴基斯坦政府还采取了一系列加强国家安全能力,促进立法和边界安全的反恐措施。而美国对巴反恐的境内挑战不仅来自于巴基斯坦各地区,还包括巴基斯坦国内政治环境,经济挑战,反恐对普通民众生活的影响等,这一部分的分析也将进一步论及巴基斯坦社会,执法机构和公民所面临的挑战。本章第二部分分析巴基斯坦反恐面临的境外挑战,将侧重于从巴基斯坦对印度和阿富汗等邻国的国家安全战略进行分析,尤其聚焦于其与邻国边界问题,印度默许恐怖分子经由两国边界地区进入巴基斯坦,阿富汗则扮演恐怖分子“代理国”的角色,破坏巴基斯坦和平与领土完整。第五章对全文进行总结并提出相关建议。

关键词：美国与巴基斯坦关系奥巴马政府反恐合作国家安全

金银纳米粒子的合成、组装及其在表面增强拉曼光谱的应用

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金银纳米粒子的合成、组装及其在表面增强拉曼光谱的应用

作者： SAIN BUX jamali 厦门大学

学位级别：硕士

广泛地说,所有直径在纳米级别的粒子(杂化纳米粒子,核壳纳米粒子等)都称之为纳米粒子。由于贵金属粒子稳定性好,易合成以及光学特性等优点,因此合成贵金属纳米粒子仍然是探针研究中最受欢迎的一部分。同时,银和金在可见光和近红外区域... 详细信息

广泛地说,所有直径在纳米级别的粒子(杂化纳米粒子,核壳纳米粒子等)都称之为纳米粒子。由于贵金属粒子稳定性好,易合成以及光学特性等优点,因此合成贵金属纳米粒子仍然是探针研究中最受欢迎的一部分。同时,银和金在可见光和近红外区域能够提供很强的光学信号,使得它们成为最受欢迎的贵金属粒子。在最近的工作中,合成纳米粒子的三个主要挑战分别是:(1)如何在硅基底上获得大范围的单层纳米粒子;(2)如何合成高产率的金纳米棒;(3)如何在金纳米棒外包裹上银壳。为了克服上述难题,我们做出很多的努力,并且取得了重要突破和结果。在第三章中,我们利用两相法成功地将银立方体单层组装在了硅基底上。首先往银立方体中加入超纯水混匀,然后加入环己烷进行超声分散;接着加入适量的乙醇,从而在环己烷/水界面形成单层膜。最后,从溶液中将单层膜取出并且沉积在硅基底上。SEM和SERS的表征结果显示,在硅基底上自组装得到的单层膜是统一均匀的。并且,根据SEM和SERS的实验结果,我们发现:银立方体的单层膜在环己烷/水这个液-液界面中,大面积下都是均匀分散的,亲水纳米粒子的界面电荷相反的分子通过静电相互作用从而自组装在基底上。这些纳米粒子可以很容易地聚集在环己烷和水的混合溶液中,同时自组装形成单层膜。在第四章中,我们系统地研究了在金纳米棒的外面生长上一层银壳的方法。为了便于比较,在合成不同尺寸的纳米粒子时,Au/Ag的摩尔比和Au纳米棒种子的量是一样的。同时,吸收实验和理论计算结果都证实了该方法的可行性。在实验中,通过加入不同量的硝酸银来进行调控纳米棒的壳层厚度。并且,核壳Au@Ag纳米棒的LSPR从可见光到近红外区域都是可调的,证明了该纳米粒子的均匀性和可调性。同时,不同尺寸的核壳纳米粒子在使用相同浓度的MBA(10-3 M)探针分子的SERS实验中表现出良好的SERS活性和稳定性。而且,尺寸为110 nm,130 nm,和150 nm的Au@Ag纳米粒子基底分别在532 nm,638 nm,和785 nm激光下显示出最好的SERS性能。另外,该结果和3D-FDTD的理论计算相吻合。此外,这种控制不同尺寸大小的Au@Ag核壳纳米粒子可以很好地进行重复。

关键词：银立方体单层膜合成技术金纳米棒核-壳纳米粒子 Au@Ag长方体

Progress in Discovery of Serum Biomarkers for Early Cancer Detection:the Case of Head and Neck Carcinomas

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Progress in Discovery of Serum Biomarkers for Early Cancer D...