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A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

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International Journal of Oral Science 2024年第2期16卷 265-279页

作者： alfredo Torres M.Angélica Michea Ákos Végvári Marion Arce Valentina Pérez Marcela Alcota Alicia morales Rolando Vernal Mauricio Budini Roman A.Zubarev Fermín E.González Laboratory of Experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and Molecular Pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RNA sequencing(scRNA-seq)dataset(GSE164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including SNCA,CA1,HBB,SLC4A1,and ANK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(SNCA,FTH1,HSPB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRNA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

Quantification of the Mixture of Hydrothermal and Fresh Water in Tectonic Valleys

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Journal of Earth Science 2020年第5期31卷 1007-1015页

作者： Janete Moran-Ramirez Jose Ivan morales-Arredondoc Maria Aurora Armienta-hernandez Jose alfredo Ramos-Leal National Council of Science and Technology National Autonomous University of MexicoInstitute of GeophysicsScientific Research CircuitUniversity CityCoyoacan 04150Mexico CityMexico National Autonomous University of Mexico Institute of GeophysicsUniversity CampusMexico CityMexico Potosino Institute for Scientific and Technological Research 78216 San Luis PotosiS.L.P.Mexico

This study was conducted to identify the origin, hydrogeochemical processes and evolution of groundwater in a tectonic valley. This study was carried out with the aim of quantifying the proportions of groundwater flows contributing to the water chemistry abstracted in a zone of convergence favored by the presence of active faults. The study area is located in the Trans-Mexican Volcanic Belt. End members methodology was applied to identify the mixing of hydrothermal with fresh groundwater, where changes in the aquifer geology result in distinct groundwater chemical signatures. Ternary mixing was quantified using conservative elements. Moreover, other evolutionary processes, such as ion exchange and silicate weathering occur due to changes in the geology of the area. In ternary mixing, each of the end members is associated with the lithology through which it circulates. The local flow contributes 70% of the water to the system, the intermediate flow contributes 14%, and the regional flow contributes 16%. Three types of water are produced: Na-HCO3, due to the interaction of water with volcanic rocks of rhyolitic composition, Na-Mg-HCO3, due to the interaction of water with volcanic rocks of basaltic-andesite composition, and Ca-HCO3, due to the interaction of water with sedimentary calcareous rocks.

关键词： hydrogeochemistry ternary mixing end members conservative elements local flow Mexico

Impact of liver enzymes on SARS-CoV-2 infection and the severity of clinical course of COVID-19

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Liver Research 2021年第1期5卷 21-27页

作者： Fátima Higuera-de la Tijera alfredo Servín-Caamaño Daniel Reyes-Herrera Argelia Flores-López Enrique J.A.Robiou-Vivero Felipe Martínez-Rivera Victor Galindo-hernández Oscar Chapa-Azuela Alfonso Chávez-morales Victor H.Rosales-Salyano Multidisciplinary Team for the Attention and Care of Patients with COVID-19 Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Gastroenterology and Hepatology Department Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Internal Medicine Department Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Hepatobiliary and Pancreatology Clinic Surgery DepartmentHospital General de México Dr.Eduardo LiceagaMexico CityMexico Intensive Care Unit Hospital General de México Dr.Eduardo LiceagaMexico CityMexico

Background and aim Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for the current pandemic,can have multi-organ *** studies show that liver injury could be a manifestation of the disease,and that liver disease could also be related to a worse *** aim was to compare the characteristics of patients with severe coronavirus disease 2019(COVID-19)due to SARS-CoV-2 who required intubation versus stable hospitalized patients to identify the early biochemical predictive factors of a severe course of COVID-19 and subsequent requirement for intubation,specifically in *** This was an observational case-control study nested in a cohort *** medical records of patients admitted for confirmed COVID-19 at a tertiary level center in Mexico City were *** and biochemical data were collected,and the characteristics of patients who required invasive mechanical ventilation(IMV)(cases)were compared with stable hospitalized patients without ventilation(controls).Results We evaluated 166 patients with COVID-19 due to SARS-CoV-2 infection;114(68.7%)were men,the mean age was 50.6±13.3 years,and 27(16.3%)required *** comparative analysis between cases and controls showed(respectively)significantly lower blood oxygen saturation(SpO_(2))(73.5±12.0%vs.83.0±6.8%,P<0.0001)and elevated alanine aminotransferase(ALT)(128(14–1123)IU/L vs.33(8–453)IU/L,P=0.003),aspartate aminotransferase(AST)(214(17–1247)vs.44(12–498)IU/L,P=0.001),lactic dehydrogenase(LDH)(764.6±401.9 IU/L vs.461.0±185.6 IU/L,P=0.001),and D-dimer(3463(524–34,227)ng/mL vs.829(152–41,923)ng/mL,P=0.003)*** in the cases group were older(58.6±12.7 years vs.49.1±12.8 years,P=0.001).Multivariate analysis showed that important factors at admission predicting the requirement for IMV during hospitalization for COVID-19 were AST≥250 IU/L(odds ratio(OR)=64.8,95%confidence interval(CI)7.5–560.3,P<0.0001)and D-dimer≥3500 ng/mL(OR=4.1,95

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Liver enzymes D-dimer Disease severity Invasive mechanical ventilation(IMV) Multi-organ failure

Optimal Parameters for in Vitro Development of the Fungus Hydrocarbonoclastic Penicillium sp.

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Advances in Chemical Engineering and Science 2013年第4期3卷 19-29页

作者： Marcia Eugenia Ojeda-morales Miguelángel hernández-Rivera JoséGabriel Martínez-Vázquez Yolanda Córdova-Bautista Yuridia Evelin hernández-Cardeno División Académica de Ingenieria y Arquitectura Universidad Juarez Autonoma de TabascoCunduacanMéxico Facultad de Salud y Ciencias A.F. Universidad SEKSantiagoChile

México has extensive areas that have been impacted by oil spills for several decades. Current bioremediation technologies mostly used microorganisms to decontaminate sites with hydrocarbons. This research evaluated the conditions for the optimal development of the strain of a hydrocarbonoclastic fungus, which was found in samples of soil contaminated with 4.0 × 105 mg·kg-1 of Total Petroleum Hydrocarbons (TPH). A completely randomized experimental design with a 3 × 3 × 4 factor arrangement was used: three levels of temperature (T1 = 29℃, T2 = 35℃ and T3 = 40℃), three of pH (pH1 = 3.5, pH2 = 5.0 and pH3 = 6.0) and four nutrients (N1 = Urea, N2 = Triple-17, N3 = Nitrophoska-Blue and N4 = Pure-Salts). Total fungi were isolated from the sampled soil and were sown in a combined carbon medium for hydrocarbonoclastic fungi and a strain was selected to be adapted to a liquid mineral medium. The selected strain was classified as Penicillium sp. Analyses of variance and mean tests were performed, using the SPSS-11.0 statistical software. The microorganisms showed the highest population growth in the treatment N2pH2T1, which reached a value of 2.1 × 106 CFU·mL-1 in a biorreactor. To reach it, by bioaugmentation, the same development of Penicillium sp. in a conditioned soil would allow to implement a bioremediation strategy with great potential to retrieve soil contaminated with hydrocarbons both in Tabasco and in general in Mexico.

关键词： Hydrocarbon Degraders Optimal Growth Penicillium sp. Hydrocarbonoclastic

Ab InitioMolecular Orbital Calculation for Optical and Electronic Properties Evaluation of Small and Medium Size Silicon Nano-Clusters Found in Silicon Rich Oxide Films

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Journal of Modern Physics 2013年第11期4卷 1-26页

作者： Néstor David Espinosa Torres José Francisco Javier Flores Gracia José Alberto Luna López Juan Carlos Ramírez García alfredo morales Sánchez José Luis Sosa Sánchez David hernández de la Luz Francisco morales morales Research Center for Advanced Materials S.C. Unit Monterrey-PIIT Apodaca México Research Center for Semiconductor Devices CIDS-ICUAP-BUAP Puebla México The Faculty of Chemical Sciences BUAP Puebla México

In systems in atomic and nano scales such as clusters or agglomerates constituted of particles from a few to less than one hundred of atoms, quantum confinement effects are very important. Their optical and electronic properties are often dependent on the size of the systems and the way in which the atoms in these clusters are bonded. Generally, these nano-structures display optical and electronic properties significantly different of those found in corresponding bulk materials. Silicon agglomerates found in Silicon Rich Oxide (SRO) films have optical properties, which have reported as depended directly on nano-crystal size. Furthermore, the room temperature photoluminescence (PL) of Silicon Rich Oxides (SRO) has repeatedly generated a huge interest due to their possible applications in optoelectronic devices. However, a plausible emission mechanism has not yet widespread acceptance of the scientific community. In this research, we employed the Density Functional Theory with a functional B3LYP and a basis set 6 - 31G* to calculate the optical and electronic properties of small (six to ten silicon atoms) and medium size clusters of silicon (constituted of eleven to fourteen silicon atoms). With the theoretical calculation of the structural and optical properties of silicon clusters, it is possible to evaluate the contribution of silicon agglomerates in the luminescent emission mechanism experimentally found in thin SRO films.

关键词： Nano-Crystals Silicon Clusters Silicon-Rich Oxide Luminescence Magic-Number

A New Era in the Management of the Hepatitis C

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International Journal of Clinical Medicine 2014年第12期5卷 660-666页

作者： alfredo Arredondo Bruce Osmani Risco morales “Amalia Simoni” Teaching Hospital Camaguey Cuba

Hepatitis C is an infection caused by the hepatitis C virus that attacks the liver and leads to inflammation. The current standard-of-care regimens include a protease inhibitor—telaprevir or boceprevir—in combination with pegylated interferon and ribavirin. Hepatitis?C treatment options on the horizon hold promise for better viral clearance with less toxicity than current regimens. There are new data about new drugs, both direct-acting antivirals while minimizing intolerable side effects or adverse events. Developed new data from 4 phase 3 trials with the hepatitis C drug sofosbuvir and ribavirin show that a 12-week regimen is effective in treating HCV genotypes 1 through 6. In the Annual Scientific Meeting and Postgraduate Course of the American College of Gastroenterology, different research was presented that was drawn from 4 phase 3 studies: NEUTRINO, FISSION, POSITRON and FUSION which enrolled different types of patients, who received Sofosbuvir with Peginterferon Alfa 2a and Ribavirin for 12 or 24 weeks in treatment;for all studies, the primary end point was sustained virologic response at 12 and 24 weeks posttreatment. In all studies, sofosbuvir was well tolerated, with a low incidence of adverse events. In conjunction with the suggested brief duration of this regimen, this indicates that drug combinations should improve treatment adherence compared with IFN-based treatment. In conclusion, 2 novel direct-acting antiviral agents—sofosbuvir and simeprevir—target various components of the HCV genome. Advantages of these drugs include a high barrier to viral resistance, a shorter duration of treatment, once-daily dosing, absence of food restrictions, few clinically significant drug interactions, and similar efficacy in all genotypes.

关键词： Hepatitis C Sustained Virologic Response Intolerable Side Effects or Adverse Events Sofosbuvir and Simeprevir

Photomechanical Ablation of 304L Stainless Steel, Aluminum Oxide (Al₂O₃) Thin Film, and Pure Silicon

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Optics and Photonics Journal 2016年第10期6卷 275-288页

作者： Gabriel de la Rosa-Santana Jose alfredo Alvarez-Chavez Hector R. Morano-Okuno Angel J. morales-Ramirez Esmeralda Uribe Instituto Tecnologico y de Estudios Superiores de Monterrey Campus Estado de Mexico Atizapan de Zaragoza Mexico Instituto Politecnico Nacional-Centro de Investigacion e InnovacionTecnologica (CIITEC-IPN) Mexico City Mexico Instituto Tecnologico y de Estudios Superiores de Monterrey Campus Queretaro Santiago de Queretaro Mexico

Recently, a number of studies have focused on micro-manufacturing processes, which find use in a variety of applications, including the production of microelectromechanical systems (MEMS). The process of ablation in materials is mainly governed by the laser source and scanning speed. The rate of material ablation is influenced by chemical and physical properties. In this work, the energy from a CO2 laser was used to ablate three different materials, namely, stainless steel 304L, a thin film of amorphous aluminum oxide (Al2O3), and pure silicon, due to their wide use in MEMS technology. The laser parameters used were an average power of 18 W and a spot size of 200 μm. The maximum depth during the photomechanical ablation process was 72 μm in the case of 304L steel and 77 μm in the case of the Al2O3 thin film for a scan rate of 24 mm/min. However, at the same scan rate, silicon did not exhibit any penetration. As expected, while increasing scanning speed the ablation depth decreases due to reduced interaction time between laser and material. The theoretical ytterbium fiber laser shown in this study can thus be employed in the manufacturing of a wide variety of materials used in the production of MEMS as well as those used in clean energy technologies.

关键词： Laser Ablation MEMS Ytterbium-Doped Fiber Laser Thin Film

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Twitter数据揭示全球社区结构

数据分析与知识发现 2020年第7期4卷 49-49页

作者：本刊讯 Leila Hedayatifar alfredo J.morales Yaneer Bar-Yam 不详

Twitter数据分析显示,受用户之间物理距离和共同性(如共同语言,相似背景等)的影响,用户个人的交流偏好有所差异,导致社区结构模式不同。虽然此前已有研究使用其他数据(如手机使用数据,Facebook朋友联系数据)识别出社区结构模式,但新英... 详细信息

Twitter数据分析显示,受用户之间物理距离和共同性(如共同语言,相似背景等)的影响,用户个人的交流偏好有所差异,导致社区结构模式不同。虽然此前已有研究使用其他数据(如手机使用数据,Facebook朋友联系数据)识别出社区结构模式,但新英格兰复杂系统研究所的一项新的研究着眼于全球社区中消息传递的集体效应,有了新的发现。研究人员使用Twitter数据中的提及机制绘制全球信息流。

关键词：新英格兰物理距离集体效应 Twitter 消息传递信息流数据分析结构模式

Alternancy Study on Rambutan(Nephelium lappaceum L.)Tree in Mexico

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American Journal of Plant Sciences 2017年第1期8卷 40-52页

作者： Rubén Joo-Pérez Carlos Hugo Avenda?o-Arrazate alfredo Sandoval-Esquivez Saúl Espinoza-Zaragoza Moisés Alonso-Báez José Luís Moreno-Martínez Rafael Ariza-Flores Carlos Raúl morales-Nieto Faculty of Agricultural Sciences Autonomous University of ChiapasHuehuetanMexico National Forestry Crops and Livestock Research Institute(INIFAP)Experimental Station Rosario IzapaTuxtla ChicoMexico Autonomous University of Chiapas HuehuetanMexico INIFAP Experimental Station IgualaGuereroMexico Autonomous University of Chihuahua ChihuahuaMexico

Rambutan growing in the state of Chiapas has brought about a demand for new plantations;however, this species has several biotic and abiotic factors that limit its production. These factors include phytosanitary problems, deficient agronomical handling, and production alternancy. Because of this, the objective of the present study was to evaluate the effect of the application of agronomical practices such as pruning, ringing, water stress, and their interaction on the rambutan alternancy. The experiment was carried out in the “La Chinita” commercial orchard located on KM. 4.5 the Huehuetan Station, municipality of Huehuetan, Chiapas, Mexico. We used 48 rambutan trees in production with an age of 14 years. Two production cycles were evaluated. The experiment was established under a divided plot experimental design in random complete blocks with a factorial arrangement and six replicates;each tree being a replicate. The study factors were: water stress, pruning, girdling, irrigation (control), and their combinations, resulting in eight treatments. The evaluation was done during flowering, fruit set, and harvest. In flowering, the treatments with permanent irrigation in both evaluated cycles (2010-2011 and 2011-2012) manifested a production alternancy behavior, with an average 36.4% flowering in the first evaluation cycle and increased to 82.1% in the second cycle. The treatments with water stress kept a proportional flowering during the first and second cycles of 97.9% and 95.3%, respectively. The water stress influenced the bunch weight (PR) variable fruit set with bigger fruits and higher bunch weight than the irrigated treatments. In production, pruning and girdling together with water deficit had no alternancy in both production cycles.

关键词： Nephelium lappaceum L. Water Stress Pruning Girdling Irrigation