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Litter production and leaf nutrient concentration and remobilization in response to climate seasonality in the central Amazon

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Journal of Forestry Research 2024年第3期35卷 131-141页

作者： Ricardo Antonio Marenco Saul alfredo Antezana-Vera Daniela pereira Dias Luiz Antonio Candido Instituto Nacional de Pesquisas da Amazonia Coordenagao de Uso da Terra e Mudanca ClimaticaAv.Andre Araujo 2936ManausAM69067-375Brazil Programa de pos-Graduagao em Agricultura no Tropico Umido Instituto Nacional de Pesquisas da Amazonia-INPAManausAMBrazil Unidade Academica de Ciencias Agrarias Universidade Federal de JataiBR 364km 195JataiGO 75801-615Brazil

Litterfall is the largest source of nutrients to for-est soils of tropical ***,variability in lit-terfall production,nutrient remobilization,and changes in leaf nutrient concentration with climate seasonality remain largely unknown for the central *** study meas-ured litterfall production,leaf nutrient remobilization,and leaf area index on a forest plateau in the central *** was measured at monthly intervals during 2014,while nitrogen,phosphorus,potassium,calcium and mag-nesium concentrations of leaf litter and canopy leaves were measured in the dry and rainy seasons,and remobilization rates *** area index was also recorded in the dry and rainy *** litterfall varied from 33.2(in the rainy season)to 87.6 g m^(-2) in the dry season,while leaf area index increased slightly in the rainy *** seasonality had no effect on concentrations of nitrogen,calcium,and magnesium,whereas phosphorous and potassium responded to rainfall seasonality *** phosphorous increased,potassium decreased during the dry *** seasons,nitrogen,potassium,and phosphorous decreased in leaf litter;calcium increased in leaf litter,while magnesium remained unaffected with leaf ***,the five nutrients had similar remobilization rates over the *** absence of climate seasonality on nutrient remobilization suggests that the current length of the dry season does not alter nutrient remobilization rates but this may change as dry periods become more prolonged in the future due to climate change.

关键词： Throughfall Nutrient cycling Climatic seasonality Leaf mass per area

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What Do Cattle Prefer in a Tropical Climate： Water Immersion or Artificial Shade？

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Journal of Life Sciences 2012年第12期6卷 1356-1362页

作者： Ana Carina Alves pereira de Mira Geraldo alfredo manuel franco pereira Cristiane Gonqalves Titto Evaldo Antonio Lencioni Titto Animal Science and Food Engineering Faculty University of Sao Paulo Pirassununga 13635-900 Brazil Institute of Mediterranean Agricultural and Environmental Sciences University of Evora Evora 7000 Portugal

Animal performance is affected by high air temperature and it is known that shade reduces the absorption of radiant temperature, and water for immersion facilitates heat loss. This study intends to find preferences of resources that contribute for the well-being of cattle and how they alterdaily behaviour. During summer, six Caracu and six Red Angus bulls were submitted to two different treatments: availability of artificial shade and water for immersion and availability of water for immersion. The categories observed were: positions (in the sun, under the shade, in the water), posture (standing, lying down) and activities (grazing, ruminating, leisure). The behavioural patterns were recorded using the focal sampling method every 15 minutes (from 6:00 a. m. to 6:00 p. m.). When shade and water for immersion coexists, cattle in this study prefer shade to avoid solar radiation. Both breeds had remained more time grazing, followed by ruminating in the Caracu breed, and by resting in the Red Angus breed. The Caracu breed had presented clear preference for the shade resource, but that fact was not always observed in the Red Angus breed. In hot climates, resources for defence against heat load, as shade and water for immersion improve the well-being of cattle.

关键词：水浸泡公牛阴影热带气候人工辐射温度行为模式安格斯

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Magnetic mitohormesis:A non-invasive therapy for inflammatory disorders?

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BIOCELL 2023年第2期47卷 239-244页

作者： alfredo franco-OBREGÓN Department of Surgery Yong Loo Lin School of MedicineInstitute of Health Technology and InnovationiHealthtechBiolonic Currents Electromagnetic Pulsing Systems LaboratoryBICEPSHealthy Longevity Translational Research ProgrammeNUS Centre for Cancer ResearchNational University of SingaporeSingapore

An organism’s survival depends on its ability to adapt to *** are the cellular integrators of environmental stressors that ultimately translate their responses at the organismal level,and are thus central to the process whereby organisms adapt to their respective *** produce molecular energy via oxidative phosphorylation that then allows cells to biosynthetically respond and adapt to changes in their *** oxygen species(ROS)are by-products of oxidative phosphorylation that can be either beneficial or damaging,depending on the context;ROS are hence both the conveyors of environmental stress as well as cellular“adaptogens”.Mitohormesis refers to the process whereby low levels of oxidative stress spur survival adaptations,whereas excessive levels stymie *** energy and frequency pulsing electromagnetic fields have been recently shown capable of stimulating mitochondrial respiration and ROS production and instilling mitohormetic survival adaptations,similarly to,yet independently of,exercise,opening avenues for the future development of Magnetic Mitohormetic interventions for the improvement of human *** viewpoint explores the possibilities and nuances of magnetic-based therapies as a form of clinical intervention to non-invasively activate magnetic mitohormesis for the management of chronic diseases.

关键词： ROS Pulsed electromagnetic fields Mitochondria Myokines Inflammation

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Bibliographical Review on Rehabilitation of Executive Functions in Patients With Developmental Coordination Disorder(DCD)

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Psychology Research 2024年第2期14卷 45-56页

作者： Keiko da Costa Oikawa Fabrício Bruno Cardoso Filipe M.Bonone Samuel pereira de Souza Vitor da Silva Loureiro Alfred Sholl-franco Faculdade Censupeg JoinvilleBrazil Faculdade Censupeg JoinvilleBrazil Universidade Federal do Rio de JaneiroRio de JaneiroBrazil

The present study aims to establish a literature review on intervention programs for executive functions(EFs)through the use of fundamental motor skills,from a neuropsychopedagogical perspective in subjects with Developmental Coordination Disorder(DCD).An exploratory study was carried out through an integrative literature *** research was carried out in the Scientific databases Electronic Library Online(SciELO),Latin American and Caribbean Literature in Health Sciences(LILACS),Virtual Health Library-Psychology Brazil(BVSPSI),Electronic Journals of Psychology(PePSIC),in the periodicals available in the Brazilian Digital Library of Theses and Dissertations(BDTD)and on the website of the Coordination for the Improvement of Higher Education Personnel(CAPES).The covering publications took place from 2018 to 2023,14 articles were selected for *** literature review made it possible to create strategies for stimulating EF and Visuomotor Functions so that educators and other professionals can better deal with students with *** was perceived the need to carry out and develop more empirical research regarding the intervention of EFs and Visuomotor Functions by educators and professionals,with a greater sampling amplitude,to increase the number of studies that enable interventions both in children and in teenagers with DCD.

关键词： developmental coordination disorder executive functions school neuropsychology stimulation of executive functions

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Body Composition, Gynecologic-Obstetric Variables, and Prolactin Levels in Patients with Breast Cancer

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Food and Nutrition Sciences 2023年第4期14卷 315-327页

作者： Luis-alfredo Jiménez-Huerta María-del-Corazón-de-Jesús Huerta-franco Ángel-Haziel Vargas-Huerta Francisco-Miguel Vargas-Luna María-Raquel Huerta-franco Department of General Surgery Mexican Institute of Social Security HGZ 1 of Colima Colima Mexico Division of Social Sciences and Technology Center for Industrial Technical Education (CETI) Guadalajara Mexico Division of Engineering and Sciences Technological Institute of Higher Studies of Monterrey (ITESM) Monterrey Mexico Department of Physical Engineering University of Guanajuato Leon Mexico Department of Applied Sciences to Work University of Guanajuato Leon Mexico

Objective: The aim of this study was to determine body composition, gynecological, and obstetric data, sex hormones, and prolactin serum levels in pre- (PREW) and postmenopausal women (PMW) with breast cancer (BC) and compare them with a control group (CG) of healthy women. Methodology: BC patients without treatment or use of hormone replacement therapy, or hormonal birth control, and without data of metastasis were included. CG was matched for age, BMI, and menstrual cycle status. FSH, LH, E2, progesterone, testosterone, and prolactin (PRL) were measured using radioimmunoassay kits. Comparisons between BC and CG were made with “t” tests, and with the Mann-Whitney U-test;χ2 test was used to compare the qualitative variables between the groups. Results: Seventy-two patients with BC, and 74 CG women were evaluated. Both groups presented overweight data, BMI (kg/mt2) = 27.21 ± 5.51 vs. 28.40 ± 4.66, p = ns, for BC patients and CG, respectively. In PREW, the age at menarche was later in BC patients compared to the CG (13.3 ± 1.36 years vs. 12.41 ± 1.27 years, p = 0.005). The PMW with BC presented a higher age at menarche and menopause compared to the women of the CG (13.51 ± 1.48 vs. 12.91 ± 1.41, p = 0.09, and 49.03 ± 2.86 vs. 45.5 ± 8.78, p = 0.03, respectively). PRL levels were significantly higher in PMW with BC, in comparison with the CG;median and minimum and maximum values (min-max) were: 14.7 ng/mL (3.6 - 52.7) vs. 5.9 ng/mL (1.9 - 33.3), p = 0.005). A higher percentage of PMW with BC (26.0% vs. 7.1%, χ2 = 5.57, p = 0.01) presented hyperprolactinemia (PRL serum levels > 20 ng/mL), compared to the GC. Conclusions: The higher levels of PRL in PMW with BC compared with CG, suggest a proliferative effect of this hormone in the affected breast tissue. This study demonstrates the need to use biological markers such as PRL to determine the risk of BC in PMW.

关键词： Breast Cancer Sex Hormones Prolactin Postmenopausal Women

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Orphan patients with inflammatory bowel disease-when we treat beyond evidence

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World Journal of Gastroenterology 2021年第47期27卷 8047-8057页

作者： Giuseppe Privitera Daniela Pugliese Loris Riccardo Lopetuso franco Scaldaferri alfredo Papa GianLodovico Rapaccini Antonio Gasbarrini Alessandro Armuzzi Dipartimento Universitario di Medicina e Chirurgia Traslazionale UniversitàCattolica del Sacro CuoreRome 00168Italy CEMAD–IBD UNIT-UnitàOperativa Complessa di Medicina Interna e Gastroenterologia Dipartimento di Scienze Mediche e ChirurgicheFondazione Policlinico Universitario"A.Gemelli"IRCCSRome 00168Italy CEMAD–IBD UNIT-UnitàOperativa Complessa di Medicina Interna e Gastroenterologia Dipartimento di Scienze Mediche e ChirurgicheFondazione Policlinico Universitario“A.Gemelli”IRCCSRome 00168Italy Department of Medicine and Ageing Sciences “G.d’Annunzio”University of Chieti-PescaraChieti 66100Italy Center for Advanced Studies and Technology(CAST) “G.d’Annunzio”University of Chieti-PescaraChieti 66100Italy

Inflammatory bowel disease(IBD)is a chronic condition that requires continuous medical *** date,the medical management of patients with moderatelyto-severely active IBD who develop dependence or resistance to corticosteroids is based on immunomodulator *** therapies are licenced after passing through three phases of randomized controlled trials(RCTs),and are subsequently adopted in clinical ***,the real-life population of IBD patients who require these therapies can significantly differ from those included in *** a matter of fact,there is a number of exclusion criteria–nearly ubiquitous in all RCTs–that prevent the enrolment of specific patients:Chronic refractory pouchitis or isolated proctitis in ulcerative colitis,short-bowel syndrome and stomas in Crohn’s disease,ileorectal anastomosis in both ulcerative colitis and Crohn’s disease,and elderly age are some representative *** this frontier article,we aim to give an overview of current literature on this topic,in order to address the main knowledge gaps that need to be filled in the upcoming years.

关键词： Pouchitis Proctitis Stoma Short-bowel Ileo-rectal anastomosis Biologics

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Infliximab does not increase colonic cancer risk associated to murine chronic colitis

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World Journal of Gastroenterology 2016年第44期22卷 9727-9733页

作者： Loris R Lopetuso Valentina Petito Tiziano Zinicola Cristina Graziani Viviana Gerardi Vincenzo Arena Maria Emiliana Caristo Andrea Poscia Giovanni Cammarota alfredo Papa Valerio Cufino Alessandro Sgambato Antonio Gasbarrini franco Scaldaferri Gastroenterology Division Catholic University of Sacred Heart Institute of Pathology Catholic University of Sacred Heart Experimental Center Catholic University of Sacred Heart Institute of Hygiene Catholic University of Sacred Heart Institute of General Pathology Catholic University of Sacred Heart

AIM To explore the influence of Infliximab(IFX) on cancer progression in a murine model of colonic cancer associated to chronic *** AOM/DSS model was induced in C57BL/6 mice. Mice were injected with IFX(5 mg/kg) during each DSS cycle while control mice received saline. Body weight, occult blood test and stool consistency were measured to calculate the disease activity index(DAI). Mice were sacrificed at week 10 and colons were analyzed macroscopically and microscopically for number of cancers and degree of inflammation. MTT assay was performed on CT26 to evaluate the potential IFX role on metabolic activity and proliferation. Cells were incubated with TNF-α or IFX or TNF-α plus IFX, and cell vitality was evaluated after 6, 24 and 48 h. The same setting was used after pre-incubation with TNF-α for 24 *** IFX significantly reduced DAI and body weight loss in mice compared with controls, preserving also colon length at sacrifice. Histological score was also reduced in treated mice. At macroscopic analysis, IFX treated mice showed a lower number of tumor lesions compared to controls. This was confirmed at microscopic analysis, although differences were not statistically significant. In vitro, IFX treated CT26 maintained similar proliferation ability at MTT test, both when exposed to IFX alone and when associated to TNF-α.CONCLUSION IFX did not increase colonic cancer risk in AOM-DSS model of cancer on chronic colitis nor influence directly the proliferation of murine colon cancer epithelial cells.

关键词： Inflammatory bowel disease Ulcerative colitis Colorectal cancer Infliximab AOM-DSS model Cancer on chronic colitis

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The Spreading Depression Propagation: How Electrochemical Patterns Distort or Create Perception

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Open Journal of Biophysics 2021年第2期11卷 133-146页

作者： Vera Maura Fernandes de Lima alfredo pereira Junior Guilherme Lima de Oliveira Centro de Biotecnologia CNEN/IPEN-SP S&atilde o Paulo Brazil Department of Human and Nutritional Sciences Biosciences Inst. UNESP Botucatu S&atilde o Paulo Brazil Sã o Paulo S&atilde o Paulo Brazil

At the transition from quiescence to propagating waves recorded in isolated retinas, a circular electric current closes in the extracellular matrix;this circular current creates a magnetic torus flow that, when entering quiescent tissue in front of the wave, recruits elements and when leaving behind, helps to build the absolute refractory state. The waving magnetic torus is the consequence of the vortex effect and explains the energy boost that drives propagation. Methods: We interpret experimental results from intrinsic and extrinsic fluorescence dyes, voltage, calcium and pH sensitive, optical signals from isolated retinas, and time series recordings using ion exchange resins: Ca, K, pH, Na, Cl recorded extracellularly at retinas, cerebellums and cortices coupled to spreading depression waves. Finally, we checked the ECoG activity, also a time series, at the transition from after discharges to spreading depression in rat hippocampus. Results: The integrated assessment of the diversified measurements led to the realization that the magnetic flow at the wavefront is a major contributor to the wave propagation mechanisms. This flow couples mass and charge flows as a swirling torus from excited to quiescent tissue. Conclusions: An alternative model of the brain is possible, apart from the classical HH and molecular biology model. Physical chemistry of charged gels and its flows explains the results. The conceptual framework uses far from equilibrium thermodynamics.

关键词： Brain Electrochemistry Retinal Model Resonance Spreading Depression Functional CNS Syndromes Vortex Effect

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Use of zebrafish embryos as avatar of patients with pancreatic cancer:A new xenotransplantation model towards personalized medicine

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World Journal of Gastroenterology 2020年第21期26卷 2792-2809页

作者： Gregorio Di franco Alice Usai Niccola Funel Matteo Palmeri Ida Elena Rosamaria Montesanti Matteo Bianchini Desirée Gianardi NiccolòFurbetta Simone Guadagni Enrico Vasile alfredo Falcone Luca Emanuele Pollina Vittoria Raffa Luca Morelli General Surgery Unit Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisa 56124Italy Department of Biology University of PisaPisa 56127Italy Division of Surgical Pathology Department of Laboratory of MedicineHospital-University of PisaPisa 56124Italy Division of Medical Oncology Pisa University HospitalPisa 56124Italy Department of Translational Research and New Technologies in Medicine and Surgery University of PisaPisa 56124Italy EndoCAS(Center for Computer Assisted Surgery) University of PisaPisa 56124Italy

BACKGROUND The response to chemotherapy treatment of patients with pancreatic ductal adenocarcinoma(PDAC)is difficult to predict and the identification of patients who most likely will benefit from aggressive chemotherapy approaches is *** concept of personalized medicine has emerged in the last years with the objective to tailor the medical treatment to the individual characteristics of each patient,and particularly to the tumor biology of each *** need for invivo xenotransplantation models for cancer patients has increased exponentially,and for this reason zebrafish avatars have gained *** studies were conducted also with PDAC *** To develop a simple,not expensive,diffusible zebrafish embryo model as avatar for patients affected by *** Tumor tissue was taken from the surgical specimen by the *** its fragmentation into small pieces,they are stained with *** pieces of stained tissue were transplanted into the yolk of wt AB zebrafish embryos with a glass capillary *** were incubated at 35°C in E3 medium supplemented with 1%Pen/Strep in the presence or absence of drugs for the following days in respect of the treatment plan(Gemcitabine;Gemcitabine and Oxaliplatin;Gemcitabine and nab-Paclitaxel;5-Fluorouracil and Folinic acid and Oxaliplatin and Irinotecan).The response of zebrafish xenografts to the chemotherapy options has been analyzed by monitoring the fluorescent stained area at 2 h post injection(hpi),1 d and 2 d post injection(dpi).In each time point,the mean size of the stained area was measured by ImageJ and it was normalized with respect to the 1 dpi time point mean relative tumor area(RTA).We evaluated the effect of the chemotherapy exposition comparing the mean RTA of each treated subgroup and the control group and evaluating the percentage reduction of the mean RTA by comparing each treated subgroup with the control *** Between July 2018 and October 2019,a t

关键词： Pancreatic ductal adenocarcinoma Zebrafish embryos Personalized medicine Xenotransplantation Chemotherapy efficacy Avatar of oncological patients

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Transhepatic fibrinolysis of mesenteric and portal vein thrombosis in a patient with uIterative colitis: A case report

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World Journal of Gastroenterology 2005年第13期11卷 2035-2038页

作者： alfredo Guglielmi Francesca Fior Orsolya Halmos Gian franco Veraldi Lorenzo Rossaro Andrea Ruzzenente Claudio Cordiano First Department of General Surgery Department of Internal Medicine Claudio Cordiano

AIM: To present a case of acute mesenteric and portal vein thrombosis treated with thrombolytic therapy in a patient with ulcerative colitis in acute phase and to review the literature on thrombolytic therapy of mesenteric-portal system. Treatment of acute portal vein thrombosis has ranged from conservative treatment with thrombolysis and anticoagulation therapy to surgical treatment with thrombectomy and/or intestinal ***: We treated our patient with intraportal infusion of plasminogen activator and then heparin through a percutaneous transhepatic ***: Thrombus resolved despite premature interruption of the thrombolytic treatment for neurological complications, which subsequently ***: Conservative management with plasminogen activator, could be considered as a good treatment for patients with acute porto-mesenteric thrombosis.

关键词：纤维蛋白肠系膜血管栓塞大肠炎病例报告

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