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Impact of chronic kidney disease on mortality in older adults treated with pacemaker implantation

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Journal of Geriatric Cardiology 2017年第10期14卷 597-603页

作者： Fabio Fabbian alfredo de giorgi Matteo Guarino Michele Malagu Matteo Bertini department of Medical Sciences Clinical Medical Unit University Hospital St. Anna University of Ferrara Ferrara Italy department of Medical Sciences Cardiology Unit University Hospital St. Anna University of Ferrara Ferrara Italy

ObjectiveTo 调查长期的肾疾病是否能否定地在为 31 愠汢瑡潩 n 跟随起来的在为回顾的观察学习连续地考虑了 538 个更老的成年人的 bradyarrhythmias.MethodsThis 的承认承认了以后。

关键词： Bradyarrhythmias Charlson comorbidity 索引长期的肾疾病 Comorbidity Glomerular 过滤率死亡心律调整器

Hypertension,abnormal blood pressure circadian pattern,and frailty:data from the literature

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Journal of Geriatric Cardiology 2018年第12期15卷 747-750页

作者： Fabio Fabbian alfredo de giorgi Rosaria Cappadona Dario Gozzi Mauro Pasin Roberto de giorgio Roberto Manfredini Faculty of Medicine Pharmacy and PreventionUniversity of FerraraFerraraItaly department of Internal Medicine General Hospital of FerraraFerraraItaly

According to the National Health and Nutrition Examination Survey(NHANES)data,more than 65%of people aged≥60 years are hypertensive.[1]Diabetes mellitus,dyslipidemia,obesity and renal failure are frequently associate... 详细信息

关键词： Blood pressure Frailty The elderly

Pulmonary embolism and internal jugular vein thrombosis as evocative clues of Lemierre's syndrome:A case report and review of the literature

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World Journal of Clinical Cases 2017年第3期5卷 112-118页

作者： alfredo de giorgi Fabio Fabbian Christian Molino Elisa Misurati Ruana Tiseo Claudia Parisi Benedetta Boari Roberto Manfredini department of Medical Sciences Clinica Medica UnitSchool of MedicineUniversity of FerraraUniversity Hospital of Ferrara

Lemierre’s syndrome(LS)is an uncommon condition with oropharyngeal infections,internal jugular vein thrombosis,and systemic metastatic septic embolization as the main features.Fusobacterium species,a group of strictly anaerobic Gram negative rod shaped bacteria,are advocated to be the main pathogen involved.We report a case of LS complicated by pulmonary embolism and pulmonary septic emboli that mimicked a neoplastic lung condition.A Medline search revealed 173 case reports of LS associated with internal jugular vein thrombosis that documented the type of microorganism.Data confirmed high prevalence in young males with Gram negative infections(83.2%).Pulmonary embolism was reported in 8.7% of cases mainly described in subjects with Gram positive infections(OR=9.786;95%CI:2.577-37.168,P=0.001),independently of age and gender.Only four fatal cases were reported.LS is an uncommon condition that could be complicated by pulmonary embolism,especially in subjects with Gram positive infections.

关键词： Lemierre’s syndrome Pulmonary embolism Fusobacterium species Internal jugular vein thrombosis Systemic septic embolization

Heart and lung, a dangerous liaison-Tako-tsubo cardiomyopathy and respiratory diseases: A systematic review

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World Journal of Cardiology 2014年第5期6卷 338-344页

作者： Roberto Manfredini Fabio Fabbian alfredo de giorgi Marco Pala Alessandra Mallozzi Menegatti Claudia Parisi Elisa Misurati Ruana Tiseo Massimo Gallerani Raffaella Salmi Eduardo Bossone Clinica Medica Azienda Ospedaliera-Universitaria of Ferrara 44124 Cona Ferrara Italy 1st Internal Medicine Unit Azienda Ospedaliera-Universitaria of Ferrara 44124 Cona Ferrara Italy 2nd Internal Medicine Unit Azienda Ospedaliera-Universitaria of Ferrara 44124 Cona Ferrara Italy Cardiology Unit Azienda Ospedaliera-Universitaria of Salerno 84131 Salerno Italy

AIM: To investigate the possible association between Tako-tsubo cardiomyopathy(TTC)-a reversible clini-cal condition mimicking an acute myocardial infarction characterized by multifactorial pathophysiologic mecha-nisms- and respiratory system diseases. METHODS: We systematically searched PubMed and EMBASE medical information sources, to identify the different triggering causes, limiting our search to ar-ticles in English. The search keywords were: "tako-tsubo cardiomyopathy", "takotsubo", "takotsubo cardiomyopa-thy", "broken heart syndrome", "stress-induced cardio-myopathy", "apical ballooning syndrome", and "ampulla cardiomyopathy in combination with respiratory dis-eases, lung, pulmonary disease. For each kind of dis-ease, we registered: author, year and country of study, patient sex, age, concurring situation, and outcome. RESULTS: Out of a total of 1725 articles found, we se-lected 37 papers reporting a total of 38 patients. As ex-pected, most patients were women(81.6%), mean age was 65 ± 10 years. Outcome was favorable in 100% of cases, and all the patients have been discharged un-eventfully in a few days. CONCLUSION: An association between respiratory diseases and TTC is likely to exist. Patients with severe respiratory diseases, due to the high dosages of β2-agonists used or to the need of invasive procedures, are highly exposed to the risk of developing TTC.

关键词： Tako-tsubo cardiomyopathy Stress cardiomyopathy Respiratory diseases Lung Chronic obstructive pulmonary disease Asthma

First-line pazopanib in patients with advanced non-clear cell renal carcinoma:An Italian case series

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World Journal of Clinical Oncology 2021年第11期12卷 1037-1046页

作者： Sebastiano Buti Melissa Bersanelli Francesco Massari Ugo de giorgi Orazio Caffo Gaetano Aurilio Umberto Basso Giacomo Carteni Claudia Caserta Luca Galli Francesco Boccardo Giuseppe Procopio Gaetano Facchini Giuseppe Fornarini alfredo Berruti Elena Fea Emanuele Naglieri Fausto Petrelli Roberto Iacovelli Camillo Porta Alessandra Mosca Medical Oncology Unit University Hospital of ParmaParma 43126Italy Medicine and Surgery department University of ParmaParma 43126Italy Division of Oncology Policlinico Sant’Orsola-Malpighi HospitalBologna 40138Italy department of Oncology IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori(I.R.S.T.)Meldola 47014Italy department of Medical Oncology Santa Chiara HospitalTrento 38122Italy department of Medical Oncology Division of Urogenital and Head and Neck TumoursEuropean Institute of Oncology IRCCSMilan 20141Italy Medical Oncology Unit 3 Istituto Oncologico Veneto IOV IRCCSCastelfranco VenetoPadova 31033Italy Division of Oncology Azienda Ospedaliera di Rilievo Nazionale A.CardarelliNapoli 80131Italy Medical Oncology Unit Azienda Ospedaliera S.MariaTerni 05100Italy Oncology Unit 2 University Hospital of PisaPisa 56126Italy Academic Unit of Medical Oncology IRCCS San Martino Polyclinic HospitalGenova 16132Italy Medical Oncology Genitourinary Section Fondazione IRCCS Istituto Nazionale Dei TumoriMilan 20133Italy departmental Unit of Clinical and Experimental Uro-Andrologic Oncology Istituto Nazionale Tumori IRCCS Fondazione G.PascaleNapoli 80131Italy Medical Oncology Unit Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)Ospedale Policlinico San MartinoGenova 16132Italy University of Brescia ASST-Spedali CiviliBresciaBrescia 25123Italy Medical Oncology Unit S Croce and Carle Teaching HospitalCuneo 12100Italy Division of Medical Oncology Istituto Tumori G Paolo IIIRCCSBari 70124Italy Medical Oncology Unit ASST Bergamo OvestTreviglioBergamo 24047Italy Medical Oncology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00161Italy Division of Oncology AOU Consorziale Policlinico di BariBari 70124Italy department of Biomedical Sciences and Human Oncology University of Bari"A.Moro"Bari 70124Italy Multidisciplinary Outpatient Oncology Clinic Candiolo Cancer InstituteFPO-IRCCSCandioloTurin 10060Italy

BACKGROUND Non-clear cell(ncc)metastatic renal-cell carcinoma(RCC)has dismal results with standard systemic therapies and a generally worse prognosis when compared to its clear-cell counterpart.New systemic combination therapies have emerged for metastatic RCC(mRCC),but the pivotal phase III trials excluded patients with nccRCC,which constitute about 30%of metastatic RCC cases.AIM To provide a piece of real-life evidence on the use of pazopanib in this patient subgroup.METHODS The present study is a multicenter retrospective observational analysis aiming to assess the activity,efficacy,and safety of pazopanib as first-line therapy for advanced nccRCC patients treated in a real-life setting.RESULTS Overall,48 patients were included.At the median follow-up of 40.6 mo,the objective response rate was 27.1%,the disease control rate was 83.3%,and the median progression-free survival and overall survival were 12.3(95%confidence interval[CI]:3.6-20.9)and 27.7(95%CI:18.2-37.1)mo,respectively.Grade 3 adverse events occurred in 20%of patients,and no grade 4 or 5 toxicities were found.CONCLUSION Pazopanib should be considered as a good first-line option for metastatic RCC with variant histology.

关键词： Pazopanib Non-clear cell Kidney cancer Renal-cell carcinoma Variant histology Tyrosine kinase inhibitors