检索结果-南通市图书馆

H pylori status and angiogenesis factors in human gastric carcinoma

World Journal of Gastroenterology 2006年第34期12卷 5465-5472页

作者： Anita Mangia Annalisa Chiriatti Girolamo Ranieri Ines Abbate Maria Coviello Giovanni Simone Francesco alfredo Zito Severino Montemurro Antonello Rucci alfredo Di Leo Stefania Tommasi Pasquale Berloco Jian Ming Xu Angelo Paradiso Clinical Experimental Oncology Laboratory National Cancer Institute 70126 Bari Italy Interventional Radiology Unit National Cancer Institute 70126 Bari Italy Chemical-Clinical-Microbiology and Immunology Laboratory Unit National Cancer Institute70126 Bari Italy Histopathology Unit National Cancer Institute 70126 Bari Italy Gastroenterology Surgical Unit National Cancer Institute Bari Italy Department of Emergency and Organ Transplantation Section of Gastroenterology University of Bari Italy Laboratory of Biochemistry IRCCS 'Saverio de Bellis' Castellana Grotte (BA) Italy Department of Gastrointestinal Cancer Beijing 307 Hospital Cancer Center Beijing China

AIM： To investigate H pylori expression in gastric cancer patients in relation to primary tumor angiogenic markers, such as microvessel density （MVD）, thymidine phosphorylase （TP）, vascular endothelial growth factor receptor-1 （VEGF-R1）, p53 and circulating VEGF levels. METHODS： Angiogenic markers were analyzed immunohistochemically in 56 primary gastric cancers. H pylori cytotoxin （vacA） and the cytotoxin-associated gene （cagA） amplification were evaluated using PCR assay. Serum H pylori IgG antibodies and serum/plasma circulating VEGF levels were detected in 39 and 38 patients by ELISA, respectively. RESULTS： A total of 69% of patients were positive for circulating IgG antibodies against Hpylori. cagA-positive H pylor/strains were found in 41% of gastric patients. vacA was found in 50% of patients; s1 strains were more highly expressed among vacA-positive patients. The presence of the s1 strain was significantly associated with cagA （P = 0.0001）. MVD was significantly correlated with both tumor VEGF expression （r = 0.361, P = 0.009） and serum VEGF levels （r = -0.347, P = 0.041）.Conversely, neither VEGF-R1 expression nor MVD was related to p53 expression. However, H pylori was not related to any angiogenic markers except for the plasma VEGF level （P = 0.026）. CONCLUSION： H pylori antigen is related to higher plasma VEGF levels, but not to angiogenic characteristics. It can be hypothesized that the toxic effects of H pylori on angiogenesis occurs in early preclinical disease phase or in long-lasting aggressive infections, but only when high H pylori IgG levels are persistent.

关键词： H pylori Gastric carcinoma Angiogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanoparticles-based nanochannels assembled on a plastic flexible substrate for label-free immunosensing

引用

Nano Research 2015年第4期8卷 1180-1188页

作者： alfredo de la Escosura-Muniz Marisol Espinoza-Castaneda Madoka Hasegawa Laetitia Philippe Arben Merkoci ICN2-Nanobioelectronics & Biosensors Group Institut Catala de Nanociencia i Nanotecnologia Campus UAB 08193 Bellaterra (Barcelona) Spain EMPA Swiss Federal Laboratories for Materials Science and Technology Feuerwerkerstrasse 39 3602Thun Switzerland ICREA-Institucio Catalana de Recerca i Esrudis Avan@ats 08010 Barcelona Spain

A novel, cheap, disposable and single-use nanoparticles-based nanochannel platform assembled on a flexible substrate for label-free immunosensing is pre- sented. This sensing platform is formed by the dip-coating of a homogeneous and assembled monolayer of carboxylated polystyrene nanospheres （PS, 200 and 500 nm-sized） onto the working area of flexible screen-printed indium tin oxide/polyethylene terephthalate （ITO/PET） electrodes. The spaces between the self-assembled nanospheres generate well-ordered nanochannels, with inter-PS particles distances of around 65 and 24 nm respectively. The formed nanochannels are used for the effective immobilization of antibodies and subsequent protein detection based on the monitoring of [Fe（CN）6]^4- flow through diffusion and the decrease in the differential pulse voltammetric signal upon immunocomplex formation. The obtained sensing system is nanochannel-size dependent and allows human immunoglobulin G （IgG）（chosen as a model analyte） to be detected at levels of 580 ng/mL. The system also exhibits an excellent specificity against other proteins present in real samples and shows good performance with a human urine sample. The developed device represents an integrated and simple biodetection system which overcomes many of the limitations of previously reported nanochannels-based approaches and can be extended in the future to several other immuno and DNA detection systems.

关键词： nanochannel dip-coating.electrochemical biosensor label-free immunosensing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modelling of adsorption of textile dyes over multi-walled carbon nanotubes:Equilibrium and kinetic

引用

Chinese Journal of Chemical Engineering 2017年第4期25卷 523-532页

作者： Danilo Vuono Enrico Catizzone alfredo Aloise Alfonso Policicchio Raffaele G.Agostino Massimo Migliori Girolamo Giordano University of Calabria Department of Environmental and Chemical Engineeringvia P.Bucci1-87036 RendeCSItaly University of Calabria Department of Physicsvia P.Bacd1-87036 RendeCSItaly

The paper deals with the application of multiwall carbon nanotubes(CNTs) to the adsorption of dyes from wastewater. Textile dyes are dangerous and diffused pollutant in wastewater, and the paper results confirmed the good adsorption ability of CNTs, with respect to classic active carbon, even for different dye types. The effect of surface treatments of CNTs was primarily investigated, revealing that neither the presence of residual catalyst nor common surface treatment(oxidation) affects the CNT's performances. Therefore less expensive nonpurified CNTs were assessed as good and economically convenient alternative for the process. In order to gain in generality in adsorption kinetic modelling, the parameters of the "best fitting" pseudo-second order model have been correlated to the main process variables(the dye initial concentration and the specific mass of CNTs.) setting-up a predictive kinetic model useful design new application of these materials in currently operating industrial operations for adsorption. In addition, isothermal data were used to screen all the relevant adsorption isotherms models and the Temkin model was confirmed as the more effective to accurately fit equilibrium data for any of the considered different dye types.

关键词： wastewater walled classic isotherms dangerous pollutant economically expensive currently adsorbent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Production of Camphene by Isomerization Reaction on Sulfated ZrO_2

引用

Chinese Journal of Chemical Engineering 2000年第1期8卷 64-67页

作者： Nora Alejandra Comelli Omar Masini alfredo Lzaro Carrascull Esther Natalia Ponzi Marta Isabel Ponzi INTEQUI(CONICET-UNSL) Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaCINDECA(CONICET-UNLP)Calle 47 N°2571900 La PlataArgentina

The kinetics of camphene production in liquid phase from α-pinene was experimentally determined in an isothermal batch reactor. To this end, a sulfated ZrO2 catalyst was used and the reaction studied in the temperature range of 370-403 K. By analyzing the experimental data, second reaction order for α-pinene was found. A kinetic model is presented which includes term for the catalyst load used. The specific rate constant at 393K was 2.19×10^-3 mol·L^-1·min^-1, the activation energy being 93kJ·mo1·^-1. Both values are within the range of literature results.

关键词：生产工艺莰烯异构化反应硫酸盐催化剂 ZrO2 反应动力学 α-蒎烯

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatocellular carcinoma in cirrhotic patients with portal hypertension:Is liver resection always contraindicated?

引用

World Journal of Gastroenterology 2011年第46期17卷 5083-5088页

作者： Andrea Ruzzenente Alessandro Valdegamberi Tommaso Campagnaro Simone Conci Silvia Pachera Calogero Iacono alfredo Guglielmi Department of Surgery Division of General Surgery"A"GB Rossi HospitalUniversity of Verona

AIM:To analyze the outcome of hepatocellular car-cinoma(HCC)resection in cirrhosis patients,related to presence of portal hypertension(PH)and extent of ***:A retrospective analysis of 135 patients with HCC on a background of cirrhosis was submitted to curative liver ***:PH was present in 44(32.5%)*** mortality and morbidity were 2.2% and 33.7%,*** survival time in patients with or without PH was 31.6 and 65.1 mo,respectively(P=0.047);in the subgroup with Child-Pugh class A cirrhosis,median survival was 65.1 mo and 60.5 mo,respectively(P=0.257).Survival for patients submitted to limited liver resection was not significantly different in presence or absence of ***,median survival for patients after resection of 2 or more segments with or without PH was 64.4 mo and 163.9 mo,respectively(P=0.035).CONCLUSION:PH is not an absolute contraindication to liver resection in Child-Pugh class A cirrhotic patients,but resection of 2 or more segments should not be recommended in patients with PH.

关键词： Liver surgery Hepatic resection Hepatocellular carcinoma Portal hypertension

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular structure, pharmacokinetics and clinical evidence of brolucizumab: a narrative review

引用

Annals of Eye Science 2021年第4期6卷 49-60页

作者： Francesco Pignatelli alfredo Niro Fedele Passidomo Giuseppe Addabbo Eye Clinic Hospital“SS.Annunziata”ASL TarantoTarantoItaly

Macular neovascularization(MNV)is the hallmark of neovascular age-related macular degeneration(nAMD),one of the leading causes of vision loss in the developed *** current MNV standard of care including frequent intravitreal anti-vascular endothelial growth factor(VEGF)injections,although has revolutionized favorably the treatment,places a substantial burden on patients,caregivers,and *** is a newly developed single-chain antibody fragment that inhibits activation of VEGF receptor 2 with in vitro affinity and potency comparable to commercially-available anti-VEGF *** small molecular weight and its design allow for high solubility and retinal tissue penetration,and improve binding affinity to the *** a high clearance rate leading to minimal systemic exposure was *** has shown similar gains in visual acuity compared with other anti-VEGF molecules but a higher and earlier resolution of nAMD related fluid,achieving sustained macular dryness with longer mantainance injection interval ranging from 8 to 12 weeks after monthly loading *** cases of ocular inflammation also including retinal vasculitis and retinal vascular occlusions referred to an immune-mediated reaction posed safety concerns on selected patients and mantainance treatment interval shorter than 8 *** present review summarizes several key points including the molecular structure and pharmacokinetics,the preclinical and clinical evidence of brolucizumab administration evaluating its efficacy,tolerability,and safety,extended dosing regimens and other indications still under clinical investigation.

关键词： Neovascular age-related macular degeneration(nAMD) anti-vascular endothelial growth factor(anti-VEGF) single-chain antibody fragment brolucizumab

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of basement structural and stratigraphic heritages on volcano behaviour and implications for human activities （the IGCP project 455）

引用

Episodes 2005年第3期28卷 158-170页

作者： Alessandro Tibaldi alfredo Mahar F. A. Lagmaye Vera V. Ponomareva Università degli Studi di Milano-Bicocca Dipartimento di Scienze Geologiche e Geotecnologie Milan Italy National Institute of Geological Sciences Quezon City Philippines Institute of Volcanology and Seismology Petropavlovsk-Kamchatsky Russia

The IGCP project 455 （2001-2005） is intended to con- tribute to the comprehension of volcano behaviour in different geodynamic settings from a poorly known perspective： the reciprocal influence exerted by volcanoes on their substrate and by the basement on the volcanoes. The main task is to assess the role of this influence in determining natural geological hazards such as eruptions, landslides and earthquakes. The geologic-tectonic control of the substrate on the volcanoes has been usually considered questionable or less important than the conditions of the deep magma source, whereas the control of volcanoes on their basement has even received very little attention. This project improves the comprehension of these phenomena by a strong interdisciplinary approach that ties data on the various geological conditions and heritages of the basement with the deformation processes and geological evolution of different volcanic edifices. We compiled stratigraphic, structural, geomorphological, geophysical, geotechnical, petrographic, geochemical and geochronological data. These data have been transferred to the laboratory-working groups, thus providing realistic numerical and physical simulation even of complex geological structures. Here we present a selection of the main results obtained for some of the studied key volcanoes. Alicudi （Italy） located in a low-tectonic rate setting, Stromboli （Italy） in extensional tectonic setting, Reventador （Ecuador） in compressional setting, and the Northern Volcanic Group of Kamchatka （Russia）, Galeras （Colombia） and Mayon （Philippines） in a transtensional setting.

关键词：火山地层地质条件人类活动

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Luminescence Characteristics of LaAlO<sub>3</sub>:Eu<sup>3+</sup>Obtained by Modified Pechini’s Method

引用

Open Journal of Synthesis Theory and Applications 2017年第1期6卷 1-12页

作者： alfredo Morales Hernández Mayra A. de León Alfaro Antonio barrera Villatoro Ciro Falcony Teodoro Rivera Montalvo Juan Zarate Medina Instituto de Investigaciones en Metalurgia y Materiales Universidad Michoacana de San Nicolás de Hidalgo Morelia México Instituto Politécnico Nacional Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada Ciudad de México México Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Ciudad de México México

The aim of the present work was to investigate the luminescent properties of europium-doped lanthanum aluminate (LaAlO3) powder prepared by Modified Pechini (MP) method. Samples were prepared at different Eu3+ concentrations and calcined at 1600°C. Structural and morphology characterizations were obtained by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscope (TEM). Luminescent properties were analyzed by photoluminescence (PL) and thermoluminescent phenomena. The XRD pattern shows pure lanthanum aluminate oxide LaAlO3 with a rhombohedral structure. Photoluminescence studies of the powders was related to 4f → 4f(5D0 → 7Fi) (i = 1, 2, 3, 4) transitions of Eu3+ ion, the most intense emission of Eu3+ in LaAlO3 was registered for the transition 5D0 → 7F1, for 5% of Eu3+. The recorded TL glow curves of excited samples showed a main TL peak, the main peak appeared its maximum as a function of excitation energy. The investigation demonstrates that polycrystalline LaAlO3:Eu3+ powders calcined at 1600°C have interesting luminescent characteristics.

关键词： Modified Pechini Method LaAlO3:Eu3+ Photoluminescence Thermoluminescence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatocellular adenoma: An unsolved diagnostic enigma

引用

World Journal of Gastroenterology 2019年第20期25卷 2442-2449页

作者： Matteo Renzulli alfredo Clemente Francesco Tovoli Salvatore Cappabianca Luigi Bolondi Rita Golfieri Radiology Unit Department of ExperimentalDiagnostic and Speciality MedicineSant’Orsola HospitalUniversity of BolognaBologna 40138Italy Radiology and Radiotherapy Unit Department of Precision MedicineUniversity of Campania "L. Vanvitelli"Naples 80138Italy Unit of Internal Medicine Department of Medical and Surgical SciencesUniversity of BolognaBologna 40138Italy

Hepatocellular adenoma (HCA) is a rare benign liver tumour associated with the use of oral contraceptives or other steroid medications which occurs predominantly in young and middle-aged women. Unlike other benign liver tumours, an HCA may be complicated by bleeding and malignant transformation. HCAs have been divided into four subtypes based on molecular and pathological features: hepatocyte nuclear factor 1α-mutated HCA, inflammatory HCA,β-catenin-mutated HCA, and unclassified HCA.β-cateninmutated HCA has the highest risk of haemorrhage or malignant transformation. In the latest upgrade of the guidelines regarding the management of benign liver tumours published in 2016 by the European Association for the Study of the Liver, magnetic resonance imaging (MRI) was recognized to be superior to all other imaging modalities in detecting HCAs and in being able to subtype HCAs up to 80%, with positive identification of 1α-mutated HCA or inflammatory HCA achievable with > 90% specificity. This review analyzed the imaging features of HCA using MRI with hepato-specific contrast agents, focusing on the limitations in the HCA characterization.

关键词： Hepatocellular adenoma Magnetic resonance imaging Hepato-specific contrast media Liver neoplasm Gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insights into induction of the immune response by the hepatitis B vaccine

引用

World Journal of Gastroenterology 2022年第31期28卷 4249-4262页

作者： Federico Alejandro Di Lello alfredo Pedro Martínez Diego Martín Flichman Microbiology Universidad de Buenos Aires.Facultad de Farmacia y Bioquímica.Instituto de Investigaciones en Bacteriología y Virología MolecularBuenos Aires C1113AADArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires C1425FQBArgentina Virology Section Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno“CEMIC”Buenos Aires C1431FWOArgentina Microbiology Universidad de Buenos AiresInstituto de Investigaciones Biomédicas en Retrovirus y Síndrome de Inmunodeficiencia AdquiridaBuenos Aires C1121ABGArgentina

After more than four decades of hepatitis B virus(HBV)vaccine implementation,its safety and efficacy in preventing HBV infection have been proven and several milestones have been *** countries have included HBV immunization schedules in their health policies and progress has been made regarding universalization of the first HBV vaccine dose at *** of these actions have significantly contributed to reducing both the incidence of HBV infection and its related ***,there are still many drawbacks to *** main concerns are the deficient coverage rate of the dose at birth and the large adult population that has not been reached timely by universal ***,the current most widely used second-generation vaccines do not induce protective immunity in 5%to 10%of the population,particularly in people over 40-years-old,obese(body mass index>25 kg/m2),heavy smokers,and patients undergoing dialysis or infection with human immunodeficiency *** developed and approved novel vaccine formulations using more potent adjuvants or multiple antigens have shown better performance,particularly in difficult *** advances re-launch the expectations of achieving the World Health Organization’s objective of completing hepatitis control by 2030.

关键词： Hepatitis B virus Vaccine Immune response Antibodies Neutralizing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：