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Identifying prognostic factors for conservative treatment outcomes in servicemen with chronic exertional compartment syndrome treated at a rehabilitation center

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Military Medical Research 2018年第3期5卷 199-206页

作者： Mariette Z.Meulekamp Peter van der Wurff alfred van der meer Cees Lucas Research and Development Military Rehabilitation CentreAardenburgDoomthe Netherlands Department of Physiotherapy HU University of Applied SciencesUtrechtthe Netherlands Department of Clinical Epidemiology Biostatistics and BioinformaticsAcademic Medical CentreUniversity of AmsterdamAmsterdamthe Netherlands

Background: Chronic exertional compartment syndrome(CECS) is a condition of pain induced by exercise, and it is characterized by muscle swelling and impaired muscle function in the lower leg. Given the diversity in the diagnosis and treatment of CECS, it is desirable to determine variables pertaining to prognosis and recovery. The purpose of this study is to identify prognostic factors for conservative treatment outcomes in servicemen with CECS who were treated at a Military Rehabilitation ***: Patients from all military services were referred from the special unit for lower leg pain at the Central Military Hospital, Utrecht, the Netherlands. Descriptive analysis was used to report the characteristics of the participants and their baseline measurements. Group differences were analyzed using a Student's t-test or MannWhitney U test, according to the normality of the data distribution. Differences between the pre-and postintervention outcomes were evaluated using the Wilcoxon signed rank test. To evaluate the magnitude of prognostic factors, a univariate logistic regression analysis was performed. The prognostic factors included age, body mass index, body fat percentage, self-efficacy beliefs, foot malalignment, intramuscular pressure, other comorbidities, protein and creatine use, smoking, alcohol use, complaint duration, physical demands, and duration of military ***: After the rehabilitation period, we observed 25 patients with a successful outcome, which was defined as a reduction in pain(≥2 points) during the capacity test measured using a verbal rating scale and 20 patients with an unsuccessful outcome. Factors demonstrating a limited increased odds ratio for an unsuccessful outcome included smoking, alcohol use, intramuscular pressure, a complaint duration of more than 6 months, and physical demands of service. However, these factors did not reach ***: This study did not identify any prognostic factors that predict the

关键词： Lower leg pain Observational study Rehabilitation

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TAUS Back in China

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中国翻译 2012年第5期33卷 60-61页

作者： Jaap van der meer TAUS

由翻译自动化用户协会(TAUS)主办,赛迪集团和中国翻译协会协办的"TAUS亚洲翻译峰会"于2012年4月25-26日在北京举行。大会主题为:语言业务创新(Language Business Innovation),重点讨论语言行业的新战略和新技术。本刊特邀TAUS会长Jaap V... 详细信息

由翻译自动化用户协会(TAUS)主办,赛迪集团和中国翻译协会协办的"TAUS亚洲翻译峰会"于2012年4月25-26日在北京举行。大会主题为:语言业务创新(Language Business Innovation),重点讨论语言行业的新战略和新技术。本刊特邀TAUS会长Jaap van der meer先生向中国的业内人士介绍此次大会的具体情况。

关键词：翻译自动化语言行业翻译方法语言学

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One-Step Reverse Osmosis Based on Riverbank Filtration for Future Drinking Water Purification

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Engineering 2022年第2期8卷 27-34页

作者： Yujia Zhai Gang Liu Walter G.J.van der meer Oasen Drinkwater Gouda 2800 ACNetherlands Faculty of Science and Technology University of TwenteEnschede 7500 AENetherlands Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Sanitary Engineering Research Group Department of Water ManagementFaculty of Civil Engineering and GeosciencesDelft University of TechnologyDelft 2600 GANetherlands

The presence of newly emerging pollutants in the aquatic environment poses great challenges for drink-ing water treatment *** to their low concentrations and unknown characteristics,emerging pol-lutants cannot be efficiently removed by conventional water treatment processes,making technically,economically,and environmentally friendly water purification technologies increasingly *** article introduces a one-step reverse osmosis(OSRO)concept consisting of riverbank filtration(RBF)and reverse osmosis(RO)for drinking water *** OSRO concept combines the relatively low-cost natural pretreatment of river water with an advanced engineered purification *** pro-vides a continuous natural source of water with stable water quality and a robust barrier for *** the pre-removal of particles,organic matter,organic micro-pollutants(OMPs),and microbes,RBF becomes an ideal source for a purification system based on RO membranes,in comparison with the direct intake of surface *** treatment removes almost 99.9%of the particles,pathogens,viruses,and OMPs,as well as the vast majority of nutrients,and thus meets the requirements for the chlorine-free delivery of drinking water with high *** OSRO treatment is cost effective com-pared with the standard conventional series of purification steps involving sprinkling filters,softening,and activated *** bank filtration(ABF),which functions as an artificial recharge in combi-nation with a sand filtration system,is proposed as an alternative for RBF in the OSRO concept to supply drinking water from locally available *** is also suggested that the OSRO concept be imple-mented with wind power as an alternative energy source in order to be more sustainable and *** OSRO-based decentralized water system is proposed for water reclaiming and *** is suggested that future water treatment focus on the combination of natural and engineered systems to pro

关键词： Drinking water treatment River bank filtration Reverse osmosis Artificial bank filtration Water reclamation and reuse

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Outcome of direct-acting antiviral treatment for patients with chronic hepatitis C virus infection: clinical benefit proven?

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 257-259页

作者： Raoel Maan Adriaan J.van der meer Department of Gastroenterology and Hepatology Erasmus MC University Medical Center RotterdamRotterdamthe Netherlands

The highly effective direct-acting antivirals(DAAs)for the treatment of chronic hepatitis C virus(HCV)infection were well-received by both patients and physicians as sustained virological response(SVR)was associated with an improved overall survival in patients with stable liver disease,even in case of cirrhosis(1).Yet,at that time these results were derived from retrospective cohort studies with long-term follow-up after interferon-based *** patients with compensated liver disease there is confidence that SVR is a clinically relevant endpoint based on consistent positive results with smart use of statistics in numerous cohort ***,however,there remains a need for long-term follow-up data showing a clinical benefit of DAA-induced SVR,preferably with high-quality prospective *** results from the French ANRS CO22 Hepather cohort,as published by *** and colleagues in the April issue of the Lancet,thus bring an important contribution to the field(2).It’s the first prospective cohort study with reasonable follow-up time to assess all-cause mortality after DAA therapy.

关键词： patients infection clinical

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Hepatocellular carcinoma (HCC) risk stratification after virological cure for hepatitis C virus (HCV)-induced cirrhosis: time to refine predictive models

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 385-387页

作者： Raoel Maan Adriaan J.van der meer Department of Gastroenterology and Hepatology Erasmus MC University Medical Center RotterdamRotterdamThe Netherlands

Direct-acting antivirals(DAAs)have revolutionized antiviral treatment for chronic hepatitis C virus(HCV)infection,especially with the interferon-free regimens of the past 5 *** a cure for a virus that has been identified(only)30 years ago is unique in medical ***,even in case of advanced liver disease,cohort studies showed that patients attaining a sustained virological response(SVR)have a 3-to 4-fold reduced risk of hepatocellular carcinoma(HCC)(1-3).

关键词： sustained interferon hepatitis

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Selective expansion and CMV-dependency in pregnancy trained human endometrial NK cells

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Cellular & Molecular Immunology 2019年第4期16卷 410-411页

作者： D.Feyaerts A.van der meer I.Joosten R.G.van der Molen Department of Laboratory Medicine Laboratory for Medical ImmunologyRadboud Institute for Molecular Life SciencesRadboud University Medical Center6500HB NijmegenThe Netherlands

Natural killer(NK)cells are innate lymphocytes that specialize in discriminating and killing altered self-cells,such as malignant and virus-infected ***,during pregnancy,local uterine NK cells do not exhibit this killing capacity and display an important regulatory role by promoting trophoblast invasion and spiral artery remodeling and ensuring correct placentation.1 Over the past decade,it has become clear that NK cells possess adaptive properties and innate immune memory.2 In humans,memory NK cells have mainly been described as expansions of NKG2C+and LILRB1+peripheral blood NK cells(pbNK),3 and pbNK cell subpopulation expansions expressing self-specific killer-immunoglobulin-like receptors(KIR)4 following cytomegalovirus(CMV)infection.

关键词： pregnancy killer invasion

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Selective expansion of human natural killer cells leads to enhanced alloreactivity

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Cellular & Molecular Immunology 2014年第2期11卷 160-168页

作者： Diana N Eissens Clive M Michelo Frank WMB Preijers Bram van Cranenbroek Houwelingen Arnold van der meer Irma Joosten Department of Laboratory Medicine--Laboratory of Medical Immunology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands and Department of Laboratory Medicine--Laboratory of Hematology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands These authors contributed equally to this work.

In allogeneic stem cell transplantation （SCT）, natural killer （NK） cells lacking their cognate inhibitory ligand can induce graft-versus-leukemia responses, without the induction of severe graft-versus-host disease （GVHD）. This feature can be exploited for cellular immunotherapy. In this study, we examined selective expansion of NK cell subsets expressing distinct killer immunoglobulin-like receptors （KIRs） within the whole human peripheral blood NK cell population, in the presence of HLA-Cw3 （C1） or Cw4 （C2） transfected K562 stimulator cells. Coculture of KIR＋ NK cells with C1 or C2 positive K562 cells, in the presence of IL-2＋ IL-15, triggered the outgrowth of NK cells that missed their cognate ligand. This resulted in an increased frequency of alloreactive KIR＋ NK cells within the whole NK cell population. Also, after preculture with K562 cells lacking their cognate ligand, we observed that this alloreactive NK population revealed higher numbers of CD107~ cells when cocultured with the relevant K562 HLA-C transfected target cells, as compared to coculture with untransfected K562 cells. This enhanced reactivity was confirmed using primary leukemic cells as target. This study demonstrates that HLA class I expression can mediate the skewing of the NK cell repertoire and enrich the population for cells with enhanced alloreactivity towards leukemic target cells. This feature may support future clinical applications of NK cell-based immunotherapy.

关键词： alloreactivity cytotoxicity immunotherapy KIR NK cells stem cell transplantation

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Effects of light intensity and photoperiod on the growth and stress response of juvenile Nile tilapia(Oreochromis niloticus)in a recirculating aquaculture system

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Aquaculture and Fisheries 2023年第1期8卷 85-90页

作者： Kui Wang Kang Li Liping Liu Cristina Tanase Rainier Mols Michiel van der meer National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China Shanghai Engineering Research Center of Aquaculture Shanghai201306China International Research Center for Marine Biosciences at Shanghai Ocean University Ministry of Science and TechnologyShanghai201306China Philips Lighting Aquaculture AE Eindhoven5656the Netherlands

Light is an essential natural factor of fish growth and development.A light regime in indoor aquaculture is critical for sustainable fish *** research aimed to investigate the effect of light intensity and photoperiod on the growth performance and stress response of Nile tilapia(Oreochromis niloticus),which is an important commercial species,in a recirculating aquaculture system(RAS).Fingerlings with an average weight of 5±0.9 g were randomly assigned to nine 1.5 m3 tanks with 145 fish in each tank,cultured under different light intensities(1000,2000,and 3000 lx)and photoperiods(12L:12D,18L:6D,24L:0D),and fed to apparent satiation twice a day for 160 *** growth of tilapia subjected to 2000 lx was significantly better than that exposed to 1000 and 3000 lx(P0.05).Light intensity and photoperiod manipulation did not cause a significant chronic stress response in *** study demonstrated that light intensity,especially at 2000 lx,and photoperiod manipulation could stimulate the growth of tilapia in the RAS and significantly affect economic *** study also served as an important reference for tilapia indoor aquaculture.

关键词： Recirculating aquaculture system Tilapia Light intensity Photoperiod Growth Stress response

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Preferential binding between intracellular organic matters and Al_(13) polymer to enhance coagulation performance

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Journal of Environmental Sciences 2019年第2期31卷 1-11页

作者： Ruiping Liu Tingting Guo Min Ma Mingquan Yan Jing Qi Chengzhi Hu Gang Liu Huijuan Liu Jiuhui Qu Walter van der meer Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Beijing University of Technology Beijing Waterworks Group Department of Environmental Engineering Peking University Sanitary Engineering Department of Water ManagementFaculty of Civil Engineering and GeosciencesDelft University of Technology State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of Sciences Science and Technology University of Twente

Coagulation is the best available method for removing intracellular organic matter(IOM),which is released from algae cells and is an important precursor to disinfection by-products in drinking water treatment. To gain insight into the best strategy to optimize IOM removal, the coagulation performance of two Al salts, i.e., aluminum chloride(AlCl_3) and polyaluminum chloride(PACl, containing 81.2% Al_(13)), was investigated to illuminate the effect of Al species distribution on IOM removal. PACl showed better removal efficiency than AlCl_3 with regard to the removal of turbidity and dissolved organic carbon(DOC), owing to the higher charge neutralization effect and greater stability of pre-formed Al_(13) species. High pressure size exclusion chromatography analysis indicated that the superiority of PACl in DOC removal could be ascribed to the higher binding affinity between Al_(13) polymer and the low and medium molecular weight(MW) fractions of IOM. The results of differential log-transformed absorbance at 254 and 350 nm indicated more significant formation of complexes between AlCl_3 and IOM, which benefits the removal of tryptophan-like proteins thereafter. Additionally,PACl showed more significant superiority compared to AlCl_3 in the removal of vances the optimization of coagulation for the removal of IOM in eutrophic water.

关键词： Intracellular organic matter Coagulation Polyaluminum chloride Molecular weight distribution Hydrophilic fraction

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Recent developments in computer assisted rehabilitation environments

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Journal of Medical Colleges of PLA(China) 2014年第3期29卷 137-142页

作者： Rob van der meer meer Health Ri?nzistraat 41 2555 JT ‘s-Gravenhage Netherlands

Computer Assisted Rehabilitation Environment(CAREN) is a system that integrates a training platform(motion base), a virtual environment, a sensor system(motion capture) and D-flow software. It is useful for both diagnostic and therapeutic use. The human gait pattern can be impaired due to disease, trauma or natural decline. Gait analysis is a useful tool to identify impaired gait patterns. Traditional gait analysis is a very time consuming process and therefore only used in exceptional cases. With new systems a quick and extensive analysis is possible and provides useful tools for therapeutic purposes. The range of systems will be described in this paper, highlighting both their diagnostic use and the therapeutic possibilities. Because wounded warriors often have an impaired gait due to amputations or other extremity trauma, these systems are very useful for military rehabilitative efforts. Additionally, the virtual reality environment creates a very challenging situation for the patient, enhancing their rehabilitation experience. For that reason several Armed Forces have these systems already in use. The most recent experiences will be discussed; including new developments both in the extension of the range of systems and the improvement and adaptation of the software. A new and promising development, the use of CAREN in a special application for patients with posttraumatic stress disorder(PTSD), will also be reviewed.

关键词： Computer assisted rehabilitation environment Virtual reality Trauma Amputations Rehabilitation Posttraumatic stress disorder Military medicine

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