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A joint computational-experimental study of intracranial aneurysms:Importance of the aspect ratio

Journal of Hydrodynamics 2016年第3期28卷 462-472页

作者： Simon Sui-Man LAI Abraham Yik-Sau TANG Anderson Chun-On TSANG Gilberto Ka-Kit LEUNG alfred cheuk-hang yu Kwok Wing CHOW Department of Electrical and Electronic Engineering University of Hong Kong Hong Kong China Department of Mechanical Engineering University of Hong Kong Hong Kong China Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong China Department of Electrical and Computer Engineering University of Waterloo Ontario Canada

Rupture of a cerebral aneurysm （abnormal swelling of blood vessel in the brain） will cause subarachnoid hemorrhage, and will result in an alarming rate of mortality and morbidity. A joint computational-experimental study is conducted to assess the importance of the aspect ratio in the dynamics of blood flow. The aspect ratio is defined here to be the ratio of the height of the aneurysm to the linear dimension of the neck. Idealized models of such aneurysms located near a bifurcation point were investigated. Numerical simulations for hemodynamic properties like shear stress and flow rate were performed. The computational results were verified experimentally with specially fabricated phantoms, blood mimicking fluid and Doppler ultrasound imaging. Excellent agreements were obtained. Two features are highlighted, providing information in the intensely debated link between rupture risk and geometric factors. On increasing the aspect ratios, firstly, a jet impinging on the distal part of the neck can be observed, and secondly, a region of positive shear stress gradient can be found there. Furthermore, computational analyses for four patient-specific models were conducted to correlate with the results of idealized models and to provide further clinical insight.

关键词： intracranial aneurysms aspect ratio Doppler ultrasound

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The effects of stent porosity on the endovascular treatment of intracranial aneurysms located near a bifurcation

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Journal of Biomedical Science and Engineering 2013年第8期6卷 812-822页

作者： Abraham Yik-Sau Tang Hiu-Ning Chan Anderson Chun-On Tsang Gilberto Ka-Kit Leung Kar-Ming Leung alfred cheuk-hang yu Kwok-Wing Chow Department of Mechanical Engineering University of Hong Kong Hong Kong China Department of Neurosurgery Kwong Wah Hospital Hong Kong China Division of Neurosurgery Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Queen Mary Hos-pital Hong Kong China Medical Engineering Program Department of Electrical and Electronic Engineering University of Hong Kong Hong Kong China

Intracranial aneurysm occurs when a cerebral artery develops an abnormal sac-like dilatation, and will cause massive bleeding in the subarachnoid space upon rupture. Endovascular stenting is a minimally invasive procedure in which a flow-diverting stent is deployed to cover the aneurysm neck, thereby restricting blood from entering the aneurysm and reducing the risk of rupture. The stent porosity, a crucial factor determining the intra-aneurysmal hemodynamics following treatment, is investigated by computational fluid dynamics techniques. Based on the computational results, a low porosity stent will dramatically reduce the flow velocity and the flow rate inside the side branch vessel. Conversely, a high porosity stent may not provide adequate flow reduction inside the aneurysm, possibly causing treatment failure. An advisable range of optimal stent porosity would be 60% to 75%, which can drastically reduce the flow rate into the aneurysm while preserving enough blood flow for the side branch vessel. Clinically, deployment of two or more flow-diverting stents may not increase treatment efficacy but can potentially lead to adverse effects due to side-branch hypoperfusion. The present quantitative analysis can also provide practical insight for future stent design.

关键词： Intracranial aneurysm Endovascular Treatment Stent Stent Porosity Computational Fluid Dynamics

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微流控模型在油气田开发中的应用

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石油科学通报 2018年第3期3卷 284-301页

作者：李俊键苏航姜汉桥于馥玮梁天博赵玉云高亚军 HOSSEIN Hejazi 中国石油大学(北京)油气探测与工程国家重点实验室北京102249 中国石油大学(北京)石油工程学院北京102249 中国石油大学(北京)非常规天然气研究院北京102249 卡尔加里大学化学与石油工程学院

在过去的30年内,微流控技术在包括疾病诊断、药物筛选、细胞分析、材料化学、环境监测、食品安全、航空航天等在内的各个领域开展应用,取得了丰硕的成果。在油气田开发领域,1952年俄克拉何马州立大学alfred Chatenever和宾夕法尼亚州立... 详细信息

在过去的30年内,微流控技术在包括疾病诊断、药物筛选、细胞分析、材料化学、环境监测、食品安全、航空航天等在内的各个领域开展应用,取得了丰硕的成果。在油气田开发领域,1952年俄克拉何马州立大学alfred Chatenever和宾夕法尼亚州立大学John ***, JR最先利用微观模型研究了剩余油的分布规律。本文介绍了1952年至今,微流控模型在油气田开发领域的发展与应用现状。目前,针对不同的研究目标,可制造不同材质的模型。模型中的流体分布情况、流动路径分析可用共聚焦显微镜、PIV(Particle Image Velocimetry,图像粒子测速系统)、CCD相机(Charge Coupled Device Camera,电荷耦合摄像机)等设备来观察和实现。微流控技术所带来的精准、定量、快速、安全的可视化研究将在油气田开发领域的油气水在裂缝、微尺度基质、纳尺度基质中的渗流规律和化学驱提高采收率等方面发挥出无可替代的作用。

关键词：微流控模型微观剩余油可视化模型油气田开发

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