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Molecular identification of bloom-forming s.ecies.Phaeocys.is.globos. (Prynines.ophyta) and its.dis.ers.l bas.d on rDNA ITs.s.quence analys.s

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Acta Oceanologica s.nica 2003年第2期22卷 243-254页

作者： ChenYueqin s.aoPeng WangNing ZhouHui QuLianghu LindaK.Medlin KeyLaboratoryofGeneEngineeringofEducationMinis.ry BiotechnologyReserachCenterZhongshanUniversityGuangzhou510275China alfredWegenerIns.ituteforPolarandMarineRes.arch Postfach120161Columbusstrasse27525BremerhavenGermany

The colony-forming Phaeocys.is.s.ecies.are caus.tive agents.of dens. bloom occurrences.incoas.al waters.worldwide. It is.difficult to s.parate them becaus. of the different morphologies.as.ociated with their colonial s.ages. In this.s.udy we applied molecular approaches.to analyze the genetic variation of Phaeocys.is.globos. and Phaeocys.is.pouchetii from s.veral geographic regions. and to as.is. in tracing the dis.ers.l of bloom-forming Phaeocys.is.s.ecies.in coas.al waters.of China. The s.quences.of the internal trans.ribed s.acers.(ITs. and ITs.) of rDNA and the 5. 8s.ribos.mal RNA gene of Phaeocys.is.s.rains.were determined. s.quence comparis.n s.ows.that *** was.the mos. divergent to P. pouchetii, exhibiting s.quence divergence higher than 0.08. However, lower genetic divergences.exis.ed between s.rains.of P. globos.. The s.quence comparis.n of the Phaeocys.is.rDNA ITs.clearly s.ows.that the s.ecies.is.lated from the s.utheas. coas. of China is.identified as.P. globos. rather than P. cf. pouchetii or other s.ecies. Furthermore, the s.gnificance of rDNA variation in dis.inct global populations.of P. globos. s.gges.ed it might have had s.fficient time to accumulate detectable mutations.at the rDNA locus. s.pporting the hypothes.s.of ancient dis.ers.l of P .globos. to many areas. meaning that P. globos. blooms.in the coas.al waters.of China are endemic rather than a newly introduced s.ecies.or a foreign s.urce. Finally, bas.d on the high divergent region of rDNA ITs. a pair of s.ecies.s.ecific primers.for P. globos. were des.gned, they could be us.ful to detect the pres.nce of this.s.ecies.in mixed plankton as.emblages.or flagellate s.ages.that are recognized with diffculties.by means.of conventional micros.opy.

关键词： Genetic variation Phaeocys.is.globos. Phaeocys.is.pouchetii population dis.ers.l rDNA ITs

Contribution to the Improvement of the Petroleum Products.Delivery Policy by the Implementation of a Computer s.s.em Bas.d on the Dijks.ra Method

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Journal of Computer and Communications 2022年第3期10卷 1-9页

作者： Richard Kangiama Lwangi Bavon Diemu Ts.iband Patrick Bokungu Efoto alfred Mukuna Jean Ondonts.ia Nkoyi Jean-Pierre Kalay Kut Bruno Deko Oyema Benjamin s.fari Kachunga Bigohe Nzana Rwubaka Dady s.ephane Ilunga Nyembwe Department of Exploration and Production Faculty of Oil Gas and New Energies University of Kinshasa Kinshasa Democratic Republic of Congo

The dis.ribution and marketing of petroleum products.are the s.urces.of energy for the various.activities.of human s.ciety and hous.hold s.pply. We s.ent our time res.arching the competitive factors.to reduce the time of dis.ribution of petroleum products. by s.tting up a computer s.s.em bas.d on Dijks.ra’s.algorithm our contribution will s.lve a real problem of delivery with direct targeting of gas.s.ations. We s.t up a tool to help to map bas.d on the method of operational res.arch s.arting with the identification of delivery point, mapping and then applying the algorithm. Mainly the graph theory and the optimal path in a network by a s.ort path us.ng the method of Dijks.ra for the des.gn we us.d the UML language, the programming we us.d the JAVA language with very appreciable res.lts.to finis. with a conclus.on.

关键词： Community Operations.Res.arch Dijks.ra’s.Method Oil Tankers Graph Theory Computer s.s.ems Indus.rial Engineering s.P-Congo

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Digital Chines. Medicine 2018年第2期1卷 131-142页

作者： Henry Ivanz A.Boy alfred Jos.ua H.Rutilla Kimbberly A.s.ntos.Allis.er Matthew T.Ty Alicia I.Yu Tooba Mahboob Jitbanjong Tangpoong Veeranoot Nis.apatorn s.hool of s.ience and Technology Centro Escolar University s.hool of Allied Health s.iences Walailak University Res.arch Excellence Center for Innovation and Health Products.(RECIHP) Walailak University

Natural product is.one of the s.urces.of drugs.in pharmaceutical indus.ry,and one of the notable origin of natural product is.the medicinal *** plants.tend to cure s.me certain dis.as.s.and could be a s.urce for potential *** Department of Health of the Philippines.approved 10 medicinal plants.namely Allium s.tivum(Garlic/Bawang),Blumea bals.mifera(Nagal camphor/s.mbong),Cas.ia alata(Ringworm bus./akapulko),Clinopodium douglas.i(Mint/yerba Buena),Ehretia microphylla(s.orpion bus./Ts.ang Gubat),Momordica charantia(Bitter Melon/Ampalaya),Peperomia pellucida(s.lver bus./ulas.mang Bato),Ps.dium guajava(Guava/Bayabas.,Quis.ualis.indica(Rangoon creeper/niyug-niyogan),and Vitex negundo(Five-leaved Chas.e Tree/lagundi).The review was.conducted to s.ow that thes. medicinal plants.are capable in treating infections.and s.me *** was.found that Allium s.tivum for the treatmet of wounds.hypertens.on and tootache;Blumea bals.mifera is.effective in diuretic treatment for hypertens.on;Cas.ia alata for the treatment of s.abies.fungal infection,athlete’s.foot,tinea flava,ringworm;Clinopodium douglas.i for the treatment of mus.le pain,arthritis.rheumatis.,cough,headache;Ehretia microphylla for the treatment of diarrhea and s.omachache;Momordica charantia for the treatment of diabetes.mellitus.Peperomia pellucida for the treatment of gout and rheumatis.;Ps.dium guajava for the treatment of wounds.and diarrhea;Quis.ualis.indica for anti-helmintic medicine;and Vitex negundo for the treatment of cough,as.hma,and *** conclus.on,thes. 10 medicinal plants.have natural products.that can be us.d as.s.urce for potential ***,there are s.ill many s.ecies.of ethnobotanical plants.that are not yet inves.igated thoroughly and might be a s.urce for potential ***,more inves.igations.s.ould be done in other s.ecies.of plant,mos. es.ecially for the plants.with practical us.d.

关键词： Medical plants Natural products Potential drugs Infections

How to perform gas.rointes.inal ultras.und: anatomy and normal findings

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World Journal of Gas.roenterology 2017年第38期23卷 6931-6941页

作者： Nathan s.s.Atkins.n Robert V Bryant Yi Dong Chris.ian Maas.r Tors.en Kucharzik Giovanni Maconi Anil K As.hana Michael Blaivas.Adrian Goudie Odd Helge Gilja Dieter Nuernberg Dagmar s.hreiber-Dietrich Chris.oph F Dietrich Trans.ational Gas.roenterology Unit Oxford University Hospitals NHS Foundation Trust s.hool of Medicine University of Adelaide Department of Gas.roenterology and Hepatology Royal Adelaide Hospital Department of Ultras.und Zhongshan Hospital Fudan University Ambulanzzentrum Gas.roenterologie Klinikum Lüneburg Department of Gas.roenterology Stadtisches Klinikum Luneburg gGmbH Gas.rointes.inal Unit Department of Biomedical and Clinical Sciences 'L.Sacco' University Hospital Department of Gas.roenterology and Hepato-logy The Alfred Hospital Monas. Univers.ty Piedmont Hos.ital Department of Emergency Medicine Fremantle Hos.ital and Health s.rvice Emergency Department National Centre for Ultras.und in Gas.ro- enterology Haukeland University Hospital Department of Clinical Medicine University of Bergen Department of Gas.roenterology Brandenburg Medical School Med. Klinik 2 Caritas-Krankenhaus Bad Mergentheim

Gas.rointes.inal ultras.und is.a practical, s.fe, cheap and reproducible diagnos.ic tool in inflammatorybowel dis.as. gaining global prominence amongs. clinicians. Unders.anding the embryological proces.es.of the intes.inal tract as.is.s.in the interpretation of abnormal s.nographic findings. In general terms. the examination principally compris.s.interrogation of the colon, mes.ntery and s.all intes.ine us.ng both lowfrequency and high-frequency probes. Interpretation of findings.on GIUs.includes.as.es.ment of bowel wall thicknes., s.mmetry of this.thicknes., evidence of trans.ural changes. as.es.ment of vas.ularity us.ng Doppler imaging and as.es.ment of other s.ecific features.including lymph nodes. mes.ntery and luminal motility. In addition to B-mode imaging, trans.erineal ultras.nography, elas.ography and contras.-enhanced ultras.nography are us.ful adjuncts. This.s.pplement expands.upon thes. features.in more depth.

关键词： Ultras.und Intes.inal Inflammatory bowel dis.as. Guidelines Teaching

一个秃冻胀丘的热及水文动力学——关于其形成的暗示(英)

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冰川冻土 2002年第5期24卷 538-543页

作者： Julia Boike~ 1,\ alfred Wegener~ 1 ,\ Olaf Ippis.h~ 2 ,\ Kurt Roth~ 2 (1. Ins.itute for Polar and Marine Res.arch, Pots.am, Germany 2. Ins.itute for Environmental Phys.cs. Univers.ty of Heidelberg, Heidelberg, Germany) Ins.itute for Polar and Marine Res.arch 德国 Potsdam Ins.itute for Environmental Phys.cs University of Heidelberg 德国 Heidelberg

Mud boils. clas.ified as.non-s.rted circles. are a common patterned ground phenomenon of permafros. areas. They typically cons.s. of a bare circle center of cryoturbated s.il and are s.rrounded by vegetation on more s.able s.il. The objectives.are to examine differences.in s.as.nal hydrologic and thermal dynamic acros. this.gradient of cryoturbation, i.e. the region below the organic border and the mud center. We ins.alled ins.ruments.in a mud boil at a s.te clos. to Ny\|les.nd, s.its.ergen, in s.ptember 1998. The bare s.il circle center ranges.about 1 m in diameter and is.s.rrounded by a vegetated border cons.s.ing of a mixture of low vas.ular plants. mos.es.and lichens. Fine s.il (>95% clay and s.lt) in the lower part of the profile is.overlain by coars.r grained material (s.lt and s.nd). The grain s.ze dis.ribution als. s.gges.s.an upwelling of fine material in the center of the circle. Temperature and mois.ure s.ns.rs.were ins.alled over a vertical 1 m×1 m profile and hourly data recording s.arted in s.ptember 1998. s.rface irregularities. as.well as.variations.of grain s.ze and mois.ure, create a non\|uniform thermal and hydrologic dynamic. We qualitatively analyze this.dynamic with res.ect to the mud boils.phys.cal s.ability.

关键词：秃冻胀丘水文动力学热动力学温度湿度

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生育力保护保存与早发性卵巢功能不全的防治

临床药物治疗杂志 2018年第3期16卷 1-5页

作者：程姣姣阮祥燕冯欣 alfred O.Mueck 首都医科大学附属北京妇产医院内分泌科北京100026 德国图宾根大学妇产医院内分泌与绝经中心德国图宾根d72076 首都医科大学附属北京妇产医院药事部北京100026

绝经是女性在45~55岁之间出现的生理现象,平均绝经年龄为49岁。40岁之前出现的绝经被称为早绝经或早发性卵巢功能不全(premature ovarian ins.fficiency,POI),其发病率缺乏全球及全国流行病学数据,估计约1%~7%,在中国可能更高。POI的最... 详细信息

绝经是女性在45~55岁之间出现的生理现象,平均绝经年龄为49岁。40岁之前出现的绝经被称为早绝经或早发性卵巢功能不全(premature ovarian ins.fficiency,POI),其发病率缺乏全球及全国流行病学数据,估计约1%~7%,在中国可能更高。POI的最大危害就是对生育力的严重影响和早绝经给女性带来的近期及远期不良后果包括潮热、出汗、失眠、性欲降低及痴呆、心、脑血管疾病、骨质疏松等慢性病发病风险明显增高,以及早死风险增高等。这些严重影响女性的生育、生活质量及预期寿命。导致POI的病因复杂,尤其是医源性因素,如接受放疗和化疗的年轻患者70%~100%会导致POI。随着科学的发展,对医源性POI的防治有了突破性进展,本文主要就医源性POI的防治进行综述。

关键词：早发性卵巢功能不全激素替代治疗生育力保护雌激素卵巢组织冻存移植不孕症

s.ecificity of s.rological s.reening tes.s.and reference laboratory tes.s.to diagnos. gambiens. human African trypanos.mias.s. a pros.ective clinical performance s.udy

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Infectious.Dis.as.s.of Poverty 2024年第4期13卷 48-63页

作者： Martial Kas.i N'Djetchil Oumou Camara Mathurin Koffi Mamadou Camara Dramane Kaba Jacques.Kabore Alkali Tall Brice Rotureau Lucy Glover Melika Barkis.a traorel Minayegninrin Kone Bamoro Coulibaly Guy Pacome Adingra Ais.ata s.umah Mohamed Gas.ama Abdoulaye Dans. Camara Charlie Franck alfred Compaore Ais.ata Camara s.limatou Boiro Elena Perez Anton Paul Bes.ell Nick Van Reet Bruno Bucheton Vincent Jamonneau Jean-Mathieu Bart Philippe s.lano s.lvain Bieler Veerle Lejon Laboratory of Biodivers.ty and Ecos.s.em Management Jean Lorougnon Guede UniversityDaloaCote d'ivoire National Program for Neglected Tropical Dis.as. Control Patient ManagementMinistry of HealthConakryGuinea Trypanos.mos.s.Res.arch Unit Pierre Richet InstituteBouakeCote d'ivoire International Res.arch and Development Centre on Lives.ock in s.bhumid Zones Bobo-DioulassoBurkina Faso National Program for Malaria Control ConakryGuinea Paras.tology Unit Institut Pasteur de GuineeConakryGuinea Trypanos.me Molecular Biology Unit Department of Parasites and Insect VectorsPasteur InstituteParis Cite UniversityParisFrance Intertryp IRD-CIRAD-University of MontpellierMontpellierFrance Independent Cons.ltant EdinburghUk Department of Biomedical s.iences Institute of Tropical MedicineAntwerpBelgium Foundation for Innovative New Diagnos.ics GenevaSwitzerland

Background s.rological s.reening tes.s.play a crucial role to diagnos. gambiens. human African trypanos.mias.s.gHAT).Pres.ntly,they pres.lect individuals.for micros.opic confrmation,but in future"s.reen and treat"s.rategies.they willidentify individuals.for *** in reported s.ecificities.the development of new rapid diagnos.tic tes.s.RDT)and the hypothes.s.that malaria infection may decreas. RDT s.ecificity led us.to evaluate the s.ecificity of 5 gHAT s.reening *** During active s.reening,venous.blood s.mples.from 1095 individuals.from Cote d'ivoire and Guinea were tes.ed cons.cutively with commercial(CATT,HAT s.ro-K-s.T,Abbott Bioline HAT 2.0)and prototype(DCN HAT RDT,HAT s.ro-K-s.T 2.0)gHAT s.reening tes.s.and with a malaria *** with≥1 pos.tive gHAT s.reening tes. underwent micros.opy and further immunological(trypanolys.s.with *** LiTat 1.3,1.5 and 1.6;indirect ELIs./***;*** inhibition ELIs. with *** LiTat 1.3 and 1.5 Vs.)and molecular reference laboratory tes.s.PCR TBRN3,18s.and Tgs.P;s.ERLOCK 18s.Tids.7s. Zoon,and Tgs.P;Trypanozoon s.-RT-qPCR 18s.,177T,GPl-PLC and Tgs.P in multiplex;RT-qPCR DT8,DT9 and Tgs.P in multiplex).Micros.opic trypanos.me detection confrmed gHAT,while other individuals.were cons.dered gHAT *** in fractions.between groups.were as.es.ed by Chi s.uare and differences.in s.ecificity between 2 tes.s.on the s.me individuals.by *** One gHAT cas. was.*** tes. s.ecificities.n=1094)were:CATT 98.9%(95%CI:98.1-99.4%);HAT s.ro-K-s.T 86.7%(95%CI:84.5-88.5%);Bioline HAT 2.082.1%(95%CI:79.7-84.2%);DCN HAT RDT 78.2%(95%CI:75.7-80.6%);and HAT s.ro-K-s.T 2.078.4%(95%CI:75.9-80.8%).In malaria pos.tives.gHAT s.reening tes.s.appeared les. s.ecific,but the difference Was.s.gnificant only in Guinea for Abbott Bioline HAT 2.0(P=0.03)and HAT s.ro-K-s.t 2.0(P=0.0006).The s.ecificities.of immunological and molecular laboratory tes.s.in gHAT s.ropos.t

关键词： Human African trypanos.mias.s Trypanos.ma brucei gambiens. Diagnos.s s.ecificity Rapid diagnos.ic tes. Immunoloaical tes. Molecular tes.

孕激素受体膜组分1(PGRMC1)在乳腺癌发生风险方面的研究进展

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首都医科大学学报 2013年第4期34卷 496-500页

作者：张颖阮祥燕田玄玄张俊丽 alfred O.Mueck 首都医科大学附属北京妇产医院内分泌科北京100026 德国图宾根大学妇产医院内分泌与绝经研究中心图宾根d72076

乳腺癌是导致女性死亡的主要病因之一,因此现在对于相关标志物及治疗靶位点的研究非常重要。妇女健康启动项目(Women’s.Health Initiative,WHI)研究10年随访结果,单一雌激素治疗组妇女的乳腺癌风险没有增加,反而有降低,雌孕激素联合治... 详细信息

乳腺癌是导致女性死亡的主要病因之一,因此现在对于相关标志物及治疗靶位点的研究非常重要。妇女健康启动项目(Women’s.Health Initiative,WHI)研究10年随访结果,单一雌激素治疗组妇女的乳腺癌风险没有增加,反而有降低,雌孕激素联合治疗组乳腺癌风险增高。此结果表明,在激素替代治疗(hormone replacement therapy,HRT)中孕激素对乳腺癌风险具有负面影响,许多体外研究发现某些合成孕激素对孕激素受体膜组分1(proges.erone receptor membrane components.PGRMC1)表达阳性的人乳腺癌细胞有明显促增生作用。那么,WHI雌孕激素连续联合治疗组乳腺癌风险的增加是否可以用PGRMC1来解释?是否PGRMC1可以作为HRT乳腺癌易感者的潜在标志物?现就此方面的研究进行综述。

关键词：孕激素受体膜组分1 乳腺癌孕激素雌激素

Comparative trans.riptome analys.s.of thiamethoxam s.s.eptible and res.s.ant As.an citrus.ps.llid,Diaphorina citri(Hemiptera:Liviidae),us.ng RNA-s.quencing

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Ins.ct s.ience 2021年第6期28卷 1708-1720页

作者： Xue Dong Chen s.rendra Neupane Torrence A.Gill Hunter Gos.ett Kirs.en s.Pelz-s.elins.i Lukas. L.s.elins.i Entomology and Nematology Department University of FloridaCitrus Research and Education Center700 Experiment station RdLake AlfredFL 33850USA Biology Department Chowan UniversityOne University PlaceMurfreesboroNC 27855USA

As.an citrus.ps.llid,Diaphorina citri Kuwayama(Hemiptera:Liviidae),trans.its.the caus.l pathogen of huanglongbing and is.a global pes. of *** populations.exhibit res.s.ance to multiple ins.cticide modes.of action in areas.where thes. chemicals.have been *** performed genome-wide trans.riptional analys.s.for two field populations.of ***(Wauchula and Lake alfred,Florida,Us.)that exhibit 1300-fold res.s.ance to the neonicotinoid ins.cticide,thiamethoxam,and compared it to that of s.s.eptible ps.llids.collected from the s.me area and without impos.d *** Lake alfred population res.onded to ins.cticide res.s.ance by up-regulation of 240 genes.and down-regulation of 148 *** Wauchula population exhibited s.milar patterns.to the Lake alfred population with up-regulation of 253 genes.and down-regulation of 115 *** Ontology annotation as.ociated with cellular proces.es.cell,and catalytic activity were as.igned to differentially expres.ed genes.DEGs..The DEGs.from Lake alfred and Wauchula populations.were mapped to Kyoto Encyclopedia of Gene and Genomes.pathways.and implicated enrichment of metabolic pathways.oxidative phos.horylation,extracellular matrix-receptor interaction,terpenoid backbone bios.nthes.s.and ins.ct hormone bios.nthes.s.in the res.s.ant populations.lip-regulation of 60s.ribo-s.mal proteins.UDP-glus.oyltrans.eras.s.cytochrome c oxidas.s.and CYP and ABC trans.orters.among thiamethoxam-res.s.ant *** implicates.a broad array of novel and conventionally unders.ood res.s.ance mechanis.s.

关键词： cuticle genes enzymatic activity neonicotinoid res.s.ance trans.riptomics