检索结果-南通市图书馆

optimizing menopausal hormone therapy:for treatment and prevention,menstrual regulation,and reduction of possible risks

引用

Global Health Journal 2022年第2期6卷 61-69页

作者： Xiangyan Ruan alfred o.mueck Department of Gynecological Endocrinology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care HospitalYaojiayuan Road 251Beijing 100026China Department of Women's Health University Hospital TuebingenCalwer Strasse 7Tuebingen 72076Germany

Menopausal hormone therapy(MHT)is used to treat menopausal complaints including the genitourinary syndrome of menopause,to prevent osteoporosis,and to treat bleeding *** these can be the indications also in young women,especially with PoI(premature ovarian insufficiency)or with surgical menopause(bilateral oophorectomy),also the old term"Hormone Replacement Therapy(HRT)”is still *** effective component is the estrogen component without relevant difference in the efficacy of the various *** preventive benefits are reduction of cardiovascular disease(including prevention of diabetes mellitus and metabolic syndrome),reduction of colon cancer,and perhaps also Alzheimer's disease,if started within a Kwindow of opportunity",*** perimenopause or within 6-10 years after *** indication for progestogen addition is to avoid the development of estrogen-dependent endometrial cancer,*** not recommended in hysterectomized *** main schedules,sequential-or continuous-combined estrogen/progestogen regimens,are used for treatment of bleeding *** this and for optimizing menstrual regulation detailed recommendations are given including proposed dosages for the available different progestogens if added to oral or transdermal estradiol in different estrogen *** WHI-study demonstrated the main risks using MHT within a“worst-case scenario",*** of MHT in old women with high risk for breast cancer and cardiovascular diseases,whereby only^conjugated equine estro-gens”and^medroxprogesterone acetate”have been *** main result was that the progestogen component is decisive for the risk of breast cancer,which according to own experimental research and observational studies may be reduced using the physiological progesterone or its isomer *** addition we propose to push forward research for screening patients with increased breast cancer risk like we have done in the past decade demons

关键词： Menopausal hormone therapy(MHT) Estrogens Progestogens Women's Health Initiative(WHI)-trial MHT-regimens MHT-indications MHT-risks

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advanced therapy of overweight or obese polycystic ovary syndrome:a prospective study

引用

Global Health Journal 2022年第2期6卷 75-79页

作者： Min Min Xiangyan Ruan alfred o.mueck Department of Gynecological Endocrinology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care Hospital Yaojiayuan Road 251Beijing 100026China Department of Womens Health University Hospital TuebingenCalwer Strasse 7Tuebingen 72076Germany

objective:To investigate the effects of orlistat combined with drospirenone/ethinylestradiol tablets(DRSP/EE)on anthropometric indices,sexual hormones,hepatorenal function parameters of overweight or obese patients with polycystic ovary syndrome(PCoS).Methods:75 overweight or obese PCoS patients[body mass index(BMI)>24 kg/m^(2)]were recruited within the Department of Gynecological Endocrinology,Beying obstetrics and Gynecology Hospital,Capital Medical University,from April 2019 to January 2020,for a prospective,randomized,open-labelled comparing *** were numbered one by one according to the order of recruitement and randomly divided into two groups,group 1 included 50 patients,orlistat plus DRSP/EE;group 2 included 25 patients treated with DRSP/EE *** groups got the same comprehensive intervention in terms of individualized,standardized managment and monitoring of life-style like diet and *** changes of anthropometric indices,sexual hormones,hepatorenal function parameters before and after three months of treatment in the two groups were ***:After three months of treatment,body weight,waist circumference(WC),hip circumference(HC)and BMI of both groups were significantly decreased(Pof body weight,WC,HC and BMI in group 1 was significantly greater than those in group 2(Posterone and sex hormone-binding globulin in both groups were significantly changed(Po significant difference in the hepatorenal function parameters between the two groups after three months treatment(P>0.05).Conclusion:To our knowledge our study is the first to investigate the effects of orlistat combined with DRSP/EE in overweight or obese PCoS patients comparing with the effect of using DRSP/EE *** combined with DRSP/EE was better than use DRSP/EE alone in getting weight loss,which provides an evidence for the choice of rational drug use in clinical practice.

关键词： overweight/obese Polycystic ovary syndrome orlistat Drospirenone/ethinylestradiol tablets

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Management strategy of infertility in polycystic ovary syndrome

引用

Global Health Journal 2022年第2期6卷 70-74页

作者： Meng Li Xiangyan Ruan alfred o.mueck Department of Gynecological Endocrinology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child.Health Care Hospital Yaojiayuan Road 251Beijing 100026China Department of Womens Health University Hospital Tuebingen Calwer Strasse 7Tuebingen 72076Germany

Polycystic ovary syndrome(PCoS)is the most common endocrine and metabolic disease in women of reproductive *** is characterized by ovulatory disruption,which can lead to *** with PCoS are also more likely to have poor pregnancy *** obese women,lifestyle interventions are recommended first,which have general health *** women who have difficulty changing their lifestyle,drugs for the treatment of obesity or bariatric surgery could be *** citrate is the first-line medication after weight loss that has been utilized in the *** is supplanting clomiphene as the best option for ovulation induction for now,particularly in patients with *** can improve ovulation and pregnancy rates;however,it has minimal effects in terms of raising live birth ***-line therapies include gonadotropins and laparoscopic ovary *** vitro fertilization can be utilized as a third-line treatment for patients with PCoS who have failed ovulation induction therapy or have other infertility *** summary,to achieve fertility,patients with PCoS require standardized individualized therapy.

关键词： Polycystic ovary syndrome Infertility Lifestyle modification ovulation induction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reproductive health for global women

引用

Global Health Journal 2021年第2期5卷 63-65页

作者： alfred o.mueck Department of Women's Health Universily Hospial TuebingenCabver Strasse 7Tuebingpn 72076Germany Department of Gynecological Endocrinology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityYaqjiayuan Road 251Bering 100026China

*** Global Health Journal(GHJ)covers general and special issues of health with importance for the global women across the *** topics published in GHJ are related to"Reproductive Health"which certainly is one of the important challenges in all countries of the world,especially in developing *** special issue on"Reproductive health for global women"has been designed by *** Ruan as guest Editor,who is the Medical Director of the Department of Gynecological Endocrinology in the Beijing obstetrics and Gynecology Hospital,Capital Medical University,China,and Guest Professor of the University Women's Hospital in Tuebingen,Germany.

关键词： Reproductive Director women

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prevention and treatment of iatrogenic premature ovarian insufficiency:r interpretation of the first Chinese guideline on ovarian tissue cryopreservation and transplantation

引用

Global Health Journal 2021年第2期5卷 70-73页

作者： Xiangyan Ruan Jiaojiao Cheng Juan Du Fengyu Jin Yanglu Li Muqing Gu alfred o.mueck Department of Gynecological Endocrinology Beying Obstetrics and Gynecology HospitalCapital Medical UniversityYaojiayuan Road 251Beijing 100026China Department of Women’s Health University Hospital TuebingenCalwer Strasse 7Tuebingen 72076Germany

In recent years,with the rapid development of medical research,cancer diagnosis and treatment technology have significantly improved young cancer patient’s survival *** therapy such as chemotherapy,radiotherapy,or hematopoietic stem cell transplantation can lead to premature ovarian *** endocrine and reproductive function of the ovary is critical to women’s physical and mental *** tissue cryopreservation and transplantation can protect not only female fertility but also preserve ovarian endocrine *** paper interprets the guidelines for ovarian tissue cryopreservation and transplantation issued by the Chinese Society of Gynecological Endocrinology affiliated to the International Society of Gynecological *** purpose of this guideline’s interpretation is to promote more medical workers to understand the technology of ovarian tissue cryopreservation and transplantation,which can provide patients with more choices of fertility protection methods and improve their quality of life.

关键词： Guideline interpretation Prevention ovarian tissue cryopreservation and transplantation Fertility preservation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gynecological endocrinological health and education for global women

引用

Global Health Journal 2022年第2期6卷 59-60页

作者： Xiangyan Ruan Jiaojiao Cheng alfred o.mueck Department of Gynecological Endocrinology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child.Health Care Hospital Yaojiayuan Road 251Beijing 100026China Department of Womens Health University Hospital Tuebingen Calwer Strasse 7Tuebingen 72076Germany

*** Global Healtii Journal focuses on global health-related topics,including global health practice,global health education,and so *** this special issue,we focus on following themes:(1)an advanced therapy;(2)management strategy of infertility in polycystic ovary syndrome(PCoS);(3)optimizing menopausal hormone therapy(MHT);and(4)an interpretation of expert *** those works are the intense and painstaking efforts made by the researchers across the world,which cover some important topics on gynecological and reproductive endocrinology and improve the clinical routine as well further researches.

关键词： routine education global

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

口服避孕药对多囊卵巢综合征患者性功能的影响

引用

首都医科大学学报 2018年第4期39卷 499-504页

作者：杜娟阮祥燕 alfred o.mueck 首都医科大学附属北京妇产医院内分泌科北京100026 德国图宾根大学妇产医院妇女健康部与妇女健康研究中心

目的评估口服避孕药(oral contraceptives,oCs)对多囊卵巢综合征(polycystic ovary syndrome,PCoS)患者性功能的影响,并分析其女性性功能障碍(female sexual dysfunction,FSD)发生的危险因素。方法研究共纳入210例门诊PCoS患者,其中服用口服避孕药者126例(oC组),未服用者84例(NoC组)。采用网络女性性功能指数(Female Sexual Function Index,FSFI)量表,并补充附加问题,评估参与者的基本信息、避孕方法、性伴侣关系稳定程度、孕产史等多个女性性功能的潜在影响因素。结果oC组FSFI总分中位数为26.35分,50.79%表现为FSD高风险;NoC组FSFI总分中位数26.85分,47.62%显示FSD高风险;两组得分相比差异无统计学意义(P=0.635)。在口服避孕药使用者中,服用35μg炔雌醇/2 mg醋酸环丙孕酮、30μg炔雌醇/3mg屈螺酮、30μg炔雌醇/150μg去氧孕烯三种不同成分口服避孕药的患者之间,FSFI得分差异无统计学意义。经Logistic回归分析,性生活是否主动、伴侣关系是否稳定是PCoS患者性功能的影响因素。结论 PCoS患者中,是否服用口服避孕药、服用不同类型口服避孕药的患者之间性功能评分差异均无统计学意义。PCoS患者性功能的潜在影响因素中,性生活是否主动、伴侣关系是否稳定与FSD高风险的发生相关。

关键词：女性性功能障碍网络女性性功能指数量表(FSFI) 影响因素多囊卵巢综合征口服避孕药

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

孕激素受体膜组分1在乳腺癌发生机制中作用的研究进展

引用

首都医科大学学报 2015年第4期36卷 583-587页

作者：张颖阮祥燕 alfred o.mueck 首都医科大学附属北京妇产医院内分泌科北京100026 德国图宾根大学妇产医院内分泌与绝经中心德国图宾根d72076

乳腺癌是导致女性死亡的主要癌症之一,但目前为止关于乳腺癌的发生机制尚未完全明确。唯一一项全球大型安慰剂对照研究,妇女健康启动项目(Women’s Health Initiative,WHI)指出,雌孕激素联合治疗组乳腺癌风险增高,单一雌激素治疗组妇女... 详细信息

乳腺癌是导致女性死亡的主要癌症之一,但目前为止关于乳腺癌的发生机制尚未完全明确。唯一一项全球大型安慰剂对照研究,妇女健康启动项目(Women’s Health Initiative,WHI)指出,雌孕激素联合治疗组乳腺癌风险增高,单一雌激素治疗组妇女的乳腺癌风险没有增加,反而有降低,说明在激素补充治疗(hormone replacement therapy,HRT)治疗中孕激素对乳腺癌风险具有负面影响。针对此结论开展了很多体外研究,发现雌孕激素联合治疗可以明显促进孕激素受体膜组分1(progesterone receptor membrane component 1,PGRMC1)表达阳性的乳腺癌细胞的增生。针对此结论,北美绝经学会官方科学杂志Menopause对此给予特别的编者按:"WHI研究中雌孕激素联合治疗组妇女乳腺癌风险增加是否可以用PGRMC1的作用来解释?PGRMC1是否可以作为一个乳腺癌风险潜在的标志物?PGRMC1高表达者是否可确定为乳腺癌易感者?"本文将就此方面的研究进行综述。

关键词：孕激素受体膜组分1 乳腺癌雌激素受体孕激素受体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

人卵巢组织冻存与移植研究进展

引用

首都医科大学学报 2017年第4期38卷 485-491页

作者：李扬璐阮祥燕 alfred o.mueck 首都医科大学附属北京妇产医院内分泌科北京100026 德国图宾根大学妇产医院内分泌与绝经中心

随着癌症治疗学的发展,癌症病人的生存率有了很大的提高。但性腺毒性治疗对肿瘤病人的生育力造成了不可逆的影响。有效的保护肿瘤病人的生育力,提高她们的生殖健康水平,是医疗工作者面临的重要问题。卵母细胞冻存、胚胎冻存、卵巢组织... 详细信息

随着癌症治疗学的发展,癌症病人的生存率有了很大的提高。但性腺毒性治疗对肿瘤病人的生育力造成了不可逆的影响。有效的保护肿瘤病人的生育力,提高她们的生殖健康水平,是医疗工作者面临的重要问题。卵母细胞冻存、胚胎冻存、卵巢组织冻存等技术的发展是为女性生育力保护提供了可能。本文将简述目前常用的生育力保护方法,重点介绍人卵巢组织冻存与移植技术在生育力保护方面的重要作用。

关键词：性腺毒性治疗生育力保护卵巢组织冻存与移植卵母细胞冻存胚胎冻存

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

围绝经期及绝经后妇女心血管疾病危险因素的变化

引用

首都医科大学学报 2016年第4期37卷 413-417页

作者：孙艳格阮祥燕 alfred o.mueck 首都医科大学附属北京妇产医院内分泌科北京100026 首都医科大学附属复兴医院月坛社区卫生服务中心北京100045 德国图宾根大学妇产医院绝经内分泌中心

心血管疾病是危害绝经后妇女健康的常见疾病,预防绝经后妇女心血管疾病的发生,首先要了解绝经过程中妇女心血管疾病危险因素的发生及变化。心血管疾病危险因素分为不可改变和可改变的两大类,不可改变因素包括年龄、性别和家族史,可改变... 详细信息

心血管疾病是危害绝经后妇女健康的常见疾病,预防绝经后妇女心血管疾病的发生,首先要了解绝经过程中妇女心血管疾病危险因素的发生及变化。心血管疾病危险因素分为不可改变和可改变的两大类,不可改变因素包括年龄、性别和家族史,可改变因素包括高血压、血脂异常、肥胖、糖耐量减低、吸烟、糖尿病和久坐。本文就围绝经期和绝经后妇女心血管疾病可改变危险因素的变化做一系统综述。

关键词：心血管疾病危险因素绝经

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：