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Renin-angiotensin system blockade: Effect on renal mRNA expression in 5/6 nephrectomized rats

Health 2013年第4期5卷 9-15页

作者： Erika Yadira Cruz-Laguna Ana ma. Gámez-méndez Hilda Vargas-Robles Amelia Ríos alfonso méndez-tenorio Bruno Escalante CINVESTAV Unidad monterrey Apodaca México Departamento de Biomedicina CINVESTAV Unidad Zacatenco México City México Laboratorio de Biotecnología y Bioinformática Genómica Escuela Nacional de Ciencias Biológicas (IPN) México City México

The aim of this study was to determinate the gene expression levels of angiotensinogen, angiotensin converting enzyme, renin, (pro)renin receptor, and the final rennin-angiotensin system (RAS) products Angiotensin (Ang) II and Ang 1-7 inthe remnant kidney of 5/6 nephrectomized rats and its response to RAS pharmacological blockade. male Wistar rats were divided into five groups: sham operated (SO), 5/6 nephrectomized (NFX), NFX + captopril (50 mg/ kg/day), NFX + losartan (10 mg/kg/day), and NFX + aliskiren (10 mg/kg/day). Animals were followed up for 60 days and protein urine excretion was measured. Systolic blood pressure, renal tissue RAS mRNA expression levels, plasma Ang II, and plasma Ang 1-7 were evaluated at day 60 after nephrectomy. Blood pressure and urine protein were increased after 5/6 nephrectomy. Ang II levels were increased 9.4 fold, whereas Ang 1-7 decreased 72.9% in NFX animals compared with SO rats. 5/6 nephrectomy increased renal angiotensinogen and (pro)renin receptor mRNA expression but down-regulated renin mRNA expression. RAS blockade restored the systolic blood pressure to normal values and slowed down urinary protein excretion, and also prevented changes in Ang II and Ang 1-7. RAS blockade reduced (pro)renin receptor, ACE, and AGT mRNA expression in the remnant kidney. However, renin mRNA expression increased compared with NFX rats. In conclusion these results suggest that inhibition of Ang II synthesis by RAS blockade is associated with renal regulation of RAS mRNA expression and this may be through a mechanism related with the Ang II/Ang 1-7 balance.

关键词： Angiotensin II Angiotensin 1-7 ACE RAS Blockade

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Using fused filament fabrication to improve the tribocorrosion behaviour of 17-4 PH SS in comparison to other metal forming techniques

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Friction 2024年第10期12卷 2325-2343页

作者： Cristina GARCÍA-CABEZÓN Juan alfonso NARANJO Celia GARCÍA-HERNÁndez Cristina BERGES Gemma HERRANZ Fernando mARTÍN-PEDROSA materials Engineering E.I.I.Universidad de ValladolidValladolid 47011Spain INEI-Escuela Técnica Superior de Ingeniería Industrial(ETSII) Universidad de Castilla La ManchaCastilla-La Mancha 13071Spain

Fused filament fabrication(FFF)is one of the additive manufacturing processes which has gained more interest because of its simplicity and *** technology is similar to the conventional metal injection moulding(mIm)process,consisting of the feedstock preparation of metal powder and polymer binders,followed by layer-by-layer 3D printing(FFF)or injection(mIm)to create green parts and,finally,debinding and ***,both technologies provide near-dense *** work presents an in-depth study of the processing method’s *** porosity,microstructure,hardness,corrosion,and tribocorrosion behaviour are compared for 17-4 PH SS samples processed from powder by additive manufacturing using FFF and mIm,as well as conventional powder metallurgy(Pm)*** samples exhibited the highest macro and microhardness,while corrosion behaviour was similar for both mIm and FFF samples,but superior in comparison to conventional Pm ***,the FFF-as fabricated samples displayed a significant improvement in tribocorrosion resistance that could be explained by the higher proportion of delta ferrite and retained austenite in their microstructure.

关键词： 17-4 PH SS fused filament fabrication(FFF) metal injection moulding(mIm) corrosion behaviour powder metallurgy(Pm) tribocorrosion behaviour

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An innovative heterogeneous transfer learning framework to enhance the scalability of deep reinforcement learning controllers in buildings with integrated energy systems

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Building Simulation 2024年第5期17卷 739-770页

作者： Davide Coraci Silvio Brandi Tianzhen Hong alfonso Capozzoli Politecnico di Torino Department of EnergyTEBE research groupBAEDA Lab.Corso Duca degli Abruzzi 24Torino10129Italy Building Technology and Urban Systems Division Lawrence Berkeley National LaboratoryOne Cyclotron RoadBerkeleyCA 94720USA

Deep Reinforcement Learning(DRL)-based control shows enhanced performance in the management of integrated energy systems when compared with Rule-Based Controllers(RBCs),but it still lacks scalability and generalisation due to the necessity of using tailored models for the training *** Learning(TL)is a potential solution to address this ***,existing TL applications in building control have been mostly tested among buildings with similar features,not addressing the need to scale up advanced control in real-world scenarios with diverse energy *** paper assesses the performance of an online heterogeneous TL strategy,comparing it with RBC and offline and online DRL controllers in a simulation setup using EnergyPlus and *** study tests the transfer in both transductive and inductive settings of a DRL policy designed to manage a chiller coupled with a Thermal Energy Storage(TES).The control policy is pre-trained on a source building and transferred to various target buildings characterised by an integrated energy system including photovoltaic and battery energy storage systems,different building envelope features,occupancy schedule and boundary conditions(e.g.,weather and price signal).The TL approach incorporates model slicing,imitation learning and fine-tuning to handle diverse state spaces and reward functions between source and target *** show that the proposed methodology leads to a reduction of 10% in electricity cost and between 10% and 40% in the mean value of the daily average temperature violation rate compared to RBC and online DRL ***,online TL maximises self-sufficiency and self-consumption by 9% and 11% with respect to ***,online TL achieves worse performance compared to offline DRL in either transductive or inductive ***,offline Deep Reinforcement Learning(DRL)agents should be trained at least for 15 episodes to reach the same level of performance as the online

关键词： transfer learning reinforcement learning building control building energy management

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Long-term trends in the abundance and breeding performance in Adélie penguins:the Argentine Ecosystem monitoring Program

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Advances in Polar Science 2024年第1期35卷 132-140页

作者： mariana A.JUÁRES Anahím.SILVESTRO Brenda C.alfonso m.mercedes SANTOS Departamento Biología de Predadores Tope Instituto Antártico Argentino(IAA)Buenos Aires B1650CSPArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos Aires C1425FQBArgentina Laboratorios Anexos Facultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1904AMAArgentina INEDES(CONICET-UNLu) Buenos Aires C1425FQBArgentina Facultad de Ciencias Naturales y museo Universidad Nacional de La PlataLa Plata B1900FWAArgentina Instituto Antártico Argentino(IAA) Buenos Aires B1650CSPArgentina

In this work,we report long-term trends in the abundance and breeding performance of Adélie penguins(Pygoscelis adeliae)nesting in three Antarctic colonies(i.e.,at martin Point,South Orkneys Islands;Stranger Point/Cabo Funes,South Shetland Islands;and Esperanza/Hope Bay in the Antarctic Peninsula)from 1995/96 to 2022/*** yearly count data of breeding groups selected,we observed a decline in the number of breeding pairs and chicks in crèche at all colonies ***,the magnitude of change was higher at Stranger Point than that in the remaining ***,the index of breeding success,which was calculated as the ratio of chicks in crèche to breeding pairs,exhibited no apparent trend throughout the study ***,it displayed greater variability at martin Point compared to the other two colonies under *** the number of chicks in crèche of Adélie penguins showed a declining pattern,the average breeding performance was similar to that reported in gentoo penguin colonies,specifically,those undergoing a population increase(even in sympatric colonies facing similar local conditions).Consequently,it is plausible to assume a reduction of the over-winter survival as a likely cause of the declining trend observed,at least in the Stranger Point and Esperanza ***,we cannot rule out local effects during the breeding season affecting the Adélie population of martin Point.

关键词： long-term monitoring Adélie penguin breeding pairs chicks crèched breeding success population trends

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Autonomous Vehicle Platoons In Urban Road Networks:A Joint Distributed Reinforcement Learning and model Predictive Control Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 141-156页

作者： Luigi D’alfonso Francesco Giannini Giuseppe Franzè Giuseppe Fedele Francesco Pupo Giancarlo Fortino IEEE the Department of Computer Engineering ModelingElectronics and SystemsUniversitàdella CalabriaVia Pietro BucciCubo 42-CRende(CS)87036Italy the Department of mechanical Engineering Energy Engineering and ManagementUniversitàdella CalabriaVia Pietro BucciCubo 42-CRende(CS)87036Italy

In this paper, platoons of autonomous vehicles operating in urban road networks are considered. From a methodological point of view, the problem of interest consists of formally characterizing vehicle state trajectory tubes by means of routing decisions complying with traffic congestion criteria. To this end, a novel distributed control architecture is conceived by taking advantage of two methodologies: deep reinforcement learning and model predictive control. On one hand, the routing decisions are obtained by using a distributed reinforcement learning algorithm that exploits available traffic data at each road junction. On the other hand, a bank of model predictive controllers is in charge of computing the more adequate control action for each involved vehicle. Such tasks are here combined into a single framework:the deep reinforcement learning output(action) is translated into a set-point to be tracked by the model predictive controller;conversely, the current vehicle position, resulting from the application of the control move, is exploited by the deep reinforcement learning unit for improving its reliability. The main novelty of the proposed solution lies in its hybrid nature: on one hand it fully exploits deep reinforcement learning capabilities for decisionmaking purposes;on the other hand, time-varying hard constraints are always satisfied during the dynamical platoon evolution imposed by the computed routing decisions. To efficiently evaluate the performance of the proposed control architecture, a co-design procedure, involving the SUmO and mATLAB platforms, is implemented so that complex operating environments can be used, and the information coming from road maps(links,junctions, obstacles, semaphores, etc.) and vehicle state trajectories can be shared and exchanged. Finally by considering as operating scenario a real entire city block and a platoon of eleven vehicles described by double-integrator models, several simulations have been performed with the a

关键词： Distributed model predictive control distributed reinforcement learning routing decisions urban road networks

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Electrifying Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ) for focalized heating in oxygen transport membranes

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Journal of Energy Chemistry 2024年第4期91卷 99-110页

作者： marwan Laqdiem Julio García-Fayos Laura Almar alfonso J.Carrillo Álvaro Represa Josém.López Nieto Sonia Escolástico David Catalán-martinez Jose m.Serra Instituto de Tecnología Química(Universitat Politècnica de València–Consejo Superior de Investigaciones Científicas) Av.Los Naranjos s/nE-46022 ValenciaSpain

Industry decarbonization requires the development of highly efficient and flexible technologies relying on renewable energy resources,especially biomass and solar/wind *** the case of pure oxygen production,oxygen transport membranes(OTms)appear as an alternative technology for the cryogenic distillation of air,the industrially-established process of producing ***,OTms could provide oxygen from different sources(air,water,CO_(2),etc.),and they are more flexible in adapting to current processes,producing oxygen at 700^(-1)000℃.Furthermore,OTms can be integrated into catalytic membrane reactors,providing new pathways for different *** first part of this study was focused on electrification on a traditional OTm material(Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)),imposing different electric currents/voltages along a capillary *** to the emerging Joule effect,the membrane-surface temperature and the associated O_(2) permeation flux could be ***,the OTm is electrically and locally heated and reaches 900℃on the surface,whereas the surrounding of the membrane was maintained at 650℃.The O_(2)permeation flux reached for the electrified membranes was~3.7 NmL min^(-1)cm^(-2),corresponding to the flux obtained with an OTm non-electrified at 900℃.The influence of depositing a porous Ce_(0.8)Tb_(0.2)O_(2-δ) catalytic/protective layer on the outer membrane surface revealed that lower surface temperatures(830℃)were detected at the same imposed electric ***,the electrification concept was demonstrated in a catalytic membrane reactor(CmR)where the oxidative dehydrogenation of ethane(ODHE)was carried *** reaction is very sensitive to temperature,and here,we demonstrate an improvement of the ethylene yield by reaching moderate temperatures in the reaction chamber while the O_(2) injection into the reaction can be easily fine-tuned.

关键词： Oxygen permeation Oxidative dehydrogenation of ethane Oxygen transport membranes Joule effect mixed ionic-electronic conductors Catalytic membrane reactors

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measuring Impact of Lean manufacturing Tools for Continuous Improvement on Economic Sustainability

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 452-474页

作者： Luis Javier márquez Figueroa Jorge Luis García-Alcaraz Ahmed I.Osman alfonso Jesús Gil López Yashar Aryanfar mika Sillanpää mamdouh El Haj Assad Department of Electrical Engineering and Computer Science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Department of Industrial Engineering and manufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico School of Chemistry and Chemical Engineering Queens UniversityBelfastNorthern IrelandUK Department of Economic and managerial Sciences University of La RiojaLa RiojaSpain Department of Chemical Engineering University of JohannesburgJohannesburgSouth Africa Department of Sustainable and Renewable Energy Engineering University of SharjahSharjahUAE

Using Lean manufacturing(Lm)tools in production processes is crucial for companies’economic,environmental,and social sustainability *** study shows a structural equation model(SEm)that shows the relationship between Lm Tools like Kaizen(KAI),Gemba(GEm),Value Stream mapping(VSm)and Key Performance Indicator(KPI)with Economic Sustainability(ECS).Seven hypotheses were evaluated with data from 179 responses to a questionnaire about the mexican maquiladora industry,showing that these variables are *** a 95%confidence level,the model was evaluated using the partial least squares *** findings indicate that the relationships between KAI and GEm and KAI and VSm have the strongest relationship,followed by VSm and ECS;however,VSm has the strongest effect on *** on these findings,it is recommended that managers adopt a continuous improvement(KAI)approach based on working directly on the shop floor(GEm and VSm)to support their decisions regarding economic growth(ECS).

关键词： Lean manufacturing economic sustainability structural equation model quality improvement

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Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases

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Neural Regeneration Research 2024年第3期19卷 571-577页

作者： Sonia Irais Gonzalez-Cano Gonzalo Flores Jorge Guevara Julio Cesar morales-medina Samuel Treviño alfonso Diaz Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico Institute of Physiology Benemerita Autonomous University of PueblaPueblaMexico Department of Biochemistry Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico Animal Reproduction Research Center CINVESTAV-Autonomous University of TlaxcalaTlaxcalaMexico

Aging is a natural phenomenon characterized by a progressive decline in physiological integrity,leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases,including cardiovascular diseases,osteoporosis,cancer,diabetes,and *** is considered the major risk factor for Parkinson’s and Alzheimer’s disease ***,diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative ***,no treatment can effectively reverse these neurodegenerative ***,some antidiabetic drugs have opened the possibility of being used against neurodegenerative *** the previous framework,Vanadium species have demonstrated a notable antidiabetic *** research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic *** results suggest that these polyoxidovanadates induce neuronal and cognitive restoration *** review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain,constituting a therapeutic alternative for aging and neurodegenerative diseases.

关键词： Alzheimer’s disease antidiabetic brain cognition diabetes insulin neurodegeneration neuroinflammation oxidative stress Vanadium species

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Advanced Oxidation Wastewater Treatment of 3 LPS of an Avocado Sauce Company,at morelia,michoacan,mexico

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Journal of Environmental Science and Engineering(A) 2024年第5期13卷 151-155页

作者： alfonso Espitia-Cabrera Francisco Javier Barrón-Santos JoséL.méndez-Antonio Héctor m.Alemán-Vásquez Omar G.Color-Vázquez Saneamiento y Planeación Ambiental Azcapotzalco CDMX 02200México Energy Department Metropolitan Autonomous University Azcapotzalco CampusCDMX 02200Mexico Environmental System Engineering Department Environmental Engineering AcademyNational School of Biological SciencesNational Polytechnic InstituteCiudad de MéxicoCDMX 07738México Planta Congeladora y Empacadora Nacional Morelia 58190MichoacánMéxico

This paper describes the wastewater treatment of 3 liters per second of capacity of discharges of capacity,from the avocado washed,as well as the production of avocado *** were pretreated with a grease and oil trap and contained small amounts of oil and grease,dissolved and total solids,organic matter and trace of organic and inorganic compounds from the vitamins and minerals of *** treatment train is located in an small surface and the train is integrated with coagulation in line with alumina in a static mixer,rapid filtration in two steps,double advanced oxidation with ozone and heterocyclic photocatalysis with a nanofilm of zinc oxide as,photocatalyzer and final adsorption of refractory compounds with activated *** treated wastewater meets the environmental regulation to urban sewerage discharges of the city,according to the results of a mexican Certified Laboratory.

关键词： Wastewater primary treatment rapid filter performance static mixer

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microstructures and mechanical properties of laser-directed energy deposited CrCoNi medium-entropy alloy

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Rare metals 2024年第7期43卷 3286-3300页

作者： Wen-Jie Zhao Chang-Yu Liu Peng-Cheng Che Zhi-Liang Ning Hong-Bo Fan Jian-Fei Sun Yong-Jiang Huang alfonso H.W.Ngan National Key Laboratory for Precision Hot Processing of metals Harbin Institute of TechnologyHarbin 150001China Space Environment Simulation Research Infrastructure Harbin Institute of TechnologyHarbin 150001China Department of mechanical Engineering The University of Hong KongHong Kong 999077China

The distinctive intrinsic heat treatment(IHT)originating from cyclic reheating in the laser-directed energy deposition(LDED) has attracted growing attention in recent *** this investigation,simulations and experimental characterizations were performed to examine the impact of IHT on the micros true ture and mechanical properties of LDED-fabricated CrCoNi medium-entropy alloy(mEA).The results show that the intensity of the IHT is proportional to the utilized laser energy density(LED).As the LED increased,significant dynamic recrystallization and grain refinement occurred within the alloy due to the enhanced intensity of ***,the high LED leads to severe hot cracking within the as-built mEA,resulting in inferior *** decreasing LED,the hot cracking was effectively ***,low LED weakened the intensity of IHT and consequently inhibited kinetic conditions of dynamic recrystallization,resulting in a heterogeneous grain structure characterized by multi-scale-sized *** structure provides significant hetero-deformation-induced hardening during plastic deformation,enabling the alloy to have a sustainable work-hardening *** expect that this work will have implications in taking full advantage of the unique IHT of the LDED process to fabricate mE As with excellent metallurgical quality and mechanical performance.

关键词： Intrinsic heat treatment Laser-directed energy deposition CrCoNi mEA Dynamic recrystallization Heterogeneous grain structure

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