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Step-by-Step Building of a Four Dimensional Fatigue Compatible Regression Model including Frequencies

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Open Journal of Statistics 2021年第6期11卷 1072-1096页

作者： Enrique Castillo alfonso fernández-Canteli Sergio Blasón Golta Khatibi Bernhard Czerny Mohammad Zareghomsheh Spanish Royal Academy of Engineering Madrid Spain Spanish Royal Academy of Sciences Madrid Spain Department of Construction and Engineering Manufacturing Polytechnic School of Gijón University of Oviedo Campus de Viesques Asturias Spain Bundesanstalt für Materialforschung und Prüfung (BAM) Berlin Germany Department 9-Component Safety Division 9.4 Weld Mechanics Berlin Germany Christian Doppler Laboratory for Lifetime and Reliability of Interfaces in Complex Multi-Material Electronics Chemical Technologies and Analytics Vienna Austria

The purpose of this research is to develop a model, with emphasis on compatibility conditions and model building, valid for high cycle fatigue design components such as wind turbines, automobiles, high speed railways and aeronautical material. In this work, we have added the frequency as one more variable to an existing fatigue model that already includes maximum stress, stress ratio and lifetime. As a result, a model and estimation method has been proposed and a random variable V has been identified, which, allows the accumulated damage and the probability of failure to be assessed for any load history in terms of stress levels, stress ranges and frequencies. Finally, the model is validated using a large set of real experimental data.

关键词： Compatibility Conditions Cumulative Damage Frequency Effect Functional Equations Regression Model

Grafting effects on bioactive compounds,chemical and agronomic traits of‘Corbarino’tomato grown under greenhouse healthy conditions

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Horticultural Plant Journal 2023年第2期9卷 273-284页

作者： Mario Parisi alfonso Pentangelo Antonietta D’Alessandro Giovanna Festa Gianluca Francese Alejandra Navarro Vincenzo Onofaro Sanajà Giuseppe Mennella CREA Research Centre for Vegetable and Ornamental Crops Via Cavalleggeri 25PontecagnanoSA 84098Italy

In tomatoes,grafting onto resistant rootstocks represents an effective strategy to control several soil-borne diseases that reduce crop profitability,especially for landraceswith little or no resistance tomultiple pathogens/*** this study,the high-value‘Corbarino’tomato landrace was grafted onto seven commercial Solanum interspecific rootstocks to evaluate graft compatibility,yield performance,and qualitative characteristics under greenhouse healthy *** rootstocks were themost effective in improving fruit yield without negatively affecting the carpometric,technological,and health-related traits of the traditional tomato.‘Dinafort’rootstock increased fresh and dry yield,harvest index,and fruit/clusters,while mean fruit weight,shape index,total and soluble solid content,simple sugars,organic acids,flavonoids,ascorbic acid,and trans-lycopene content did not differ with respect to the ungrafted‘Corbarino’.‘Interpro’rootstock also showed promising results for the overall yield and quality traits,although it reduced the trans-lycopene content in the fruit.‘Silex’rootstock showed the highest harvest index as result of decreased *** fruit quality induced by‘Silex’was satisfactory and high levels of simple sugars,flavonoids,ascorbic acid,and trans-lycopene were also ***,graft success,especially for‘Dinafort’and‘Silex’,needs to be improved by investigating more suitable methods for seedling production,grafting,acclimatization,etc.

关键词： Solanum lycopersicum L Local variety Yield Graft compatibility Sugars Organic acids Health-related compounds

In vitro polymerization of the dopamine-borate melanin precursor:A proof-of-concept regarding^(10)boron neutron-capture therapy for melanoma

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BIOCELL 2023年第4期47卷 919-928页

作者： JUAN C.STOCKERT SILVINA A.ROMERO MARCELO N.FELIX-POZZI alfonso BLÁZQUEZ-CASTRO Instituto de Oncología“Angel H.Roffo” Área InvestigaciónFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresC1417DTBArgentina Centro Integrativo de Biología y Química Aplicada Universidad Bernardo O’HigginsSantiago8370854Chile Departamento de Micro y Nanotecnología Instituto de Nanociencias y NanotecnologíaCentro Atómico ConstituyentesComisión Nacional de Energía AtómicaBuenos AiresCP 1650Argentina Departamento de Biología Universidad Autónoma de MadridMadrid28049Spain

The^(10)boron neutron-capture therapy(BNCT)is an emerging antitumoral method that shows increasing biomedical *** is based on the selective accumulation of the^(10)boron isotope within the tumor,which is then irradiated with low-energy thermal neutrons,generating nuclear fission that produces 7lithium,4helium,andγ*** catechol-borate esters have been rather overlooked as precursors of melanin biosynthesis,and therefore,a proof-of-concept approach for using dopamine-borate(DABO)as a suitable boron-containing candidate for potential BNCT is presented *** can spontaneously oxidize and autopolymerize in vitro,giving a soluble,eumelaninlike brown-black poly-DABO *** melanoma cell cultures treated with 1 mM DABO for 24 and 48 h were viable and showed no signs of damage or cell *** stability and possible trans-esterification of DABO is shortly *** calculations and quantitative structure-activity relationships(QSAR)analysis of DABO and the BNCT agent BPA indicated that they should be cell permeant and accumulate within lysosomes and *** modeling allows visualization of both the DABO precursor and the structure of a borate derivative of the proposed catechol-porphycene model for eumelanin,showing interesting features from molecular orbital *** main difference between DABO and other agents,such as BPA,is that it is not a boronic acid nor a boron *** simple catechol-borate ester(protected from oxidation and blackening)could be administrated to living cells and organisms,in which biosynthesis of boron-melanin in melanoma melanocytes can lead to improved BNCT.

关键词： ^(10)Boron Borate esters Catechols Dopamine Eumelanin Melanoma

Ecological distribution and population structure of Litsea glaucescens(Lauraceae)in the ravines of Sierra Fría and Sierra Laurel,Central Mexico

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Journal of Mountain Science 2022年第7期19卷 1945-1960页

作者： Mara Irais FLORES-GALLEGOS Edmundo GARCIA-MOYA Angelica ROMERO-MANZANARES Mario LUNA-CAVAZOS Martin alfonso MENDOZA-BRISENO Heike VIBRANS Posgrado en Botánica Colegio de PostgraduadosCampus Montecillo.Km 36.5carretera México-TexcocoMontecilloTexcocoEdo.de México56230México Colegio de Postgraduados Campus Veracruz.Carretera Jalapa Veracruz Km 88.5Altamirano91690VeracruzMéxico

Litsea glaucescens Kunth(Mexican bay leaf,laurel)has a wide distribution in Mexico,growing at both riparian and rupicolous environments in the mountainous region of the Central Highlands of the *** Fría-Sierra Laurel is a protected natural area covered by a dry *** Mexican bay leaf is associated with the oak forest,especially on *** species has been considered at risk in recent *** research is focused on analyzing the elements of the environment of the ravines,which are influencing the distribution and establishment of laurel populations in the *** mountainous regions of Aguascalientes were selected,Sierra Fría and Sierra *** ravines of the basin were selected to obtain environmental *** registered were topographic,edaphic,and *** component analysis was used to identify ecological factors associated with the presence of *** bay leaf populations were registered in 10 *** the structural level in the community,29 woody species were registered,Mexican bay leaf had an Importance Value Index of 15.8,ranking 10th among all *** of laurel were classified by size classes(S,individuals with heights ranging from 0 to 20 cm;S,heights ranging from 0.2 to 1.0 m;S,heights between 1 and 2 m with light trace of flowering;S,heights greater than 2 m with flowering greater than 30% of the canopy;and S,individuals with heights greater than 5 m,curved trunk and basal regrowth)to obtain the population *** importance index value for all the species in the riparian community was calculated to the community *** factors that characterized the presence of Mexican bay leaf were a high percentage of rock coverage(90%),less mulch depth,and sandy loam shallow *** that showed higher cation exchange capacity had a higher presence of individuals of the S,S,and Ssize *** Sindividuals were found in shady places with 97% of intercepted *** o

关键词： Dry Forest Ephemeral stream Importance Value Index Mexican bay leaf Population structure Principal Component Analysis

Effectiveness of statins *** on reducing postprandial hypertriglyceridemia in dyslipidemic population:A systematic review and network meta-analysis

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Journal of Sport and Health Science 2022年第5期11卷 567-577页

作者： Laura Alvarez-Jimenez alfonso Moreno-Cabanas Miguel Ramirez-Jimenez Felix Morales-Palomo Juan FOrtega Ricardo Mora-Rodriguez Exercise Physiology Lab at Toledo Sports Science DepartmentUniversity of Castilla-La ManchaToledo 45004Spain

Background:Individuals at risk of suffering cardiovascular disease(CVD) present with larger increases in blood trigyceride(TG) concentration after a high-fat meal than do healthy *** postprandial hypertriglyceride levels are an independent risk factor for *** of statins and a bout of prolonged exercise are both effective in lowering postprandial hypertriglyceride *** aimed to evaluate the comparative effectiveness of statins vs.a bout of aerobic exercise in reducing fasting and postprandial TG(PPTG) concentrations in indiv、duals at high nsk of developing ***:Thirty-seven sltudies from a systematic literature search of the PubMed,EMBASE,and Cochrane databases were included in this *** selected studies conducted trials involving statin therapy(n=20) or a bout of aerobic exercise(n=19) and measured their impact on PPTG levels as the *** studies analyzed both treatments and were included in *** meta-analysis was constructed using a random-effects model to calculate the mean difference(MD).The Student t test was used to compare the data sets for statins ***:Overall,statin and exercise interventions showed similar reductions in PPTG levels,with an MD of-0.65 mmol/L for statins(95% confidence interval(95%CI):-0.54 to-0.77;p <0.001) and-0.46 mmol/L for exercise(95%CI:-0.21 to-0.71;p <0.01).However,statins lowered fasting TG levels more than exercise(MD=-1.54 mmol/L,95%CI:-2.25 to-0.83;p=0.009).Conclusion:Although aerobic exercise is effective in lowering blood TG levels,statins seem to be more efficient,especially in the fasted state.A combination of exercise and statins might reveal a valuable approach to the treatment and prevention of *** studies are required to determine the underlying mechanisms and the possible additive effects of these interventions.

关键词： Aerobic exercise Cardiovascular disease Hydroxymethylglutaryl-CoA reductase inhibitor Meta-analysis Metabolic syndrome

Thyroid Metastases from Clear Cell Renal Carcinoma: Presentation of an Unusual Case and Literature Review

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Journal of Cancer Therapy 2017年第11期8卷 941-947页

作者： Rafael Cholvi Calduch Raquel alfonso-Ballester Clara Alfaro-Cervelló Norberto Cassinello fernández Joaquín Ortega Serrano Departments of Surgery Clinic University Hospital of Valencia Valencia Spain Departments of Pathology Clinic University Hospital of Valencia Valencia Spain

Clear cell type renal cell carcinoma is a malignant tumor that can metastasize to many locations, but unusually spreads to thyroid. Therefore it is important to know the oncological background of the patient and to perform a complete immunohistochemical analysis of the thyroid lesion to obtain a correct diagnosis. Thyroidectomy can be considered in patients with no other metastasis or in those who present compressive symptoms as a palliative measure. We expose the case of a patient with clear cell type renal cell carcinoma, with a previously known bone metastasis of renal origin and symptomatic goiter containing a nodule that was found to be a metastasic lesion.

关键词： Clear Cell Type Renal Cell Carcinoma Thyroid Metastasis Immunohistochemistry Thyroidectomy

Anaerobic Biotransformation of Nitro-Compounds to Amines by Bovine Rumen Fluid

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Green and Sustainable Chemistry 2011年第3期1卷 47-53页

作者： alfonso Rodríguez Ignacio Irazoqui Guzmán álvarez Cecilia Cajarville José Luis Repetto Mercedes gonzález Hugo Cerecetto 不详

Microorganims of the bovine rumen fluid biocatalyzed the reduction of nitro-compound substrates to yield the respective amines. This enzymatic process, using ruminal contents, has rarely been reported in associa- tion with the bioreduction of nitro groups. The biotransformation reactions catalyzed by this system were de- pendent of both the electronic characteristics and the area/volume of the nitro-substrates confirming the processes are enzymatic. The semi-preparative scale biotransformation went by in good yield showing the rumen fluid may be employed in the synthesis of amines under very mild conditions and, moreover, it may have application in the bioremediation of nitro-compounds.

关键词： Biotransformation Nitro-Compounds Amines Rumen Ruminal Fluid Bovine

Beneficial effects of deep cryogenic treatment on mechanical properties of additively manufactured high entropy alloy:cyclic vs single cryogenic cooling

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Journal of Materials Science & Technology 2022年第20期115卷 40-51页

作者： Hongge Li Wenjie Zhao Tian Chen Yongjiang Huang Jianfei Sun Ping Zhu Yunzhuo Lu alfonso H.W.Ngan Daqing Wei Qing Du Yongchun Zou School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Engineering Dalian Jiaotong UniversityDalian 116028China Department of Mechanical Engineering The University of Hong KongHong KongChina Center of Analysis Measurement and Computing Harbin Institute of TechnologyHarbin 150001China

Additively manufactured(AM)metallic materials commonly possess substantial tensile surface residual stress,which is detrimental to the load-bearing service ***,we demonstrated that deep cryogenic treatment(DCT)is an effective method for improving the tensile properties of CoCrFeMnNi high-entropy alloy(HEA)samples fabricated by laser melting deposition(LMD),by introducing high compressive residual stress and deformation microstructures without destroying the AM ***,carrying out the DCT in a single-step mode does not improve the residual stress gradients inherent from the LMD process,which are undesirable as the mechanical properties will not be homogeneous within the *** this work,we show that carrying out the DCT in a cyclic mode with repeated cryogenic cooling and reheating can significantly homogenize the residual stress in LMD-fabricated Co Cr Fe Mn Ni HEA,and improve tensile strength and ductility,compared with single-step DCT of the same cryogenic soaking *** cyclic DCT,the thermal stress is re-elevated to a high value at each cryogenic cooling step,leading to the formation of denser and more intersecting reinforcing crystalline defects and hcp phase transformation,compared to single-step DCT of the same total cryogenic soaking duration in which the thermal stress relaxes towards a low value over *** enhancement of defect formation in the cyclic mode of DCT also leads to more uniform residual stress distribution in the sample after the *** results here provide important insights on optimizing DCT processes for post-fabrication improvement of mechanical properties of AM metallic net shapes.

关键词： Additive manufacturing High entropy alloy Deep cryogenic treatment Residual stress Mechanical properties

Congenital Absence of Pericardium:The Largest Systematic Review in the Field on 247 Worldwide Cases(1977-Now)

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Congenital Heart Disease 2023年第6期18卷 595-610页

作者： Pier Paolo Bassareo Aurelio Secinaro Paolo Ciliberti Massimo Chessa Marco alfonso Perrone Kevin Patrick Walsh Colin Joseph Mcmahon Mater Misericordiae University Hospital National Adult Congenital Heart Disease ServiceDublinD07 R2WYIreland Children’s Health Ireland Crumlin DublinIreland School of Medicine University College of DublinDublinIreland Advanced Cardiovascular Imaging Unit Bambino GesùChildren’s HospitalIRCCSRomeItaly Department of Cardiac Surgery CardiologyHeart and Lung Transplantation Bambino Gesu’Children’s HospitalIRCCSRomeItaly Adult Congenital Heart Disease UNIT Paediatric and Adult Congenital Heart CentreIRCCS-Policlinico San DonatoSan Donato MilaneseMilanItaly School of Medicine Vita Salute San Raffaele UniversityMilanItaly Division of Cardiology and CardioLab Department of Clinical Sciences and Translational MedicineUniversity of Rome Tor VergataRomeItaly

Background:Congenital absence of pericardium(CAP),also known as pericardial agenesis,represents an uncommon cardiac abnormality and mostly incidental *** can be subdivided into complete and partial(left or right-sided)*** of its infrequency,just case reports and a few case series have been released so *** paper represents the largest systematic review in the *** features(age at diagnosis,type,gender,clinical presentation,electrocardiography,imaging(ultrasounds,CT/MRI),concomitant cardiac defects,and outcome)were ***:The electronic database PubMed was investigated from its establishment up to July 15th,*** case reports and case series were *** studies,papers that were not in English,Spanish,and Italian,and those manuscripts not reporting at least seven of the nine analysed *** ruled *** analysed data were reported mostly in terms of ***:One hundred eighty studies were included encompassing 247 *** than half of reviewed CAP cases were in males(63.2%).The mean age at diagnosis was 31.8±19.3 years;a range of 32 weeks of gestation-81 years).23.5%of the patients did not report any *** most common clinical presentations were chest pain(35.2%)and dyspnoea(29.2%).The most commonly seen ECG changes were right axis deviation(28.7%)and right bundle branch block(23.9%).CAP was suspected or diagnosed by echocardiography in 20.1%of *** diagnosis was made by CT and/or MRI in 61.9%of *** was left-sided in 71.2%,complete in 23.1%,and right-sided in 5.7%.A concomitant congenital heart defect was found in 22.7%,especially in the form of atrial septal defect(6.5%)and patency of ductus arteriosus(2.8%).The pericardial repair was required in 12.9% of the incomplete forms of the *** did the complete form require surgical *** outcome appeared favourable in the vast majority of cases,with just 18 deaths(7.3%).Discussion:The main limitation of this syste

关键词： Congenital absence pericardium pericardial agenesis electrocardiography echocardiography computed tomography cardiac magnetic resonance imaging