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Dietary supplementation of zinc oxide modulates intestinal functionality during the post-weaning period in clinically healthy piglets

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journal of Animal Science and Biotechnology 2024年第1期15卷 313-328页

作者： Dirkjan Schokker Soumya K.Kar Els Willems Alex Bossers Ruud A.Dekker alfons j.m.j.nsman Wageningen Bioveterinary Research LelystadThe Netherlands Wageningen Livestock Research Wageningen University&ResearchWageningenThe Netherlands Royal Agrifirm Group ApeldoornThe Netherlands Institute for Risk Assessment Sciences Utrecht UniversityUtrechtThe Netherlands

Background To improve our understanding of host and intestinal microbiome interaction,this research investigated the effects of a high-level zinc oxide in the diet as model intervention on the intestinal microbiome and small intestinal functionality in clinically healthy post-weaning *** study 1,piglets received either a high concentration of zinc(Zn)as zinc oxide(Zn O,Zn,2,690 mg/kg)or a low Zn concentration(100 mg/kg)in the diet during the post weaning period(d 14–23).The effects on the piglet's small intestinal microbiome and functionality of intestinal tissue were *** study 2,the impact of timing of the dietary zinc intervention was investigated,i.e.,between d 0–14 and/or d 14–23 post weaning,and the consecutive effects on the piglet's intestinal functionality,here referring to microbiota composition and diversity and gene expression *** Differences in the small intestinal functionality were observed during the post weaning period between piglets receiving a diet with a low or high concentration Zn O content.A shift in the microbiota composition in the small intestine was observed that could be characterized as a non-pathological change,where mainly the commensals *** the immediate post weaning period,i.e.,d 0–14,the highest number of differentially expressed genes(DEGs)in intestinal tissue were observed between animals receiving a diet with a low or high concentration Zn O content,i.e.,23 DEGs in jejunal tissue and 11 DEGs in ileal *** genes are involved in biological processes related to immunity and inflammatory *** example,genes CD59 and REG3G were downregulated in the animals receiving a diet with a high concentration Zn O content compared to low Zn O content in both jejunum and ileum *** the second study,a similar result was obtained regarding the expression of genes in intestinal tissue related to immune pathways when comparing piglets receiving a diet with a high concentration Zn O con

关键词： Immune system Intestinal functionality microbiota Piglets Zinc oxide

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The effects of starter microbiota and the early life feeding of medium chain triglycerides on the gastric transcriptome profile of 2-or 3-week-old cesarean delivered piglets

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journal of Animal Science and Biotechnology 2018年第1期9卷 196-207页

作者： Paolo Trevisi Davide Priori Vincenzo motta Diana Luise alfons j.m.j.nsman Sietse-jan Koopmans Paolo Bosi DISTAL University of Bologna Viale Fanin 46 40127 Bologna Italy Wageningen University and Research Wageningen The Netherlands

Background： The stomach is an underestimated key interface between the ingesta and the digestive system, affecting the digestion and playing an important role in several endocrine functions. The quality of starter microbiota and the early life feeding of medium chain triglycerides may affect porcine gastric maturation. Two trials（T1, T2） were carried out on 12 and 24 cesarean-delivered piglets（birth, d0）, divided over two microbiota treatments, but slaughtered and sampled at two or three weeks of age, respectively. All piglets were fed orally： sow serum（T1） or pasteurized sow colostrum（T2） on d0; simple starter microbiota（Lactobacillus amylovorus, Clostridium glycolicum and Parabacteroides spp.）（d1-d3）; complex microbiota inoculum（sow diluted feces, CA） or a placebo（simple association, SA）（d3-d4） and milk replacer ad libitum（d0-d4）. The The T1 piglets and half of the T2 piglets were then fed a moist diet（CTRL）; the remaining half of the T2 piglets were fed the CTRL diet fortified with medium chain triglycerides and 7% coconut oil（mCT）. Total m RNA from the oxyntic mucosa was analyzed using Affymetrix？Porcine Gene array strips. Exploratory functional analysis of the resulting values was carried out using Gene Set Enrichment ***： Complex microbiota upregulated 11 gene sets in piglets of each age group vs. SA. Of these sets, 6 were upregulated at both ages, including the set of gene markers of oxyntic mucosa. In comparison with the piglets receiving SA, the CA enriched the genes in the sets related to interferon response when the CTRL diet was given while the same sets were impoverished by CA with the mCT ***： Early colonization with a complex starter microbiota promoted the functional maturation of the oxyntic mucosa in an age-dependent manner. The dietary fatty acid source may have affected the recruitment and the maturation of the immune cells, particularly when the piglets were early associated with a simplified starter microbiota.

关键词： Development microbiota Pig Stomach Transcriptome

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Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers

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journal of Animal Science and Biotechnology 2020年第4期11卷 1026-1032页

作者： Soumya K.Kar Bart van der Hee Linda m.P.Loonen Nico Taverne johanna j.Taverne-Thiele Dirkjan Schokker mari A.Smits alfons j.m.j.nsman jerry m.Wells Host microbe Interactomics Group Wageningen University&ResearchDe Elst 16708 WD WageningenThe Netherlands Laboratory of microbiology Wageningen University&ResearchStippeneng 46708 WE WageningenThe Netherlands Wageningen Livestock Research Wageningen University&ResearchDe Elst 16708 WD WageningenThe Netherlands

Here, we describe the use of monolayers of intestinal epithelial cells derived from intestinal organoids and transcriptomics to investigate the direct effects of dietary protein sources on epithelial function. mechanically dissociated 3 D organoids of mouse duodenum were used to generate a polarized epithelium containing all cell types found in the tissue of origin. The organoid-derived cell monolayers were exposed to 4%(w/v) of ‘undigested(non-hydrolysed)-soluble' fraction of protein sources used as feed ingredients [soybean meal(SBm) and casein], or alternative protein sources(spray dried plasma protein, and yellow meal worm), or controls for 6 h prior to RNA isolation and transcriptomics. All protein sources altered expression of unique biological processes in the epithelial cells. Exposure of intestinal organoids to SBm downregulated expression of retinol and retinoid metabolic processes as well as cholesterol and lipid biosynthetic pathways, consistent with the reported hypotriglyceridaemic effect of soy protein in vivo. These findings support the use of intestinal organoids as models to evaluate complex interactions between dietary ingredients and the intestinal epithelium and highlights some unique host effects of alternative protein sources in animal feed and potentially human food.

关键词： Alternative protein sources Casein Intestinal organoids Organoids Soybean meal Spray dried plasma protein Transcriptomics Yellow meal worm

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On the diversity of fungi from soda soils

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Fungal Diversity 2016年第1期76卷 27-74页

作者： Alexey A.Grum-Grzhimaylo marina L.Georgieva Sofiya A.Bondarenko alfons j.m.Debets Elena N.Bilanenko Laboratory of Genetics Plant Sciences GroupWageningen UniversityDroevendaalsesteeg 16708 PB WageningenThe Netherlands Gause Institute of New Antibiotics Federal State Budgetary Scientific InstitutionBol’shaya Pirogovskaya 11119021 MoscowRussia Faculty of Biology Lomonosov Moscow State UniversityLeninskie Gory 1-12119234 MoscowRussia

The diversity of filamentous fungi that can grow at high ambient pH values(i.e.,8–11)remains largely *** we study 100 alkalitolerant and alkaliphilic isolates from the soils around the basin of soda lakes in Asia and Africa to assess the major evolutionary lineages and morphologies pertinent to the alkaliphilic trait in filamentous *** Emericellopsis lineage(Hypocreales,Hypocreomycetidae),along with Plectosphaerellaceae(Hypocreomycetidae),Pleosporaceae(Dothideomycetes),Chaetomiaceae(Sordariomycetidae)families appeared to be overrepresented with strong alkalitolerants and effective *** particular,Sodiomyces species(Plectosphaerellaceae),Acrostalagmus luteoalbus(Plectosphaerellaceae),Emericellopsis alkalina(Hypocreales),Thielavia sp.(Chaetomiaceae),and Alternaria ***(Pleosporaceae)grew best at high ambient *** pH tolerance of Chordomyces antarcticum,Acrostalagmus luteoalbus and some other species was largely affected by the presence of extra Na+in the growth *** alkalitolerants included Scopulariopsis members(microascales),Fusarium,Cladosporium,and many asexual acremonium-like species from *** alkalitolerants were represented by sporadic isolates of Penicillium,Purpureocillium lilacinum,and Alternaria alternata species,with the growth optimum at neutral or acidic *** alkalitolerants develop loose dry chains of spores easily dispersed by *** presence at low frequency with the growth optimum at neutral or acidic pH leads us to treat them as transient species in the alkaline soils,as those are also ubiquitous saprobes in normal *** phylogenetic analyses show that the alkaliphilic trait in filamentous fungi has evolved several *** lineages harboring strong alkalitolerants derived from the known marine-borne fungi(Emericellopsis,Alternaria ***),or fall within the fungi associated with halophytic grasses(Pleosporaceae).Soda soils contain a diversity of fungi that ra

关键词： Alkaliphilic fungi pH Soda soils Extremophile Sodiomyces Acrostalagmus Chordomyces Verticillium Emericellopsis Acremonium Scopulariopsis Alternaria Thielavia Plectosphaerellaceae Pleosporaceae

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Dietary supplementation of zinc oxide modulates intestinal functionality during the post-weaning period in clinically healthy piglets

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畜牧与生物技术杂志(英文版) 2024年第1期

作者： Dirkjan Schokker Soumya K.Kar Els Willems Alex Bossers Ruud A.Dekker alfons j.m.j.nsman

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Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers.

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畜牧与生物技术杂志(英文版) 2020年第4期

作者： Soumya K.Kar Bart van der Hee Linda m.P.Loonen Nico Taverne johanna j.Taverne-Thiele Dirkjan Schokker mari A.Smits alfons j.m.j.nsman jerry m.Wells

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超体质量减肥手术后的体形塑造：手术花费如何？

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中国美容整形外科杂志 2013年第7期24卷 I0023-I0023页

作者： Alyssa j. Reiffel Natalia jimenez Yoann H. millet Briar L. Dent Nikola Lekic Whitney A. Burrell alfons L. Pomp Gregory F. Dakin jason A. Spector 朱丽娜(译) 魏峰(译) 高景恒(译) 张晨(译) 不详《中国美容整形外科杂志》编辑部大连大学附属新华医院

前言在美国，每年进行的超体质量减肥手术超过22万次．体质量大世减轻继而带来患者大量多余的皮肤、较差外观，进而导致生活质量下降。尽管我们已经知道超体质越减肥手术的频次，但是超体质量减肥手术后体形塑造患者的比例仍然未知。

关键词：超体质量减肥手术体形塑造手术后花费生活质量患者

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